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Somers Town is an inner city district in North West London. It has been strongly influenced by the three mainline north London railway termini: Euston (1838), St Pancras (1868) and King's Cross (1852), together with the Midland Railway Somers Town Goods Depot (1887) next to St Pancras, where the British Library now stands. It was named after Charles Cocks, 1st Baron Somers (1725–1806). The area was originally granted by William III to John Somers (1651–1716), Lord Chancellor and Baron Somers of Evesham. Historically, the name "Somers Town" was used for the larger triangular area between the Pancras, Hampstead, and Euston Roads, In 1830 the first on duty fatality for the newly founded Metropolitan Police occurred when PC Joseph Grantham was kicked to death while trying to break up a street fight in Smiths Place, Somers Town. The Polygon deteriorated socially as the surrounding land was subsequently sold off in smaller lots for cheaper housing, especially after the start of construction in the 1830s of the railway lines into Euston, St Pancras and King's Cross. In this period the area housed a large transient population of labourers and the population density of the area soared.

When St Luke's Church, near King's Cross, was demolished to make way for the construction of the Midland Railway's St Pancras station and its Midland Grand Hotel, the estimated 12,000 inhabitants of Somers Town at that time were deprived of that place of worship, as the church building was re erected in Kentish Town, though St Mary's remained and St Matthew's Oakley Square was added in 1856. In 1868 the lace merchant and philanthropist George Moore funded a new church, known as Christ Church and an associated school in Chalton Street with an entrance in Ossulston Street. The school accommodated about 600 children. Christ Church and the adjacent school were destroyed in a World War II bombing raid and no trace remains today, the site being occupied by a children's play area and sports court, with its parish transferred to Old Saint Pancras Church. By the late 19th century most of the houses in the Polygon were in multiple occupation, and overcrowding was severe with whole families sometimes living in one room, as confirmed by the social surveys of Charles Booth and Irene Barclay. Charles Dickens lived in the Polygon briefly as a child and knew the area well. The Polygon, where he once lived, appears in Chapter 52 of The Pickwick Papers (1836), when Mr Pickwick's solicitor's clerk, arriving at Gray's Inn just before ten o'clock, says he heard the clocks strike half past nine as he walked through Somers Town: "It went the half hour as I came through The Polygon." The building makes its appearance again in Bleak House (1852), when it served as the home of Harold Skimpole. In David Copperfield (1850), Johnson (now Cranleigh) Street was the thoroughfare near the Royal Veterinary College, Camden Town, where the Micawbers lived, when Traddles, David Copperfield's friend and schoolfellow, was their lodger. In A Tale of Two Cities (1859) Roger Cly, the Old Bailey informant, was buried in Old St Pancras Churchyard. The funeral over, later that night Jerry Cruncher and his companions went "fishing" (body snatching), trying unsuccessfully to 'resurrect' Cly. Robert Blincoe (1792–1860), on whose life story Oliver Twist (1838) may be based, was a child inmate at the St Pancras Workhouse. A central character in Dickens’ Our Mutual Friend (1865) is Nicodemus Boffin, nicknamed 'The Golden Dustman' because of the wealth he inherited from his old employer John Harmon, who had made his fortune as a dust contractor at Somers Town. An infirmary was added to the St Pancras Workhouse, adjacent to St Pancras Old Church in 1848, later becoming the St Pancras Hospital, the only hospital in the area not to have closed since 1980. Its current site includes buildings previously used by the Workhouse. St Mary's Dispensary (later the Elizabeth Garrett Anderson Hospital) opened at 144 Euston Road in 1866, followed by the National Temperance Hospital at 110 112 Hampstead Road in 1873.

Improvement of the slum housing conditions, amongst the worst in the capital, was first undertaken by St Pancras Borough Council in 1906 at Goldington Buildings, at the junction of Pancras Road and Royal College Street, and continued on a larger scale by the St Pancras House Improvement Society (subsequently the St Pancras & Humanist Housing Association, the present owner of Goldington Buildings) which was established in 1924. Its founders were Church of England priest Father Basil Jellicoe and Irene Barclay, the first woman in Britain to qualify as a chartered surveyor. The Society's Sidney Street and Drummond Street estates incorporated sculpture panels of Doultonware designed by Gilbert Bayes and ornamental finials for the washing line posts designed by the same artist: these are now mostly destroyed or replaced with replicas. The Hospital for Tropical Diseases moved onto the St Pancras Hospital site in 1948. Further social housing was built by the London County Council, which began construction of the Ossulston Estate in 1927. There remains a small number of older Grade 2 listed properties, mostly Georgian terraced houses. During the early 1970s the neighborhood comprising Greater London Council owned housing in Charrington, Penryn, Platt and Medburn Streets was a centre for the squatting movement.

