Введение
Структура в среднем мозге
Structure in the midbrain
In neuroanatomy, the superior colliculus is a structure lying on the roof of the mammalian midbrain. The adjective form tectal is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers (stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor related neurons, capable of activating eye movements as well as other responses. In other vertebrates the number of layers in the homologous optic tectum varies. and shifts in attention that do not involve any overt movements. The two inferior colliculi are situated immediately inferior/caudal to the superior colliculi; the inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin for quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent. The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. In the optic tectum this nearby structure is known as the nucleus isthmi. Structure
The superior colliculus is a synaptic layered structure. The top three layers are called superficial:Lamina I or SZ, the stratum zonale, is a thin layer consisting of small myelinated axons together with marginal and horizontal cells. Lamina II or SGS, the stratum griseum superficiale ("superficial gray layer"), contains many neurons of various shapes and sizes. Lamina III or SO, the stratum opticum ("optic layer"), consists mainly of axons coming from the optic tract. Next come two intermediate layers:Lamina IV or SGI, the stratum griseum intermedium ("intermediate gray layer"), is the thickest layer, and is filled with many neurons of many sizes. This layer is often as thick as all the other layers together. It is often subdivided into "upper" and "lower" parts. Lamina V or SAI, the stratum album intermedium ("intermediate white layer"), consists mainly of fibers from various sources. Finally come the two deep layers:Lamina VI or SGP, the stratum griseum profundum ("deep gray layer"), consists of loosely packed neurons and myelinated fibers. Lamina VII or SAP', the stratum album profundum ("deep white layer"), lying directly above the periaqueductal gray, consists entirely of fibers. The superficial layers receive input mainly from the retina, vision related areas of the cerebral cortex, and two tectal related structures called the pretectum and parabigeminal nucleus. The retinal input encompasses the entire superficial zone, and is bilateral, although the contralateral portion is more extensive. The cortical input comes most heavily from the primary visual cortex (area 17, V1), the secondary visual cortex (areas 18 and 19), and the frontal eye fields. The parabigeminal nucleus plays a very important role in tectal function that is described below. In contrast to the vision dominated inputs to the superficial layers, the intermediate and deep layers receive inputs from a very diverse set of sensory and motor structures. Most areas of the cerebral cortex project to these layers, although the input from "association" areas tends to be heavier than the input from primary sensory or motor areas. However, the cortical areas involved, and the strength of their relative projections differs across species. Another important input comes from the substantia nigra, pars reticulata, a component of the basal ganglia. This projection uses the inhibitory neurotransmitter GABA, and is thought to exert a "gating" effect on the superior colliculus. The intermediate and deep layers also receive input from the spinal trigeminal nucleus, which conveys somatosensory information from the face, as well as the hypothalamus, zona incerta, thalamus, and inferior colliculus. In addition to their distinctive inputs, the superficial and deep zones of the superior colliculus also have distinctive outputs. One of the most important outputs goes to the pulvinar and lateral intermediate areas of the thalamus, which in turn project to areas of the cerebral cortex that are involved in controlling eye movements. There are also projections from the superficial zone to the pretectal nuclei, lateral geniculate nucleus of the thalamus, and the parabigeminal nucleus. The projections from the deeper layers are more extensive. There are two large descending pathways, traveling to the brainstem and spinal cord, and numerous ascending projections to a variety of sensory and motor centers, including several that are involved in generating eye movements. Both colliculi also have descending projections to the paramedian pontine reticular formation and spinal cord, and thus can be involved in responses to stimuli faster than cortical processing would allow. Mosaic structure
On detailed examination, the collicular layers are actually not smooth sheets, but divided into a honeycomb arrangement of discrete columns. The clearest indication of columnar structure comes from the cholinergic inputs arising from the parabigeminal nucleus, whose terminals form evenly spaced clusters that extend from top to bottom of the tectum. Several other neurochemical markers including calretinin, parvalbumin, GAP 43, and NMDA receptors, and connections with numerous other brain structures in the brainstem and diencephalon, also show a corresponding inhomogeneity. The total number of columns has been estimated at around 100. From the 1970s to 1990s, however, neural recordings from mammals, mostly monkeys, focused primarily on the role of the superior colliculus in controlling eye movements. This line of investigation came to dominate the literature to such a degree that the majority opinion was that eye movement control is the only important function in mammals, a view still reflected in many current textbooks. In the late 1990s, however, experiments using animals whose heads were free to move showed clearly that the SC actually produces gaze shifts, usually composed of combined head and eye movements, rather than eye movements per se. This discovery reawakened interest in the full breadth of functions of the superior colliculus, and led to studies of multisensory integration in a variety of species and situations. Nevertheless, the role of the SC in controlling eye movements is understood in much greater depth than any other function. Behavioral studies have shown that the SC is not needed for object recognition, but plays a critical role in the ability to direct behaviors toward specific objects, and can support this ability even in the absence of the cerebral cortex. Thus, cats with major damage to the visual cortex cannot recognize objects, but may still be able to follow and orient toward moving stimuli, although more slowly than usual. If one half of the SC is removed, however, the cats will circle constantly toward the side of the lesion, and orient compulsively toward objects located there, but fail to orient at all toward objects located in the opposite hemifield. These deficits diminish over time but never disappear. Eye movements
In primates, eye movements can be divided into several types: fixation, in which the eyes are directed toward a motionless object, with eye movements only to compensate for movements of the head; smooth pursuit, in which the eyes move steadily to track a moving object; saccades, in which the eyes move very rapidly from one location to another; and vergence, in which the eyes move simultaneously in opposite directions to obtain or maintain single binocular vision. The superior colliculus is involved in all of these, but its role in saccades has been studied most intensively. Each of the two colliculi — one on each side of the brain — contains a two dimensional map representing half of the visual field. The fovea — the region of maximum sensitivity — is represented at the front edge of the map, and the periphery at the back edge. Eye movements are evoked by activity in the deep layers of the SC. During fixation, neurons near the front edge — the foveal zone — are tonically active. During smooth pursuit, neurons a small distance from the front edge are activated, leading to small eye movements. For saccades, neurons are activated in a region that represents the point to which the saccade will be directed. Just prior to a saccade, activity rapidly builds up at the target location and decreases in other parts of the SC. The coding is rather broad, so that for any given saccade the activity profile forms a "hill" that encompasses a substantial fraction of the collicular map: The location of the peak of this "hill" represents the saccade target. The SC encodes the target of a gaze shift, but it does not seem to specify the precise movements needed to get there. The decomposition of a gaze shift into head and eye movements and the precise trajectory of the eye during a saccade depend on integration of collicular and non collicular signals by downstream motor areas, in ways that are not yet well understood. Regardless of how the movement is evoked or performed, the SC encodes it in "retinotopic" coordinates: that is, the location of the SC 'hill" corresponds to a fixed location on the retina. This seems to contradict the observation that stimulation of a single point on the SC can result in different gaze shift directions, depending on initial eye orientation. However, it has been shown that this is because the retinal location of a stimulus is a non linear function of target location, eye orientation, and the spherical geometry of the eye. There has been some controversy about whether the SC merely commands eye movements, and leaves the execution to other structures, or whether it actively participates in the performance of a saccade. In 1991, Munoz et al., on the basis of data they collected, argued that, during a saccade, the "hill" of activity in the SC moves gradually, to reflect the changing offset of the eye from the target location while the saccade is progressing. At present, the predominant view is that, although the "hill" does shift slightly during a saccade, it does not shift in the steady and proportionate way that the "moving hill" hypothesis predicts. However, moving hills may play another role in the superior colliculus; more recent experiments have demonstrated a continuously moving hill of visual memory activity when the eyes move slowly while a separate saccade target is retained. The output from the motor sector of the SC goes to a set of midbrain and brainstem nuclei, which transform the "place" code used by the SC into the "rate" code used by oculomotor neurons. Eye movements are generated by six muscles, arranged in three orthogonally aligned pairs. Thus, at the level of the final common path, eye movements are encoded in essentially a Cartesian coordinate system. Although the SC receives a strong input directly from the retina, in primates it is largely under the control of the cerebral cortex, which contains several areas that are involved in determining eye movements. The frontal eye fields, a portion of the motor cortex, are involved in triggering intentional saccades, and an adjoining area, the supplementary eye fields, are involved in organizing groups of saccades into sequences. The parietal eye fields, farther back in the brain, are involved mainly in reflexive saccades, made in response to changes in the view. Recent evidence suggests that the primary visual cortex (V1) guides reflexive eye movements, according to V1 Saliency Hypothesis, using a bottom up saliency map of the visual field generated in V1 from external visual inputs. The SC only receives visual inputs in its superficial layers, whereas the deeper layers of the colliculus receive also auditory and somatosensory inputs and are connected to many sensorimotor areas of the brain. The colliculus as a whole is thought to help orient the head and eyes toward something seen and heard. The superior colliculus also receives auditory information from the inferior colliculus. This auditory information is integrated with the visual information already present to produce the ventriloquism effect. Distractibility
As well as being related to eye movements, the SC appears to have an important role to play in the circuitry underpinning distractibility. Heightened distractibility occurs in normal aging and is also a central feature in a number of medical conditions, including attention deficit hyperactivity disorder (ADHD). Research has shown that lesions to the SC in a number of species can result in heightened distractibility and, in humans, removing the inhibitory control on the SC from the pre frontal cortex, therefore increasing activity in the area, also increases distractibility. Research in an animal model of ADHD, the spontaneously hypertensive rat, also shows altered collicular dependent behaviours and physiology. Other animals
Other mammals
Primates
It is usually accepted that the primate superior colliculus is unique among mammals, in that it does not contain a complete map of the visual field seen by the contralateral eye. Instead, like the visual cortex and lateral geniculate nucleus, each colliculus represents only the contralateral half of the visual field, up to the midline, and excludes a representation of the ipsilateral half. This functional characteristic is explained by the absence, in primates, of anatomical connections between the retinal ganglion cells in the temporal half of the retina and the contralateral superior colliculus. In other mammals, the retinal ganglion cells throughout the contralateral retina project to the contralateral colliculus. This distinction between primates and non primates has been one of the key lines of evidence in support of the flying primates theory proposed by Australian neuroscientist Jack Pettigrew in 1986, after he discovered that flying foxes (megabats) resemble primates in terms of the pattern of anatomical connections between the retina and superior colliculus. Cats
In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem. Bats
Bats are not, in fact, blind, but they depend much more on echolocation than vision for navigation and prey capture. They obtain information about the surrounding world by emitting sonar chirps and then listening for the echoes. Their brains are highly specialized for this process, and some of these specializations appear in the superior colliculus. In bats, the retinal projection occupies only a thin zone just beneath the surface, but there are extensive inputs from auditory areas, and outputs to motor areas capable of orienting the ears, head, or body. Echoes coming from different directions activate neurons at different locations in the collicular layers, and activation of collicular neurons influences the chirps that the bats emit. Thus, there is a strong case that the superior colliculus performs the same sorts of functions for the auditory guided behaviors of bats that it performs for the visual guided behaviors of other species. Bats are usually classified into two main groups: Microchiroptera (the most numerous, and commonly found throughout the world), and Megachiroptera (fruit bats, found in Asia, Africa and Australasia). With one exception, Megabats do not echolocate, and rely on a developed sense of vision to navigate. The visual receptive fields of neurons in the superior colliculus in these animals form a precise map of the retina, similar to that found in cats and primates. Rodents
The superior colliculus in rodents have been hypothesized to mediate sensory guided approach and avoidance behaviors. Studies employing circuit analysis tools on mouse superior colliculus have revealed several important functions. In a series of studies, researchers have identified a set of Ying Yang circuit modules in the superior colliculus to initiate prey capture and predator avoidance behaviors in mice. By using single cell RNA sequencing, researchers have analyzed the gene expression profiles of superior colliculus neurons and identified the unique genetic markers of these circuit modules. Other vertebrates
Optic tectum
The optic tectum is the visual center in the non mammalian brain which develops from the alar plate of the mesencephalon. In these other vertebrates the connections from the optic tectum are important for the recognition and reaction to various sized objects which is facilitated by excitatory optic nerve transmitters like L glutamate. Disrupting visual experience early on in zebrafish development results in a change in tectal activity. Changes in tectal activity resulted in an inability to successfully hunt and capture prey. Hypothalamus inhibitory signaling to the deep tectal neuropil is important in tectal processing in zebrafish larvae. The tectal neuropil contains structures including periventricular neuronal axons and dendrites. The neuropil also contains GABAergic superficial inhibitory neurons located in stratum opticum. Instead of a large cerebral cortex, zebrafish have a relatively large optic tectum that is hypothesized to carry out some of the visual processing that the cortex performs in mammals. Recent lesion studies have suggested that the optic tectum has no influence over higher order motion responses like the optomotor response or the optokinetic response, but may be more integral to lower order cues in motion perception like in the identification of small objects. The optic tectum is one of the fundamental components of the vertebrate brain, existing across a range of species. Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic tracts to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow (In the superior colliculus the like structure is termed the parabigeminal nucleus). The nucleus isthmii is divided into two parts, called isthmus pars magnocellularis (Imc; "the part with the large cells") and isthmus pars parvocellularis'' (Ipc); "the part with the small cells"). Connections between the three areas — optic tectum, Ipc, and Imc — are topographic. Neurons in the superficial layers of the optic tectum project to corresponding points in the Ipc and Imc. The projections to the Ipc are tightly focused, while the projections to the Imc are somewhat more diffuse. Ipc gives rise to tightly focused cholinergic projections both to Imc and the optic tectum. In the optic tectum, the cholinergic inputs from Ipc ramify to give rise to terminals that extend across an entire column, from top to bottom. Imc, in contrast, gives rise to GABAergic projections to Ipc and optic tectum that spread very broadly in the lateral dimensions, encompassing most of the retinotopic map. Thus, the tectum Ipc Imc circuit causes tectal activity to produce recurrent feedback that involves tightly focused excitation of a small column of neighboring tectal neurons, together with global inhibition of distant tectal neurons. The optic tectum is involved in many responses including swimming in fish, flight in birds, tongue strikes toward prey in frogs, and fang strikes in snakes. In some species, including fish and birds, the optic tectum, also known as the optic lobe, is one of the largest components of the brain. In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. In amphibians, reptiles, and especially birds it is also a very significant component.
In neuroanatomy, the superior colliculus is a structure lying on the roof of the mammalian midbrain. The adjective form tectal is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers (stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor related neurons, capable of activating eye movements as well as other responses. In other vertebrates the number of layers in the homologous optic tectum varies. and shifts in attention that do not involve any overt movements. The two inferior colliculi are situated immediately inferior/caudal to the superior colliculi; the inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin for quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent. The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. In the optic tectum this nearby structure is known as the nucleus isthmi. Structure
The superior colliculus is a synaptic layered structure. The top three layers are called superficial:Lamina I or SZ, the stratum zonale, is a thin layer consisting of small myelinated axons together with marginal and horizontal cells. Lamina II or SGS, the stratum griseum superficiale ("superficial gray layer"), contains many neurons of various shapes and sizes. Lamina III or SO, the stratum opticum ("optic layer"), consists mainly of axons coming from the optic tract. Next come two intermediate layers:Lamina IV or SGI, the stratum griseum intermedium ("intermediate gray layer"), is the thickest layer, and is filled with many neurons of many sizes. This layer is often as thick as all the other layers together. It is often subdivided into "upper" and "lower" parts. Lamina V or SAI, the stratum album intermedium ("intermediate white layer"), consists mainly of fibers from various sources. Finally come the two deep layers:Lamina VI or SGP, the stratum griseum profundum ("deep gray layer"), consists of loosely packed neurons and myelinated fibers. Lamina VII or SAP', the stratum album profundum ("deep white layer"), lying directly above the periaqueductal gray, consists entirely of fibers. The superficial layers receive input mainly from the retina, vision related areas of the cerebral cortex, and two tectal related structures called the pretectum and parabigeminal nucleus. The retinal input encompasses the entire superficial zone, and is bilateral, although the contralateral portion is more extensive. The cortical input comes most heavily from the primary visual cortex (area 17, V1), the secondary visual cortex (areas 18 and 19), and the frontal eye fields. The parabigeminal nucleus plays a very important role in tectal function that is described below. In contrast to the vision dominated inputs to the superficial layers, the intermediate and deep layers receive inputs from a very diverse set of sensory and motor structures. Most areas of the cerebral cortex project to these layers, although the input from "association" areas tends to be heavier than the input from primary sensory or motor areas. However, the cortical areas involved, and the strength of their relative projections differs across species. Another important input comes from the substantia nigra, pars reticulata, a component of the basal ganglia. This projection uses the inhibitory neurotransmitter GABA, and is thought to exert a "gating" effect on the superior colliculus. The intermediate and deep layers also receive input from the spinal trigeminal nucleus, which conveys somatosensory information from the face, as well as the hypothalamus, zona incerta, thalamus, and inferior colliculus. In addition to their distinctive inputs, the superficial and deep zones of the superior colliculus also have distinctive outputs. One of the most important outputs goes to the pulvinar and lateral intermediate areas of the thalamus, which in turn project to areas of the cerebral cortex that are involved in controlling eye movements. There are also projections from the superficial zone to the pretectal nuclei, lateral geniculate nucleus of the thalamus, and the parabigeminal nucleus. The projections from the deeper layers are more extensive. There are two large descending pathways, traveling to the brainstem and spinal cord, and numerous ascending projections to a variety of sensory and motor centers, including several that are involved in generating eye movements. Both colliculi also have descending projections to the paramedian pontine reticular formation and spinal cord, and thus can be involved in responses to stimuli faster than cortical processing would allow. Mosaic structure
On detailed examination, the collicular layers are actually not smooth sheets, but divided into a honeycomb arrangement of discrete columns. The clearest indication of columnar structure comes from the cholinergic inputs arising from the parabigeminal nucleus, whose terminals form evenly spaced clusters that extend from top to bottom of the tectum. Several other neurochemical markers including calretinin, parvalbumin, GAP 43, and NMDA receptors, and connections with numerous other brain structures in the brainstem and diencephalon, also show a corresponding inhomogeneity. The total number of columns has been estimated at around 100. From the 1970s to 1990s, however, neural recordings from mammals, mostly monkeys, focused primarily on the role of the superior colliculus in controlling eye movements. This line of investigation came to dominate the literature to such a degree that the majority opinion was that eye movement control is the only important function in mammals, a view still reflected in many current textbooks. In the late 1990s, however, experiments using animals whose heads were free to move showed clearly that the SC actually produces gaze shifts, usually composed of combined head and eye movements, rather than eye movements per se. This discovery reawakened interest in the full breadth of functions of the superior colliculus, and led to studies of multisensory integration in a variety of species and situations. Nevertheless, the role of the SC in controlling eye movements is understood in much greater depth than any other function. Behavioral studies have shown that the SC is not needed for object recognition, but plays a critical role in the ability to direct behaviors toward specific objects, and can support this ability even in the absence of the cerebral cortex. Thus, cats with major damage to the visual cortex cannot recognize objects, but may still be able to follow and orient toward moving stimuli, although more slowly than usual. If one half of the SC is removed, however, the cats will circle constantly toward the side of the lesion, and orient compulsively toward objects located there, but fail to orient at all toward objects located in the opposite hemifield. These deficits diminish over time but never disappear. Eye movements
In primates, eye movements can be divided into several types: fixation, in which the eyes are directed toward a motionless object, with eye movements only to compensate for movements of the head; smooth pursuit, in which the eyes move steadily to track a moving object; saccades, in which the eyes move very rapidly from one location to another; and vergence, in which the eyes move simultaneously in opposite directions to obtain or maintain single binocular vision. The superior colliculus is involved in all of these, but its role in saccades has been studied most intensively. Each of the two colliculi — one on each side of the brain — contains a two dimensional map representing half of the visual field. The fovea — the region of maximum sensitivity — is represented at the front edge of the map, and the periphery at the back edge. Eye movements are evoked by activity in the deep layers of the SC. During fixation, neurons near the front edge — the foveal zone — are tonically active. During smooth pursuit, neurons a small distance from the front edge are activated, leading to small eye movements. For saccades, neurons are activated in a region that represents the point to which the saccade will be directed. Just prior to a saccade, activity rapidly builds up at the target location and decreases in other parts of the SC. The coding is rather broad, so that for any given saccade the activity profile forms a "hill" that encompasses a substantial fraction of the collicular map: The location of the peak of this "hill" represents the saccade target. The SC encodes the target of a gaze shift, but it does not seem to specify the precise movements needed to get there. The decomposition of a gaze shift into head and eye movements and the precise trajectory of the eye during a saccade depend on integration of collicular and non collicular signals by downstream motor areas, in ways that are not yet well understood. Regardless of how the movement is evoked or performed, the SC encodes it in "retinotopic" coordinates: that is, the location of the SC 'hill" corresponds to a fixed location on the retina. This seems to contradict the observation that stimulation of a single point on the SC can result in different gaze shift directions, depending on initial eye orientation. However, it has been shown that this is because the retinal location of a stimulus is a non linear function of target location, eye orientation, and the spherical geometry of the eye. There has been some controversy about whether the SC merely commands eye movements, and leaves the execution to other structures, or whether it actively participates in the performance of a saccade. In 1991, Munoz et al., on the basis of data they collected, argued that, during a saccade, the "hill" of activity in the SC moves gradually, to reflect the changing offset of the eye from the target location while the saccade is progressing. At present, the predominant view is that, although the "hill" does shift slightly during a saccade, it does not shift in the steady and proportionate way that the "moving hill" hypothesis predicts. However, moving hills may play another role in the superior colliculus; more recent experiments have demonstrated a continuously moving hill of visual memory activity when the eyes move slowly while a separate saccade target is retained. The output from the motor sector of the SC goes to a set of midbrain and brainstem nuclei, which transform the "place" code used by the SC into the "rate" code used by oculomotor neurons. Eye movements are generated by six muscles, arranged in three orthogonally aligned pairs. Thus, at the level of the final common path, eye movements are encoded in essentially a Cartesian coordinate system. Although the SC receives a strong input directly from the retina, in primates it is largely under the control of the cerebral cortex, which contains several areas that are involved in determining eye movements. The frontal eye fields, a portion of the motor cortex, are involved in triggering intentional saccades, and an adjoining area, the supplementary eye fields, are involved in organizing groups of saccades into sequences. The parietal eye fields, farther back in the brain, are involved mainly in reflexive saccades, made in response to changes in the view. Recent evidence suggests that the primary visual cortex (V1) guides reflexive eye movements, according to V1 Saliency Hypothesis, using a bottom up saliency map of the visual field generated in V1 from external visual inputs. The SC only receives visual inputs in its superficial layers, whereas the deeper layers of the colliculus receive also auditory and somatosensory inputs and are connected to many sensorimotor areas of the brain. The colliculus as a whole is thought to help orient the head and eyes toward something seen and heard. The superior colliculus also receives auditory information from the inferior colliculus. This auditory information is integrated with the visual information already present to produce the ventriloquism effect. Distractibility
