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Newington Green is an open space in North London between Islington and Hackney. It gives its name to the surrounding area, roughly bounded by Ball's Pond Road to the south, Petherton Road to the west, Green Lanes and Matthias Road to the north, and Boleyn Road to the east. The Green is in N16 and the area is covered by the N16, N1 and N5 postcodes. Newington Green Meeting House is situated near the park.

The 17th century diarist Samuel Pepys was sent to Newington Green and Kingsland by his mother in order to benefit from the fresh air and open spaces of what was then a rural area.

Newington Green's history is marked by several streets in the area taking their name from this period, such as King Henry's Walk, Boleyn Road (formerly Ann Boleyn's Walk), Wolsey Road and Queen Elizabeth's Walk. Many other thoroughfares are named after the Mildmay estate, including Mildmay Park, Mildmay Grove North and Mildmay Grove South. Sir Walter Mildmay was the Chancellor of the Exchequer under Elizabeth I. He was one of the special commissioners in the trial of Mary, Queen of Scots, and founded Emmanuel College, Cambridge in 1584. His grandson Sir Henry Mildmay served as MP and was Master of the Jewel House for Charles I. Henry was critical of the king's religious policies, supported Parliament during the civil wars and attended the king's trial. After the Restoration Henry was arrested for his part in the regicide, but granted leniency because he had refused to sign the king's death warrant. Instead of the death penalty he was sent to the Tower of London, stripped of his knighthood and his estates and sentenced to life imprisonment. Mildmay Mission Hospital was founded in the 1890s, inspired by the work of the Reverend William Pennefather during the cholera epidemic of 1866. It was absorbed into the National Health Service (NHS) in 1948, and in the 1980s began pioneering work into the treatment of patients with HIV/AIDS, which it continues. In February 2024, the North London line and West London line of the London Overground were announced to be renamed the 'Mildmay line' after the hospital for August. Mildmay Park, located on the street of the same name, was a station on the North London Railway. Opened in 1880, it closed in 1934. The station building was demolished in 1987, but remnants of the platforms can still be seen at track level.

The area became the home of English Dissenters during the 17th century. Following the religious upheavals after the Restoration, some Protestants chose to remain in England and maintain their faith openly, but they had to live with the restrictions the state placed upon them. They moved to places tolerant of them; often they set up educational establishments, known in general as dissenting academies, which were intellectually and morally more rigorous than the universities. One such place was Newington Green, then still an agricultural village, but conveniently near London.) Oliver Cromwell's family had links there: his great granddaughter Mary was born at the Green on 11 April 1691. A critical mass of "dissident intellectuals, pedagogues with reforming ideas and Dissenters" and "the well to do edge of radical Protestantism" clustered around Newington Green, and other villages nearby such as Stoke Newington and Hackney. Not all of these free thinkers were Unitarians: other notables include the Quaker physician John Coakley Lettsome and the Anglican pacifist Vicesimus Knox. One such academy was set up on north of the Green, run by Charles Morton. One of the academy's students was Daniel Defoe, the writer, journalist and spy famous for his novel Robinson Crusoe. Another pupil was the controversial poet Samuel Wesley, father of John Wesley, the great religious leader. A later schoolmaster was the Rev. James Burgh, author of The Dignity of Human Nature and Thoughts on Education, who opened his Dissenting Academy on the green in 1750 and sent his pupils to the church there. He arrived in 1758 with his wife Sarah, and took up residence in No. 54 the Green, in the middle of a terrace even then a hundred years old (The building still survives as London's oldest brick terrace, dated 1658). Many important politicians, thinkers, reformers, and writers visited him at Newington Green, including Founding Fathers of the United States, British politicians such as Lord Lyttleton, the Earl of Shelburne, Earl Stanhope (known as "Citizen Stanhope"), and even the Prime Minister William Pitt ; philosophers David Hume and Adam Smith; agitators such as prison reformer John Howard, gadfly John Horne Tooke and husband and wife John and Ann Jebb. Price was fortunate in forming close friendships among his neighbours and congregants. One was Thomas Rogers, father of poet and banker Samuel Rogers, a merchant turned banker who had married into a long established Dissenting family and lived at No. 56 the Green. Another was the Rev. James Burgh, author of The Dignity of Human Nature and Thoughts on Education, who opened his Dissenting Academy on the green in 1750 and sent his pupils to Price's sermons. Price, Rogers, and Burgh formed a dining club, eating at each other's houses in rotation. When Joseph Priestley's support of dissent led to the riots named after him, he fled Birmingham and headed for the sanctuary of Newington Green, where Rogers took him in. One of the most important residents of the Green was the early feminist Mary Wollstonecraft, who moved her fledgling school for girls from Islington to Newington Green in 1784. It was Mrs Burgh, widow of the educationalist, who used her influence to find the young schoolmistress a house to rent and 20 students to fill it. The flavour of the village and the approach of these Rational Dissenters appealed to Wollstonecraft: they were hard working, humane, critical but uncynical, and respectful towards women. The ideas Wollstonecraft ingested from the sermons at NGUC pushed her towards a political awakening. A couple of years after she left Newington Green, these seeds germinated into A Vindication of the Rights of Men, a response to Burke's denunciation of the French Revolution and attack on Price. In 1792 she published the work for which she is best remembered, A Vindication of the Rights of Woman, in the spirit of rationalism extending Price's arguments about equality to women. Newington Green had made its mark on Mary, and through this founding work of feminist philosophy, on the world. A Sculpture for Mary Wollstonecraft was unveiled in Newington Green on November 10, 2020.

