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Former department of France encompassing Paris and its suburbs

Seine is a former department of France, which encompassed Paris and its immediate suburbs. It was the only enclaved department of France, being surrounded entirely by the former Seine et Oise department. Its prefecture was Paris and its INSEE number was 75. The Seine department was disbanded in 1968 and its territory divided among four new departments: Paris, Hauts de Seine, Seine Saint Denis and Val de Marne.

From 1929 to its abolition in 1968, the department consisted of the City of Paris and 80 surrounding suburban communes. It had an area of 480 km2 (185 sq. miles), 22% of that area being the City of Paris and 78% being suburbs. It was the only enclaved department in France. It was divided into three arrondissements: Paris, Sceaux and Saint Denis. For most of the Seine department's existence, its prefect also exercised direct authority over the City of Paris as well. As a result, Paris was the only commune without a mayor; it had theoretically less autonomy than the smallest commune.

Seine was created on 4 March 1790, as the department of Paris (Département de Paris). In 1795, it was renamed as the department of Seine (Département de la Seine) after the Seine River flowing through it. At the first census of the French Republic in 1801, the Seine department had 631,585 inhabitants (87% of them living in the City of Paris, 13% in the suburbs) and was the second most populous department of the vast Napoleonic Empire (behind Nord), more populous than even the dense departments of what is now Belgium and the Netherlands. With the growth of Paris and its suburbs over the next 150 years, the population of the Seine department increased tremendously.

At the 2006 census, the population of the communes that had previously comprised the Seine department was 5,496,468. The population of the department peaked in 1968 at 5,700,754. It then lost inhabitants until 1999 (with a nadir of 5,203,818 inhabitants at the 1999 census) as residents increasingly relocated to the more distant suburbs of the metropolitan area of Paris, but since 1999 it has regained some inhabitants, with a population increase of 292,650 inhabitants between 1999 and 2006. This new population growth after a long period of decline is comparable to what is observed in the central areas of other large Western metropolises such as Inner London. Of the new departments created in 1968, Paris was the most populous in 2006 with 2,181,371 inhabitants. The Paris department is currently the second most populous of France behind that of Nord.