Франческо Реди: Экспериментальды биологияның негізін қалаушы және паразитологияның әкесі

Italian naturalist and poet

Francesco Redi (18 February 1626 – 1 March 1697) was an Italian physician, naturalist, biologist, and poet. He is referred to as the "founder of experimental biology", and as the "father of modern parasitology". He was the first person to challenge the theory of spontaneous generation by demonstrating that maggots come from eggs of flies. Having a doctoral degree in both medicine and philosophy from the University of Pisa at the age of 21, he worked in various cities of Italy. A rationalist of his time, he was a critic of verifiable myths, such as spontaneous generation. His most famous experiments are described in his magnum opus Esperienze intorno alla generazione degl'insetti (Experiments on the Generation of Insects), published in 1668. He disproved that vipers drink wine and could break glasses, and that their venom was poisonous when ingested. He correctly observed that snake venoms were produced from the fangs, not the gallbladder, as was believed. He was also the first to recognize and correctly describe details of about 180 parasites, including Fasciola hepatica and Ascaris lumbricoides. He also distinguished earthworms from helminths (like tapeworms, flukes, and roundworms). He possibly originated the use of the control, the basis of experimental design in modern biology. A collection of his poems first published in 1685 Bacco in Toscana (Bacchus in Tuscany) is considered among the finest works of 17th century Italian poetry, and for which the Grand Duke Cosimo III gave him a medal of honor.

The son of Gregorio Redi and Cecilia de Ghinci, Francesco Redi was born in Arezzo on 18 February 1626. His father was a renowned physician at Florence. After schooling with the Jesuits, Francesco Redi attended the University of Pisa from where he obtained his doctoral degrees in medicine and philosophy in 1647, at the age of 21. He died in his sleep on 1 March 1697 in Pisa and his remains were returned to Arezzo for interment. A collection of his letters is held at the National Library of Medicine in Bethesda, Maryland.

In 1664 Redi wrote his first monumental work Osservazioni intorno alle vipere (Observations on Vipers) to his friend Lorenzo Magalotti, secretary of the Accademia del Cimento. In this he began to break the prevailing scientific myths (which he called "unmasking of the untruths") such as vipers drink wine and shatter glasses, their venom is poisonous if swallowed, the head of dead viper is an antidote, the viper's venom is produced from the gallbladder, and so on. He explained rather how snake venom is unrelated to the snake’s bite, an idea contrary to popular belief. He performed a series of experiments on the effects of snakebites, and demonstrated that venom was poisonous only when it enters the bloodstream via a bite, and that the fang contains venom in the form of yellow fluid. He even showed that by applying a tight ligature before the wound, the passage of venom into the heart could be prevented. This work marked the beginning of experimental toxinology/toxicology.

Redi is best known for his series of experiments, published in 1668 as Esperienze intorno alla generazione degl'insetti (Experiments on the Generation of Insects), which is regarded as his masterpiece and a milestone in the history of modern science. The book is one of the first steps in refuting "spontaneous generation"—a theory also known as Aristotelian abiogenesis. At the time, prevailing wisdom was that maggots arose spontaneously from rotting meat. Redi continued his experiments by capturing the maggots and waiting for them to metamorphose, which they did, becoming flies. Also, when dead flies or maggots were put in sealed jars with dead animals or veal, no maggots appeared, but when the same thing was done with living flies, maggots did. His interpretations were always based on biblical passages, such as his famous adage: omne vivum ex vivo ("All life comes from life").

Redi was the first to describe ectoparasites in his Esperienze intorno alla generazione degl'insetti. His notable illustrations in the book are those relevant to ticks, including deer ticks and tiger ticks; it also contains the first depiction of the larva of Cephenemyiinae, the nasal flies of deer, as well as the sheep liver fluke (Fasciola hepatica). His next treatise in 1684 titled Osservazioni intorno agli animali viventi che si trovano negli animali viventi (Observations on Living Animals, that are in Living Animals) recorded the descriptions and the illustrations of more than 100 parasites. In it he also differentiates the earthworm (generally regarded as a helminth) and Ascaris lumbricoides, the human roundworm. An important innovation from the book is his experiments in chemotherapy in which he employed the "control"', the basis of experimental design in modern biological research. He described some 180 species of parasites. Perhaps, his most significant observation was that parasites produce eggs and develop from them, which contradicted the prevailing opinion that they are produced spontaneously.

As a poet, Redi is best known for the dithyramb Bacco in Toscana (Bacchus in Tuscany), which first appeared in 1685. His bacchanalian poem in praise of Tuscan wines is still read in Italy today. He taught the Tuscan language as a lettore pubblico di lingua toscana in Florence in 1666. He also composed many other literary works, including his Letters, and Arianna Inferma. The larval stage of parasitic fluke called "redia" is named after Redi by another Italian zoologist, Filippo de Filippi, in 1837. A scientific journal Redia, an Italian journal of zoology, is named in his honor, which was first published in 1903. A European viper subspecies, Vipera aspis francisciredi Laurenti, 1768, is named after him.