Майлық қабықшасының алдыңғы бөлігі: жекелік, шешім қабылдау және әлеуметтік мінез-құлық

Part of the brain responsible for personality, decision making, and social behavior
This brain region is involved in a wide range of higher order cognitive functions, including speech formation (Broca's area), gaze (frontal eye fields), working memory (dorsolateral prefrontal cortex), and risk processing (e. g. ventromedial prefrontal cortex). The basic activity of this brain region is considered to be orchestration of thoughts and actions in accordance with internal goals. Many authors have indicated an integral link between a person's will to live, personality, and the functions of the prefrontal cortex. This brain region has been implicated in executive functions, such as planning, decision making, working memory, personality expression, moderating social behavior and controlling certain aspects of speech and language. Executive function relates to abilities to differentiate among conflicting thoughts, determine good and bad, better and best, same and different, future consequences of current activities, working toward a defined goal, prediction of outcomes, expectation based on actions, and social "control" (the ability to suppress urges that, if not suppressed, could lead to socially unacceptable outcomes). The frontal cortex supports concrete rule learning, with more anterior regions supporting rule learning at higher levels of abstraction.

The prefrontal cortex has been defined based on cytoarchitectonics by the presence of a cortical granular layer IV. It is not entirely clear who first used this criterion. Many of the early cytoarchitectonic researchers restricted the use of the term prefrontal to a much smaller region of cortex including the gyrus rectus and the gyrus rostralis (Campbell, 1905; G. E. Smith, 1907; Brodmann, 1909; von Economo and Koskinas, 1925). In 1935, however, Jacobsen used the term prefrontal to distinguish granular prefrontal areas from agranular motor and premotor areas. In terms of Brodmann areas, the prefrontal cortex traditionally includes areas 8, 9, 10, 11, 12, 13, 14, 24, 25, 32, 44, 45, 46, and 47, The main problem with this definition is that it works well only in primates but not in nonprimates, as the latter lack a granular layer IV.

The prefrontal cortex is highly interconnected with much of the brain, including extensive connections with other cortical, subcortical and brain stem sites. The dorsal prefrontal cortex is especially interconnected with brain regions involved with attention, cognition and action, while the ventral prefrontal cortex interconnects with brain regions involved with emotion. The prefrontal cortex also receives inputs from the brainstem arousal systems, and its function is particularly dependent on its neurochemical environment. Thus, there is coordination between one's state of arousal and mental state. The interplay between the prefrontal cortex and socioemotional system of the brain is relevant for adolescent development, as proposed by the Dual Systems Model. The medial prefrontal cortex has been implicated in the generation of slow wave sleep (SWS), and prefrontal atrophy has been linked to decreases in SWS. Prefrontal atrophy occurs naturally as individuals age, and it has been demonstrated that older adults experience impairments in memory consolidation as their medial prefrontal cortices degrade. These brain areas are implicated in memory retrieval and consolidation, language processing, and association of emotions. These connections allow the VLPFC to mediate explicit and implicit memory retrieval and integrate it with language stimulus to help plan coherent speech. In other words, choosing the correct words and staying "on topic" during conversation come from the VLPFC.

The original studies of Fuster and of Goldman Rakic emphasized the fundamental ability of the prefrontal cortex to represent information not currently in the environment, and the central role of this function in creating the "mental sketch pad". Goldman Rakic spoke of how this representational knowledge was used to intelligently guide thought, action, and emotion, including the inhibition of inappropriate thoughts, distractions, actions, and feelings. In this way, working memory can be seen as fundamental to attention and behavioral inhibition. Fuster speaks of how this prefrontal ability allows the wedding of past to future, allowing both cross temporal and cross modal associations in the creation of goal directed, perception action cycles. This ability to represent underlies all other higher executive functions. Shimamura proposed Dynamic Filtering Theory to describe the role of the prefrontal cortex in executive functions. The prefrontal cortex is presumed to act as a high level gating or filtering mechanism that enhances goal directed activations and inhibits irrelevant activations. This filtering mechanism enables executive control at various levels of processing, including selecting, maintaining, updating, and rerouting activations. It has also been used to explain emotional regulation. Miller and Cohen proposed an Integrative Theory of Prefrontal Cortex Function, that arises from the original work of Goldman Rakic and Fuster. The two theorize that "cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represents goals and means to achieve them. They provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task". In essence, the two theorize that the prefrontal cortex guides the inputs and connections, which allows for cognitive control of our actions. The prefrontal cortex is of significant importance when top down processing is needed. Top down processing by definition is when behavior is guided by internal states or intentions. According to the two, "The PFC is critical in situations when the mappings between sensory inputs, thoughts, and actions either are weakly established relative to other existing ones or are rapidly changing". When analyzing and thinking about attributes of other individuals, the medial prefrontal cortex is activated, however, it is not activated when contemplating the characteristics of inanimate objects. Studies using fMRI have shown that the medial prefrontal cortex (mPFC), specifically the anterior medial prefrontal cortex (amPFC), may modulate mimicry behavior. Neuroscientists are suggesting that social priming influences activity and processing in the amPFC, and that this area of the prefrontal cortex modulates mimicry responses and behavior. As of recent, researchers have used neuroimaging techniques to find that along with the basal ganglia, the prefrontal cortex is involved with learning exemplars, which is part of the exemplar theory, one of the three main ways our mind categorizes things. The exemplar theory states that we categorize judgements by comparing it to a similar past experience within our stored memories. A 2014 meta analysis by Professor Nicole P. Yuan from the University of Arizona found that larger prefrontal cortex volume and greater PFC cortical thickness were associated with better executive performance.