As well as being related to eye movements, the SC appears to have an important role to play in the circuitry underpinning distractibility. Heightened distractibility occurs in normal aging and is also a central feature in a number of medical conditions, including attention deficit hyperactivity disorder (ADHD). Research has shown that lesions to the SC in a number of species can result in heightened distractibility and, in humans, removing the inhibitory control on the SC from the pre frontal cortex, therefore increasing activity in the area, also increases distractibility. Research in an animal model of ADHD, the spontaneously hypertensive rat, also shows altered collicular dependent behaviours and physiology. Other animals
Other mammals
Primates
It is usually accepted that the primate superior colliculus is unique among mammals, in that it does not contain a complete map of the visual field seen by the contralateral eye. Instead, like the visual cortex and lateral geniculate nucleus, each colliculus represents only the contralateral half of the visual field, up to the midline, and excludes a representation of the ipsilateral half. This functional characteristic is explained by the absence, in primates, of anatomical connections between the retinal ganglion cells in the temporal half of the retina and the contralateral superior colliculus. In other mammals, the retinal ganglion cells throughout the contralateral retina project to the contralateral colliculus. This distinction between primates and non primates has been one of the key lines of evidence in support of the flying primates theory proposed by Australian neuroscientist Jack Pettigrew in 1986, after he discovered that flying foxes (megabats) resemble primates in terms of the pattern of anatomical connections between the retina and superior colliculus. Cats
In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem. Bats
Bats are not, in fact, blind, but they depend much more on echolocation than vision for navigation and prey capture. They obtain information about the surrounding world by emitting sonar chirps and then listening for the echoes. Their brains are highly specialized for this process, and some of these specializations appear in the superior colliculus. In bats, the retinal projection occupies only a thin zone just beneath the surface, but there are extensive inputs from auditory areas, and outputs to motor areas capable of orienting the ears, head, or body. Echoes coming from different directions activate neurons at different locations in the collicular layers, and activation of collicular neurons influences the chirps that the bats emit. Thus, there is a strong case that the superior colliculus performs the same sorts of functions for the auditory guided behaviors of bats that it performs for the visual guided behaviors of other species. Bats are usually classified into two main groups: Microchiroptera (the most numerous, and commonly found throughout the world), and Megachiroptera (fruit bats, found in Asia, Africa and Australasia). With one exception, Megabats do not echolocate, and rely on a developed sense of vision to navigate. The visual receptive fields of neurons in the superior colliculus in these animals form a precise map of the retina, similar to that found in cats and primates. Rodents
The superior colliculus in rodents have been hypothesized to mediate sensory guided approach and avoidance behaviors. Studies employing circuit analysis tools on mouse superior colliculus have revealed several important functions. In a series of studies, researchers have identified a set of Ying Yang circuit modules in the superior colliculus to initiate prey capture and predator avoidance behaviors in mice. By using single cell RNA sequencing, researchers have analyzed the gene expression profiles of superior colliculus neurons and identified the unique genetic markers of these circuit modules. Other vertebrates
Optic tectum
The optic tectum is the visual center in the non mammalian brain which develops from the alar plate of the mesencephalon. In these other vertebrates the connections from the optic tectum are important for the recognition and reaction to various sized objects which is facilitated by excitatory optic nerve transmitters like L glutamate. Disrupting visual experience early on in zebrafish development results in a change in tectal activity. Changes in tectal activity resulted in an inability to successfully hunt and capture prey. Hypothalamus inhibitory signaling to the deep tectal neuropil is important in tectal processing in zebrafish larvae. The tectal neuropil contains structures including periventricular neuronal axons and dendrites. The neuropil also contains GABAergic superficial inhibitory neurons located in stratum opticum. Instead of a large cerebral cortex, zebrafish have a relatively large optic tectum that is hypothesized to carry out some of the visual processing that the cortex performs in mammals. Recent lesion studies have suggested that the optic tectum has no influence over higher order motion responses like the optomotor response or the optokinetic response, but may be more integral to lower order cues in motion perception like in the identification of small objects. The optic tectum is one of the fundamental components of the vertebrate brain, existing across a range of species. Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic tracts to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow (In the superior colliculus the like structure is termed the parabigeminal nucleus). The nucleus isthmii is divided into two parts, called isthmus pars magnocellularis (Imc; "the part with the large cells") and isthmus pars parvocellularis'' (Ipc); "the part with the small cells"). Connections between the three areas — optic tectum, Ipc, and Imc — are topographic. Neurons in the superficial layers of the optic tectum project to corresponding points in the Ipc and Imc. The projections to the Ipc are tightly focused, while the projections to the Imc are somewhat more diffuse. Ipc gives rise to tightly focused cholinergic projections both to Imc and the optic tectum. In the optic tectum, the cholinergic inputs from Ipc ramify to give rise to terminals that extend across an entire column, from top to bottom. Imc, in contrast, gives rise to GABAergic projections to Ipc and optic tectum that spread very broadly in the lateral dimensions, encompassing most of the retinotopic map. Thus, the tectum Ipc Imc circuit causes tectal activity to produce recurrent feedback that involves tightly focused excitation of a small column of neighboring tectal neurons, together with global inhibition of distant tectal neurons. The optic tectum is involved in many responses including swimming in fish, flight in birds, tongue strikes toward prey in frogs, and fang strikes in snakes. In some species, including fish and birds, the optic tectum, also known as the optic lobe, is one of the largest components of the brain. In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. In amphibians, reptiles, and especially birds it is also a very significant component.
В нейроанатомии верхний бугорок – это структура, расположенная на крыше среднего мозга млекопитающих. Прилагательное «тектальный» обычно используется для обозначения обеих структур. У млекопитающих верхний бугорок формирует основной компонент среднего мозга. Это парная структура, и вместе с парными нижними бугорками образует четверохолмие. Верхний бугорок представляет собой слоистую структуру с паттерном, схожим у всех млекопитающих. Слои можно объединить в поверхностные слои (stratum opticum и выше) и оставшиеся более глубокие слои. Нейроны в поверхностных слоях получают прямой вход из сетчатки и реагируют почти исключительно на зрительные стимулы. Многие нейроны в более глубоких слоях также реагируют на другие модальности, а некоторые – на стимулы из нескольких модальностей. В более глубоких слоях также содержится популяция моторных нейронов, способных активировать движения глаз, а также другие реакции. У других позвоночных количество слоев в гомологичном зрительном бугорке варьируется, а также происходят сдвиги внимания, не включающие явных движений. Два нижних бугорка расположены непосредственно под/каудально от верхних бугорков; нижние и верхние бугорки вместе известны как четверохолмие (от латинского quadruplet bodies – «четырехчастные тела»). Верхние бугорки крупнее нижних, хотя нижние бугорки более выражены. Рукав верхнего бугорка (или верхний рукав) – это ветвь, отходящая латерально от верхнего бугорка и, проходя к таламусу между пульвинаром и медиальным коленчатым ядром, частично продолжается в возвышение, называемое латеральным коленчатым ядром, а частично – в зрительный тракт. Верхний бугорок связан с близлежащей структурой, называемой парабигеминальным ядром, часто именуемым его спутником. В зрительном бугорке эта близлежащая структура известна как ядро моста.
Structure in the midbrain
In neuroanatomy, the superior colliculus is a structure lying on the roof of the mammalian midbrain. The adjective form tectal is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers (stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor related neurons, capable of activating eye movements as well as other responses. In other vertebrates the number of layers in the homologous optic tectum varies. and shifts in attention that do not involve any overt movements. The two inferior colliculi are situated immediately inferior/caudal to the superior colliculi; the inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin for quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent. The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. In the optic tectum this nearby structure is known as the nucleus isthmi. Structure
The superior colliculus is a synaptic layered structure. The top three layers are called superficial:Lamina I or SZ, the stratum zonale, is a thin layer consisting of small myelinated axons together with marginal and horizontal cells. Lamina II or SGS, the stratum griseum superficiale ("superficial gray layer"), contains many neurons of various shapes and sizes. Lamina III or SO, the stratum opticum ("optic layer"), consists mainly of axons coming from the optic tract. Next come two intermediate layers:Lamina IV or SGI, the stratum griseum intermedium ("intermediate gray layer"), is the thickest layer, and is filled with many neurons of many sizes. This layer is often as thick as all the other layers together. It is often subdivided into "upper" and "lower" parts. Lamina V or SAI, the stratum album intermedium ("intermediate white layer"), consists mainly of fibers from various sources. Finally come the two deep layers:Lamina VI or SGP, the stratum griseum profundum ("deep gray layer"), consists of loosely packed neurons and myelinated fibers. Lamina VII or SAP', the stratum album profundum ("deep white layer"), lying directly above the periaqueductal gray, consists entirely of fibers. The superficial layers receive input mainly from the retina, vision related areas of the cerebral cortex, and two tectal related structures called the pretectum and parabigeminal nucleus. The retinal input encompasses the entire superficial zone, and is bilateral, although the contralateral portion is more extensive. The cortical input comes most heavily from the primary visual cortex (area 17, V1), the secondary visual cortex (areas 18 and 19), and the frontal eye fields. The parabigeminal nucleus plays a very important role in tectal function that is described below. In contrast to the vision dominated inputs to the superficial layers, the intermediate and deep layers receive inputs from a very diverse set of sensory and motor structures. Most areas of the cerebral cortex project to these layers, although the input from "association" areas tends to be heavier than the input from primary sensory or motor areas. However, the cortical areas involved, and the strength of their relative projections differs across species. Another important input comes from the substantia nigra, pars reticulata, a component of the basal ganglia. This projection uses the inhibitory neurotransmitter GABA, and is thought to exert a "gating" effect on the superior colliculus. The intermediate and deep layers also receive input from the spinal trigeminal nucleus, which conveys somatosensory information from the face, as well as the hypothalamus, zona incerta, thalamus, and inferior colliculus. In addition to their distinctive inputs, the superficial and deep zones of the superior colliculus also have distinctive outputs. One of the most important outputs goes to the pulvinar and lateral intermediate areas of the thalamus, which in turn project to areas of the cerebral cortex that are involved in controlling eye movements. There are also projections from the superficial zone to the pretectal nuclei, lateral geniculate nucleus of the thalamus, and the parabigeminal nucleus. The projections from the deeper layers are more extensive. There are two large descending pathways, traveling to the brainstem and spinal cord, and numerous ascending projections to a variety of sensory and motor centers, including several that are involved in generating eye movements. Both colliculi also have descending projections to the paramedian pontine reticular formation and spinal cord, and thus can be involved in responses to stimuli faster than cortical processing would allow. Mosaic structure
On detailed examination, the collicular layers are actually not smooth sheets, but divided into a honeycomb arrangement of discrete columns. The clearest indication of columnar structure comes from the cholinergic inputs arising from the parabigeminal nucleus, whose terminals form evenly spaced clusters that extend from top to bottom of the tectum. Several other neurochemical markers including calretinin, parvalbumin, GAP 43, and NMDA receptors, and connections with numerous other brain structures in the brainstem and diencephalon, also show a corresponding inhomogeneity. The total number of columns has been estimated at around 100. From the 1970s to 1990s, however, neural recordings from mammals, mostly monkeys, focused primarily on the role of the superior colliculus in controlling eye movements. This line of investigation came to dominate the literature to such a degree that the majority opinion was that eye movement control is the only important function in mammals, a view still reflected in many current textbooks. In the late 1990s, however, experiments using animals whose heads were free to move showed clearly that the SC actually produces gaze shifts, usually composed of combined head and eye movements, rather than eye movements per se. This discovery reawakened interest in the full breadth of functions of the superior colliculus, and led to studies of multisensory integration in a variety of species and situations. Nevertheless, the role of the SC in controlling eye movements is understood in much greater depth than any other function. Behavioral studies have shown that the SC is not needed for object recognition, but plays a critical role in the ability to direct behaviors toward specific objects, and can support this ability even in the absence of the cerebral cortex. Thus, cats with major damage to the visual cortex cannot recognize objects, but may still be able to follow and orient toward moving stimuli, although more slowly than usual. If one half of the SC is removed, however, the cats will circle constantly toward the side of the lesion, and orient compulsively toward objects located there, but fail to orient at all toward objects located in the opposite hemifield. These deficits diminish over time but never disappear. Eye movements
In primates, eye movements can be divided into several types: fixation, in which the eyes are directed toward a motionless object, with eye movements only to compensate for movements of the head; smooth pursuit, in which the eyes move steadily to track a moving object; saccades, in which the eyes move very rapidly from one location to another; and vergence, in which the eyes move simultaneously in opposite directions to obtain or maintain single binocular vision. The superior colliculus is involved in all of these, but its role in saccades has been studied most intensively. Each of the two colliculi — one on each side of the brain — contains a two dimensional map representing half of the visual field. The fovea — the region of maximum sensitivity — is represented at the front edge of the map, and the periphery at the back edge. Eye movements are evoked by activity in the deep layers of the SC. During fixation, neurons near the front edge — the foveal zone — are tonically active. During smooth pursuit, neurons a small distance from the front edge are activated, leading to small eye movements. For saccades, neurons are activated in a region that represents the point to which the saccade will be directed. Just prior to a saccade, activity rapidly builds up at the target location and decreases in other parts of the SC. The coding is rather broad, so that for any given saccade the activity profile forms a "hill" that encompasses a substantial fraction of the collicular map: The location of the peak of this "hill" represents the saccade target. The SC encodes the target of a gaze shift, but it does not seem to specify the precise movements needed to get there. The decomposition of a gaze shift into head and eye movements and the precise trajectory of the eye during a saccade depend on integration of collicular and non collicular signals by downstream motor areas, in ways that are not yet well understood. Regardless of how the movement is evoked or performed, the SC encodes it in "retinotopic" coordinates: that is, the location of the SC 'hill" corresponds to a fixed location on the retina. This seems to contradict the observation that stimulation of a single point on the SC can result in different gaze shift directions, depending on initial eye orientation. However, it has been shown that this is because the retinal location of a stimulus is a non linear function of target location, eye orientation, and the spherical geometry of the eye. There has been some controversy about whether the SC merely commands eye movements, and leaves the execution to other structures, or whether it actively participates in the performance of a saccade. In 1991, Munoz et al., on the basis of data they collected, argued that, during a saccade, the "hill" of activity in the SC moves gradually, to reflect the changing offset of the eye from the target location while the saccade is progressing. At present, the predominant view is that, although the "hill" does shift slightly during a saccade, it does not shift in the steady and proportionate way that the "moving hill" hypothesis predicts. However, moving hills may play another role in the superior colliculus; more recent experiments have demonstrated a continuously moving hill of visual memory activity when the eyes move slowly while a separate saccade target is retained. The output from the motor sector of the SC goes to a set of midbrain and brainstem nuclei, which transform the "place" code used by the SC into the "rate" code used by oculomotor neurons. Eye movements are generated by six muscles, arranged in three orthogonally aligned pairs. Thus, at the level of the final common path, eye movements are encoded in essentially a Cartesian coordinate system. Although the SC receives a strong input directly from the retina, in primates it is largely under the control of the cerebral cortex, which contains several areas that are involved in determining eye movements. The frontal eye fields, a portion of the motor cortex, are involved in triggering intentional saccades, and an adjoining area, the supplementary eye fields, are involved in organizing groups of saccades into sequences. The parietal eye fields, farther back in the brain, are involved mainly in reflexive saccades, made in response to changes in the view. Recent evidence suggests that the primary visual cortex (V1) guides reflexive eye movements, according to V1 Saliency Hypothesis, using a bottom up saliency map of the visual field generated in V1 from external visual inputs. The SC only receives visual inputs in its superficial layers, whereas the deeper layers of the colliculus receive also auditory and somatosensory inputs and are connected to many sensorimotor areas of the brain. The colliculus as a whole is thought to help orient the head and eyes toward something seen and heard. The superior colliculus also receives auditory information from the inferior colliculus. This auditory information is integrated with the visual information already present to produce the ventriloquism effect. Distractibility
As well as being related to eye movements, the SC appears to have an important role to play in the circuitry underpinning distractibility. Heightened distractibility occurs in normal aging and is also a central feature in a number of medical conditions, including attention deficit hyperactivity disorder (ADHD). Research has shown that lesions to the SC in a number of species can result in heightened distractibility and, in humans, removing the inhibitory control on the SC from the pre frontal cortex, therefore increasing activity in the area, also increases distractibility. Research in an animal model of ADHD, the spontaneously hypertensive rat, also shows altered collicular dependent behaviours and physiology. Other animals
Other mammals
Primates
It is usually accepted that the primate superior colliculus is unique among mammals, in that it does not contain a complete map of the visual field seen by the contralateral eye. Instead, like the visual cortex and lateral geniculate nucleus, each colliculus represents only the contralateral half of the visual field, up to the midline, and excludes a representation of the ipsilateral half. This functional characteristic is explained by the absence, in primates, of anatomical connections between the retinal ganglion cells in the temporal half of the retina and the contralateral superior colliculus. In other mammals, the retinal ganglion cells throughout the contralateral retina project to the contralateral colliculus. This distinction between primates and non primates has been one of the key lines of evidence in support of the flying primates theory proposed by Australian neuroscientist Jack Pettigrew in 1986, after he discovered that flying foxes (megabats) resemble primates in terms of the pattern of anatomical connections between the retina and superior colliculus. Cats
In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem. Bats
Bats are not, in fact, blind, but they depend much more on echolocation than vision for navigation and prey capture. They obtain information about the surrounding world by emitting sonar chirps and then listening for the echoes. Their brains are highly specialized for this process, and some of these specializations appear in the superior colliculus. In bats, the retinal projection occupies only a thin zone just beneath the surface, but there are extensive inputs from auditory areas, and outputs to motor areas capable of orienting the ears, head, or body. Echoes coming from different directions activate neurons at different locations in the collicular layers, and activation of collicular neurons influences the chirps that the bats emit. Thus, there is a strong case that the superior colliculus performs the same sorts of functions for the auditory guided behaviors of bats that it performs for the visual guided behaviors of other species. Bats are usually classified into two main groups: Microchiroptera (the most numerous, and commonly found throughout the world), and Megachiroptera (fruit bats, found in Asia, Africa and Australasia). With one exception, Megabats do not echolocate, and rely on a developed sense of vision to navigate. The visual receptive fields of neurons in the superior colliculus in these animals form a precise map of the retina, similar to that found in cats and primates. Rodents
The superior colliculus in rodents have been hypothesized to mediate sensory guided approach and avoidance behaviors. Studies employing circuit analysis tools on mouse superior colliculus have revealed several important functions. In a series of studies, researchers have identified a set of Ying Yang circuit modules in the superior colliculus to initiate prey capture and predator avoidance behaviors in mice. By using single cell RNA sequencing, researchers have analyzed the gene expression profiles of superior colliculus neurons and identified the unique genetic markers of these circuit modules. Other vertebrates
Optic tectum
The optic tectum is the visual center in the non mammalian brain which develops from the alar plate of the mesencephalon. In these other vertebrates the connections from the optic tectum are important for the recognition and reaction to various sized objects which is facilitated by excitatory optic nerve transmitters like L glutamate. Disrupting visual experience early on in zebrafish development results in a change in tectal activity. Changes in tectal activity resulted in an inability to successfully hunt and capture prey. Hypothalamus inhibitory signaling to the deep tectal neuropil is important in tectal processing in zebrafish larvae. The tectal neuropil contains structures including periventricular neuronal axons and dendrites. The neuropil also contains GABAergic superficial inhibitory neurons located in stratum opticum. Instead of a large cerebral cortex, zebrafish have a relatively large optic tectum that is hypothesized to carry out some of the visual processing that the cortex performs in mammals. Recent lesion studies have suggested that the optic tectum has no influence over higher order motion responses like the optomotor response or the optokinetic response, but may be more integral to lower order cues in motion perception like in the identification of small objects. The optic tectum is one of the fundamental components of the vertebrate brain, existing across a range of species. Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic tracts to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow (In the superior colliculus the like structure is termed the parabigeminal nucleus). The nucleus isthmii is divided into two parts, called isthmus pars magnocellularis (Imc; "the part with the large cells") and isthmus pars parvocellularis'' (Ipc); "the part with the small cells"). Connections between the three areas — optic tectum, Ipc, and Imc — are topographic. Neurons in the superficial layers of the optic tectum project to corresponding points in the Ipc and Imc. The projections to the Ipc are tightly focused, while the projections to the Imc are somewhat more diffuse. Ipc gives rise to tightly focused cholinergic projections both to Imc and the optic tectum. In the optic tectum, the cholinergic inputs from Ipc ramify to give rise to terminals that extend across an entire column, from top to bottom. Imc, in contrast, gives rise to GABAergic projections to Ipc and optic tectum that spread very broadly in the lateral dimensions, encompassing most of the retinotopic map. Thus, the tectum Ipc Imc circuit causes tectal activity to produce recurrent feedback that involves tightly focused excitation of a small column of neighboring tectal neurons, together with global inhibition of distant tectal neurons. The optic tectum is involved in many responses including swimming in fish, flight in birds, tongue strikes toward prey in frogs, and fang strikes in snakes. In some species, including fish and birds, the optic tectum, also known as the optic lobe, is one of the largest components of the brain. In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. In amphibians, reptiles, and especially birds it is also a very significant component.
