Хромосома инверсиясы: түрлері, себептері және маңызы

Chromosome rearrangement in which a segment of a chromosome is reversed

An inversion is a chromosome rearrangement in which a segment of a chromosome becomes inverted within its original position. An inversion occurs when a chromosome undergoes a two breaks within the chromosomal arm, and the segment between the two breaks inserts itself in the opposite direction in the same chromosome arm. The breakpoints of inversions often happen in regions of repetitive nucleotides, and the regions may be reused in other inversions. Chromosomal segments in inversions can be as small as 1 kilobases or as large as 100 megabases. The number of genes captured by an inversion can range from a handful of genes to hundreds of genes. Inversions can happen either through ectopic recombination between repetitive sequences, or through chromosomal breakage followed by non homologous end joining. Inversions are of two types: paracentric and pericentric. Paracentric inversions do not include the centromere, and both breakpoints occur in one arm of the chromosome. Pericentric inversions span the centromere, and there is a breakpoint in each arm. Inversions usually do not cause any abnormalities in carriers, as long as the rearrangement is balanced, with no extra or missing DNA. However, in individuals which are heterozygous for an inversion, there is an increased production of abnormal chromatids (this occurs when crossing over occurs within the span of the inversion). This leads to lowered fertility, due to production of unbalanced gametes. Inversions do not involve either loss or gain of genetic information; they simply rearrange the linear DNA sequence.

Cytogenetic techniques may be able to detect inversions, or inversions may be inferred from genetic analysis. Nevertheless, in most species, small inversions go undetected. More recently, comparative genomics has been used to detect chromosomal inversions, by mapping the genome. Population genomics may also be used to detect inversions, using areas of high linkage disequilibrium as indicators for possible inversion sites. Human families that may be carriers of inversions may be offered genetic counseling and genetic testing.

The first evidence of a chromosomal inversion was found in 1921 by Alfred Sturtevant in Drosophila melanogaster. Since then, inversions have been found in a all eukaryotes. One of the more recent models of inversions is the Kirkpatrick and Barton Model (2006), which states that inversions are selectively advantageous by linking together adaptive alleles. By physically linking co adapted variants at multiple genes into distinct versions (haplotypes) of an inversion, selection should be more efficient in driving these variants to high frequency in a population. This is in contrast to non inverted regions, which may allow adaptive and maladaptive alleles to be carried.

When an inversion carrying chromosome is paired with a non inverted homologous chromosome (Inversion heterozygotes) during meiosis, they fail to synapse properly and inversion loops are formed. A crossing over within the loop can produce unbalanced gametes. In a paracentric inversion, recombination results in one dicentric chromatid and one acentric chromatid. During Anaphase, both recombinants are faced with problems. The acentric chromatid is pulled to one pole or the other, and the dicentric recombinant generates dicentric bridges as it is pulled in two directions. In a pericentric inversion, similar imbalanced chromosomes are produced. The recombinant chromosomes resulting from these crosses include deletions and duplications. The offspring produced by such gametes are mostly inviable, and therefore, recombination is indirectly suppressed within inverted regions. Chromosomal inversions have gained a lot of attention in evolutionary research due to their potential role in local adaptation and speciation. Because non recombining inversion haplotypes may harbor multiple co adapted gene variants, inversions are thought to facilitate local adaptation to different environments because natural selection is more efficient in driving such linked adaptive variants to high frequency within a population. However, empirically demonstrating the presence of linked, co adapted gene variants within inversions is difficult because inversion haplotypes do not recombine. Moreover, this possible positive effect of chromosomal inversions for adaptation to different environments rests on the assumption that adaptive gene variants linked into distinct inversion haplotypes are indeed co adapted. This idea is, however, likely violated in situations where populations experience spatially or temporally varying selection. Because of fluctuating selection on inversion linked variants, the absence of recombination between inversion haplotypes harboring distinct gene variants may then constrain rather than help adaptation to distinct environments. The importance of chromosomal inversions in adaptation to different environments therefore remains an open empirical problem in evolutionary genetics. Inversion polymorphism can be established in two ways. Genetic drift or selection can result in fixation of an inversion in a local population. Inversion polymorphism can result from gene flow between this population and a population without the inversion. Balancing selection can also result in inversion polymorphism by frequency dependence or overdominance. Inversions have been essential to sex chromosome evolution. In mammals, the Y chromosome is unable to recombine with the X chromosome, almost along its entire length. This non recombining portion results from a series of inversions that overlap. Decreased recombination rate between sex determining loci and sex anatagonistic genes is favored by selection. This causes linkage disequilibrium between the male determining locus and an allele at another locus that is beneficial to males. This can happen through inversions resulting in a non recombining block including both loci, as is the case in the mammalian Y chromosome. Inversions can be involved in speciation in multiple ways. Since heterozygote inversions can be underdominant, they can cause hybrid fitness loss, resulting in post zygotic isolation. They can also accumulate selected differences between species, causing both pre and post zygotic isolation.

The International System for Human Cytogenomic Nomenclature (ISCN) is an international standard for human chromosome nomenclature, which includes band names, symbols, and abbreviated terms used in the description of human chromosome and chromosome abnormalities. Abbreviations include inv for inversions.

Brenden Adams: former holder of the Guinness World Record for tallest teenager. His height is caused by an inversion of chromosome 12. An example of chromosomal Inversion in organisms is demonstrated in the insect, Coelopa frigida. This particular species of Coelopa have a variation of chromosomal inversions that allow the species to create a series of physical differences. Individual C. frigida that are larger do not undergo a chromosomal inversion, whereas individuals that are smaller do undergo a chromosomal inversion.