In 1602, it was proposed that a new river should be constructed to provide London with its first clean, fresh water. Sir Hugh Myddleton, a Welsh goldsmith and philanthropist, was given the responsibility, and in 1609 he built a canal from the Hertfordshire rivers of Chadwell and Amwell, 38 miles to the New River Head in Clerkenwell. Originally open to the air, the aqueduct flowed down the centre of the present day Petherton Road. It was later covered for sanitary reasons. In 1808, Rochemont Barbauld was appointed minister to Newington Green Unitarian Church. His wife, Anna Laetitia Barbauld (1743–1825), was a prolific writer, admired by Samuel Johnson and William Wordsworth. She enjoyed a long friendship with Joseph Priestley and William Enfield, starting from their years together at the Warrington Academy in the 1760s, where her father was a tutor. She wrote poems (including a tribute to Priestley), hymns, children's literature, and political and religious tracts. She was an abolitionist, addressing one of her works to William Wilberforce. In 1793, he saw her contribution to the Pamphlet War, "Sins of the Government, Sins of the Nation". Two years later she wrote The Rights of Women, but this was not published until her death thirty years later. Rochemont eventually went violently insane, attacked his wife and committed suicide by drowning himself in the river. In 1946, the supply was redirected at Stoke Newington, and in 1990 the New River was replaced by deep mains. Part of the New River's original course through Canonbury has now been turned into an ornamental walk.

Other religious institutions existed nearby. Jews fleeing the pogroms of the Russian Empire established a congregation by 1876, and built the Dalston Synagogue in adjoining Poets Road in 1885. This became one of the leading synagogues of London, with Jacob Koussevitzsky as its cantor from 1936. For a period from the end of the nineteenth century, the Newington Green Area was host to a large Jewish population, which was beginning to leave the East End and move northwards towards Stoke Newington and Stamford Hill. The original Adath Israel orthodox congregation was founded in 1911 and its first permanent building was in Alma Road, off Green Lanes, before moving on towards Stoke Newington and the other side of Clissold Park in the 1950s. A large United Synagogue was built in Poets Road near Dalston Junction Station in the 1870s. In the 1930s, the Poets Road Synagogue was the home of one of the world's leading cantors, a member of the Kusevitsky family. At its height in 1960, the Poets Road Synagogue had 463 male seat holders. The synagogue remained active until it closed down in the late 1960s, as the remaining Jewish population moved on further afield and its site was sold. In 1970, the building and its stained glass windows were demolished and replaced by a block of council flats.