In neuroanatomy, the superior colliculus is a structure lying on the roof of the mammalian midbrain. The adjective form tectal is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers (stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor related neurons, capable of activating eye movements as well as other responses. In other vertebrates the number of layers in the homologous optic tectum varies. and shifts in attention that do not involve any overt movements. The two inferior colliculi are situated immediately inferior/caudal to the superior colliculi; the inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin for quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent. The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. In the optic tectum this nearby structure is known as the nucleus isthmi. Structure
The superior colliculus is a synaptic layered structure. The top three layers are called superficial:Lamina I or SZ, the stratum zonale, is a thin layer consisting of small myelinated axons together with marginal and horizontal cells. Lamina II or SGS, the stratum griseum superficiale ("superficial gray layer"), contains many neurons of various shapes and sizes. Lamina III or SO, the stratum opticum ("optic layer"), consists mainly of axons coming from the optic tract. Next come two intermediate layers:Lamina IV or SGI, the stratum griseum intermedium ("intermediate gray layer"), is the thickest layer, and is filled with many neurons of many sizes. This layer is often as thick as all the other layers together. It is often subdivided into "upper" and "lower" parts. Lamina V or SAI, the stratum album intermedium ("intermediate white layer"), consists mainly of fibers from various sources. Finally come the two deep layers:Lamina VI or SGP, the stratum griseum profundum ("deep gray layer"), consists of loosely packed neurons and myelinated fibers. Lamina VII or SAP', the stratum album profundum ("deep white layer"), lying directly above the periaqueductal gray, consists entirely of fibers. The superficial layers receive input mainly from the retina, vision related areas of the cerebral cortex, and two tectal related structures called the pretectum and parabigeminal nucleus. The retinal input encompasses the entire superficial zone, and is bilateral, although the contralateral portion is more extensive. The cortical input comes most heavily from the primary visual cortex (area 17, V1), the secondary visual cortex (areas 18 and 19), and the frontal eye fields. The parabigeminal nucleus plays a very important role in tectal function that is described below. In contrast to the vision dominated inputs to the superficial layers, the intermediate and deep layers receive inputs from a very diverse set of sensory and motor structures. Most areas of the cerebral cortex project to these layers, although the input from "association" areas tends to be heavier than the input from primary sensory or motor areas. However, the cortical areas involved, and the strength of their relative projections differs across species. Another important input comes from the substantia nigra, pars reticulata, a component of the basal ganglia. This projection uses the inhibitory neurotransmitter GABA, and is thought to exert a "gating" effect on the superior colliculus. The intermediate and deep layers also receive input from the spinal trigeminal nucleus, which conveys somatosensory information from the face, as well as the hypothalamus, zona incerta, thalamus, and inferior colliculus. In addition to their distinctive inputs, the superficial and deep zones of the superior colliculus also have distinctive outputs. One of the most important outputs goes to the pulvinar and lateral intermediate areas of the thalamus, which in turn project to areas of the cerebral cortex that are involved in controlling eye movements. There are also projections from the superficial zone to the pretectal nuclei, lateral geniculate nucleus of the thalamus, and the parabigeminal nucleus. The projections from the deeper layers are more extensive. There are two large descending pathways, traveling to the brainstem and spinal cord, and numerous ascending projections to a variety of sensory and motor centers, including several that are involved in generating eye movements. Both colliculi also have descending projections to the paramedian pontine reticular formation and spinal cord, and thus can be involved in responses to stimuli faster than cortical processing would allow. Mosaic structure
On detailed examination, the collicular layers are actually not smooth sheets, but divided into a honeycomb arrangement of discrete columns. The clearest indication of columnar structure comes from the cholinergic inputs arising from the parabigeminal nucleus, whose terminals form evenly spaced clusters that extend from top to bottom of the tectum. Several other neurochemical markers including calretinin, parvalbumin, GAP 43, and NMDA receptors, and connections with numerous other brain structures in the brainstem and diencephalon, also show a corresponding inhomogeneity. The total number of columns has been estimated at around 100. From the 1970s to 1990s, however, neural recordings from mammals, mostly monkeys, focused primarily on the role of the superior colliculus in controlling eye movements. This line of investigation came to dominate the literature to such a degree that the majority opinion was that eye movement control is the only important function in mammals, a view still reflected in many current textbooks. In the late 1990s, however, experiments using animals whose heads were free to move showed clearly that the SC actually produces gaze shifts, usually composed of combined head and eye movements, rather than eye movements per se. This discovery reawakened interest in the full breadth of functions of the superior colliculus, and led to studies of multisensory integration in a variety of species and situations. Nevertheless, the role of the SC in controlling eye movements is understood in much greater depth than any other function. Behavioral studies have shown that the SC is not needed for object recognition, but plays a critical role in the ability to direct behaviors toward specific objects, and can support this ability even in the absence of the cerebral cortex. Thus, cats with major damage to the visual cortex cannot recognize objects, but may still be able to follow and orient toward moving stimuli, although more slowly than usual. If one half of the SC is removed, however, the cats will circle constantly toward the side of the lesion, and orient compulsively toward objects located there, but fail to orient at all toward objects located in the opposite hemifield. These deficits diminish over time but never disappear. Eye movements
In primates, eye movements can be divided into several types: fixation, in which the eyes are directed toward a motionless object, with eye movements only to compensate for movements of the head; smooth pursuit, in which the eyes move steadily to track a moving object; saccades, in which the eyes move very rapidly from one location to another; and vergence, in which the eyes move simultaneously in opposite directions to obtain or maintain single binocular vision. The superior colliculus is involved in all of these, but its role in saccades has been studied most intensively. Each of the two colliculi — one on each side of the brain — contains a two dimensional map representing half of the visual field. The fovea — the region of maximum sensitivity — is represented at the front edge of the map, and the periphery at the back edge. Eye movements are evoked by activity in the deep layers of the SC. During fixation, neurons near the front edge — the foveal zone — are tonically active. During smooth pursuit, neurons a small distance from the front edge are activated, leading to small eye movements. For saccades, neurons are activated in a region that represents the point to which the saccade will be directed. Just prior to a saccade, activity rapidly builds up at the target location and decreases in other parts of the SC. The coding is rather broad, so that for any given saccade the activity profile forms a "hill" that encompasses a substantial fraction of the collicular map: The location of the peak of this "hill" represents the saccade target. The SC encodes the target of a gaze shift, but it does not seem to specify the precise movements needed to get there. The decomposition of a gaze shift into head and eye movements and the precise trajectory of the eye during a saccade depend on integration of collicular and non collicular signals by downstream motor areas, in ways that are not yet well understood. Regardless of how the movement is evoked or performed, the SC encodes it in "retinotopic" coordinates: that is, the location of the SC 'hill" corresponds to a fixed location on the retina. This seems to contradict the observation that stimulation of a single point on the SC can result in different gaze shift directions, depending on initial eye orientation. However, it has been shown that this is because the retinal location of a stimulus is a non linear function of target location, eye orientation, and the spherical geometry of the eye. There has been some controversy about whether the SC merely commands eye movements, and leaves the execution to other structures, or whether it actively participates in the performance of a saccade. In 1991, Munoz et al., on the basis of data they collected, argued that, during a saccade, the "hill" of activity in the SC moves gradually, to reflect the changing offset of the eye from the target location while the saccade is progressing. At present, the predominant view is that, although the "hill" does shift slightly during a saccade, it does not shift in the steady and proportionate way that the "moving hill" hypothesis predicts. However, moving hills may play another role in the superior colliculus; more recent experiments have demonstrated a continuously moving hill of visual memory activity when the eyes move slowly while a separate saccade target is retained. The output from the motor sector of the SC goes to a set of midbrain and brainstem nuclei, which transform the "place" code used by the SC into the "rate" code used by oculomotor neurons. Eye movements are generated by six muscles, arranged in three orthogonally aligned pairs. Thus, at the level of the final common path, eye movements are encoded in essentially a Cartesian coordinate system. Although the SC receives a strong input directly from the retina, in primates it is largely under the control of the cerebral cortex, which contains several areas that are involved in determining eye movements. The frontal eye fields, a portion of the motor cortex, are involved in triggering intentional saccades, and an adjoining area, the supplementary eye fields, are involved in organizing groups of saccades into sequences. The parietal eye fields, farther back in the brain, are involved mainly in reflexive saccades, made in response to changes in the view. Recent evidence suggests that the primary visual cortex (V1) guides reflexive eye movements, according to V1 Saliency Hypothesis, using a bottom up saliency map of the visual field generated in V1 from external visual inputs. The SC only receives visual inputs in its superficial layers, whereas the deeper layers of the colliculus receive also auditory and somatosensory inputs and are connected to many sensorimotor areas of the brain. The colliculus as a whole is thought to help orient the head and eyes toward something seen and heard. The superior colliculus also receives auditory information from the inferior colliculus. This auditory information is integrated with the visual information already present to produce the ventriloquism effect. Distractibility
As well as being related to eye movements, the SC appears to have an important role to play in the circuitry underpinning distractibility. Heightened distractibility occurs in normal aging and is also a central feature in a number of medical conditions, including attention deficit hyperactivity disorder (ADHD). Research has shown that lesions to the SC in a number of species can result in heightened distractibility and, in humans, removing the inhibitory control on the SC from the pre frontal cortex, therefore increasing activity in the area, also increases distractibility. Research in an animal model of ADHD, the spontaneously hypertensive rat, also shows altered collicular dependent behaviours and physiology. Other animals
Other mammals
Primates
It is usually accepted that the primate superior colliculus is unique among mammals, in that it does not contain a complete map of the visual field seen by the contralateral eye. Instead, like the visual cortex and lateral geniculate nucleus, each colliculus represents only the contralateral half of the visual field, up to the midline, and excludes a representation of the ipsilateral half. This functional characteristic is explained by the absence, in primates, of anatomical connections between the retinal ganglion cells in the temporal half of the retina and the contralateral superior colliculus. In other mammals, the retinal ganglion cells throughout the contralateral retina project to the contralateral colliculus. This distinction between primates and non primates has been one of the key lines of evidence in support of the flying primates theory proposed by Australian neuroscientist Jack Pettigrew in 1986, after he discovered that flying foxes (megabats) resemble primates in terms of the pattern of anatomical connections between the retina and superior colliculus. Cats
In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem. Bats
Bats are not, in fact, blind, but they depend much more on echolocation than vision for navigation and prey capture. They obtain information about the surrounding world by emitting sonar chirps and then listening for the echoes. Their brains are highly specialized for this process, and some of these specializations appear in the superior colliculus. In bats, the retinal projection occupies only a thin zone just beneath the surface, but there are extensive inputs from auditory areas, and outputs to motor areas capable of orienting the ears, head, or body. Echoes coming from different directions activate neurons at different locations in the collicular layers, and activation of collicular neurons influences the chirps that the bats emit. Thus, there is a strong case that the superior colliculus performs the same sorts of functions for the auditory guided behaviors of bats that it performs for the visual guided behaviors of other species. Bats are usually classified into two main groups: Microchiroptera (the most numerous, and commonly found throughout the world), and Megachiroptera (fruit bats, found in Asia, Africa and Australasia). With one exception, Megabats do not echolocate, and rely on a developed sense of vision to navigate. The visual receptive fields of neurons in the superior colliculus in these animals form a precise map of the retina, similar to that found in cats and primates. Rodents
The superior colliculus in rodents have been hypothesized to mediate sensory guided approach and avoidance behaviors. Studies employing circuit analysis tools on mouse superior colliculus have revealed several important functions. In a series of studies, researchers have identified a set of Ying Yang circuit modules in the superior colliculus to initiate prey capture and predator avoidance behaviors in mice. By using single cell RNA sequencing, researchers have analyzed the gene expression profiles of superior colliculus neurons and identified the unique genetic markers of these circuit modules. Other vertebrates
Optic tectum
The optic tectum is the visual center in the non mammalian brain which develops from the alar plate of the mesencephalon. In these other vertebrates the connections from the optic tectum are important for the recognition and reaction to various sized objects which is facilitated by excitatory optic nerve transmitters like L glutamate. Disrupting visual experience early on in zebrafish development results in a change in tectal activity. Changes in tectal activity resulted in an inability to successfully hunt and capture prey. Hypothalamus inhibitory signaling to the deep tectal neuropil is important in tectal processing in zebrafish larvae. The tectal neuropil contains structures including periventricular neuronal axons and dendrites. The neuropil also contains GABAergic superficial inhibitory neurons located in stratum opticum. Instead of a large cerebral cortex, zebrafish have a relatively large optic tectum that is hypothesized to carry out some of the visual processing that the cortex performs in mammals. Recent lesion studies have suggested that the optic tectum has no influence over higher order motion responses like the optomotor response or the optokinetic response, but may be more integral to lower order cues in motion perception like in the identification of small objects. The optic tectum is one of the fundamental components of the vertebrate brain, existing across a range of species. Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic tracts to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow (In the superior colliculus the like structure is termed the parabigeminal nucleus). The nucleus isthmii is divided into two parts, called isthmus pars magnocellularis (Imc; "the part with the large cells") and isthmus pars parvocellularis'' (Ipc); "the part with the small cells"). Connections between the three areas — optic tectum, Ipc, and Imc — are topographic. Neurons in the superficial layers of the optic tectum project to corresponding points in the Ipc and Imc. The projections to the Ipc are tightly focused, while the projections to the Imc are somewhat more diffuse. Ipc gives rise to tightly focused cholinergic projections both to Imc and the optic tectum. In the optic tectum, the cholinergic inputs from Ipc ramify to give rise to terminals that extend across an entire column, from top to bottom. Imc, in contrast, gives rise to GABAergic projections to Ipc and optic tectum that spread very broadly in the lateral dimensions, encompassing most of the retinotopic map. Thus, the tectum Ipc Imc circuit causes tectal activity to produce recurrent feedback that involves tightly focused excitation of a small column of neighboring tectal neurons, together with global inhibition of distant tectal neurons. The optic tectum is involved in many responses including swimming in fish, flight in birds, tongue strikes toward prey in frogs, and fang strikes in snakes. In some species, including fish and birds, the optic tectum, also known as the optic lobe, is one of the largest components of the brain. In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. In amphibians, reptiles, and especially birds it is also a very significant component.
Структура
Structure in the midbrain
In neuroanatomy, the superior colliculus is a structure lying on the roof of the mammalian midbrain. The adjective form tectal is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers (stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor related neurons, capable of activating eye movements as well as other responses. In other vertebrates the number of layers in the homologous optic tectum varies. and shifts in attention that do not involve any overt movements. The two inferior colliculi are situated immediately inferior/caudal to the superior colliculi; the inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin for quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent. The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. In the optic tectum this nearby structure is known as the nucleus isthmi. Structure
The superior colliculus is a synaptic layered structure. The top three layers are called superficial:Lamina I or SZ, the stratum zonale, is a thin layer consisting of small myelinated axons together with marginal and horizontal cells. Lamina II or SGS, the stratum griseum superficiale ("superficial gray layer"), contains many neurons of various shapes and sizes. Lamina III or SO, the stratum opticum ("optic layer"), consists mainly of axons coming from the optic tract. Next come two intermediate layers:Lamina IV or SGI, the stratum griseum intermedium ("intermediate gray layer"), is the thickest layer, and is filled with many neurons of many sizes. This layer is often as thick as all the other layers together. It is often subdivided into "upper" and "lower" parts. Lamina V or SAI, the stratum album intermedium ("intermediate white layer"), consists mainly of fibers from various sources. Finally come the two deep layers:Lamina VI or SGP, the stratum griseum profundum ("deep gray layer"), consists of loosely packed neurons and myelinated fibers. Lamina VII or SAP', the stratum album profundum ("deep white layer"), lying directly above the periaqueductal gray, consists entirely of fibers. The superficial layers receive input mainly from the retina, vision related areas of the cerebral cortex, and two tectal related structures called the pretectum and parabigeminal nucleus. The retinal input encompasses the entire superficial zone, and is bilateral, although the contralateral portion is more extensive. The cortical input comes most heavily from the primary visual cortex (area 17, V1), the secondary visual cortex (areas 18 and 19), and the frontal eye fields. The parabigeminal nucleus plays a very important role in tectal function that is described below. In contrast to the vision dominated inputs to the superficial layers, the intermediate and deep layers receive inputs from a very diverse set of sensory and motor structures. Most areas of the cerebral cortex project to these layers, although the input from "association" areas tends to be heavier than the input from primary sensory or motor areas. However, the cortical areas involved, and the strength of their relative projections differs across species. Another important input comes from the substantia nigra, pars reticulata, a component of the basal ganglia. This projection uses the inhibitory neurotransmitter GABA, and is thought to exert a "gating" effect on the superior colliculus. The intermediate and deep layers also receive input from the spinal trigeminal nucleus, which conveys somatosensory information from the face, as well as the hypothalamus, zona incerta, thalamus, and inferior colliculus. In addition to their distinctive inputs, the superficial and deep zones of the superior colliculus also have distinctive outputs. One of the most important outputs goes to the pulvinar and lateral intermediate areas of the thalamus, which in turn project to areas of the cerebral cortex that are involved in controlling eye movements. There are also projections from the superficial zone to the pretectal nuclei, lateral geniculate nucleus of the thalamus, and the parabigeminal nucleus. The projections from the deeper layers are more extensive. There are two large descending pathways, traveling to the brainstem and spinal cord, and numerous ascending projections to a variety of sensory and motor centers, including several that are involved in generating eye movements. Both colliculi also have descending projections to the paramedian pontine reticular formation and spinal cord, and thus can be involved in responses to stimuli faster than cortical processing would allow. Mosaic structure
On detailed examination, the collicular layers are actually not smooth sheets, but divided into a honeycomb arrangement of discrete columns. The clearest indication of columnar structure comes from the cholinergic inputs arising from the parabigeminal nucleus, whose terminals form evenly spaced clusters that extend from top to bottom of the tectum. Several other neurochemical markers including calretinin, parvalbumin, GAP 43, and NMDA receptors, and connections with numerous other brain structures in the brainstem and diencephalon, also show a corresponding inhomogeneity. The total number of columns has been estimated at around 100. From the 1970s to 1990s, however, neural recordings from mammals, mostly monkeys, focused primarily on the role of the superior colliculus in controlling eye movements. This line of investigation came to dominate the literature to such a degree that the majority opinion was that eye movement control is the only important function in mammals, a view still reflected in many current textbooks. In the late 1990s, however, experiments using animals whose heads were free to move showed clearly that the SC actually produces gaze shifts, usually composed of combined head and eye movements, rather than eye movements per se. This discovery reawakened interest in the full breadth of functions of the superior colliculus, and led to studies of multisensory integration in a variety of species and situations. Nevertheless, the role of the SC in controlling eye movements is understood in much greater depth than any other function. Behavioral studies have shown that the SC is not needed for object recognition, but plays a critical role in the ability to direct behaviors toward specific objects, and can support this ability even in the absence of the cerebral cortex. Thus, cats with major damage to the visual cortex cannot recognize objects, but may still be able to follow and orient toward moving stimuli, although more slowly than usual. If one half of the SC is removed, however, the cats will circle constantly toward the side of the lesion, and orient compulsively toward objects located there, but fail to orient at all toward objects located in the opposite hemifield. These deficits diminish over time but never disappear. Eye movements
In primates, eye movements can be divided into several types: fixation, in which the eyes are directed toward a motionless object, with eye movements only to compensate for movements of the head; smooth pursuit, in which the eyes move steadily to track a moving object; saccades, in which the eyes move very rapidly from one location to another; and vergence, in which the eyes move simultaneously in opposite directions to obtain or maintain single binocular vision. The superior colliculus is involved in all of these, but its role in saccades has been studied most intensively. Each of the two colliculi — one on each side of the brain — contains a two dimensional map representing half of the visual field. The fovea — the region of maximum sensitivity — is represented at the front edge of the map, and the periphery at the back edge. Eye movements are evoked by activity in the deep layers of the SC. During fixation, neurons near the front edge — the foveal zone — are tonically active. During smooth pursuit, neurons a small distance from the front edge are activated, leading to small eye movements. For saccades, neurons are activated in a region that represents the point to which the saccade will be directed. Just prior to a saccade, activity rapidly builds up at the target location and decreases in other parts of the SC. The coding is rather broad, so that for any given saccade the activity profile forms a "hill" that encompasses a substantial fraction of the collicular map: The location of the peak of this "hill" represents the saccade target. The SC encodes the target of a gaze shift, but it does not seem to specify the precise movements needed to get there. The decomposition of a gaze shift into head and eye movements and the precise trajectory of the eye during a saccade depend on integration of collicular and non collicular signals by downstream motor areas, in ways that are not yet well understood. Regardless of how the movement is evoked or performed, the SC encodes it in "retinotopic" coordinates: that is, the location of the SC 'hill" corresponds to a fixed location on the retina. This seems to contradict the observation that stimulation of a single point on the SC can result in different gaze shift directions, depending on initial eye orientation. However, it has been shown that this is because the retinal location of a stimulus is a non linear function of target location, eye orientation, and the spherical geometry of the eye. There has been some controversy about whether the SC merely commands eye movements, and leaves the execution to other structures, or whether it actively participates in the performance of a saccade. In 1991, Munoz et al., on the basis of data they collected, argued that, during a saccade, the "hill" of activity in the SC moves gradually, to reflect the changing offset of the eye from the target location while the saccade is progressing. At present, the predominant view is that, although the "hill" does shift slightly during a saccade, it does not shift in the steady and proportionate way that the "moving hill" hypothesis predicts. However, moving hills may play another role in the superior colliculus; more recent experiments have demonstrated a continuously moving hill of visual memory activity when the eyes move slowly while a separate saccade target is retained. The output from the motor sector of the SC goes to a set of midbrain and brainstem nuclei, which transform the "place" code used by the SC into the "rate" code used by oculomotor neurons. Eye movements are generated by six muscles, arranged in three orthogonally aligned pairs. Thus, at the level of the final common path, eye movements are encoded in essentially a Cartesian coordinate system. Although the SC receives a strong input directly from the retina, in primates it is largely under the control of the cerebral cortex, which contains several areas that are involved in determining eye movements. The frontal eye fields, a portion of the motor cortex, are involved in triggering intentional saccades, and an adjoining area, the supplementary eye fields, are involved in organizing groups of saccades into sequences. The parietal eye fields, farther back in the brain, are involved mainly in reflexive saccades, made in response to changes in the view. Recent evidence suggests that the primary visual cortex (V1) guides reflexive eye movements, according to V1 Saliency Hypothesis, using a bottom up saliency map of the visual field generated in V1 from external visual inputs. The SC only receives visual inputs in its superficial layers, whereas the deeper layers of the colliculus receive also auditory and somatosensory inputs and are connected to many sensorimotor areas of the brain. The colliculus as a whole is thought to help orient the head and eyes toward something seen and heard. The superior colliculus also receives auditory information from the inferior colliculus. This auditory information is integrated with the visual information already present to produce the ventriloquism effect. Distractibility
