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Document written by hand

A manuscript (abbreviated MS for singular and MSS for plural) was, traditionally, any document written by hand or typewritten, as opposed to mechanically printed or reproduced in some indirect or automated way. More recently, the term has come to be understood to further include any written, typed, or word processed copy of an author's work, as distinguished from the rendition as a printed version of the same. Before the arrival of prints, all documents and books were manuscripts. Manuscripts are not defined by their contents, which may combine writing with mathematical calculations, maps, music notation, explanatory figures, or illustrations.

The word "manuscript" derives from the manūscriptum (from manus, hand and scriptum from scribere, to write). The study of the writing (the "hand") in surviving manuscripts is termed palaeography (or paleography). The traditional abbreviations are MS for manuscript and MSS for manuscripts, while the forms MS., ms or ms. for singular, and MSS., mss or mss. for plural (with or without the full stop, all uppercase or all lowercase) are also accepted. The second s is not simply the plural; by an old convention, a doubling of the last letter of the abbreviation expresses the plural, just as pp. means "pages". A manuscript may be a codex (i. e. bound as a book), a scroll, or bound differently or consist of loose pages. Illuminated manuscripts are enriched with pictures, border decorations, elaborately embossed initial letters or full page illustrations.

The mechanical reproduction of a manuscript is called facsimile. Digital reproductions can be called (high resolution) scans or digital images.

Before the inventions of printing, in China by woodblock and in Europe by movable type in a printing press, all written documents had to be both produced and reproduced by hand. In the west, manuscripts were produced in form of scrolls (volumen in Latin) or books (codex, plural codices). Manuscripts were produced on vellum and other parchment, on papyrus, and on paper. In Indian Subcontinent and Southeast Asia, palm leaf manuscripts, with a distinctive long rectangular shape, were used dating back to the 5th century BCE or earlier, and in some cases continued to be used until the 19th century. In China, bamboo and wooden slips were used prior to the introduction of paper. In Russia, birch bark documents as old as from the 11th century have survived. Paper spread from China via the Islamic world to Europe by the 14th century, and by the late 15th century had largely replaced parchment for many purposes there. When Greek or Latin works were published, numerous professional copies were sometimes made simultaneously by scribes in a scriptorium, each making a single copy from an original that was declaimed aloud. The oldest written manuscripts have been preserved by the perfect dryness of their Middle Eastern resting places, whether placed within sarcophagi in Egyptian tombs, or reused as mummy wrappings, discarded in the middens of Oxyrhynchus or secreted for safe keeping in jars and buried (Nag Hammadi library) or stored in dry caves (Dead Sea scrolls). Volcanic ash preserved some of the Roman library of the Villa of the Papyri in Herculaneum. Manuscripts in Tocharian languages, written on palm leaves, survived in desert burials in the Tarim Basin of Central Asia. Ironically, the manuscripts that were being most carefully preserved in the libraries of antiquity are virtually all lost. Papyrus has a life of at most a century or two in relatively humid Italian or Greek conditions; only those works copied onto parchment, usually after the general conversion to Christianity, have survived, and by no means all of those. Originally, all books were in manuscript form. In China, and later other parts of East Asia, woodblock printing was used for books from about the 7th century. The earliest dated example is the Diamond Sutra of 868. In the Islamic world and the West, all books were in manuscript until the introduction of movable type printing in about 1450. Manuscript copying of books continued for a least a century, as printing remained expensive. Private or government documents remained hand written until the invention of the typewriter in the late 19th century. Because of the likelihood of errors being introduced each time a manuscript was copied, the filiation of different versions of the same text is a fundamental part of the study and criticism of all texts that have been transmitted in manuscript. In Southeast Asia, in the first millennium, documents of sufficiently great importance were inscribed on soft metallic sheets such as copperplate, softened by refiner's fire and inscribed with a metal stylus. In the Philippines, for example, as early as 900 AD, specimen documents were not inscribed by stylus, but were punched much like the style of today's dot matrix printers. This type of document was rare compared to the usual leaves and bamboo staves that were inscribed. However, neither the leaves nor paper were as durable as the metal document in the hot, humid climate. In Burma, the kammavaca, Buddhist manuscripts, were inscribed on brass, copper or ivory sheets, and even on discarded monk robes folded and lacquered. In Italy some important Etruscan texts were similarly inscribed on thin gold plates: similar sheets have been discovered in Bulgaria. Technically, these are all inscriptions rather than manuscripts. In the Western world, from the classical period through the early centuries of the Christian era, manuscripts were written without spaces between the words (scriptio continua), which makes them especially hard for the untrained to read. Extant copies of these early manuscripts written in Greek or Latin and usually dating from the 4th century to the 8th century, are classified according to their use of either all upper case or all lower case letters. Hebrew manuscripts, such as the Dead Sea scrolls make no such differentiation. Manuscripts using all upper case letters are called majuscule, those using all lower case are called minuscule. Usually, the majuscule scripts such as uncial are written with much more care. The scribe lifted his pen between each stroke, producing an unmistakable effect of regularity and formality. On the other hand, while minuscule scripts can be written with pen lift, they may also be cursive, that is, use little or no pen lift.

