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Guyzance, historically Guizance, is a small village or hamlet and former civil parish, now in the parish of Acklington, in Northumberland, England. It is located on the River Coquet, roughly 6 miles south of Alnwick and around 3 miles west of Amble. Guyzance is one of only two places in Great Britain with a zance ending; the other is Penzance in Cornwall. The similar names are co incidence, however. In 1951 the parish had a population of 128.

The village consists of one small street of single storey facing cottages, and a number of scattered cottages, farms and large houses. Numbers 1, 2 and 4 are at the east end, on the north side of the street, and form a single terrace. They date from the 18th century, but were remodelled in the 19th century. There was formerly a fourth cottage, No. 3, but this has been incorporated into No. 4, and its front door blocked up. The left hand end wall of No. 4 includes two blind windows and there is a Victorian post box built into it. After two more recent cottages is the old school, which was probably originally a cottage, and is now the village rooms. It also dates from the 18th century, and was remodelled in 1852. Attached to the old school and the final building on the north side of the road is No. 5 and an adjoining former joiners shop, which were built and remodelled at similar times to numbers 1 to 4. Crossing to the south side of the road, No. 6 is opposite the old school, and has a similar history. After a gap, numbers 7 and 8 are opposite numbers 1 to 4. They were originally a row of three cottages, built and remodelled at the same time as the others, but reduced from three to two dwellings in the 20th century. To the rear of No. 8 are some 18th century outbuildings, with attached pigsties, privies and middens, which were altered in the 19th century. The main building contains three blacksmith's windows. All of the buildings and their associated garden walls are grade II listed. Guyzance Hall is a grade II listed structure. It was built as a farmhouse for Barnhill Farm around 1800, but was extended to become a country house in 1894, when the architect William Henry Knowles designed major extensions for the owner J D Milburn. This included a range with a ballroom, built in neo Tudor style, and the same style was used for a tower added in 1920. The hall, which sits in of land, has 15 bedrooms and was bought by the Rev. Robert Parker in 2008. It became a popular venue for weddings, and Parker sold it for around £6 million in 2016, only retaining a cottage in the grounds for his personal use. The estate has two lodges, and the west lodge, which was built to an "L"–shaped plan in the early 20th century is also grade II listed. It is a single storey building in free Tudor style, although parts of it have a basement. Some 130 feet (40 m) to the east is an arched bridge, built of rock faced stone with cast iron and wrought iron posts and chains. It was constructed at a similar time to the lodge, and carries the drive over Quarry Burn. To the south of the housing are the remains of a chapel. The nave dates from the 11th or 12th century, while the chancel dates from the 13th or 14th century. The floor of the building is covered with concrete paving added in the 19th century, and there is a memorial to the Tate family dated 1864. There was a Premonstratensian nunnery in the vicinity, founded by Richard Tison in the 12th century, but it had become disused by about 1500, and became a parochial curacy. It is unclear whether the ruins were part of the nunnery or not, as a monastery church and a church of Guyzance are mentioned in early documents, and the ruins could be either. In addition to being grade II* listed, the site is also a scheduled ancient monument. Guyzance Mill, a ruined 19th century water powered corn and feed mill is located on the west bank of the river, with a large dam built across the channel. The iron and timber undershot water wheel is internal to the building, but was probably external when the mill was built. The building has three storeys, and despite its condition, still has some stones, gearing and machinery in position. The present building is not the first on the site, as a mill at this location was documented in 1336, and it may have also been a fulling mill at one point. Some upstream from Guyzance Bridge, and just above the confluence of the Hazon Burn with the River Coquet, is a horseshoe dam built by the civil engineer John Smeaton in 1775. His clients were Edward Cook of Brainshaugh and John Archbold of Acton. The downstream face, which is 8 feet (2 m) high, is vertical and constructed of squared stone. The curved dam has a radius of 170 feet (52 m) and fed a millrace on the south bank of the river. The water powered Acklington Park Iron and Tin Works, but this did not last long, and John Reed converted the building into a woollen mill in 1791. It ceased to be used for this purpose in 1884, and was derelict until 1915, when Ellwood Holmes from Newcastle used it to make hydrate of alumina. It was one of the first factories to be powered by hydroelectricity, after Holmes had a Gilks water turbine fitted into the millrace. This operation was also fairly short lived, as the Duke of Northumberland refused to renew the lease in 1930 following pollution of the river. The building was converted into flats in 1968. The bridge at the eastern end of the site was built around 1865. It has three segmental arches, constructed of rock faced stone, and is also grade II listed. Around a mile north of the main street lies Bank House Farm. Originally a stone built 19th Century farm, the property was converted into a number of smaller residences in the 1990s. On the west side lies the original farmhouse and several smaller buildings, all of which have now been converted into twelve separate holiday lets. Over the road on the east side are a number of old outbuildings which, alongside some newer builds, now make up several permanent residences. Over the field to the east of the main farm also lies a row old agricultural workers houses, known as Bank House Cottages.

On 17 January 1945, ten soldiers drowned while taking part in a military exercise at Guyzance, on the River Coquet. The river was in full flood and their boat was swept over Smeaton's weir, after which it capsized. The men, all aged 18, were weighed down by full combat gear. In 1995, a memorial service was held to mark the 50th anniversary of the tragedy and a plaque was unveiled. The campaign for a memorial had been spearheaded by Burnett Seyburn, who had been a lance corporal at the time of the original tragedy, and Vera Vaggs, a Northumbrian historian. As well as raising money locally, they obtained support from the National Lottery, the War Graves Commission, local landowner Sir Anthony Milburn and the Asda supermarket chain.

Guyzance was formerly a township in Shilbottle parish, from 1866 Guyzance was a civil parish in its own right until it was abolished on 1 April 1955 and merged with Acklington.