As well as being related to eye movements, the SC appears to have an important role to play in the circuitry underpinning distractibility. Heightened distractibility occurs in normal aging and is also a central feature in a number of medical conditions, including attention deficit hyperactivity disorder (ADHD). Research has shown that lesions to the SC in a number of species can result in heightened distractibility and, in humans, removing the inhibitory control on the SC from the pre frontal cortex, therefore increasing activity in the area, also increases distractibility. Research in an animal model of ADHD, the spontaneously hypertensive rat, also shows altered collicular dependent behaviours and physiology. Other animals
Other mammals
Primates
It is usually accepted that the primate superior colliculus is unique among mammals, in that it does not contain a complete map of the visual field seen by the contralateral eye. Instead, like the visual cortex and lateral geniculate nucleus, each colliculus represents only the contralateral half of the visual field, up to the midline, and excludes a representation of the ipsilateral half. This functional characteristic is explained by the absence, in primates, of anatomical connections between the retinal ganglion cells in the temporal half of the retina and the contralateral superior colliculus. In other mammals, the retinal ganglion cells throughout the contralateral retina project to the contralateral colliculus. This distinction between primates and non primates has been one of the key lines of evidence in support of the flying primates theory proposed by Australian neuroscientist Jack Pettigrew in 1986, after he discovered that flying foxes (megabats) resemble primates in terms of the pattern of anatomical connections between the retina and superior colliculus. Cats
In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem. Bats
Bats are not, in fact, blind, but they depend much more on echolocation than vision for navigation and prey capture. They obtain information about the surrounding world by emitting sonar chirps and then listening for the echoes. Their brains are highly specialized for this process, and some of these specializations appear in the superior colliculus. In bats, the retinal projection occupies only a thin zone just beneath the surface, but there are extensive inputs from auditory areas, and outputs to motor areas capable of orienting the ears, head, or body. Echoes coming from different directions activate neurons at different locations in the collicular layers, and activation of collicular neurons influences the chirps that the bats emit. Thus, there is a strong case that the superior colliculus performs the same sorts of functions for the auditory guided behaviors of bats that it performs for the visual guided behaviors of other species. Bats are usually classified into two main groups: Microchiroptera (the most numerous, and commonly found throughout the world), and Megachiroptera (fruit bats, found in Asia, Africa and Australasia). With one exception, Megabats do not echolocate, and rely on a developed sense of vision to navigate. The visual receptive fields of neurons in the superior colliculus in these animals form a precise map of the retina, similar to that found in cats and primates. Rodents
The superior colliculus in rodents have been hypothesized to mediate sensory guided approach and avoidance behaviors. Studies employing circuit analysis tools on mouse superior colliculus have revealed several important functions. In a series of studies, researchers have identified a set of Ying Yang circuit modules in the superior colliculus to initiate prey capture and predator avoidance behaviors in mice. By using single cell RNA sequencing, researchers have analyzed the gene expression profiles of superior colliculus neurons and identified the unique genetic markers of these circuit modules. Other vertebrates
Optic tectum
The optic tectum is the visual center in the non mammalian brain which develops from the alar plate of the mesencephalon. In these other vertebrates the connections from the optic tectum are important for the recognition and reaction to various sized objects which is facilitated by excitatory optic nerve transmitters like L glutamate. Disrupting visual experience early on in zebrafish development results in a change in tectal activity. Changes in tectal activity resulted in an inability to successfully hunt and capture prey. Hypothalamus inhibitory signaling to the deep tectal neuropil is important in tectal processing in zebrafish larvae. The tectal neuropil contains structures including periventricular neuronal axons and dendrites. The neuropil also contains GABAergic superficial inhibitory neurons located in stratum opticum. Instead of a large cerebral cortex, zebrafish have a relatively large optic tectum that is hypothesized to carry out some of the visual processing that the cortex performs in mammals. Recent lesion studies have suggested that the optic tectum has no influence over higher order motion responses like the optomotor response or the optokinetic response, but may be more integral to lower order cues in motion perception like in the identification of small objects. The optic tectum is one of the fundamental components of the vertebrate brain, existing across a range of species. Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic tracts to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow (In the superior colliculus the like structure is termed the parabigeminal nucleus). The nucleus isthmii is divided into two parts, called isthmus pars magnocellularis (Imc; "the part with the large cells") and isthmus pars parvocellularis'' (Ipc); "the part with the small cells"). Connections between the three areas — optic tectum, Ipc, and Imc — are topographic. Neurons in the superficial layers of the optic tectum project to corresponding points in the Ipc and Imc. The projections to the Ipc are tightly focused, while the projections to the Imc are somewhat more diffuse. Ipc gives rise to tightly focused cholinergic projections both to Imc and the optic tectum. In the optic tectum, the cholinergic inputs from Ipc ramify to give rise to terminals that extend across an entire column, from top to bottom. Imc, in contrast, gives rise to GABAergic projections to Ipc and optic tectum that spread very broadly in the lateral dimensions, encompassing most of the retinotopic map. Thus, the tectum Ipc Imc circuit causes tectal activity to produce recurrent feedback that involves tightly focused excitation of a small column of neighboring tectal neurons, together with global inhibition of distant tectal neurons. The optic tectum is involved in many responses including swimming in fish, flight in birds, tongue strikes toward prey in frogs, and fang strikes in snakes. In some species, including fish and birds, the optic tectum, also known as the optic lobe, is one of the largest components of the brain. In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. In amphibians, reptiles, and especially birds it is also a very significant component.
In neuroanatomy, the superior colliculus is a structure lying on the roof of the mammalian midbrain. The adjective form tectal is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers (stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor related neurons, capable of activating eye movements as well as other responses. In other vertebrates the number of layers in the homologous optic tectum varies. and shifts in attention that do not involve any overt movements. The two inferior colliculi are situated immediately inferior/caudal to the superior colliculi; the inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin for quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent. The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. In the optic tectum this nearby structure is known as the nucleus isthmi. Structure
The superior colliculus is a synaptic layered structure. The top three layers are called superficial:Lamina I or SZ, the stratum zonale, is a thin layer consisting of small myelinated axons together with marginal and horizontal cells. Lamina II or SGS, the stratum griseum superficiale ("superficial gray layer"), contains many neurons of various shapes and sizes. Lamina III or SO, the stratum opticum ("optic layer"), consists mainly of axons coming from the optic tract. Next come two intermediate layers:Lamina IV or SGI, the stratum griseum intermedium ("intermediate gray layer"), is the thickest layer, and is filled with many neurons of many sizes. This layer is often as thick as all the other layers together. It is often subdivided into "upper" and "lower" parts. Lamina V or SAI, the stratum album intermedium ("intermediate white layer"), consists mainly of fibers from various sources. Finally come the two deep layers:Lamina VI or SGP, the stratum griseum profundum ("deep gray layer"), consists of loosely packed neurons and myelinated fibers. Lamina VII or SAP', the stratum album profundum ("deep white layer"), lying directly above the periaqueductal gray, consists entirely of fibers. The superficial layers receive input mainly from the retina, vision related areas of the cerebral cortex, and two tectal related structures called the pretectum and parabigeminal nucleus. The retinal input encompasses the entire superficial zone, and is bilateral, although the contralateral portion is more extensive. The cortical input comes most heavily from the primary visual cortex (area 17, V1), the secondary visual cortex (areas 18 and 19), and the frontal eye fields. The parabigeminal nucleus plays a very important role in tectal function that is described below. In contrast to the vision dominated inputs to the superficial layers, the intermediate and deep layers receive inputs from a very diverse set of sensory and motor structures. Most areas of the cerebral cortex project to these layers, although the input from "association" areas tends to be heavier than the input from primary sensory or motor areas. However, the cortical areas involved, and the strength of their relative projections differs across species. Another important input comes from the substantia nigra, pars reticulata, a component of the basal ganglia. This projection uses the inhibitory neurotransmitter GABA, and is thought to exert a "gating" effect on the superior colliculus. The intermediate and deep layers also receive input from the spinal trigeminal nucleus, which conveys somatosensory information from the face, as well as the hypothalamus, zona incerta, thalamus, and inferior colliculus. In addition to their distinctive inputs, the superficial and deep zones of the superior colliculus also have distinctive outputs. One of the most important outputs goes to the pulvinar and lateral intermediate areas of the thalamus, which in turn project to areas of the cerebral cortex that are involved in controlling eye movements. There are also projections from the superficial zone to the pretectal nuclei, lateral geniculate nucleus of the thalamus, and the parabigeminal nucleus. The projections from the deeper layers are more extensive. There are two large descending pathways, traveling to the brainstem and spinal cord, and numerous ascending projections to a variety of sensory and motor centers, including several that are involved in generating eye movements. Both colliculi also have descending projections to the paramedian pontine reticular formation and spinal cord, and thus can be involved in responses to stimuli faster than cortical processing would allow. Mosaic structure
On detailed examination, the collicular layers are actually not smooth sheets, but divided into a honeycomb arrangement of discrete columns. The clearest indication of columnar structure comes from the cholinergic inputs arising from the parabigeminal nucleus, whose terminals form evenly spaced clusters that extend from top to bottom of the tectum. Several other neurochemical markers including calretinin, parvalbumin, GAP 43, and NMDA receptors, and connections with numerous other brain structures in the brainstem and diencephalon, also show a corresponding inhomogeneity. The total number of columns has been estimated at around 100. From the 1970s to 1990s, however, neural recordings from mammals, mostly monkeys, focused primarily on the role of the superior colliculus in controlling eye movements. This line of investigation came to dominate the literature to such a degree that the majority opinion was that eye movement control is the only important function in mammals, a view still reflected in many current textbooks. In the late 1990s, however, experiments using animals whose heads were free to move showed clearly that the SC actually produces gaze shifts, usually composed of combined head and eye movements, rather than eye movements per se. This discovery reawakened interest in the full breadth of functions of the superior colliculus, and led to studies of multisensory integration in a variety of species and situations. Nevertheless, the role of the SC in controlling eye movements is understood in much greater depth than any other function. Behavioral studies have shown that the SC is not needed for object recognition, but plays a critical role in the ability to direct behaviors toward specific objects, and can support this ability even in the absence of the cerebral cortex. Thus, cats with major damage to the visual cortex cannot recognize objects, but may still be able to follow and orient toward moving stimuli, although more slowly than usual. If one half of the SC is removed, however, the cats will circle constantly toward the side of the lesion, and orient compulsively toward objects located there, but fail to orient at all toward objects located in the opposite hemifield. These deficits diminish over time but never disappear. Eye movements
In primates, eye movements can be divided into several types: fixation, in which the eyes are directed toward a motionless object, with eye movements only to compensate for movements of the head; smooth pursuit, in which the eyes move steadily to track a moving object; saccades, in which the eyes move very rapidly from one location to another; and vergence, in which the eyes move simultaneously in opposite directions to obtain or maintain single binocular vision. The superior colliculus is involved in all of these, but its role in saccades has been studied most intensively. Each of the two colliculi — one on each side of the brain — contains a two dimensional map representing half of the visual field. The fovea — the region of maximum sensitivity — is represented at the front edge of the map, and the periphery at the back edge. Eye movements are evoked by activity in the deep layers of the SC. During fixation, neurons near the front edge — the foveal zone — are tonically active. During smooth pursuit, neurons a small distance from the front edge are activated, leading to small eye movements. For saccades, neurons are activated in a region that represents the point to which the saccade will be directed. Just prior to a saccade, activity rapidly builds up at the target location and decreases in other parts of the SC. The coding is rather broad, so that for any given saccade the activity profile forms a "hill" that encompasses a substantial fraction of the collicular map: The location of the peak of this "hill" represents the saccade target. The SC encodes the target of a gaze shift, but it does not seem to specify the precise movements needed to get there. The decomposition of a gaze shift into head and eye movements and the precise trajectory of the eye during a saccade depend on integration of collicular and non collicular signals by downstream motor areas, in ways that are not yet well understood. Regardless of how the movement is evoked or performed, the SC encodes it in "retinotopic" coordinates: that is, the location of the SC 'hill" corresponds to a fixed location on the retina. This seems to contradict the observation that stimulation of a single point on the SC can result in different gaze shift directions, depending on initial eye orientation. However, it has been shown that this is because the retinal location of a stimulus is a non linear function of target location, eye orientation, and the spherical geometry of the eye. There has been some controversy about whether the SC merely commands eye movements, and leaves the execution to other structures, or whether it actively participates in the performance of a saccade. In 1991, Munoz et al., on the basis of data they collected, argued that, during a saccade, the "hill" of activity in the SC moves gradually, to reflect the changing offset of the eye from the target location while the saccade is progressing. At present, the predominant view is that, although the "hill" does shift slightly during a saccade, it does not shift in the steady and proportionate way that the "moving hill" hypothesis predicts. However, moving hills may play another role in the superior colliculus; more recent experiments have demonstrated a continuously moving hill of visual memory activity when the eyes move slowly while a separate saccade target is retained. The output from the motor sector of the SC goes to a set of midbrain and brainstem nuclei, which transform the "place" code used by the SC into the "rate" code used by oculomotor neurons. Eye movements are generated by six muscles, arranged in three orthogonally aligned pairs. Thus, at the level of the final common path, eye movements are encoded in essentially a Cartesian coordinate system. Although the SC receives a strong input directly from the retina, in primates it is largely under the control of the cerebral cortex, which contains several areas that are involved in determining eye movements. The frontal eye fields, a portion of the motor cortex, are involved in triggering intentional saccades, and an adjoining area, the supplementary eye fields, are involved in organizing groups of saccades into sequences. The parietal eye fields, farther back in the brain, are involved mainly in reflexive saccades, made in response to changes in the view. Recent evidence suggests that the primary visual cortex (V1) guides reflexive eye movements, according to V1 Saliency Hypothesis, using a bottom up saliency map of the visual field generated in V1 from external visual inputs. The SC only receives visual inputs in its superficial layers, whereas the deeper layers of the colliculus receive also auditory and somatosensory inputs and are connected to many sensorimotor areas of the brain. The colliculus as a whole is thought to help orient the head and eyes toward something seen and heard. The superior colliculus also receives auditory information from the inferior colliculus. This auditory information is integrated with the visual information already present to produce the ventriloquism effect. Distractibility
As well as being related to eye movements, the SC appears to have an important role to play in the circuitry underpinning distractibility. Heightened distractibility occurs in normal aging and is also a central feature in a number of medical conditions, including attention deficit hyperactivity disorder (ADHD). Research has shown that lesions to the SC in a number of species can result in heightened distractibility and, in humans, removing the inhibitory control on the SC from the pre frontal cortex, therefore increasing activity in the area, also increases distractibility. Research in an animal model of ADHD, the spontaneously hypertensive rat, also shows altered collicular dependent behaviours and physiology. Other animals
Other mammals
Primates
It is usually accepted that the primate superior colliculus is unique among mammals, in that it does not contain a complete map of the visual field seen by the contralateral eye. Instead, like the visual cortex and lateral geniculate nucleus, each colliculus represents only the contralateral half of the visual field, up to the midline, and excludes a representation of the ipsilateral half. This functional characteristic is explained by the absence, in primates, of anatomical connections between the retinal ganglion cells in the temporal half of the retina and the contralateral superior colliculus. In other mammals, the retinal ganglion cells throughout the contralateral retina project to the contralateral colliculus. This distinction between primates and non primates has been one of the key lines of evidence in support of the flying primates theory proposed by Australian neuroscientist Jack Pettigrew in 1986, after he discovered that flying foxes (megabats) resemble primates in terms of the pattern of anatomical connections between the retina and superior colliculus. Cats
In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem. Bats
Bats are not, in fact, blind, but they depend much more on echolocation than vision for navigation and prey capture. They obtain information about the surrounding world by emitting sonar chirps and then listening for the echoes. Their brains are highly specialized for this process, and some of these specializations appear in the superior colliculus. In bats, the retinal projection occupies only a thin zone just beneath the surface, but there are extensive inputs from auditory areas, and outputs to motor areas capable of orienting the ears, head, or body. Echoes coming from different directions activate neurons at different locations in the collicular layers, and activation of collicular neurons influences the chirps that the bats emit. Thus, there is a strong case that the superior colliculus performs the same sorts of functions for the auditory guided behaviors of bats that it performs for the visual guided behaviors of other species. Bats are usually classified into two main groups: Microchiroptera (the most numerous, and commonly found throughout the world), and Megachiroptera (fruit bats, found in Asia, Africa and Australasia). With one exception, Megabats do not echolocate, and rely on a developed sense of vision to navigate. The visual receptive fields of neurons in the superior colliculus in these animals form a precise map of the retina, similar to that found in cats and primates. Rodents
The superior colliculus in rodents have been hypothesized to mediate sensory guided approach and avoidance behaviors. Studies employing circuit analysis tools on mouse superior colliculus have revealed several important functions. In a series of studies, researchers have identified a set of Ying Yang circuit modules in the superior colliculus to initiate prey capture and predator avoidance behaviors in mice. By using single cell RNA sequencing, researchers have analyzed the gene expression profiles of superior colliculus neurons and identified the unique genetic markers of these circuit modules. Other vertebrates
Optic tectum
The optic tectum is the visual center in the non mammalian brain which develops from the alar plate of the mesencephalon. In these other vertebrates the connections from the optic tectum are important for the recognition and reaction to various sized objects which is facilitated by excitatory optic nerve transmitters like L glutamate. Disrupting visual experience early on in zebrafish development results in a change in tectal activity. Changes in tectal activity resulted in an inability to successfully hunt and capture prey. Hypothalamus inhibitory signaling to the deep tectal neuropil is important in tectal processing in zebrafish larvae. The tectal neuropil contains structures including periventricular neuronal axons and dendrites. The neuropil also contains GABAergic superficial inhibitory neurons located in stratum opticum. Instead of a large cerebral cortex, zebrafish have a relatively large optic tectum that is hypothesized to carry out some of the visual processing that the cortex performs in mammals. Recent lesion studies have suggested that the optic tectum has no influence over higher order motion responses like the optomotor response or the optokinetic response, but may be more integral to lower order cues in motion perception like in the identification of small objects. The optic tectum is one of the fundamental components of the vertebrate brain, existing across a range of species. Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic tracts to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow (In the superior colliculus the like structure is termed the parabigeminal nucleus). The nucleus isthmii is divided into two parts, called isthmus pars magnocellularis (Imc; "the part with the large cells") and isthmus pars parvocellularis'' (Ipc); "the part with the small cells"). Connections between the three areas — optic tectum, Ipc, and Imc — are topographic. Neurons in the superficial layers of the optic tectum project to corresponding points in the Ipc and Imc. The projections to the Ipc are tightly focused, while the projections to the Imc are somewhat more diffuse. Ipc gives rise to tightly focused cholinergic projections both to Imc and the optic tectum. In the optic tectum, the cholinergic inputs from Ipc ramify to give rise to terminals that extend across an entire column, from top to bottom. Imc, in contrast, gives rise to GABAergic projections to Ipc and optic tectum that spread very broadly in the lateral dimensions, encompassing most of the retinotopic map. Thus, the tectum Ipc Imc circuit causes tectal activity to produce recurrent feedback that involves tightly focused excitation of a small column of neighboring tectal neurons, together with global inhibition of distant tectal neurons. The optic tectum is involved in many responses including swimming in fish, flight in birds, tongue strikes toward prey in frogs, and fang strikes in snakes. In some species, including fish and birds, the optic tectum, also known as the optic lobe, is one of the largest components of the brain. In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. In amphibians, reptiles, and especially birds it is also a very significant component.