In the early part of the 19th century, there was a change in the character of Newington Green. After a patient struggle of 150 years, the English Dissenters were finally freed from their civil disabilities with the passage of the Doctrine of the Trinity Act 1813. With, it seemed, nothing left to fight for on that front, Nonconformists no longer needed the security of the Newington Green, and the area lost some of its intellectual cohesiveness. The church touched a low point. The nature of Newington Green had changed—the fresh bucolic village had been swallowed up by London's relentless growth, and had become a "thriving and expanding suburb". With this growth of prosperity also came a tide of poverty, and this was to prove the mission for the Victorian era. A hundred years before, the ethos had been one of almost Puritan self reliance, but now the Dickensian poverty, evident in cholera epidemics and rampant malnutrition, made social responsibility an urgent necessity. The minister who guided the first 25 years of this (1839–1864) was Thomas Cromwell, FSA (1792–1870). (Like many Anglican vicars, one of his hobbies was local history.) In 1840, a Sunday school was set up for poor children, and soon thereafter a Domestic Mission Society, to visit the poor in their homes. A library and a savings club emphasised self help. A regular day school ran from 1860 for ten years, until primary education became the responsibility of the state with the passing of the Elementary Education Act 1870. The "small but energetic community" continued to campaign on the larger political stage. Religious freedom and self improvement were their watchwords. In the last decades of the 19th century, the church thrived and its congregation grew to 80 subscribers. The London Sunday School Society recognised the one at Newington Green as the best in its class, educating up to 200 children and necessitating the construction in 1887 of the schoolhouse immediately behind the main church building. A range of groups sprang up, ranging from intellectual (a Society for Mutual Theological Study) to recreational (cycling and cricket). Young men's and young women's groups met, as did the mothers' meeting, a Provident Society, and teetotalism (abstinence from alcohol) support for adults and children. Other issues of concern were education, social reform and women's suffrage. Some individuals who lived at the Green during this period included Thomas Rees, the minister after Barbauld, who was a leading authority of the history of Unitarianism, and made connections with the Unitarian Church of Transylvania. Alexander Gilchrist, son of another minister, was the biographer of William Blake. Andrew Pritchard improved the microscope and studied microscopic organisms; he was a friend of Michael Faraday and for him, science and religion were one. He led the Newington Green Conversation Society, membership restricted to 16, a successor to the Mutual Instruction Society. Marian Pritchard is described as an unsung heroine, and "one of the leaders of modern Unitarianism". She set up Oxford Summer Schools for the training of Sunday School teachers and Winifred House Invalid Children's Convalescent Home. John Stuart Mill recalls his family living in Newington Green "from 1810 to the end of 1813"; it was at the time "an almost rustic neighbourhood", and it was during walks with his father before breakfast "generally in the green lanes towards Hornsey" ("my earliest recollections of green fields and wild flowers") that John Stuart would recount to James Mill what he had learnt reading the previous day.

Then came 1914, and the horrors of World War I. Men from Newington Green fell in battle. Meanwhile, many of the older people with long family ties to Newington Green simply died. The professional middle class had largely left the area. By 1930 "it was whispered that the church could not survive", but it did, with an influential supporter, an alderman and councillor in the Borough of Stoke Newington. Although attendance at services was small, other activities drew in crowds: 100 to the temperance meetings, for example. The outbreak of World War II meant that children were evacuated temporarily from London, so the Sunday Schools and Young People's Leagues ceased for a time. The Sunday services never missed a week, however, even when the building was badly damaged by a landmine blast: they just moved to the schoolhouse. After the war, the ministry focused on building bridges between races and faiths, e. g. with the Jewish community of North London, and was recognised by the World Congress of Faiths. Services were often attended by local politicians, including the mayor of Stoke Newington. Leaders for the national Unitarian movement continued to be found within the congregation at Newington Green. In 1979 the Newington Green Action Group (NGAG) was formed with the aim of regenerating the area. NGAG worked with Islington Council on this project and traffic calming measures were installed to ease the notorious local congestion, with additional pedestrian crossings providing easier and safer access to the Green on foot. The Green was regenerated to include more lawn space, a play area and a café. New planting has enhanced the Green and was chosen to encourage biodiversity.