Brandywine High School

Brandywine High School is a public secondary school located near Talleys Corner in unincorporated New Castle County, Delaware, with a Wilmington postal address. Although the school is not within the Wilmington city limits, it does serve some parts of the city north of the Brandywine River. It is a part of the Brandywine School District. Rebecca Reggio is the current principal of Brandywine High School.

Brandywine High School was established in 1958. Its building was designed by Wilmington architects Whiteside, Moeckel & Carbonell in the International Style and completed in 1959.

Brandywine is a member of the Delaware Interscholastic Athletic Association (DIAA). The Bulldogs compete in Flight B of the Blue Hen Conference with a full slate of teams in all three sports seasons:

Brandywine's sports include: cross country, field hockey, football, soccer, volleyball, cheerleading, basketball, swimming, wrestling, cheerleading, indoor track, baseball, softball, golf, lacrosse, tennis, and track and field.

In 2021, U. S. News & World Report ranked Brandywine #5,392 out of almost 24,000 public schools across the United States and Niche ranked it in the top 50% best public schools for athletes in New Castle County. The school was recognized by the Blue Ribbon Schools Program for the 1982–1983 school year.

First lady Jill Biden spoke from the classroom in which she formerly taught at the school (room 232) for her remote address to the 2020 Democratic National Convention. Biden's husband Joe Biden was in the high school at the moment he formally was nominated for president during the convention.