Верхний бугорок представляет собой синаптически слоистую структуру. Верхние три слоя называются поверхностными: lamina I или SZ, зональный слой – тонкий слой, состоящий из мелких миелинизированных аксонов вместе с краевыми и горизонтальными клетками. Lamina II или SGS, stratum griseum superficiale («поверхностный серый слой»), содержит множество нейронов различных форм и размеров. Lamina III или SO, stratum opticum («оптический слой»), состоит в основном из аксонов, поступающих из зрительного тракта. Далее следуют два промежуточных слоя: lamina IV или SGI, stratum griseum intermedium («промежуточный серый слой») – самый толстый слой, заполненный множеством нейронов разных размеров. Этот слой часто такой же толщины, как все остальные слои вместе взятые. Он часто подразделяется на «верхнюю» и «нижнюю» части. Lamina V или SAI, stratum album intermedium («промежуточный белый слой»), состоит в основном из волокон из различных источников. Наконец, два глубоких слоя: lamina VI или SGP, stratum griseum profundum («глубокий серый слой»), состоит из неплотно упакованных нейронов и миелинизированных волокон. Lamina VII или SAP', stratum album profundum («глубокий белый слой»), расположен непосредственно над периакведуктальным серым веществом и состоит полностью из волокон. Поверхностные слои получают входные сигналы в основном из сетчатки, зрительных областей коры головного мозга и двух структур, связанных с бугорком, – претектума и парабигеминального ядра. Вход из сетчатки охватывает всю поверхностную зону и является билатеральным, хотя контрлатеральная часть более обширна. Кортикальный вход поступает в основном из первичной зрительной коры (область 17, V1), вторичной зрительной коры (области 18 и 19) и лобных полей глаз. Парабигеминальное ядро играет очень важную роль в функции бугорка, которая описана ниже. В отличие от визуально доминирующих входов в поверхностные слои, промежуточные и глубокие слои получают входы из очень разнообразного набора сенсорных и моторных структур. Большинство областей коры головного мозга проецируют в эти слои, хотя вход из «ассоциативных» областей, как правило, сильнее, чем вход из первичных сенсорных или моторных областей. Однако вовлеченные корковые области и сила их относительных проекций различаются у разных видов. Другой важный вход поступает из черной субстанции, pars reticulata – компонента базальных ганглиев. Эта проекция использует ингибирующий нейротрансмиттер ГАМК и, как считается, оказывает «запирающее» действие на верхний бугорок. Промежуточные и глубокие слои также получают вход из спинно-тройничного ядра, которое передает соматосенсорную информацию от лица, а также из гипоталамуса, zona incerta, таламуса и нижнего бугорка. Помимо своих отличительных входов, поверхностные и глубокие зоны верхнего бугорка также имеют отличительные выходы. Один из наиболее важных выходов направляется в пульвинар и латеральные промежуточные области таламуса, которые, в свою очередь, проецируются в области коры головного мозга, участвующие в контроле движений глаз. Существуют также проекции из поверхностной зоны в ядра претектума, латеральное коленчатое ядро таламуса и парабигеминальное ядро. Проекции из более глубоких слоев более обширны. Существуют два крупных нисходящих пути, идущих к стволу мозга и спинному мозгу, и многочисленные восходящие проекции в различные сенсорные и моторные центры, включая несколько, участвующих в генерации движений глаз. Оба бугорка также имеют нисходящие проекции к парамедианному ретикулярному образованию моста и спинному мозгу и, таким образом, могут быть вовлечены в реакции на стимулы быстрее, чем обработка корой.
Structure in the midbrain
In neuroanatomy, the superior colliculus is a structure lying on the roof of the mammalian midbrain. The adjective form tectal is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers (stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor related neurons, capable of activating eye movements as well as other responses. In other vertebrates the number of layers in the homologous optic tectum varies. and shifts in attention that do not involve any overt movements. The two inferior colliculi are situated immediately inferior/caudal to the superior colliculi; the inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin for quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent. The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. In the optic tectum this nearby structure is known as the nucleus isthmi. Structure
The superior colliculus is a synaptic layered structure. The top three layers are called superficial:Lamina I or SZ, the stratum zonale, is a thin layer consisting of small myelinated axons together with marginal and horizontal cells. Lamina II or SGS, the stratum griseum superficiale ("superficial gray layer"), contains many neurons of various shapes and sizes. Lamina III or SO, the stratum opticum ("optic layer"), consists mainly of axons coming from the optic tract. Next come two intermediate layers:Lamina IV or SGI, the stratum griseum intermedium ("intermediate gray layer"), is the thickest layer, and is filled with many neurons of many sizes. This layer is often as thick as all the other layers together. It is often subdivided into "upper" and "lower" parts. Lamina V or SAI, the stratum album intermedium ("intermediate white layer"), consists mainly of fibers from various sources. Finally come the two deep layers:Lamina VI or SGP, the stratum griseum profundum ("deep gray layer"), consists of loosely packed neurons and myelinated fibers. Lamina VII or SAP', the stratum album profundum ("deep white layer"), lying directly above the periaqueductal gray, consists entirely of fibers. The superficial layers receive input mainly from the retina, vision related areas of the cerebral cortex, and two tectal related structures called the pretectum and parabigeminal nucleus. The retinal input encompasses the entire superficial zone, and is bilateral, although the contralateral portion is more extensive. The cortical input comes most heavily from the primary visual cortex (area 17, V1), the secondary visual cortex (areas 18 and 19), and the frontal eye fields. The parabigeminal nucleus plays a very important role in tectal function that is described below. In contrast to the vision dominated inputs to the superficial layers, the intermediate and deep layers receive inputs from a very diverse set of sensory and motor structures. Most areas of the cerebral cortex project to these layers, although the input from "association" areas tends to be heavier than the input from primary sensory or motor areas. However, the cortical areas involved, and the strength of their relative projections differs across species. Another important input comes from the substantia nigra, pars reticulata, a component of the basal ganglia. This projection uses the inhibitory neurotransmitter GABA, and is thought to exert a "gating" effect on the superior colliculus. The intermediate and deep layers also receive input from the spinal trigeminal nucleus, which conveys somatosensory information from the face, as well as the hypothalamus, zona incerta, thalamus, and inferior colliculus. In addition to their distinctive inputs, the superficial and deep zones of the superior colliculus also have distinctive outputs. One of the most important outputs goes to the pulvinar and lateral intermediate areas of the thalamus, which in turn project to areas of the cerebral cortex that are involved in controlling eye movements. There are also projections from the superficial zone to the pretectal nuclei, lateral geniculate nucleus of the thalamus, and the parabigeminal nucleus. The projections from the deeper layers are more extensive. There are two large descending pathways, traveling to the brainstem and spinal cord, and numerous ascending projections to a variety of sensory and motor centers, including several that are involved in generating eye movements. Both colliculi also have descending projections to the paramedian pontine reticular formation and spinal cord, and thus can be involved in responses to stimuli faster than cortical processing would allow. Mosaic structure
On detailed examination, the collicular layers are actually not smooth sheets, but divided into a honeycomb arrangement of discrete columns. The clearest indication of columnar structure comes from the cholinergic inputs arising from the parabigeminal nucleus, whose terminals form evenly spaced clusters that extend from top to bottom of the tectum. Several other neurochemical markers including calretinin, parvalbumin, GAP 43, and NMDA receptors, and connections with numerous other brain structures in the brainstem and diencephalon, also show a corresponding inhomogeneity. The total number of columns has been estimated at around 100. From the 1970s to 1990s, however, neural recordings from mammals, mostly monkeys, focused primarily on the role of the superior colliculus in controlling eye movements. This line of investigation came to dominate the literature to such a degree that the majority opinion was that eye movement control is the only important function in mammals, a view still reflected in many current textbooks. In the late 1990s, however, experiments using animals whose heads were free to move showed clearly that the SC actually produces gaze shifts, usually composed of combined head and eye movements, rather than eye movements per se. This discovery reawakened interest in the full breadth of functions of the superior colliculus, and led to studies of multisensory integration in a variety of species and situations. Nevertheless, the role of the SC in controlling eye movements is understood in much greater depth than any other function. Behavioral studies have shown that the SC is not needed for object recognition, but plays a critical role in the ability to direct behaviors toward specific objects, and can support this ability even in the absence of the cerebral cortex. Thus, cats with major damage to the visual cortex cannot recognize objects, but may still be able to follow and orient toward moving stimuli, although more slowly than usual. If one half of the SC is removed, however, the cats will circle constantly toward the side of the lesion, and orient compulsively toward objects located there, but fail to orient at all toward objects located in the opposite hemifield. These deficits diminish over time but never disappear. Eye movements
In primates, eye movements can be divided into several types: fixation, in which the eyes are directed toward a motionless object, with eye movements only to compensate for movements of the head; smooth pursuit, in which the eyes move steadily to track a moving object; saccades, in which the eyes move very rapidly from one location to another; and vergence, in which the eyes move simultaneously in opposite directions to obtain or maintain single binocular vision. The superior colliculus is involved in all of these, but its role in saccades has been studied most intensively. Each of the two colliculi — one on each side of the brain — contains a two dimensional map representing half of the visual field. The fovea — the region of maximum sensitivity — is represented at the front edge of the map, and the periphery at the back edge. Eye movements are evoked by activity in the deep layers of the SC. During fixation, neurons near the front edge — the foveal zone — are tonically active. During smooth pursuit, neurons a small distance from the front edge are activated, leading to small eye movements. For saccades, neurons are activated in a region that represents the point to which the saccade will be directed. Just prior to a saccade, activity rapidly builds up at the target location and decreases in other parts of the SC. The coding is rather broad, so that for any given saccade the activity profile forms a "hill" that encompasses a substantial fraction of the collicular map: The location of the peak of this "hill" represents the saccade target. The SC encodes the target of a gaze shift, but it does not seem to specify the precise movements needed to get there. The decomposition of a gaze shift into head and eye movements and the precise trajectory of the eye during a saccade depend on integration of collicular and non collicular signals by downstream motor areas, in ways that are not yet well understood. Regardless of how the movement is evoked or performed, the SC encodes it in "retinotopic" coordinates: that is, the location of the SC 'hill" corresponds to a fixed location on the retina. This seems to contradict the observation that stimulation of a single point on the SC can result in different gaze shift directions, depending on initial eye orientation. However, it has been shown that this is because the retinal location of a stimulus is a non linear function of target location, eye orientation, and the spherical geometry of the eye. There has been some controversy about whether the SC merely commands eye movements, and leaves the execution to other structures, or whether it actively participates in the performance of a saccade. In 1991, Munoz et al., on the basis of data they collected, argued that, during a saccade, the "hill" of activity in the SC moves gradually, to reflect the changing offset of the eye from the target location while the saccade is progressing. At present, the predominant view is that, although the "hill" does shift slightly during a saccade, it does not shift in the steady and proportionate way that the "moving hill" hypothesis predicts. However, moving hills may play another role in the superior colliculus; more recent experiments have demonstrated a continuously moving hill of visual memory activity when the eyes move slowly while a separate saccade target is retained. The output from the motor sector of the SC goes to a set of midbrain and brainstem nuclei, which transform the "place" code used by the SC into the "rate" code used by oculomotor neurons. Eye movements are generated by six muscles, arranged in three orthogonally aligned pairs. Thus, at the level of the final common path, eye movements are encoded in essentially a Cartesian coordinate system. Although the SC receives a strong input directly from the retina, in primates it is largely under the control of the cerebral cortex, which contains several areas that are involved in determining eye movements. The frontal eye fields, a portion of the motor cortex, are involved in triggering intentional saccades, and an adjoining area, the supplementary eye fields, are involved in organizing groups of saccades into sequences. The parietal eye fields, farther back in the brain, are involved mainly in reflexive saccades, made in response to changes in the view. Recent evidence suggests that the primary visual cortex (V1) guides reflexive eye movements, according to V1 Saliency Hypothesis, using a bottom up saliency map of the visual field generated in V1 from external visual inputs. The SC only receives visual inputs in its superficial layers, whereas the deeper layers of the colliculus receive also auditory and somatosensory inputs and are connected to many sensorimotor areas of the brain. The colliculus as a whole is thought to help orient the head and eyes toward something seen and heard. The superior colliculus also receives auditory information from the inferior colliculus. This auditory information is integrated with the visual information already present to produce the ventriloquism effect. Distractibility
As well as being related to eye movements, the SC appears to have an important role to play in the circuitry underpinning distractibility. Heightened distractibility occurs in normal aging and is also a central feature in a number of medical conditions, including attention deficit hyperactivity disorder (ADHD). Research has shown that lesions to the SC in a number of species can result in heightened distractibility and, in humans, removing the inhibitory control on the SC from the pre frontal cortex, therefore increasing activity in the area, also increases distractibility. Research in an animal model of ADHD, the spontaneously hypertensive rat, also shows altered collicular dependent behaviours and physiology. Other animals
Other mammals
Primates
It is usually accepted that the primate superior colliculus is unique among mammals, in that it does not contain a complete map of the visual field seen by the contralateral eye. Instead, like the visual cortex and lateral geniculate nucleus, each colliculus represents only the contralateral half of the visual field, up to the midline, and excludes a representation of the ipsilateral half. This functional characteristic is explained by the absence, in primates, of anatomical connections between the retinal ganglion cells in the temporal half of the retina and the contralateral superior colliculus. In other mammals, the retinal ganglion cells throughout the contralateral retina project to the contralateral colliculus. This distinction between primates and non primates has been one of the key lines of evidence in support of the flying primates theory proposed by Australian neuroscientist Jack Pettigrew in 1986, after he discovered that flying foxes (megabats) resemble primates in terms of the pattern of anatomical connections between the retina and superior colliculus. Cats
In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem. Bats
Bats are not, in fact, blind, but they depend much more on echolocation than vision for navigation and prey capture. They obtain information about the surrounding world by emitting sonar chirps and then listening for the echoes. Their brains are highly specialized for this process, and some of these specializations appear in the superior colliculus. In bats, the retinal projection occupies only a thin zone just beneath the surface, but there are extensive inputs from auditory areas, and outputs to motor areas capable of orienting the ears, head, or body. Echoes coming from different directions activate neurons at different locations in the collicular layers, and activation of collicular neurons influences the chirps that the bats emit. Thus, there is a strong case that the superior colliculus performs the same sorts of functions for the auditory guided behaviors of bats that it performs for the visual guided behaviors of other species. Bats are usually classified into two main groups: Microchiroptera (the most numerous, and commonly found throughout the world), and Megachiroptera (fruit bats, found in Asia, Africa and Australasia). With one exception, Megabats do not echolocate, and rely on a developed sense of vision to navigate. The visual receptive fields of neurons in the superior colliculus in these animals form a precise map of the retina, similar to that found in cats and primates. Rodents
The superior colliculus in rodents have been hypothesized to mediate sensory guided approach and avoidance behaviors. Studies employing circuit analysis tools on mouse superior colliculus have revealed several important functions. In a series of studies, researchers have identified a set of Ying Yang circuit modules in the superior colliculus to initiate prey capture and predator avoidance behaviors in mice. By using single cell RNA sequencing, researchers have analyzed the gene expression profiles of superior colliculus neurons and identified the unique genetic markers of these circuit modules. Other vertebrates
Optic tectum
The optic tectum is the visual center in the non mammalian brain which develops from the alar plate of the mesencephalon. In these other vertebrates the connections from the optic tectum are important for the recognition and reaction to various sized objects which is facilitated by excitatory optic nerve transmitters like L glutamate. Disrupting visual experience early on in zebrafish development results in a change in tectal activity. Changes in tectal activity resulted in an inability to successfully hunt and capture prey. Hypothalamus inhibitory signaling to the deep tectal neuropil is important in tectal processing in zebrafish larvae. The tectal neuropil contains structures including periventricular neuronal axons and dendrites. The neuropil also contains GABAergic superficial inhibitory neurons located in stratum opticum. Instead of a large cerebral cortex, zebrafish have a relatively large optic tectum that is hypothesized to carry out some of the visual processing that the cortex performs in mammals. Recent lesion studies have suggested that the optic tectum has no influence over higher order motion responses like the optomotor response or the optokinetic response, but may be more integral to lower order cues in motion perception like in the identification of small objects. The optic tectum is one of the fundamental components of the vertebrate brain, existing across a range of species. Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic tracts to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow (In the superior colliculus the like structure is termed the parabigeminal nucleus). The nucleus isthmii is divided into two parts, called isthmus pars magnocellularis (Imc; "the part with the large cells") and isthmus pars parvocellularis'' (Ipc); "the part with the small cells"). Connections between the three areas — optic tectum, Ipc, and Imc — are topographic. Neurons in the superficial layers of the optic tectum project to corresponding points in the Ipc and Imc. The projections to the Ipc are tightly focused, while the projections to the Imc are somewhat more diffuse. Ipc gives rise to tightly focused cholinergic projections both to Imc and the optic tectum. In the optic tectum, the cholinergic inputs from Ipc ramify to give rise to terminals that extend across an entire column, from top to bottom. Imc, in contrast, gives rise to GABAergic projections to Ipc and optic tectum that spread very broadly in the lateral dimensions, encompassing most of the retinotopic map. Thus, the tectum Ipc Imc circuit causes tectal activity to produce recurrent feedback that involves tightly focused excitation of a small column of neighboring tectal neurons, together with global inhibition of distant tectal neurons. The optic tectum is involved in many responses including swimming in fish, flight in birds, tongue strikes toward prey in frogs, and fang strikes in snakes. In some species, including fish and birds, the optic tectum, also known as the optic lobe, is one of the largest components of the brain. In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. In amphibians, reptiles, and especially birds it is also a very significant component.
