Санту-Антау аралы: Кабо-Верде архипелагының ең ірі аралы

Westernmost and largest of the Barlavento islands of Cape Verde

Santo Antão (Portuguese for "Saint Anthony") is the northwesternmost island of Cape Verde. At , it is the largest of the Barlavento Islands group, and the second largest island of Cape Verde. The nearest island is São Vicente to the southeast, separated by the sea channel Canal de São Vicente. Its population was 38,200 in mid 2019, making it the fourth most populous island of Cape Verde after Santiago, São Vicente and Sal. Its largest city is Porto Novo located on the southern coast (population 9,310 in 2010).

Santo Antão is long (east west) and wide (north south). Settlement of the island started in the first half of the 16th century. The main settlement was Ribeira Grande. Other settlements such as Ponta do Sol, Pombas and Porto Novo developed in the 19th century. In 1732 the Municipality of Santo Antão was created, with its seat in the town Ribeira Grande. In 1867 this was divided into the municipality of Paul (covering the area of current Paul and Porto Novo) and the municipality of Ribeira Grande. These were merged in 1895 into one municipality. The municipalities of Paul and Ribeira Grande were recreated in 1917. The municipality of Porto Novo was created in 1962 when the parishes of São João Baptista and Santo André were separated from the older Municipality of Paul.

Fishing and agriculture are the main industries on the island.

The island's agriculture products include sugar cane, yams, cassava, bananas, mangoes, and grain. The main product on the island is a kind of rum known as grogue. Mills continue to distill grogue in the Paul Valley. Due to its mountainous nature, most of the island's plantations are done in terraces, obviating the use of machinery and requiring immense manual labor. Recently, some experiences using drip irrigation have been taking place in order to mitigate the drought conditions. The exportation of many of the island's agriculture products to other islands has been prohibited for nearly two decades because of the millipede (Spinotarsus caboverdus) blight, but the quarantine was lifted in 2008.

Tourism is becoming one of the most dominant industries on the island. There has been some investment in Rural tourism infrastructures. Hiking, Trekking and Cultural tourism account for most of the touristic offer of this island.

Santo Antão has 50 endangered species of flora which has the most number in the nation. Several flora found in the island that are also found in some parts of the archipelago includes Aeonium gorgoneum, Artemisia gorgonum, Campanula jacobaea, the Conyza species of feae, pannosa and varia, Echium stenosiphon, Kickxia webbiana, Lavandula rotundifolia, Limonium braunii, Micromeria forbesii, Sonchus daltonii, Capeverdean navelwort (Umbilicus schmidtii) and Verbascum capitis viridis. Flora found only in the island include Tornabenea insularis and ribeirensis. Santo Antão has different species of birds including the Cape Verde (Iago) sparrow, reptiles including the Cape Verde wall gecko and insects including the spider Tetragnatha torrensis, the moth Scopula paneliusi and the water bear Echiniscus clavispinosus. The island does not have a lot of animal life comparing to other islands. Along its shores, most of the marine life are within Canal de São Vicente.

Other than Portuguese (official language), the majority of the population speaks Cape Verdean Creole.