In the 1980s, some council tenants took advantage of the 'right to buy' scheme and bought their homes at a substantial discount. Later they moved away from the area. The consequence was an influx of young semi professional people, resulting in a changing population. Somers Town experienced ethnic tension between whites and Bengalis in the early 1990s, climaxing in the murder of Richard Everitt in 1994. Major construction work along the eastern side of Somers Town was completed in 2008, to allow for the Eurostar trains to arrive at the refurbished St Pancras station. This involved the excavation of part of the St Pancras Old Churchyard, the human remains being re interred at St Pancras and Islington Cemetery in East Finchley. Land at Brill Place, previously earmarked for later phases of the British Library development, became available when the library expansion was cancelled and was used as site offices for the High Speed 1 terminal development and partly to allow for excavation of a tunnel for the new Thameslink station. It was then acquired as the site for the Francis Crick Institute (formerly the UK Centre for Medical Research and Innovation), a major medical research institute established by a partnership of Cancer Research UK, Imperial College London, King's College London, the Medical Research Council, University College London (UCL) and the Wellcome Trust.

A number of significant films have been set in Somers Town: the 1955 Ealing comedy The Ladykillers with Alec Guinness and Peter Sellers; Neil Jordan's Mona Lisa of 1986, featuring Bob Hoskins; Mike Leigh's 1988 film High Hopes; Anthony Minghella's 2006 romantic drama Breaking and Entering starring Jude Law and Juliette Binoche; and in 2008 Shane Meadows's Somers Town, which was filmed almost entirely in and around Phoenix Court, a low rise council property in Purchese Street. The area is mentioned in the Pogues song 'Transmetropolitan', the first song written by the band, who used to live nearby in St Pancras.

Somers Town has a flourishing street market, held in Chalton Street, Wednesday to Friday. The START (Somers Town Art) Festival of Cultures is held on the second Saturday in July, on the site of the market. It is the biggest street festival in the Camden borough and attracts about 10,000 people, bringing together the area's diverse cultural communities.

All the area's hospitals have closed since 1980, apart from St Pancras Hospital, whose large red brick building fronting the complex to the north of St Pancras Gardens is still residential, chiefly as a rehabilitation hospital for the elderly. Other buildings house the headquarters of Camden NHS Primary Care Trust. It also accommodates parts of Islington Primary Care Trust, the Huntley Centre (a mental health unit) and St Pancras Coroner's Court.

There are two secondary schools in the area, the Roman Catholic co educational Maria Fidelis Convent School FCJ in Phoenix Road, and the state Regent High School in Charrington Street. Regent High School was established in 1877 and has gone through several name changes, more recently as Sir William Collins Secondary School, then as South Camden Community School. Somers Town Community Sports Centre was built on part of the school playground. The building is leased to a charitable trust that is jointly managed by the school and UCL (UCL is based a few hundred metres to the south of Euston Road and is a major employer of local residents). It is used for 17% of available hours by UCLU's sports teams for training and home matches and for recreational sport by UCL students. As part of Building Schools for the Future plans to expand the school, it is probable that the sports centre will be reintegrated back into the school campus. There are also three primary schools: Edith Neville (state), St Aloysius (state aided Catholic) and St Mary and St Pancras (state aided Church of England). The latter has been built beneath Somerset Court, four floors of university student accommodation units. The children's charity Scene & Heard is also based in Somers Town. It offers a unique mentoring project that partners the inner city children of Somers Town with volunteer theatre professionals, providing each child who participates with quality one on one adult attention and an experience of personal success through the process of writing and performing plays.

The nearest London Underground stations are Mornington Crescent, Euston and King's Cross St Pancras. National Rail services operate from the nearby London King's Cross, London St Pancras and London Euston stations. St Pancras International is the terminus for Eurostar services and was the London terminus for the Javelin fast train service to London Olympic Park.