In neuroanatomy, the superior colliculus is a structure lying on the roof of the mammalian midbrain. The adjective form tectal is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers (stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor related neurons, capable of activating eye movements as well as other responses. In other vertebrates the number of layers in the homologous optic tectum varies. and shifts in attention that do not involve any overt movements. The two inferior colliculi are situated immediately inferior/caudal to the superior colliculi; the inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin for quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent. The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. In the optic tectum this nearby structure is known as the nucleus isthmi. Structure
The superior colliculus is a synaptic layered structure. The top three layers are called superficial:Lamina I or SZ, the stratum zonale, is a thin layer consisting of small myelinated axons together with marginal and horizontal cells. Lamina II or SGS, the stratum griseum superficiale ("superficial gray layer"), contains many neurons of various shapes and sizes. Lamina III or SO, the stratum opticum ("optic layer"), consists mainly of axons coming from the optic tract. Next come two intermediate layers:Lamina IV or SGI, the stratum griseum intermedium ("intermediate gray layer"), is the thickest layer, and is filled with many neurons of many sizes. This layer is often as thick as all the other layers together. It is often subdivided into "upper" and "lower" parts. Lamina V or SAI, the stratum album intermedium ("intermediate white layer"), consists mainly of fibers from various sources. Finally come the two deep layers:Lamina VI or SGP, the stratum griseum profundum ("deep gray layer"), consists of loosely packed neurons and myelinated fibers. Lamina VII or SAP', the stratum album profundum ("deep white layer"), lying directly above the periaqueductal gray, consists entirely of fibers. The superficial layers receive input mainly from the retina, vision related areas of the cerebral cortex, and two tectal related structures called the pretectum and parabigeminal nucleus. The retinal input encompasses the entire superficial zone, and is bilateral, although the contralateral portion is more extensive. The cortical input comes most heavily from the primary visual cortex (area 17, V1), the secondary visual cortex (areas 18 and 19), and the frontal eye fields. The parabigeminal nucleus plays a very important role in tectal function that is described below. In contrast to the vision dominated inputs to the superficial layers, the intermediate and deep layers receive inputs from a very diverse set of sensory and motor structures. Most areas of the cerebral cortex project to these layers, although the input from "association" areas tends to be heavier than the input from primary sensory or motor areas. However, the cortical areas involved, and the strength of their relative projections differs across species. Another important input comes from the substantia nigra, pars reticulata, a component of the basal ganglia. This projection uses the inhibitory neurotransmitter GABA, and is thought to exert a "gating" effect on the superior colliculus. The intermediate and deep layers also receive input from the spinal trigeminal nucleus, which conveys somatosensory information from the face, as well as the hypothalamus, zona incerta, thalamus, and inferior colliculus. In addition to their distinctive inputs, the superficial and deep zones of the superior colliculus also have distinctive outputs. One of the most important outputs goes to the pulvinar and lateral intermediate areas of the thalamus, which in turn project to areas of the cerebral cortex that are involved in controlling eye movements. There are also projections from the superficial zone to the pretectal nuclei, lateral geniculate nucleus of the thalamus, and the parabigeminal nucleus. The projections from the deeper layers are more extensive. There are two large descending pathways, traveling to the brainstem and spinal cord, and numerous ascending projections to a variety of sensory and motor centers, including several that are involved in generating eye movements. Both colliculi also have descending projections to the paramedian pontine reticular formation and spinal cord, and thus can be involved in responses to stimuli faster than cortical processing would allow. Mosaic structure
On detailed examination, the collicular layers are actually not smooth sheets, but divided into a honeycomb arrangement of discrete columns. The clearest indication of columnar structure comes from the cholinergic inputs arising from the parabigeminal nucleus, whose terminals form evenly spaced clusters that extend from top to bottom of the tectum. Several other neurochemical markers including calretinin, parvalbumin, GAP 43, and NMDA receptors, and connections with numerous other brain structures in the brainstem and diencephalon, also show a corresponding inhomogeneity. The total number of columns has been estimated at around 100. From the 1970s to 1990s, however, neural recordings from mammals, mostly monkeys, focused primarily on the role of the superior colliculus in controlling eye movements. This line of investigation came to dominate the literature to such a degree that the majority opinion was that eye movement control is the only important function in mammals, a view still reflected in many current textbooks. In the late 1990s, however, experiments using animals whose heads were free to move showed clearly that the SC actually produces gaze shifts, usually composed of combined head and eye movements, rather than eye movements per se. This discovery reawakened interest in the full breadth of functions of the superior colliculus, and led to studies of multisensory integration in a variety of species and situations. Nevertheless, the role of the SC in controlling eye movements is understood in much greater depth than any other function. Behavioral studies have shown that the SC is not needed for object recognition, but plays a critical role in the ability to direct behaviors toward specific objects, and can support this ability even in the absence of the cerebral cortex. Thus, cats with major damage to the visual cortex cannot recognize objects, but may still be able to follow and orient toward moving stimuli, although more slowly than usual. If one half of the SC is removed, however, the cats will circle constantly toward the side of the lesion, and orient compulsively toward objects located there, but fail to orient at all toward objects located in the opposite hemifield. These deficits diminish over time but never disappear. Eye movements
In primates, eye movements can be divided into several types: fixation, in which the eyes are directed toward a motionless object, with eye movements only to compensate for movements of the head; smooth pursuit, in which the eyes move steadily to track a moving object; saccades, in which the eyes move very rapidly from one location to another; and vergence, in which the eyes move simultaneously in opposite directions to obtain or maintain single binocular vision. The superior colliculus is involved in all of these, but its role in saccades has been studied most intensively. Each of the two colliculi — one on each side of the brain — contains a two dimensional map representing half of the visual field. The fovea — the region of maximum sensitivity — is represented at the front edge of the map, and the periphery at the back edge. Eye movements are evoked by activity in the deep layers of the SC. During fixation, neurons near the front edge — the foveal zone — are tonically active. During smooth pursuit, neurons a small distance from the front edge are activated, leading to small eye movements. For saccades, neurons are activated in a region that represents the point to which the saccade will be directed. Just prior to a saccade, activity rapidly builds up at the target location and decreases in other parts of the SC. The coding is rather broad, so that for any given saccade the activity profile forms a "hill" that encompasses a substantial fraction of the collicular map: The location of the peak of this "hill" represents the saccade target. The SC encodes the target of a gaze shift, but it does not seem to specify the precise movements needed to get there. The decomposition of a gaze shift into head and eye movements and the precise trajectory of the eye during a saccade depend on integration of collicular and non collicular signals by downstream motor areas, in ways that are not yet well understood. Regardless of how the movement is evoked or performed, the SC encodes it in "retinotopic" coordinates: that is, the location of the SC 'hill" corresponds to a fixed location on the retina. This seems to contradict the observation that stimulation of a single point on the SC can result in different gaze shift directions, depending on initial eye orientation. However, it has been shown that this is because the retinal location of a stimulus is a non linear function of target location, eye orientation, and the spherical geometry of the eye. There has been some controversy about whether the SC merely commands eye movements, and leaves the execution to other structures, or whether it actively participates in the performance of a saccade. In 1991, Munoz et al., on the basis of data they collected, argued that, during a saccade, the "hill" of activity in the SC moves gradually, to reflect the changing offset of the eye from the target location while the saccade is progressing. At present, the predominant view is that, although the "hill" does shift slightly during a saccade, it does not shift in the steady and proportionate way that the "moving hill" hypothesis predicts. However, moving hills may play another role in the superior colliculus; more recent experiments have demonstrated a continuously moving hill of visual memory activity when the eyes move slowly while a separate saccade target is retained. The output from the motor sector of the SC goes to a set of midbrain and brainstem nuclei, which transform the "place" code used by the SC into the "rate" code used by oculomotor neurons. Eye movements are generated by six muscles, arranged in three orthogonally aligned pairs. Thus, at the level of the final common path, eye movements are encoded in essentially a Cartesian coordinate system. Although the SC receives a strong input directly from the retina, in primates it is largely under the control of the cerebral cortex, which contains several areas that are involved in determining eye movements. The frontal eye fields, a portion of the motor cortex, are involved in triggering intentional saccades, and an adjoining area, the supplementary eye fields, are involved in organizing groups of saccades into sequences. The parietal eye fields, farther back in the brain, are involved mainly in reflexive saccades, made in response to changes in the view. Recent evidence suggests that the primary visual cortex (V1) guides reflexive eye movements, according to V1 Saliency Hypothesis, using a bottom up saliency map of the visual field generated in V1 from external visual inputs. The SC only receives visual inputs in its superficial layers, whereas the deeper layers of the colliculus receive also auditory and somatosensory inputs and are connected to many sensorimotor areas of the brain. The colliculus as a whole is thought to help orient the head and eyes toward something seen and heard. The superior colliculus also receives auditory information from the inferior colliculus. This auditory information is integrated with the visual information already present to produce the ventriloquism effect. Distractibility
As well as being related to eye movements, the SC appears to have an important role to play in the circuitry underpinning distractibility. Heightened distractibility occurs in normal aging and is also a central feature in a number of medical conditions, including attention deficit hyperactivity disorder (ADHD). Research has shown that lesions to the SC in a number of species can result in heightened distractibility and, in humans, removing the inhibitory control on the SC from the pre frontal cortex, therefore increasing activity in the area, also increases distractibility. Research in an animal model of ADHD, the spontaneously hypertensive rat, also shows altered collicular dependent behaviours and physiology. Other animals
Other mammals
Primates
It is usually accepted that the primate superior colliculus is unique among mammals, in that it does not contain a complete map of the visual field seen by the contralateral eye. Instead, like the visual cortex and lateral geniculate nucleus, each colliculus represents only the contralateral half of the visual field, up to the midline, and excludes a representation of the ipsilateral half. This functional characteristic is explained by the absence, in primates, of anatomical connections between the retinal ganglion cells in the temporal half of the retina and the contralateral superior colliculus. In other mammals, the retinal ganglion cells throughout the contralateral retina project to the contralateral colliculus. This distinction between primates and non primates has been one of the key lines of evidence in support of the flying primates theory proposed by Australian neuroscientist Jack Pettigrew in 1986, after he discovered that flying foxes (megabats) resemble primates in terms of the pattern of anatomical connections between the retina and superior colliculus. Cats
In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem. Bats
Bats are not, in fact, blind, but they depend much more on echolocation than vision for navigation and prey capture. They obtain information about the surrounding world by emitting sonar chirps and then listening for the echoes. Their brains are highly specialized for this process, and some of these specializations appear in the superior colliculus. In bats, the retinal projection occupies only a thin zone just beneath the surface, but there are extensive inputs from auditory areas, and outputs to motor areas capable of orienting the ears, head, or body. Echoes coming from different directions activate neurons at different locations in the collicular layers, and activation of collicular neurons influences the chirps that the bats emit. Thus, there is a strong case that the superior colliculus performs the same sorts of functions for the auditory guided behaviors of bats that it performs for the visual guided behaviors of other species. Bats are usually classified into two main groups: Microchiroptera (the most numerous, and commonly found throughout the world), and Megachiroptera (fruit bats, found in Asia, Africa and Australasia). With one exception, Megabats do not echolocate, and rely on a developed sense of vision to navigate. The visual receptive fields of neurons in the superior colliculus in these animals form a precise map of the retina, similar to that found in cats and primates. Rodents
The superior colliculus in rodents have been hypothesized to mediate sensory guided approach and avoidance behaviors. Studies employing circuit analysis tools on mouse superior colliculus have revealed several important functions. In a series of studies, researchers have identified a set of Ying Yang circuit modules in the superior colliculus to initiate prey capture and predator avoidance behaviors in mice. By using single cell RNA sequencing, researchers have analyzed the gene expression profiles of superior colliculus neurons and identified the unique genetic markers of these circuit modules. Other vertebrates
Optic tectum
The optic tectum is the visual center in the non mammalian brain which develops from the alar plate of the mesencephalon. In these other vertebrates the connections from the optic tectum are important for the recognition and reaction to various sized objects which is facilitated by excitatory optic nerve transmitters like L glutamate. Disrupting visual experience early on in zebrafish development results in a change in tectal activity. Changes in tectal activity resulted in an inability to successfully hunt and capture prey. Hypothalamus inhibitory signaling to the deep tectal neuropil is important in tectal processing in zebrafish larvae. The tectal neuropil contains structures including periventricular neuronal axons and dendrites. The neuropil also contains GABAergic superficial inhibitory neurons located in stratum opticum. Instead of a large cerebral cortex, zebrafish have a relatively large optic tectum that is hypothesized to carry out some of the visual processing that the cortex performs in mammals. Recent lesion studies have suggested that the optic tectum has no influence over higher order motion responses like the optomotor response or the optokinetic response, but may be more integral to lower order cues in motion perception like in the identification of small objects. The optic tectum is one of the fundamental components of the vertebrate brain, existing across a range of species. Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic tracts to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow (In the superior colliculus the like structure is termed the parabigeminal nucleus). The nucleus isthmii is divided into two parts, called isthmus pars magnocellularis (Imc; "the part with the large cells") and isthmus pars parvocellularis'' (Ipc); "the part with the small cells"). Connections between the three areas — optic tectum, Ipc, and Imc — are topographic. Neurons in the superficial layers of the optic tectum project to corresponding points in the Ipc and Imc. The projections to the Ipc are tightly focused, while the projections to the Imc are somewhat more diffuse. Ipc gives rise to tightly focused cholinergic projections both to Imc and the optic tectum. In the optic tectum, the cholinergic inputs from Ipc ramify to give rise to terminals that extend across an entire column, from top to bottom. Imc, in contrast, gives rise to GABAergic projections to Ipc and optic tectum that spread very broadly in the lateral dimensions, encompassing most of the retinotopic map. Thus, the tectum Ipc Imc circuit causes tectal activity to produce recurrent feedback that involves tightly focused excitation of a small column of neighboring tectal neurons, together with global inhibition of distant tectal neurons. The optic tectum is involved in many responses including swimming in fish, flight in birds, tongue strikes toward prey in frogs, and fang strikes in snakes. In some species, including fish and birds, the optic tectum, also known as the optic lobe, is one of the largest components of the brain. In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. In amphibians, reptiles, and especially birds it is also a very significant component.
Мозаичная структура
Structure in the midbrain
In neuroanatomy, the superior colliculus is a structure lying on the roof of the mammalian midbrain. The adjective form tectal is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers (stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor related neurons, capable of activating eye movements as well as other responses. In other vertebrates the number of layers in the homologous optic tectum varies. and shifts in attention that do not involve any overt movements. The two inferior colliculi are situated immediately inferior/caudal to the superior colliculi; the inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin for quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent. The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. In the optic tectum this nearby structure is known as the nucleus isthmi. Structure
The superior colliculus is a synaptic layered structure. The top three layers are called superficial:Lamina I or SZ, the stratum zonale, is a thin layer consisting of small myelinated axons together with marginal and horizontal cells. Lamina II or SGS, the stratum griseum superficiale ("superficial gray layer"), contains many neurons of various shapes and sizes. Lamina III or SO, the stratum opticum ("optic layer"), consists mainly of axons coming from the optic tract. Next come two intermediate layers:Lamina IV or SGI, the stratum griseum intermedium ("intermediate gray layer"), is the thickest layer, and is filled with many neurons of many sizes. This layer is often as thick as all the other layers together. It is often subdivided into "upper" and "lower" parts. Lamina V or SAI, the stratum album intermedium ("intermediate white layer"), consists mainly of fibers from various sources. Finally come the two deep layers:Lamina VI or SGP, the stratum griseum profundum ("deep gray layer"), consists of loosely packed neurons and myelinated fibers. Lamina VII or SAP', the stratum album profundum ("deep white layer"), lying directly above the periaqueductal gray, consists entirely of fibers. The superficial layers receive input mainly from the retina, vision related areas of the cerebral cortex, and two tectal related structures called the pretectum and parabigeminal nucleus. The retinal input encompasses the entire superficial zone, and is bilateral, although the contralateral portion is more extensive. The cortical input comes most heavily from the primary visual cortex (area 17, V1), the secondary visual cortex (areas 18 and 19), and the frontal eye fields. The parabigeminal nucleus plays a very important role in tectal function that is described below. In contrast to the vision dominated inputs to the superficial layers, the intermediate and deep layers receive inputs from a very diverse set of sensory and motor structures. Most areas of the cerebral cortex project to these layers, although the input from "association" areas tends to be heavier than the input from primary sensory or motor areas. However, the cortical areas involved, and the strength of their relative projections differs across species. Another important input comes from the substantia nigra, pars reticulata, a component of the basal ganglia. This projection uses the inhibitory neurotransmitter GABA, and is thought to exert a "gating" effect on the superior colliculus. The intermediate and deep layers also receive input from the spinal trigeminal nucleus, which conveys somatosensory information from the face, as well as the hypothalamus, zona incerta, thalamus, and inferior colliculus. In addition to their distinctive inputs, the superficial and deep zones of the superior colliculus also have distinctive outputs. One of the most important outputs goes to the pulvinar and lateral intermediate areas of the thalamus, which in turn project to areas of the cerebral cortex that are involved in controlling eye movements. There are also projections from the superficial zone to the pretectal nuclei, lateral geniculate nucleus of the thalamus, and the parabigeminal nucleus. The projections from the deeper layers are more extensive. There are two large descending pathways, traveling to the brainstem and spinal cord, and numerous ascending projections to a variety of sensory and motor centers, including several that are involved in generating eye movements. Both colliculi also have descending projections to the paramedian pontine reticular formation and spinal cord, and thus can be involved in responses to stimuli faster than cortical processing would allow. Mosaic structure
On detailed examination, the collicular layers are actually not smooth sheets, but divided into a honeycomb arrangement of discrete columns. The clearest indication of columnar structure comes from the cholinergic inputs arising from the parabigeminal nucleus, whose terminals form evenly spaced clusters that extend from top to bottom of the tectum. Several other neurochemical markers including calretinin, parvalbumin, GAP 43, and NMDA receptors, and connections with numerous other brain structures in the brainstem and diencephalon, also show a corresponding inhomogeneity. The total number of columns has been estimated at around 100. From the 1970s to 1990s, however, neural recordings from mammals, mostly monkeys, focused primarily on the role of the superior colliculus in controlling eye movements. This line of investigation came to dominate the literature to such a degree that the majority opinion was that eye movement control is the only important function in mammals, a view still reflected in many current textbooks. In the late 1990s, however, experiments using animals whose heads were free to move showed clearly that the SC actually produces gaze shifts, usually composed of combined head and eye movements, rather than eye movements per se. This discovery reawakened interest in the full breadth of functions of the superior colliculus, and led to studies of multisensory integration in a variety of species and situations. Nevertheless, the role of the SC in controlling eye movements is understood in much greater depth than any other function. Behavioral studies have shown that the SC is not needed for object recognition, but plays a critical role in the ability to direct behaviors toward specific objects, and can support this ability even in the absence of the cerebral cortex. Thus, cats with major damage to the visual cortex cannot recognize objects, but may still be able to follow and orient toward moving stimuli, although more slowly than usual. If one half of the SC is removed, however, the cats will circle constantly toward the side of the lesion, and orient compulsively toward objects located there, but fail to orient at all toward objects located in the opposite hemifield. These deficits diminish over time but never disappear. Eye movements
In primates, eye movements can be divided into several types: fixation, in which the eyes are directed toward a motionless object, with eye movements only to compensate for movements of the head; smooth pursuit, in which the eyes move steadily to track a moving object; saccades, in which the eyes move very rapidly from one location to another; and vergence, in which the eyes move simultaneously in opposite directions to obtain or maintain single binocular vision. The superior colliculus is involved in all of these, but its role in saccades has been studied most intensively. Each of the two colliculi — one on each side of the brain — contains a two dimensional map representing half of the visual field. The fovea — the region of maximum sensitivity — is represented at the front edge of the map, and the periphery at the back edge. Eye movements are evoked by activity in the deep layers of the SC. During fixation, neurons near the front edge — the foveal zone — are tonically active. During smooth pursuit, neurons a small distance from the front edge are activated, leading to small eye movements. For saccades, neurons are activated in a region that represents the point to which the saccade will be directed. Just prior to a saccade, activity rapidly builds up at the target location and decreases in other parts of the SC. The coding is rather broad, so that for any given saccade the activity profile forms a "hill" that encompasses a substantial fraction of the collicular map: The location of the peak of this "hill" represents the saccade target. The SC encodes the target of a gaze shift, but it does not seem to specify the precise movements needed to get there. The decomposition of a gaze shift into head and eye movements and the precise trajectory of the eye during a saccade depend on integration of collicular and non collicular signals by downstream motor areas, in ways that are not yet well understood. Regardless of how the movement is evoked or performed, the SC encodes it in "retinotopic" coordinates: that is, the location of the SC 'hill" corresponds to a fixed location on the retina. This seems to contradict the observation that stimulation of a single point on the SC can result in different gaze shift directions, depending on initial eye orientation. However, it has been shown that this is because the retinal location of a stimulus is a non linear function of target location, eye orientation, and the spherical geometry of the eye. There has been some controversy about whether the SC merely commands eye movements, and leaves the execution to other structures, or whether it actively participates in the performance of a saccade. In 1991, Munoz et al., on the basis of data they collected, argued that, during a saccade, the "hill" of activity in the SC moves gradually, to reflect the changing offset of the eye from the target location while the saccade is progressing. At present, the predominant view is that, although the "hill" does shift slightly during a saccade, it does not shift in the steady and proportionate way that the "moving hill" hypothesis predicts. However, moving hills may play another role in the superior colliculus; more recent experiments have demonstrated a continuously moving hill of visual memory activity when the eyes move slowly while a separate saccade target is retained. The output from the motor sector of the SC goes to a set of midbrain and brainstem nuclei, which transform the "place" code used by the SC into the "rate" code used by oculomotor neurons. Eye movements are generated by six muscles, arranged in three orthogonally aligned pairs. Thus, at the level of the final common path, eye movements are encoded in essentially a Cartesian coordinate system. Although the SC receives a strong input directly from the retina, in primates it is largely under the control of the cerebral cortex, which contains several areas that are involved in determining eye movements. The frontal eye fields, a portion of the motor cortex, are involved in triggering intentional saccades, and an adjoining area, the supplementary eye fields, are involved in organizing groups of saccades into sequences. The parietal eye fields, farther back in the brain, are involved mainly in reflexive saccades, made in response to changes in the view. Recent evidence suggests that the primary visual cortex (V1) guides reflexive eye movements, according to V1 Saliency Hypothesis, using a bottom up saliency map of the visual field generated in V1 from external visual inputs. The SC only receives visual inputs in its superficial layers, whereas the deeper layers of the colliculus receive also auditory and somatosensory inputs and are connected to many sensorimotor areas of the brain. The colliculus as a whole is thought to help orient the head and eyes toward something seen and heard. The superior colliculus also receives auditory information from the inferior colliculus. This auditory information is integrated with the visual information already present to produce the ventriloquism effect. Distractibility
As well as being related to eye movements, the SC appears to have an important role to play in the circuitry underpinning distractibility. Heightened distractibility occurs in normal aging and is also a central feature in a number of medical conditions, including attention deficit hyperactivity disorder (ADHD). Research has shown that lesions to the SC in a number of species can result in heightened distractibility and, in humans, removing the inhibitory control on the SC from the pre frontal cortex, therefore increasing activity in the area, also increases distractibility. Research in an animal model of ADHD, the spontaneously hypertensive rat, also shows altered collicular dependent behaviours and physiology. Other animals
Other mammals
Primates
It is usually accepted that the primate superior colliculus is unique among mammals, in that it does not contain a complete map of the visual field seen by the contralateral eye. Instead, like the visual cortex and lateral geniculate nucleus, each colliculus represents only the contralateral half of the visual field, up to the midline, and excludes a representation of the ipsilateral half. This functional characteristic is explained by the absence, in primates, of anatomical connections between the retinal ganglion cells in the temporal half of the retina and the contralateral superior colliculus. In other mammals, the retinal ganglion cells throughout the contralateral retina project to the contralateral colliculus. This distinction between primates and non primates has been one of the key lines of evidence in support of the flying primates theory proposed by Australian neuroscientist Jack Pettigrew in 1986, after he discovered that flying foxes (megabats) resemble primates in terms of the pattern of anatomical connections between the retina and superior colliculus. Cats
In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem. Bats
Bats are not, in fact, blind, but they depend much more on echolocation than vision for navigation and prey capture. They obtain information about the surrounding world by emitting sonar chirps and then listening for the echoes. Their brains are highly specialized for this process, and some of these specializations appear in the superior colliculus. In bats, the retinal projection occupies only a thin zone just beneath the surface, but there are extensive inputs from auditory areas, and outputs to motor areas capable of orienting the ears, head, or body. Echoes coming from different directions activate neurons at different locations in the collicular layers, and activation of collicular neurons influences the chirps that the bats emit. Thus, there is a strong case that the superior colliculus performs the same sorts of functions for the auditory guided behaviors of bats that it performs for the visual guided behaviors of other species. Bats are usually classified into two main groups: Microchiroptera (the most numerous, and commonly found throughout the world), and Megachiroptera (fruit bats, found in Asia, Africa and Australasia). With one exception, Megabats do not echolocate, and rely on a developed sense of vision to navigate. The visual receptive fields of neurons in the superior colliculus in these animals form a precise map of the retina, similar to that found in cats and primates. Rodents
The superior colliculus in rodents have been hypothesized to mediate sensory guided approach and avoidance behaviors. Studies employing circuit analysis tools on mouse superior colliculus have revealed several important functions. In a series of studies, researchers have identified a set of Ying Yang circuit modules in the superior colliculus to initiate prey capture and predator avoidance behaviors in mice. By using single cell RNA sequencing, researchers have analyzed the gene expression profiles of superior colliculus neurons and identified the unique genetic markers of these circuit modules. Other vertebrates
Optic tectum
The optic tectum is the visual center in the non mammalian brain which develops from the alar plate of the mesencephalon. In these other vertebrates the connections from the optic tectum are important for the recognition and reaction to various sized objects which is facilitated by excitatory optic nerve transmitters like L glutamate. Disrupting visual experience early on in zebrafish development results in a change in tectal activity. Changes in tectal activity resulted in an inability to successfully hunt and capture prey. Hypothalamus inhibitory signaling to the deep tectal neuropil is important in tectal processing in zebrafish larvae. The tectal neuropil contains structures including periventricular neuronal axons and dendrites. The neuropil also contains GABAergic superficial inhibitory neurons located in stratum opticum. Instead of a large cerebral cortex, zebrafish have a relatively large optic tectum that is hypothesized to carry out some of the visual processing that the cortex performs in mammals. Recent lesion studies have suggested that the optic tectum has no influence over higher order motion responses like the optomotor response or the optokinetic response, but may be more integral to lower order cues in motion perception like in the identification of small objects. The optic tectum is one of the fundamental components of the vertebrate brain, existing across a range of species. Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic tracts to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow (In the superior colliculus the like structure is termed the parabigeminal nucleus). The nucleus isthmii is divided into two parts, called isthmus pars magnocellularis (Imc; "the part with the large cells") and isthmus pars parvocellularis'' (Ipc); "the part with the small cells"). Connections between the three areas — optic tectum, Ipc, and Imc — are topographic. Neurons in the superficial layers of the optic tectum project to corresponding points in the Ipc and Imc. The projections to the Ipc are tightly focused, while the projections to the Imc are somewhat more diffuse. Ipc gives rise to tightly focused cholinergic projections both to Imc and the optic tectum. In the optic tectum, the cholinergic inputs from Ipc ramify to give rise to terminals that extend across an entire column, from top to bottom. Imc, in contrast, gives rise to GABAergic projections to Ipc and optic tectum that spread very broadly in the lateral dimensions, encompassing most of the retinotopic map. Thus, the tectum Ipc Imc circuit causes tectal activity to produce recurrent feedback that involves tightly focused excitation of a small column of neighboring tectal neurons, together with global inhibition of distant tectal neurons. The optic tectum is involved in many responses including swimming in fish, flight in birds, tongue strikes toward prey in frogs, and fang strikes in snakes. In some species, including fish and birds, the optic tectum, also known as the optic lobe, is one of the largest components of the brain. In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. In amphibians, reptiles, and especially birds it is also a very significant component.
