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Chemical reaction that attaches an acetyl group to a compound

In chemistry, acetylation is an organic esterification reaction with acetic acid. It introduces an acetyl group into a chemical compound. Such compounds are termed acetate esters or simply acetates. Deacetylation is the opposite reaction, the removal of an acetyl group from a chemical compound.

Deacylations "play crucial roles in gene transcription and most likely in all eukaryotic biological processes that involve chromatin". Acetylation/deacetylation of histones also plays a role in gene expression and cancer. These modifications are effected by enzymes called histone acetyltransferases (HATs) and histone deacetylases (HDACs). Two general mechanisms are known for deacetylation. One mechanism involves zinc binding to the acetyl oxygen. Another family of deacetylases require NAD+, which transfers an ribosyl group to the acetyl oxygen.

Acetate esters and acetamides are generally prepared by acetylations. Acetylations are often used in making C acetyl bonds in Friedel Crafts reactions. Carbanions and their equivalents are susceptible to acetylations.

Cellulose is a polyol and thus susceptible to acetylation, which is achieved using acetic anhydride. Acetylation disrupts hydrogen bonding, which otherwise dominates the properties of cellulose. Consequently, the cellulose esters are soluble in organic solvents and can be cast into fibers and films.

Transacetylation uses vinyl acetate as an acetyl donor and lipase as a catalyst. This methodology allows the preparation of enantio enriched alcohols and acetates.