Потомак өзенінің Гарри У. Найс және Томас Миддлтон көпірінің жаңғырту жобасы

This two lane bridge carries U. S. Route 301, which is a spur of U. S. Route 1 and a popular north–south alternative for bypassing the Baltimore Washington Metropolitan Area and its frequently congested roads such as Interstate 95, Interstate 495 (Capital Beltway), and the Woodrow Wilson Bridge to the north along the Potomac River. In 2014, the bridge handled approximately 6.4 million vehicles, with a daily average of approximately 17,500. The bridge is narrow (one 11 feet (3 m) lane in each direction with no shoulders), steep (up to 3.75 percent grade), and has a reduced speed limit ( on the main span, even slower through the southbound toll gates and plaza). By contrast, the approach roads on both sides of the bridge feature four 12 feet (4 m) lanes (2 in each direction), full shoulders, and speed limits. This combination forces vehicles to slow and merge as they cross the bridge, which often results in backups. In response to the bridge's traffic issues, the Maryland Transportation Authority initiated the Governor Harry W. Nice Memorial Bridge Improvement Project in June 2006, which would contemplate improvement of bridge traffic either by widening the bridge or by replacing it altogether. Planning continued for another year, and by the end of 2007, The Washington Post reported that six alternatives had been identified. Ultimately, the decision was made to replace the bridge altogether five years later with a wider one with two lanes per direction.

President Franklin D. Roosevelt presided over the ground breaking ceremony for the bridge in 1938. Known as the Potomac River Bridge when opened in December 1940, the bridge was renamed in 1967 for Harry W. Nice (1877–1941) who served as governor of Maryland from 1935 to 1939. The bridge was the first south of Washington, D. C. to provide a highway link between Maryland and Virginia. In October 2018, the name of retiring state Senator Thomas M. Middleton was added to the bridge, making it officially the Governor Harry W. Nice Memorial/Senator Thomas "Mac" Middleton Bridge. In March 2020, all electronic tolling was implemented as a result of the COVID 19 pandemic, with tolls payable through E ZPass or Video Tolling, which uses automatic license plate recognition. All electronic tolling was made permanent in August 2020.

In December 2012, it was reported that the Maryland Transportation Authority (MDTA) completed a study of the Nice Bridge and received approval from the federal government to replace the current structure with a span with four lanes and a bike/pedestrian path, to be located just north of the existing bridge, which will be removed upon completion of the replacement crossing. The MDTA estimated the cost of a replacement span at about $850 million, but funding was not identified as of 2012. The project is being coordinated with the Virginia Department of Transportation (VDOT), and is proceeding in conjunction with the Maryland State Highway Administration's U. S. Route 301 South Corridor Transportation Study
and the U. S. Route 301 Waldorf Area Transportation Improvements Project. On November 21, 2013, Governor Martin O’Malley announced that the MDTA Board has approved an additional $50 million in its final six year capital program (FY 2014 – FY 2019) to fund initial design and right of way acquisition for the project to replace the Governor Harry W. Nice Memorial Bridge (US 301), which connects Charles County, Maryland and King George County, Virginia, across the Potomac River. The planning phase of the project was completed in fall 2012. The selected alternative consists of a new four lane bridge built parallel to, and north of, the existing bridge, which would be removed upon completion of the new bridge. Opposition to a new bridge from Governor Larry Hogan had prevented construction from being scheduled. However, on November 21, 2016, the Maryland Transportation Authority Board voted unanimously to build a new, 4 lane bridge just north of the current structure. Construction began in July 2020. A ribbon cutting ceremony for the new bridge was held on October 12, 2022, with Governor Hogan in attendance, while the bridge opened to traffic the following day. The approved bridge design has several design alterations which shave more than $200 million from the originally projected price of around $1 billion, allowing Governor Hogan to shift his support in favor of the bridge. One of the major redesign choices was the removal of the multi use path for pedestrians and bicycles, citing low projected usage; in its stead, Will Pines, chief engineer of the MDTA, states that the bridge will be open for cyclists to share the lane with motor vehicles, similar to the present arrangement on the Thomas J. Hatem Bridge on US 40. Demolition of the old bridge began on March 21, 2023.

Former Majority Leader of the United States House of Representatives Steny Hoyer, along with US Senators Ben Cardin and Chris Van Hollen, objected to plans to demolish the old bridge following the new one's completion, suggesting an independent study be conducted to explore the possibility that the old bridge itself could be used for recreational and bike traffic, but Transportation Secretary Jim Ports countered by contending that financial and logistical challenges were too great to keep the old bridge in place. The future of the old bridge fell to U. S. District Judge Deborah L. Boardman, who declined to issue an injunction blocking the demolition Tuesday, October 11, 2022, saying after a three hour hearing that the groups had not met standards to halt the plans — a pause the state estimated would cost taxpayers $21,500 each day. The decision appeared to end a years long dispute, part of a battle over how to accommodate non drivers on a major river crossing that was designed to last a century. Demolition began on March 21, 2023.