In neuroanatomy, the superior colliculus is a structure lying on the roof of the mammalian midbrain. The adjective form tectal is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers (stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor related neurons, capable of activating eye movements as well as other responses. In other vertebrates the number of layers in the homologous optic tectum varies. and shifts in attention that do not involve any overt movements. The two inferior colliculi are situated immediately inferior/caudal to the superior colliculi; the inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin for quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent. The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. In the optic tectum this nearby structure is known as the nucleus isthmi. Structure
The superior colliculus is a synaptic layered structure. The top three layers are called superficial:Lamina I or SZ, the stratum zonale, is a thin layer consisting of small myelinated axons together with marginal and horizontal cells. Lamina II or SGS, the stratum griseum superficiale ("superficial gray layer"), contains many neurons of various shapes and sizes. Lamina III or SO, the stratum opticum ("optic layer"), consists mainly of axons coming from the optic tract. Next come two intermediate layers:Lamina IV or SGI, the stratum griseum intermedium ("intermediate gray layer"), is the thickest layer, and is filled with many neurons of many sizes. This layer is often as thick as all the other layers together. It is often subdivided into "upper" and "lower" parts. Lamina V or SAI, the stratum album intermedium ("intermediate white layer"), consists mainly of fibers from various sources. Finally come the two deep layers:Lamina VI or SGP, the stratum griseum profundum ("deep gray layer"), consists of loosely packed neurons and myelinated fibers. Lamina VII or SAP', the stratum album profundum ("deep white layer"), lying directly above the periaqueductal gray, consists entirely of fibers. The superficial layers receive input mainly from the retina, vision related areas of the cerebral cortex, and two tectal related structures called the pretectum and parabigeminal nucleus. The retinal input encompasses the entire superficial zone, and is bilateral, although the contralateral portion is more extensive. The cortical input comes most heavily from the primary visual cortex (area 17, V1), the secondary visual cortex (areas 18 and 19), and the frontal eye fields. The parabigeminal nucleus plays a very important role in tectal function that is described below. In contrast to the vision dominated inputs to the superficial layers, the intermediate and deep layers receive inputs from a very diverse set of sensory and motor structures. Most areas of the cerebral cortex project to these layers, although the input from "association" areas tends to be heavier than the input from primary sensory or motor areas. However, the cortical areas involved, and the strength of their relative projections differs across species. Another important input comes from the substantia nigra, pars reticulata, a component of the basal ganglia. This projection uses the inhibitory neurotransmitter GABA, and is thought to exert a "gating" effect on the superior colliculus. The intermediate and deep layers also receive input from the spinal trigeminal nucleus, which conveys somatosensory information from the face, as well as the hypothalamus, zona incerta, thalamus, and inferior colliculus. In addition to their distinctive inputs, the superficial and deep zones of the superior colliculus also have distinctive outputs. One of the most important outputs goes to the pulvinar and lateral intermediate areas of the thalamus, which in turn project to areas of the cerebral cortex that are involved in controlling eye movements. There are also projections from the superficial zone to the pretectal nuclei, lateral geniculate nucleus of the thalamus, and the parabigeminal nucleus. The projections from the deeper layers are more extensive. There are two large descending pathways, traveling to the brainstem and spinal cord, and numerous ascending projections to a variety of sensory and motor centers, including several that are involved in generating eye movements. Both colliculi also have descending projections to the paramedian pontine reticular formation and spinal cord, and thus can be involved in responses to stimuli faster than cortical processing would allow. Mosaic structure
On detailed examination, the collicular layers are actually not smooth sheets, but divided into a honeycomb arrangement of discrete columns. The clearest indication of columnar structure comes from the cholinergic inputs arising from the parabigeminal nucleus, whose terminals form evenly spaced clusters that extend from top to bottom of the tectum. Several other neurochemical markers including calretinin, parvalbumin, GAP 43, and NMDA receptors, and connections with numerous other brain structures in the brainstem and diencephalon, also show a corresponding inhomogeneity. The total number of columns has been estimated at around 100. From the 1970s to 1990s, however, neural recordings from mammals, mostly monkeys, focused primarily on the role of the superior colliculus in controlling eye movements. This line of investigation came to dominate the literature to such a degree that the majority opinion was that eye movement control is the only important function in mammals, a view still reflected in many current textbooks. In the late 1990s, however, experiments using animals whose heads were free to move showed clearly that the SC actually produces gaze shifts, usually composed of combined head and eye movements, rather than eye movements per se. This discovery reawakened interest in the full breadth of functions of the superior colliculus, and led to studies of multisensory integration in a variety of species and situations. Nevertheless, the role of the SC in controlling eye movements is understood in much greater depth than any other function. Behavioral studies have shown that the SC is not needed for object recognition, but plays a critical role in the ability to direct behaviors toward specific objects, and can support this ability even in the absence of the cerebral cortex. Thus, cats with major damage to the visual cortex cannot recognize objects, but may still be able to follow and orient toward moving stimuli, although more slowly than usual. If one half of the SC is removed, however, the cats will circle constantly toward the side of the lesion, and orient compulsively toward objects located there, but fail to orient at all toward objects located in the opposite hemifield. These deficits diminish over time but never disappear. Eye movements
In primates, eye movements can be divided into several types: fixation, in which the eyes are directed toward a motionless object, with eye movements only to compensate for movements of the head; smooth pursuit, in which the eyes move steadily to track a moving object; saccades, in which the eyes move very rapidly from one location to another; and vergence, in which the eyes move simultaneously in opposite directions to obtain or maintain single binocular vision. The superior colliculus is involved in all of these, but its role in saccades has been studied most intensively. Each of the two colliculi — one on each side of the brain — contains a two dimensional map representing half of the visual field. The fovea — the region of maximum sensitivity — is represented at the front edge of the map, and the periphery at the back edge. Eye movements are evoked by activity in the deep layers of the SC. During fixation, neurons near the front edge — the foveal zone — are tonically active. During smooth pursuit, neurons a small distance from the front edge are activated, leading to small eye movements. For saccades, neurons are activated in a region that represents the point to which the saccade will be directed. Just prior to a saccade, activity rapidly builds up at the target location and decreases in other parts of the SC. The coding is rather broad, so that for any given saccade the activity profile forms a "hill" that encompasses a substantial fraction of the collicular map: The location of the peak of this "hill" represents the saccade target. The SC encodes the target of a gaze shift, but it does not seem to specify the precise movements needed to get there. The decomposition of a gaze shift into head and eye movements and the precise trajectory of the eye during a saccade depend on integration of collicular and non collicular signals by downstream motor areas, in ways that are not yet well understood. Regardless of how the movement is evoked or performed, the SC encodes it in "retinotopic" coordinates: that is, the location of the SC 'hill" corresponds to a fixed location on the retina. This seems to contradict the observation that stimulation of a single point on the SC can result in different gaze shift directions, depending on initial eye orientation. However, it has been shown that this is because the retinal location of a stimulus is a non linear function of target location, eye orientation, and the spherical geometry of the eye. There has been some controversy about whether the SC merely commands eye movements, and leaves the execution to other structures, or whether it actively participates in the performance of a saccade. In 1991, Munoz et al., on the basis of data they collected, argued that, during a saccade, the "hill" of activity in the SC moves gradually, to reflect the changing offset of the eye from the target location while the saccade is progressing. At present, the predominant view is that, although the "hill" does shift slightly during a saccade, it does not shift in the steady and proportionate way that the "moving hill" hypothesis predicts. However, moving hills may play another role in the superior colliculus; more recent experiments have demonstrated a continuously moving hill of visual memory activity when the eyes move slowly while a separate saccade target is retained. The output from the motor sector of the SC goes to a set of midbrain and brainstem nuclei, which transform the "place" code used by the SC into the "rate" code used by oculomotor neurons. Eye movements are generated by six muscles, arranged in three orthogonally aligned pairs. Thus, at the level of the final common path, eye movements are encoded in essentially a Cartesian coordinate system. Although the SC receives a strong input directly from the retina, in primates it is largely under the control of the cerebral cortex, which contains several areas that are involved in determining eye movements. The frontal eye fields, a portion of the motor cortex, are involved in triggering intentional saccades, and an adjoining area, the supplementary eye fields, are involved in organizing groups of saccades into sequences. The parietal eye fields, farther back in the brain, are involved mainly in reflexive saccades, made in response to changes in the view. Recent evidence suggests that the primary visual cortex (V1) guides reflexive eye movements, according to V1 Saliency Hypothesis, using a bottom up saliency map of the visual field generated in V1 from external visual inputs. The SC only receives visual inputs in its superficial layers, whereas the deeper layers of the colliculus receive also auditory and somatosensory inputs and are connected to many sensorimotor areas of the brain. The colliculus as a whole is thought to help orient the head and eyes toward something seen and heard. The superior colliculus also receives auditory information from the inferior colliculus. This auditory information is integrated with the visual information already present to produce the ventriloquism effect. Distractibility
As well as being related to eye movements, the SC appears to have an important role to play in the circuitry underpinning distractibility. Heightened distractibility occurs in normal aging and is also a central feature in a number of medical conditions, including attention deficit hyperactivity disorder (ADHD). Research has shown that lesions to the SC in a number of species can result in heightened distractibility and, in humans, removing the inhibitory control on the SC from the pre frontal cortex, therefore increasing activity in the area, also increases distractibility. Research in an animal model of ADHD, the spontaneously hypertensive rat, also shows altered collicular dependent behaviours and physiology. Other animals
Other mammals
Primates
It is usually accepted that the primate superior colliculus is unique among mammals, in that it does not contain a complete map of the visual field seen by the contralateral eye. Instead, like the visual cortex and lateral geniculate nucleus, each colliculus represents only the contralateral half of the visual field, up to the midline, and excludes a representation of the ipsilateral half. This functional characteristic is explained by the absence, in primates, of anatomical connections between the retinal ganglion cells in the temporal half of the retina and the contralateral superior colliculus. In other mammals, the retinal ganglion cells throughout the contralateral retina project to the contralateral colliculus. This distinction between primates and non primates has been one of the key lines of evidence in support of the flying primates theory proposed by Australian neuroscientist Jack Pettigrew in 1986, after he discovered that flying foxes (megabats) resemble primates in terms of the pattern of anatomical connections between the retina and superior colliculus. Cats
In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem. Bats
Bats are not, in fact, blind, but they depend much more on echolocation than vision for navigation and prey capture. They obtain information about the surrounding world by emitting sonar chirps and then listening for the echoes. Their brains are highly specialized for this process, and some of these specializations appear in the superior colliculus. In bats, the retinal projection occupies only a thin zone just beneath the surface, but there are extensive inputs from auditory areas, and outputs to motor areas capable of orienting the ears, head, or body. Echoes coming from different directions activate neurons at different locations in the collicular layers, and activation of collicular neurons influences the chirps that the bats emit. Thus, there is a strong case that the superior colliculus performs the same sorts of functions for the auditory guided behaviors of bats that it performs for the visual guided behaviors of other species. Bats are usually classified into two main groups: Microchiroptera (the most numerous, and commonly found throughout the world), and Megachiroptera (fruit bats, found in Asia, Africa and Australasia). With one exception, Megabats do not echolocate, and rely on a developed sense of vision to navigate. The visual receptive fields of neurons in the superior colliculus in these animals form a precise map of the retina, similar to that found in cats and primates. Rodents
The superior colliculus in rodents have been hypothesized to mediate sensory guided approach and avoidance behaviors. Studies employing circuit analysis tools on mouse superior colliculus have revealed several important functions. In a series of studies, researchers have identified a set of Ying Yang circuit modules in the superior colliculus to initiate prey capture and predator avoidance behaviors in mice. By using single cell RNA sequencing, researchers have analyzed the gene expression profiles of superior colliculus neurons and identified the unique genetic markers of these circuit modules. Other vertebrates
Optic tectum
The optic tectum is the visual center in the non mammalian brain which develops from the alar plate of the mesencephalon. In these other vertebrates the connections from the optic tectum are important for the recognition and reaction to various sized objects which is facilitated by excitatory optic nerve transmitters like L glutamate. Disrupting visual experience early on in zebrafish development results in a change in tectal activity. Changes in tectal activity resulted in an inability to successfully hunt and capture prey. Hypothalamus inhibitory signaling to the deep tectal neuropil is important in tectal processing in zebrafish larvae. The tectal neuropil contains structures including periventricular neuronal axons and dendrites. The neuropil also contains GABAergic superficial inhibitory neurons located in stratum opticum. Instead of a large cerebral cortex, zebrafish have a relatively large optic tectum that is hypothesized to carry out some of the visual processing that the cortex performs in mammals. Recent lesion studies have suggested that the optic tectum has no influence over higher order motion responses like the optomotor response or the optokinetic response, but may be more integral to lower order cues in motion perception like in the identification of small objects. The optic tectum is one of the fundamental components of the vertebrate brain, existing across a range of species. Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic tracts to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow (In the superior colliculus the like structure is termed the parabigeminal nucleus). The nucleus isthmii is divided into two parts, called isthmus pars magnocellularis (Imc; "the part with the large cells") and isthmus pars parvocellularis'' (Ipc); "the part with the small cells"). Connections between the three areas — optic tectum, Ipc, and Imc — are topographic. Neurons in the superficial layers of the optic tectum project to corresponding points in the Ipc and Imc. The projections to the Ipc are tightly focused, while the projections to the Imc are somewhat more diffuse. Ipc gives rise to tightly focused cholinergic projections both to Imc and the optic tectum. In the optic tectum, the cholinergic inputs from Ipc ramify to give rise to terminals that extend across an entire column, from top to bottom. Imc, in contrast, gives rise to GABAergic projections to Ipc and optic tectum that spread very broadly in the lateral dimensions, encompassing most of the retinotopic map. Thus, the tectum Ipc Imc circuit causes tectal activity to produce recurrent feedback that involves tightly focused excitation of a small column of neighboring tectal neurons, together with global inhibition of distant tectal neurons. The optic tectum is involved in many responses including swimming in fish, flight in birds, tongue strikes toward prey in frogs, and fang strikes in snakes. In some species, including fish and birds, the optic tectum, also known as the optic lobe, is one of the largest components of the brain. In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. In amphibians, reptiles, and especially birds it is also a very significant component.
При детальном изучении слои бугорка на самом деле не являются гладкими пластинами, а разделены на сотовидную структуру из дискретных колонн. Наиболее четким указанием на столбчатую структуру являются холинергические входы, исходящие из парабигеминального ядра, чьи терминалы образуют равномерно расположенные скопления, простирающиеся сверху донизу тектома. Несколько других нейрохимических маркеров, включая кальретинин, парвальбумин, GAP 43 и NMDA-рецепторы, а также связи с многочисленными другими структурами мозга в стволе мозга и диэнцефалоне, также демонстрируют соответствующую неоднородность. Общее количество колонн оценивается примерно в 100. Однако с 1970-х по 1990-е годы нейронные записи у млекопитающих, в основном у обезьян, были сосредоточены главным образом на роли верхнего бугорка в контроле движений глаз. Эта линия исследований настолько доминировала в литературе, что преобладающим мнением было то, что контроль движений глаз – единственная важная функция у млекопитающих, точка зрения, которая все еще отражена во многих современных учебниках. Однако в конце 1990-х годов эксперименты с животными, чьи головы были свободны для движения, четко показали, что верхний бугорок фактически производит сдвиги взгляда, обычно состоящие из комбинированных движений головы и глаз, а не движений глаз как таковых. Это открытие возродило интерес к полноте функций верхнего бугорка и привело к изучению мультисенсорной интеграции в различных видах и ситуациях. Тем не менее, роль верхнего бугорка в контроле движений глаз понимается гораздо глубже, чем любая другая функция. Поведенческие исследования показали, что верхний бугорок не нужен для распознавания объектов, но играет решающую роль в способности направлять поведение на конкретные объекты и может поддерживать эту способность даже в отсутствие коры головного мозга. Таким образом, кошки с серьезным повреждением зрительной коры не могут распознавать объекты, но все же могут следовать и ориентироваться на движущиеся стимулы, хотя и медленнее, чем обычно. Однако, если удалить половину верхнего бугорка, кошки будут постоянно кружиться в сторону поражения и навязчиво ориентироваться на объекты, расположенные там, но не будут ориентироваться на объекты, расположенные в противоположном полушарии. Эти дефициты со временем уменьшаются, но никогда не исчезают.
