David Botstein

American biologist

David Botstein (born September 8, 1942) is an American biologist who is the chief scientific officer of Calico. He was the director of the Lewis Sigler Institute for Integrative Genomics at Princeton University from 2003 to 2013, where he remains an Anthony B. Evnin Professor of Genomics.

Botstein graduated from the Bronx High School of Science in 1959, and Harvard University in 1963. He started his Ph. D. work under Maurice Sanford Fox at the Massachusetts Institute of Technology, then moved and received a Ph. D. from the University of Michigan in 1967 for work on P22 phage.

Botstein taught at the Massachusetts Institute of Technology, where he became a professor of genetics. Botstein joined Genentech, Inc. in 1987 as vice president – science. In 1990, he became chairman of the Department of Genetics at Stanford University. Botstein was elected to the U. S. National Academy of Sciences in 1981 and to the Institute of Medicine in 1993. Botstein is the director of the Integrated Science Program at Princeton University. In 1980, Botstein and his colleagues Ray White, Mark Skolnick, and Ronald W. Davis proposed a method for constructing a genetic linkage map using restriction fragment length polymorphisms that was used in subsequent years to identify several human disease genes including Huntington's and BRCA1. Variations of this method were used in the mapping efforts that predated and enabled the sequencing phase of the Human Genome Project. In 1998, Botstein and his postdoctoral fellow Michael Eisen, together with graduate student Paul Spellman and colleague Patrick Brown, developed a statistical method and graphical interface that is widely used to interpret genomic data including microarray data. This approach was refined and applied for diverse applications, including for a molecular classification of heterogenous tumors using gene expression. These efforts included work on discovery of tumor subtypes with Lou Staudt, Ash Alizadeh and Ronald Levy, yielding a refined classification of diffuse large B cell lymphomas, and in painting the molecular portraits for refined classification of breast cancers with Anne Lise Børresen Dale and Charles Perou. He has subsequently worked on the creation of the influential Gene Ontology with Michael Ashburner and Suzanna Lewis. He is one of the founding editors of the journal Molecular Biology of the Cell, along with Erkki Ruoslahti and Keith Yamamoto. In 2013, Botstein was named chief scientific officer of Google's anti aging health startup Calico.

Botstein has won the Eli Lilly and Company Award in Microbiology (1978), the Genetics Society of America Medal (1988, with Ira Herskowitz), In 2016, Semantic Scholar AI program included Botstein on its list of most top ten most influential biomedical researchers.

Botstein is an alumnus of Camp Rising Sun. He is the brother of the conductor Leon Botstein. Both of Botstein's parents were physicians.