Islamic manuscripts were produced in different ways depending on their use and time period. Parchment (vellum) was a common way to produce manuscripts. Manuscripts eventually transitioned to using paper in later centuries with the diffusion of paper making in the Islamic empire. When Muslims encountered paper in Central Asia, its use and production spread to Iran, Iraq, Syria, Egypt, and North Africa during the 8th century.

4,203 of Timbuktu's manuscripts were burned or stolen during the armed conflict in Mali between 2012 and 2013. 90% of these manuscripts were saved by the population organized around the NGO "Sauvegarde et valorisation des manuscrits pour la défense de la culture islamique" (SAVAMA DCI). Some 350,000 manuscripts were transported to safety, and 300,000 of them were still in Bamako in 2022. An international consultation on the safeguarding, accessibility and promotion of ancient manuscripts in the Sahel was held at the UNESCO office in Bamako in 2020.]] Most surviving pre modern manuscripts use the codex format (as in a modern book), which had replaced the scroll by Late Antiquity. Parchment or vellum, as the best type of parchment is known, had also replaced papyrus, which was not nearly so long lived and has survived to the present almost exclusively in the very dry climate of Egypt, although it was widely used across the Roman world. Parchment is made of animal skin, normally calf, sheep, or goat, but also other animals. With all skins, the quality of the finished product is based on how much preparation and skill was put into turning the skin into parchment. Parchment made from calf or sheep was the most common in Northern Europe, while civilizations in Southern Europe preferred goatskin. Often, if the parchment is white or cream in color and veins from the animal can still be seen, it is calfskin. If it is yellow, greasy or in some cases shiny, then it was made from sheepskin. Caroline minuscule is a calligraphic script developed as a writing standard in Europe so that the Latin alphabet could be easily recognized by the literate class from different regions. It was used in the Holy Roman Empire between approximately 800 and 1200. Codices, classical and Christian texts, and educational material were written in Carolingian minuscule throughout the Carolingian Renaissance. The script developed into blackletter and became obsolete, though its revival in the Italian renaissance forms the basis of more recent scripts. All the individual letters are Caroline; but just as with English Protogothic Bookhand it evolved. This can be seen most notably in the arm of the letter h. It has a hairline that tapers out by curving to the left. When first read the German Protogothic h looks like the German Protogothic b. Many more scripts sprang out of the German Protogothic Bookhand. After those came Bastard Anglicana, which is best described as: The Bible was the center of medieval religious life. Along with the Bible came scores of commentaries. Commentaries were written in volumes, with some focusing on just single pages of scripture. Across Europe, there were universities that prided themselves on their biblical knowledge. Along with universities, certain cities also had their own celebrities of biblical knowledge during the medieval period.

A book of hours is a type of devotional text which was widely popular during the Middle Ages. They are the most common type of surviving medieval illuminated manuscripts. Each book of hours contain a similar collection of texts, prayers, and psalms but decoration can vary between each and each example. Many have minimal illumination, often restricted to ornamented initials, but books of hours made for wealthier patrons can be extremely extravagant with full page miniatures. These books were used for owners to recite prayers privately eight different times, or hours, of the day.

Along with Bibles, large numbers of manuscripts made in the Middle Ages were received in Church. Due to the complex church system of rituals and worship these books were the most elegantly written and finely decorated of all medieval manuscripts. Liturgical books usually came in two varieties. Those used during mass and those for divine office.

In book, magazine, and music publishing, a manuscript is an autograph or copy of a work, written by an author, composer or copyist. Such manuscripts generally follow standardized typographic and formatting rules, in which case they can be called fair copy (whether original or copy). The staff paper commonly used for handwritten music is, for this reason, often called "manuscript paper".

In film and theatre, a manuscript, or script for short, is an author's or dramatist's text, used by a theatre company or film crew during the production of the work's performance or filming. More specifically, a motion picture manuscript is called a screenplay; a television manuscript, a teleplay; a manuscript for the theatre, a stage play; and a manuscript for audio only performance is often called a radio play, even when the recorded performance is disseminated via non radio means.

In insurance, a manuscript policy is one that is negotiated between the insurer and the policyholder, as opposed to an off the shelf form supplied by the insurer.

About 300,000 Latin, 55,000 Greek, 30,000 Armenian and 12,000 Georgian medieval manuscripts have survived. National Geographic estimates that 700,000 African manuscripts have survived at the University of Timbuktu in Mali.