Уридин монофосфат: қасиеттері, метаболизмі және қолданылуы

chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 446304818
| ImageFile =Uridinmonophosphat protoniert. svg
| ImageAlt = Skeletal formula of UMP
| ImageFile1 = Uridine monophosphate anion 3D ball. png
| ImageAlt1 = Ball and stick model of the UMP molecule as an anion
| IUPACName =[(2R,3S,4R,5R) 5 (2,4 Dioxopyrimidin 1 yl) 3,4 dihydroxyoxolan 2 yl]methyl dihydrogen phosphate
| OtherNames =Uridylic acid; Uridine 5' monophosphate; 5' Uridylic acid; Uridine 5' phosphate; Uridine phosphate; 5' UMP; Uridine 5' phosphoric acid
|Section1=
|Section2=Chembox Properties
| C=9 | H=13 | N=2 | O=9 | P=1
| Appearance =
| pKa = 1.0, 6.4, 9.5
| Density =
| MeltingPtC = 202
| MeltingPt notes = (decomposes)
| BoilingPt =
| Solubility = good, also in methanol

Uridine monophosphate is formed from Orotidine 5' monophosphate (orotidylic acid) in a decarboxylation reaction catalyzed by the enzyme orotidylate decarboxylase. Uncatalyzed, the decarboxylation reaction is extremely slow (estimated to occur on average one time per 78 million years). Adequately catalyzed, the reaction takes place once per second, an increase of 1017 fold. In humans, the orotidylate decarboxylase function is carried out by the protein UMP synthase. Defective UMP synthase can result in orotic aciduria, a metabolic disorder.

In a study, gerbils fed a combination of uridine monophosphate, choline, and docosahexaenoic acid (DHA) were found to have significantly improved performance in running mazes over those not fed the supplements, implying an increase in cognitive function.

In brain research studies, uridine monophosphate is used as a convenient delivery compound for uridine. Uridine is the active component of this compound. Uridine is present in many foods, mainly in the form of RNA. Non phosphorylated uridine is not bioavailable beyond first pass metabolism, as it is almost entirely catabolised in the liver and gastrointestinal tract.