Росс Ривер вирусы: Австралия мен Оңтүстік Тынық мұхиты аймағында таралған RNA вирусы

Species of RNA virus

Ross River virus (RRV) is a small encapsulated single strand RNA Alphavirus endemic to Australia, Papua New Guinea and other islands in the South Pacific. It is responsible for a type of mosquito borne, non lethal but extremely debilitating tropical disease known as Ross River fever, previously termed "epidemic polyarthritis". There is no known cure, and it can last in the host's system for up to 20 years. The virus is suspected to be enzootic in populations of various native Australian mammals, and has been found on occasion in horses.

Taxonomically, Ross River virus belongs to the virus genus Alphavirus, which is part of the family Togaviridae. The alphaviruses are a group of small enveloped single strand positive sense RNA viruses. RRV belongs to a subgroup of "Old World" (Eurasian African Australasian) alphaviruses, and belongs to the SF antigenic complex of the genus Alphavirus. Because RRV is transmitted by mosquitos, it is considered an arbovirus, a non taxonomic term for viruses borne by arthropod vectors.

In 1928, an outbreak of acute febrile arthritis was recorded in Narrandera and Hay in New South Wales, Australia. In 1943, several outbreaks of arthralgia and arthritis were described in the Northern Territory, Queensland and the Schouten Islands, off the northern coast of Papua New Guinea. The name "epidemic polyarthritis" was coined for the disease. In 1956, an epidemic occurred in the Murray Valley which was compared to "acute viral polyarthritis" caused by the Chikungunya virus. The Australian disease seemed to progress in a milder fashion. In 1956, serological testing suggested an unknown new species of alphavirus (group A arbovirus) was the likely culprit. For a time, it was thought to be a separate species, but is now considered conspecific with Ross River virus. In 1959, a new alphavirus was identified in samples from a mosquito (Aedes vigilax) trapped in the Ross River, located in Townsville, Queensland, Australia. Further serological testing showed that patients who had suffered "epidemic polyarthritis" in Queensland had antibodies to the virus. The new virus was named Ross River virus, and the disease Ross River fever. As of September 2006, there has never been a report of a case of Ross River virus acquired within New Zealand. Separate mosquito species may act as vector, widespread across areas and seasonal/geographical locations. In southern and northern regions, the Aedes group (A. camptorhynchus and A. vigilax) are the main RRV carriers. However, inland the Culex annulirostris is the main carrier with Aedes mosquitoes becoming active during wet seasons.

Due to the expansion and housing demand in the south west of Western Australia, residential development is occurring closer to wetlands in spite of the fact that the ecosystem is known for mosquito breeding. Particularly in the Peel region where living near water is desirable for aesthetic value. A study comparing the risk of contracting Ross River virus (RRV) and the distance of the dwellings from Muddy Lakes. The reports showed within a one kilometre buffer zone there were approximately 1550 mosquitos in traps per night with 89% of them being Ae. camptorhynchus decreasing to approximately 450 mosquitos with 57% Ae. camptorhynchus at the six kilometre buffer zone. The study suggests that there is a significantly higher risk of contracting RRV when living closer to Muddy Lakes however, there was a rise in the two kilometre buffer zone of 3700 mosquitos with 94% Ae. camptorhynchus. A similar trend in the study same study conducted in the Peel region resulting in less mosquitoes the further away the buffer distance. Although this occurred around a decade ago, the data analysed the total RRV cases per 1000 persons for each 500m buffer zone. This shows an elevated risk of contracting the disease if living in close proximity to the Leschenault Estuary, within 2 km being the strongest disease risk gradient. which illustrate that factors such as camping, light coloured clothing, exposure to certain flora and fauna and specific protective mechanisms are able to increase or decrease the likelihood of contracting the virus. By increasing the frequency of camping the individual's risk increases eight fold, suggesting that an increased exposure to wildlife increases risk. This is shown by the narrow 95% confidence interval of 1.07–4.35 within the study. For example, an individual's exposure to kangaroos, wallabies and bromeliad plants also increased risk, suggesting that they are reservoirs for infection, breeding sites for mosquitoes and potential vectors of the virus. Ross River virus antibodies have been found in captive populations of tammar wallabies and wallaroos in urban areas in New South Wales, Australia, and are potential reservoirs for the virus. Although these areas show a higher risk for the virus, humans should still enjoy the wildlife but consider that preventive mechanisms as increasingly important while camping.

Ross River virus can be easily prevented through small behavioural mechanisms which should be of high importance in tropical areas and during participation of outdoor activities. Firstly, insect repellent should be rigorously used as to prevent bites from insects that specifically include mosquitoes which are vectors that carry the disease. A study in tropical Australia

Ross River virus can cause multiple symptoms in someone who is infected, the most common being arthritis or joint pain. Other symptoms include a rash on the limbs of the body, which often occurs roughly 10 days after arthritis begins. Lymph nodes may enlarge, most commonly in the arm pits or groin region, and rarely a feeling of 'pins and needles' in the persons hands and feet, but only occurs in a small number of people. The virus also causes moderate symptoms in horses. The symptoms of Ross River virus are important to recognise for early diagnosis and therefore early treatment. Symptoms have been illustrated in a case report of an infected Thuringian traveller returning from South East Australia. This case showed flu like symptoms that include fever, chills, headache and pains in the body. Additionally, joint pain arose in which some joints become swollen and joint stiffness was particularly noticeable. A clinical examination of the infected individual shows a significant decrease of specific antibodies despite the normal blood count levels. A rash is a good indication that is likely to occur but usually disappears after ten days. The symptoms of Ross River virus are important to be aware of so that early treatment can be administered before the virus worsens. The time between catching the disease and experiencing symptoms is anywhere between three days to three weeks, usually it takes about 1–2 weeks. A person can be tested for Ross River virus by a blood test, other illnesses may need to be excluded before diagnosis.

Testing for Ross River virus should occur in patients who are experiencing acute polyarthritis, tiredness and/or rashes (~90%) with a history of travel within areas prone to infection from the virus. Serology (blood tests) is the appropriate manner by which to diagnose Ross River virus. Within 7 days of infection, the virus produces Immunoglobulin M (IgM) and is a presumptive positive diagnosis. IgM may persist for months or even years and therefore false positives may be triggered by Barmah Forest virus, rubella, Q fever or rheumatoid factor. To completely test for Ross River virus, a second serology test must be conducted 10–14 days after the first. The patient may then be declared positive for Ross River virus infection if there is a 4 fold increase of IgM antibody count.