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Height in relation to a specified reference point

Altitude is a distance measurement, usually in the vertical or "up" direction, between a reference datum and a point or object. The exact definition and reference datum varies according to the context (e. g., aviation, geometry, geographical survey, sport, or atmospheric pressure). Although the term altitude is commonly used to mean the height above sea level of a location, in geography the term elevation is often preferred for this usage. Vertical distance measurements in the "down" direction are commonly referred to as depth.

Regions on the Earth's surface (or in its atmosphere) that are high above mean sea level are referred to as high altitude. High altitude is sometimes defined to begin at 8000 feet (2438 m) above sea level.

The temperature profile of the atmosphere is a result of an interaction between radiation and convection. Sunlight in the visible spectrum hits the ground and heats it. The ground then heats the air at the surface. If radiation were the only way to transfer heat from the ground to space, the greenhouse effect of gases in the atmosphere would keep the ground at roughly , and the temperature would decay exponentially with height. However, when air is hot, it tends to expand, which lowers its density. Thus, hot air tends to rise and transfer heat upward. This is the process of convection. Convection comes to equilibrium when a parcel of air at a given altitude has the same density as its surroundings. Air is a poor conductor of heat, so a parcel of air will rise and fall without exchanging heat. This is known as an adiabatic process, which has a characteristic pressure temperature curve. As the pressure gets lower, the temperature decreases. The rate of decrease of temperature with elevation is known as the adiabatic lapse rate, which is approximately 9.8 °C per kilometer (or per 1000 feet) of altitude. As an average, the International Civil Aviation Organization (ICAO) defines an international standard atmosphere (ISA) with a temperature lapse rate of 6.49 °C per kilometer (3.56 °F per 1,000 feet). The actual lapse rate can vary by altitude and by location. Finally, only the troposphere (up to approximately of altitude) in the Earth's atmosphere undergoes notable convection; in the stratosphere, there is little vertical convection.

Medicine recognizes that altitudes above start to affect humans, and there is no record of humans living at extreme altitudes above for more than two years. As the altitude increases, atmospheric pressure decreases, which affects humans by reducing the partial pressure of oxygen. The lack of oxygen above 8000 feet (2438 m) can cause serious illnesses such as altitude sickness, high altitude pulmonary edema, and high altitude cerebral edema. The higher the altitude, the more likely are serious effects. It can take days or weeks to adapt to high altitude. However, above , (in the "death zone"), altitude acclimatization becomes impossible. There is a significantly lower overall mortality rate for permanent residents at higher altitudes. Additionally, there is a dose response relationship between increasing elevation and decreasing obesity prevalence in the United States. In addition, the recent hypothesis suggests that high altitude could be protective against Alzheimer's disease via action of erythropoietin, a hormone released by kidney in response to hypoxia. However, people living at higher elevations have a statistically significant higher rate of suicide. The cause for the increased suicide risk is unknown so far. For endurance events (races of 5,000 metres or more) the predominant effect is the reduction in oxygen which generally reduces the athlete's performance at high altitude. Sports organizations acknowledge the effects of altitude on performance: the International Association of Athletic Federations (IAAF), for example, marks record performances achieved at an altitude greater than with the letter "A". Athletes also can take advantage of altitude acclimatization to increase their performance. The same changes that help the body cope with high altitude increase performance back at sea level. These changes are the basis of altitude training which forms an integral part of the training of athletes in a number of endurance sports including track and field, distance running, triathlon, cycling and swimming.

Decreased oxygen availability and decreased temperature make life at high altitude challenging. Despite these environmental conditions, many species have been successfully adapted at high altitudes. Animals have developed physiological adaptations to enhance oxygen uptake and delivery to tissues which can be used to sustain metabolism. The strategies used by animals to adapt to high altitude depend on their morphology and phylogeny. For example, small mammals face the challenge of maintaining body heat in cold temperatures, due to their small volume to surface area ratio. As oxygen is used as a source of metabolic heat production, the hypobaric hypoxia at high altitudes is problematic. There is also a general trend of smaller body sizes and lower species richness at high altitudes, likely due to lower oxygen partial pressures. These factors may decrease productivity in high altitude habitats, meaning there will be less energy available for consumption, growth, and activity. However, some species, such as birds, thrive at high altitude. Birds thrive because of physiological features that are advantageous for high altitude flight.