A widely accepted theory regarding the function of the brain's prefrontal cortex is that it serves as a store of short term memory. This idea was first formulated by Jacobsen, who reported in 1936 that damage to the primate prefrontal cortex caused short term memory deficits. Karl Pribram and colleagues (1952) identified the part of the prefrontal cortex responsible for this deficit as area 46, also known as the dorsolateral prefrontal cortex (dlPFC). More recently, Goldman Rakic and colleagues (1993) evoked short term memory loss in localized regions of space by temporary inactivation of portions of the dlPFC. Once the concept of working memory (see also Baddeley's model of working memory) was established in contemporary neuroscience by Alan Baddeley (1986), these neuropsychological findings contributed to the theory that the prefrontal cortex implements working memory and, in some extreme formulations, only working memory. In the 1990s this theory developed a wide following, and it became the predominant theory of PF function, especially for nonhuman primates. The concept of working memory used by proponents of this theory focused mostly on the short term maintenance of information, and rather less on the manipulation or monitoring of such information or on the use of that information for decisions. Consistent with the idea that the prefrontal cortex functions predominantly in maintenance memory, delay period activity in the PF has often been interpreted as a memory trace. (The phrase "delay period activity" applies to neuronal activity that follows the transient presentation of an instruction cue and persists until a subsequent "go" or "trigger" signal.) To explore alternative interpretations of delay period activity in the prefrontal cortex, Lebedev et al. (2004) investigated the discharge rates of single prefrontal neurons as monkeys attended to a stimulus marking one location while remembering a different, unmarked location.

Various areas of the prefrontal cortex have been implicated in a multitude of critical functions regarding speech production, language comprehension, and response planning before speaking. those who excessively consume sexually explicit materials; suicides; those incarcerated; criminals; sociopaths; those affected by lead poisoning; and daily male cannabis users (only 13 people were tested). It is believed that at least some of the human abilities to feel guilt or remorse, and to interpret reality, are dependent on a well functioning prefrontal cortex. The advanced neurocircuitry and self regulatory function of the human prefrontal cortex is also associated with the higher sentience in humans, as the prefrontal cortex in humans occupies a far larger percentage of the brain than in any other animal. And it is theorized that, as the brain has tripled in size over five million years of human evolution, the prefrontal cortex has increased in size sixfold. A review on executive functions in healthy exercising individuals noted that the left and right halves of the prefrontal cortex, which is divided by the medial longitudinal fissure, appears to become more interconnected in response to consistent aerobic exercise. Two reviews of structural neuroimaging research indicate that marked improvements in prefrontal and hippocampal gray matter volume occur in healthy adults that engage in medium intensity exercise for several months. A functional neuroimaging review of meditation based practices suggested that practicing mindfulness enhances prefrontal activation, which was noted to be correlated with increased well being and reduced anxiety, although cohort studies are needed to better solidify this theory. Treatments with anti cancer drugs often are toxic to the cells of the brain, leading to memory loss and cognitive dysfunction that can persist long after the period of exposure. Such a condition is referred to as chemo brain. To determine the basis of this condition, mice were treated with the chemotherapeutic agent mitomycin C. In the prefrontal cortex, this treatment resulted in an increase of the oxidative DNA damage 8 oxodG, a decrease in the enzyme OGG1 that ordinarily repairs such damage, and epigenetic alterations. Chronic intake of alcohol leads to persistent alterations in brain function including altered decision making ability. The prefrontal cortex of chronic alcoholics has been shown to be vulnerable to oxidative DNA damage and neuronal cell death.

Perhaps the seminal case in prefrontal cortex function is that of Phineas Gage, whose left frontal lobe was destroyed when a large iron rod was driven through his head in an 1848 accident. The standard presentation is that, although Gage retained normal memory, speech and motor skills, his personality changed radically: He became irritable, quick tempered, and impatient—characteristics he did not previously display — so that friends described him as "no longer Gage"; and, whereas he had previously been a capable and efficient worker, afterward he was unable to complete. However, careful analysis of primary evidence shows that descriptions of Gage's psychological changes are usually exaggerated when held against the description given by Gage's doctor, the most striking feature being that changes described years after Gage's death are far more dramatic than anything reported while he was alive. Subsequent studies on patients with prefrontal injuries have shown that the patients verbalized what the most appropriate social responses would be under certain circumstances. Yet, when actually performing, they instead pursued behavior aimed at immediate gratification, despite knowing the longer term results would be self defeating. The interpretation of this data indicates that not only are skills of comparison and understanding of eventual outcomes harbored in the prefrontal cortex but the prefrontal cortex (when functioning correctly) controls the mental option to delay immediate gratification for a better or more rewarding longer term gratification result. This ability to wait for a reward is one of the key pieces that define optimal executive function of the human brain. There is much current research devoted to understanding the role of the prefrontal cortex in neurological disorders. Clinical trials have begun on certain drugs that have been shown to improve prefrontal cortex function, including guanfacine, which acts through the alpha 2A adrenergic receptor. A downstream target of this drug, the HCN channel, is one of the most recent areas of exploration in prefrontal cortex pharmacology.

The term "prefrontal" as describing a part of the brain appears to have been introduced by Richard Owen in 1868. For him, the prefrontal area was restricted to the anterior most part of the frontal lobe (approximately corresponding to the frontal pole). It has been hypothesized that his choice of the term was based on the prefrontal bone present in most amphibians and reptiles.