Structure in the midbrain
In neuroanatomy, the superior colliculus is a structure lying on the roof of the mammalian midbrain. The adjective form tectal is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers (stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor related neurons, capable of activating eye movements as well as other responses. In other vertebrates the number of layers in the homologous optic tectum varies. and shifts in attention that do not involve any overt movements. The two inferior colliculi are situated immediately inferior/caudal to the superior colliculi; the inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin for quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent. The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. In the optic tectum this nearby structure is known as the nucleus isthmi. Structure
The superior colliculus is a synaptic layered structure. The top three layers are called superficial:Lamina I or SZ, the stratum zonale, is a thin layer consisting of small myelinated axons together with marginal and horizontal cells. Lamina II or SGS, the stratum griseum superficiale ("superficial gray layer"), contains many neurons of various shapes and sizes. Lamina III or SO, the stratum opticum ("optic layer"), consists mainly of axons coming from the optic tract. Next come two intermediate layers:Lamina IV or SGI, the stratum griseum intermedium ("intermediate gray layer"), is the thickest layer, and is filled with many neurons of many sizes. This layer is often as thick as all the other layers together. It is often subdivided into "upper" and "lower" parts. Lamina V or SAI, the stratum album intermedium ("intermediate white layer"), consists mainly of fibers from various sources. Finally come the two deep layers:Lamina VI or SGP, the stratum griseum profundum ("deep gray layer"), consists of loosely packed neurons and myelinated fibers. Lamina VII or SAP', the stratum album profundum ("deep white layer"), lying directly above the periaqueductal gray, consists entirely of fibers. The superficial layers receive input mainly from the retina, vision related areas of the cerebral cortex, and two tectal related structures called the pretectum and parabigeminal nucleus. The retinal input encompasses the entire superficial zone, and is bilateral, although the contralateral portion is more extensive. The cortical input comes most heavily from the primary visual cortex (area 17, V1), the secondary visual cortex (areas 18 and 19), and the frontal eye fields. The parabigeminal nucleus plays a very important role in tectal function that is described below. In contrast to the vision dominated inputs to the superficial layers, the intermediate and deep layers receive inputs from a very diverse set of sensory and motor structures. Most areas of the cerebral cortex project to these layers, although the input from "association" areas tends to be heavier than the input from primary sensory or motor areas. However, the cortical areas involved, and the strength of their relative projections differs across species. Another important input comes from the substantia nigra, pars reticulata, a component of the basal ganglia. This projection uses the inhibitory neurotransmitter GABA, and is thought to exert a "gating" effect on the superior colliculus. The intermediate and deep layers also receive input from the spinal trigeminal nucleus, which conveys somatosensory information from the face, as well as the hypothalamus, zona incerta, thalamus, and inferior colliculus. In addition to their distinctive inputs, the superficial and deep zones of the superior colliculus also have distinctive outputs. One of the most important outputs goes to the pulvinar and lateral intermediate areas of the thalamus, which in turn project to areas of the cerebral cortex that are involved in controlling eye movements. There are also projections from the superficial zone to the pretectal nuclei, lateral geniculate nucleus of the thalamus, and the parabigeminal nucleus. The projections from the deeper layers are more extensive. There are two large descending pathways, traveling to the brainstem and spinal cord, and numerous ascending projections to a variety of sensory and motor centers, including several that are involved in generating eye movements. Both colliculi also have descending projections to the paramedian pontine reticular formation and spinal cord, and thus can be involved in responses to stimuli faster than cortical processing would allow. Mosaic structure
On detailed examination, the collicular layers are actually not smooth sheets, but divided into a honeycomb arrangement of discrete columns. The clearest indication of columnar structure comes from the cholinergic inputs arising from the parabigeminal nucleus, whose terminals form evenly spaced clusters that extend from top to bottom of the tectum. Several other neurochemical markers including calretinin, parvalbumin, GAP 43, and NMDA receptors, and connections with numerous other brain structures in the brainstem and diencephalon, also show a corresponding inhomogeneity. The total number of columns has been estimated at around 100. From the 1970s to 1990s, however, neural recordings from mammals, mostly monkeys, focused primarily on the role of the superior colliculus in controlling eye movements. This line of investigation came to dominate the literature to such a degree that the majority opinion was that eye movement control is the only important function in mammals, a view still reflected in many current textbooks. In the late 1990s, however, experiments using animals whose heads were free to move showed clearly that the SC actually produces gaze shifts, usually composed of combined head and eye movements, rather than eye movements per se. This discovery reawakened interest in the full breadth of functions of the superior colliculus, and led to studies of multisensory integration in a variety of species and situations. Nevertheless, the role of the SC in controlling eye movements is understood in much greater depth than any other function. Behavioral studies have shown that the SC is not needed for object recognition, but plays a critical role in the ability to direct behaviors toward specific objects, and can support this ability even in the absence of the cerebral cortex. Thus, cats with major damage to the visual cortex cannot recognize objects, but may still be able to follow and orient toward moving stimuli, although more slowly than usual. If one half of the SC is removed, however, the cats will circle constantly toward the side of the lesion, and orient compulsively toward objects located there, but fail to orient at all toward objects located in the opposite hemifield. These deficits diminish over time but never disappear. Eye movements
In primates, eye movements can be divided into several types: fixation, in which the eyes are directed toward a motionless object, with eye movements only to compensate for movements of the head; smooth pursuit, in which the eyes move steadily to track a moving object; saccades, in which the eyes move very rapidly from one location to another; and vergence, in which the eyes move simultaneously in opposite directions to obtain or maintain single binocular vision. The superior colliculus is involved in all of these, but its role in saccades has been studied most intensively. Each of the two colliculi — one on each side of the brain — contains a two dimensional map representing half of the visual field. The fovea — the region of maximum sensitivity — is represented at the front edge of the map, and the periphery at the back edge. Eye movements are evoked by activity in the deep layers of the SC. During fixation, neurons near the front edge — the foveal zone — are tonically active. During smooth pursuit, neurons a small distance from the front edge are activated, leading to small eye movements. For saccades, neurons are activated in a region that represents the point to which the saccade will be directed. Just prior to a saccade, activity rapidly builds up at the target location and decreases in other parts of the SC. The coding is rather broad, so that for any given saccade the activity profile forms a "hill" that encompasses a substantial fraction of the collicular map: The location of the peak of this "hill" represents the saccade target. The SC encodes the target of a gaze shift, but it does not seem to specify the precise movements needed to get there. The decomposition of a gaze shift into head and eye movements and the precise trajectory of the eye during a saccade depend on integration of collicular and non collicular signals by downstream motor areas, in ways that are not yet well understood. Regardless of how the movement is evoked or performed, the SC encodes it in "retinotopic" coordinates: that is, the location of the SC 'hill" corresponds to a fixed location on the retina. This seems to contradict the observation that stimulation of a single point on the SC can result in different gaze shift directions, depending on initial eye orientation. However, it has been shown that this is because the retinal location of a stimulus is a non linear function of target location, eye orientation, and the spherical geometry of the eye. There has been some controversy about whether the SC merely commands eye movements, and leaves the execution to other structures, or whether it actively participates in the performance of a saccade. In 1991, Munoz et al., on the basis of data they collected, argued that, during a saccade, the "hill" of activity in the SC moves gradually, to reflect the changing offset of the eye from the target location while the saccade is progressing. At present, the predominant view is that, although the "hill" does shift slightly during a saccade, it does not shift in the steady and proportionate way that the "moving hill" hypothesis predicts. However, moving hills may play another role in the superior colliculus; more recent experiments have demonstrated a continuously moving hill of visual memory activity when the eyes move slowly while a separate saccade target is retained. The output from the motor sector of the SC goes to a set of midbrain and brainstem nuclei, which transform the "place" code used by the SC into the "rate" code used by oculomotor neurons. Eye movements are generated by six muscles, arranged in three orthogonally aligned pairs. Thus, at the level of the final common path, eye movements are encoded in essentially a Cartesian coordinate system. Although the SC receives a strong input directly from the retina, in primates it is largely under the control of the cerebral cortex, which contains several areas that are involved in determining eye movements. The frontal eye fields, a portion of the motor cortex, are involved in triggering intentional saccades, and an adjoining area, the supplementary eye fields, are involved in organizing groups of saccades into sequences. The parietal eye fields, farther back in the brain, are involved mainly in reflexive saccades, made in response to changes in the view. Recent evidence suggests that the primary visual cortex (V1) guides reflexive eye movements, according to V1 Saliency Hypothesis, using a bottom up saliency map of the visual field generated in V1 from external visual inputs. The SC only receives visual inputs in its superficial layers, whereas the deeper layers of the colliculus receive also auditory and somatosensory inputs and are connected to many sensorimotor areas of the brain. The colliculus as a whole is thought to help orient the head and eyes toward something seen and heard. The superior colliculus also receives auditory information from the inferior colliculus. This auditory information is integrated with the visual information already present to produce the ventriloquism effect. Distractibility
As well as being related to eye movements, the SC appears to have an important role to play in the circuitry underpinning distractibility. Heightened distractibility occurs in normal aging and is also a central feature in a number of medical conditions, including attention deficit hyperactivity disorder (ADHD). Research has shown that lesions to the SC in a number of species can result in heightened distractibility and, in humans, removing the inhibitory control on the SC from the pre frontal cortex, therefore increasing activity in the area, also increases distractibility. Research in an animal model of ADHD, the spontaneously hypertensive rat, also shows altered collicular dependent behaviours and physiology. Other animals
Other mammals
Primates
It is usually accepted that the primate superior colliculus is unique among mammals, in that it does not contain a complete map of the visual field seen by the contralateral eye. Instead, like the visual cortex and lateral geniculate nucleus, each colliculus represents only the contralateral half of the visual field, up to the midline, and excludes a representation of the ipsilateral half. This functional characteristic is explained by the absence, in primates, of anatomical connections between the retinal ganglion cells in the temporal half of the retina and the contralateral superior colliculus. In other mammals, the retinal ganglion cells throughout the contralateral retina project to the contralateral colliculus. This distinction between primates and non primates has been one of the key lines of evidence in support of the flying primates theory proposed by Australian neuroscientist Jack Pettigrew in 1986, after he discovered that flying foxes (megabats) resemble primates in terms of the pattern of anatomical connections between the retina and superior colliculus. Cats
In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem. Bats
Bats are not, in fact, blind, but they depend much more on echolocation than vision for navigation and prey capture. They obtain information about the surrounding world by emitting sonar chirps and then listening for the echoes. Their brains are highly specialized for this process, and some of these specializations appear in the superior colliculus. In bats, the retinal projection occupies only a thin zone just beneath the surface, but there are extensive inputs from auditory areas, and outputs to motor areas capable of orienting the ears, head, or body. Echoes coming from different directions activate neurons at different locations in the collicular layers, and activation of collicular neurons influences the chirps that the bats emit. Thus, there is a strong case that the superior colliculus performs the same sorts of functions for the auditory guided behaviors of bats that it performs for the visual guided behaviors of other species. Bats are usually classified into two main groups: Microchiroptera (the most numerous, and commonly found throughout the world), and Megachiroptera (fruit bats, found in Asia, Africa and Australasia). With one exception, Megabats do not echolocate, and rely on a developed sense of vision to navigate. The visual receptive fields of neurons in the superior colliculus in these animals form a precise map of the retina, similar to that found in cats and primates. Rodents
The superior colliculus in rodents have been hypothesized to mediate sensory guided approach and avoidance behaviors. Studies employing circuit analysis tools on mouse superior colliculus have revealed several important functions. In a series of studies, researchers have identified a set of Ying Yang circuit modules in the superior colliculus to initiate prey capture and predator avoidance behaviors in mice. By using single cell RNA sequencing, researchers have analyzed the gene expression profiles of superior colliculus neurons and identified the unique genetic markers of these circuit modules. Other vertebrates
Optic tectum
The optic tectum is the visual center in the non mammalian brain which develops from the alar plate of the mesencephalon. In these other vertebrates the connections from the optic tectum are important for the recognition and reaction to various sized objects which is facilitated by excitatory optic nerve transmitters like L glutamate. Disrupting visual experience early on in zebrafish development results in a change in tectal activity. Changes in tectal activity resulted in an inability to successfully hunt and capture prey. Hypothalamus inhibitory signaling to the deep tectal neuropil is important in tectal processing in zebrafish larvae. The tectal neuropil contains structures including periventricular neuronal axons and dendrites. The neuropil also contains GABAergic superficial inhibitory neurons located in stratum opticum. Instead of a large cerebral cortex, zebrafish have a relatively large optic tectum that is hypothesized to carry out some of the visual processing that the cortex performs in mammals. Recent lesion studies have suggested that the optic tectum has no influence over higher order motion responses like the optomotor response or the optokinetic response, but may be more integral to lower order cues in motion perception like in the identification of small objects. The optic tectum is one of the fundamental components of the vertebrate brain, existing across a range of species. Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic tracts to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow (In the superior colliculus the like structure is termed the parabigeminal nucleus). The nucleus isthmii is divided into two parts, called isthmus pars magnocellularis (Imc; "the part with the large cells") and isthmus pars parvocellularis'' (Ipc); "the part with the small cells"). Connections between the three areas — optic tectum, Ipc, and Imc — are topographic. Neurons in the superficial layers of the optic tectum project to corresponding points in the Ipc and Imc. The projections to the Ipc are tightly focused, while the projections to the Imc are somewhat more diffuse. Ipc gives rise to tightly focused cholinergic projections both to Imc and the optic tectum. In the optic tectum, the cholinergic inputs from Ipc ramify to give rise to terminals that extend across an entire column, from top to bottom. Imc, in contrast, gives rise to GABAergic projections to Ipc and optic tectum that spread very broadly in the lateral dimensions, encompassing most of the retinotopic map. Thus, the tectum Ipc Imc circuit causes tectal activity to produce recurrent feedback that involves tightly focused excitation of a small column of neighboring tectal neurons, together with global inhibition of distant tectal neurons. The optic tectum is involved in many responses including swimming in fish, flight in birds, tongue strikes toward prey in frogs, and fang strikes in snakes. In some species, including fish and birds, the optic tectum, also known as the optic lobe, is one of the largest components of the brain. In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. In amphibians, reptiles, and especially birds it is also a very significant component.
In neuroanatomy, the superior colliculus is a structure lying on the roof of the mammalian midbrain. The adjective form tectal is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers (stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor related neurons, capable of activating eye movements as well as other responses. In other vertebrates the number of layers in the homologous optic tectum varies. and shifts in attention that do not involve any overt movements. The two inferior colliculi are situated immediately inferior/caudal to the superior colliculi; the inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin for quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent. The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. In the optic tectum this nearby structure is known as the nucleus isthmi. Structure
The superior colliculus is a synaptic layered structure. The top three layers are called superficial:Lamina I or SZ, the stratum zonale, is a thin layer consisting of small myelinated axons together with marginal and horizontal cells. Lamina II or SGS, the stratum griseum superficiale ("superficial gray layer"), contains many neurons of various shapes and sizes. Lamina III or SO, the stratum opticum ("optic layer"), consists mainly of axons coming from the optic tract. Next come two intermediate layers:Lamina IV or SGI, the stratum griseum intermedium ("intermediate gray layer"), is the thickest layer, and is filled with many neurons of many sizes. This layer is often as thick as all the other layers together. It is often subdivided into "upper" and "lower" parts. Lamina V or SAI, the stratum album intermedium ("intermediate white layer"), consists mainly of fibers from various sources. Finally come the two deep layers:Lamina VI or SGP, the stratum griseum profundum ("deep gray layer"), consists of loosely packed neurons and myelinated fibers. Lamina VII or SAP', the stratum album profundum ("deep white layer"), lying directly above the periaqueductal gray, consists entirely of fibers. The superficial layers receive input mainly from the retina, vision related areas of the cerebral cortex, and two tectal related structures called the pretectum and parabigeminal nucleus. The retinal input encompasses the entire superficial zone, and is bilateral, although the contralateral portion is more extensive. The cortical input comes most heavily from the primary visual cortex (area 17, V1), the secondary visual cortex (areas 18 and 19), and the frontal eye fields. The parabigeminal nucleus plays a very important role in tectal function that is described below. In contrast to the vision dominated inputs to the superficial layers, the intermediate and deep layers receive inputs from a very diverse set of sensory and motor structures. Most areas of the cerebral cortex project to these layers, although the input from "association" areas tends to be heavier than the input from primary sensory or motor areas. However, the cortical areas involved, and the strength of their relative projections differs across species. Another important input comes from the substantia nigra, pars reticulata, a component of the basal ganglia. This projection uses the inhibitory neurotransmitter GABA, and is thought to exert a "gating" effect on the superior colliculus. The intermediate and deep layers also receive input from the spinal trigeminal nucleus, which conveys somatosensory information from the face, as well as the hypothalamus, zona incerta, thalamus, and inferior colliculus. In addition to their distinctive inputs, the superficial and deep zones of the superior colliculus also have distinctive outputs. One of the most important outputs goes to the pulvinar and lateral intermediate areas of the thalamus, which in turn project to areas of the cerebral cortex that are involved in controlling eye movements. There are also projections from the superficial zone to the pretectal nuclei, lateral geniculate nucleus of the thalamus, and the parabigeminal nucleus. The projections from the deeper layers are more extensive. There are two large descending pathways, traveling to the brainstem and spinal cord, and numerous ascending projections to a variety of sensory and motor centers, including several that are involved in generating eye movements. Both colliculi also have descending projections to the paramedian pontine reticular formation and spinal cord, and thus can be involved in responses to stimuli faster than cortical processing would allow. Mosaic structure
On detailed examination, the collicular layers are actually not smooth sheets, but divided into a honeycomb arrangement of discrete columns. The clearest indication of columnar structure comes from the cholinergic inputs arising from the parabigeminal nucleus, whose terminals form evenly spaced clusters that extend from top to bottom of the tectum. Several other neurochemical markers including calretinin, parvalbumin, GAP 43, and NMDA receptors, and connections with numerous other brain structures in the brainstem and diencephalon, also show a corresponding inhomogeneity. The total number of columns has been estimated at around 100. From the 1970s to 1990s, however, neural recordings from mammals, mostly monkeys, focused primarily on the role of the superior colliculus in controlling eye movements. This line of investigation came to dominate the literature to such a degree that the majority opinion was that eye movement control is the only important function in mammals, a view still reflected in many current textbooks. In the late 1990s, however, experiments using animals whose heads were free to move showed clearly that the SC actually produces gaze shifts, usually composed of combined head and eye movements, rather than eye movements per se. This discovery reawakened interest in the full breadth of functions of the superior colliculus, and led to studies of multisensory integration in a variety of species and situations. Nevertheless, the role of the SC in controlling eye movements is understood in much greater depth than any other function. Behavioral studies have shown that the SC is not needed for object recognition, but plays a critical role in the ability to direct behaviors toward specific objects, and can support this ability even in the absence of the cerebral cortex. Thus, cats with major damage to the visual cortex cannot recognize objects, but may still be able to follow and orient toward moving stimuli, although more slowly than usual. If one half of the SC is removed, however, the cats will circle constantly toward the side of the lesion, and orient compulsively toward objects located there, but fail to orient at all toward objects located in the opposite hemifield. These deficits diminish over time but never disappear. Eye movements
In primates, eye movements can be divided into several types: fixation, in which the eyes are directed toward a motionless object, with eye movements only to compensate for movements of the head; smooth pursuit, in which the eyes move steadily to track a moving object; saccades, in which the eyes move very rapidly from one location to another; and vergence, in which the eyes move simultaneously in opposite directions to obtain or maintain single binocular vision. The superior colliculus is involved in all of these, but its role in saccades has been studied most intensively. Each of the two colliculi — one on each side of the brain — contains a two dimensional map representing half of the visual field. The fovea — the region of maximum sensitivity — is represented at the front edge of the map, and the periphery at the back edge. Eye movements are evoked by activity in the deep layers of the SC. During fixation, neurons near the front edge — the foveal zone — are tonically active. During smooth pursuit, neurons a small distance from the front edge are activated, leading to small eye movements. For saccades, neurons are activated in a region that represents the point to which the saccade will be directed. Just prior to a saccade, activity rapidly builds up at the target location and decreases in other parts of the SC. The coding is rather broad, so that for any given saccade the activity profile forms a "hill" that encompasses a substantial fraction of the collicular map: The location of the peak of this "hill" represents the saccade target. The SC encodes the target of a gaze shift, but it does not seem to specify the precise movements needed to get there. The decomposition of a gaze shift into head and eye movements and the precise trajectory of the eye during a saccade depend on integration of collicular and non collicular signals by downstream motor areas, in ways that are not yet well understood. Regardless of how the movement is evoked or performed, the SC encodes it in "retinotopic" coordinates: that is, the location of the SC 'hill" corresponds to a fixed location on the retina. This seems to contradict the observation that stimulation of a single point on the SC can result in different gaze shift directions, depending on initial eye orientation. However, it has been shown that this is because the retinal location of a stimulus is a non linear function of target location, eye orientation, and the spherical geometry of the eye. There has been some controversy about whether the SC merely commands eye movements, and leaves the execution to other structures, or whether it actively participates in the performance of a saccade. In 1991, Munoz et al., on the basis of data they collected, argued that, during a saccade, the "hill" of activity in the SC moves gradually, to reflect the changing offset of the eye from the target location while the saccade is progressing. At present, the predominant view is that, although the "hill" does shift slightly during a saccade, it does not shift in the steady and proportionate way that the "moving hill" hypothesis predicts. However, moving hills may play another role in the superior colliculus; more recent experiments have demonstrated a continuously moving hill of visual memory activity when the eyes move slowly while a separate saccade target is retained. The output from the motor sector of the SC goes to a set of midbrain and brainstem nuclei, which transform the "place" code used by the SC into the "rate" code used by oculomotor neurons. Eye movements are generated by six muscles, arranged in three orthogonally aligned pairs. Thus, at the level of the final common path, eye movements are encoded in essentially a Cartesian coordinate system. Although the SC receives a strong input directly from the retina, in primates it is largely under the control of the cerebral cortex, which contains several areas that are involved in determining eye movements. The frontal eye fields, a portion of the motor cortex, are involved in triggering intentional saccades, and an adjoining area, the supplementary eye fields, are involved in organizing groups of saccades into sequences. The parietal eye fields, farther back in the brain, are involved mainly in reflexive saccades, made in response to changes in the view. Recent evidence suggests that the primary visual cortex (V1) guides reflexive eye movements, according to V1 Saliency Hypothesis, using a bottom up saliency map of the visual field generated in V1 from external visual inputs. The SC only receives visual inputs in its superficial layers, whereas the deeper layers of the colliculus receive also auditory and somatosensory inputs and are connected to many sensorimotor areas of the brain. The colliculus as a whole is thought to help orient the head and eyes toward something seen and heard. The superior colliculus also receives auditory information from the inferior colliculus. This auditory information is integrated with the visual information already present to produce the ventriloquism effect. Distractibility
As well as being related to eye movements, the SC appears to have an important role to play in the circuitry underpinning distractibility. Heightened distractibility occurs in normal aging and is also a central feature in a number of medical conditions, including attention deficit hyperactivity disorder (ADHD). Research has shown that lesions to the SC in a number of species can result in heightened distractibility and, in humans, removing the inhibitory control on the SC from the pre frontal cortex, therefore increasing activity in the area, also increases distractibility. Research in an animal model of ADHD, the spontaneously hypertensive rat, also shows altered collicular dependent behaviours and physiology. Other animals
Other mammals
Primates
It is usually accepted that the primate superior colliculus is unique among mammals, in that it does not contain a complete map of the visual field seen by the contralateral eye. Instead, like the visual cortex and lateral geniculate nucleus, each colliculus represents only the contralateral half of the visual field, up to the midline, and excludes a representation of the ipsilateral half. This functional characteristic is explained by the absence, in primates, of anatomical connections between the retinal ganglion cells in the temporal half of the retina and the contralateral superior colliculus. In other mammals, the retinal ganglion cells throughout the contralateral retina project to the contralateral colliculus. This distinction between primates and non primates has been one of the key lines of evidence in support of the flying primates theory proposed by Australian neuroscientist Jack Pettigrew in 1986, after he discovered that flying foxes (megabats) resemble primates in terms of the pattern of anatomical connections between the retina and superior colliculus. Cats
In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem. Bats
Bats are not, in fact, blind, but they depend much more on echolocation than vision for navigation and prey capture. They obtain information about the surrounding world by emitting sonar chirps and then listening for the echoes. Their brains are highly specialized for this process, and some of these specializations appear in the superior colliculus. In bats, the retinal projection occupies only a thin zone just beneath the surface, but there are extensive inputs from auditory areas, and outputs to motor areas capable of orienting the ears, head, or body. Echoes coming from different directions activate neurons at different locations in the collicular layers, and activation of collicular neurons influences the chirps that the bats emit. Thus, there is a strong case that the superior colliculus performs the same sorts of functions for the auditory guided behaviors of bats that it performs for the visual guided behaviors of other species. Bats are usually classified into two main groups: Microchiroptera (the most numerous, and commonly found throughout the world), and Megachiroptera (fruit bats, found in Asia, Africa and Australasia). With one exception, Megabats do not echolocate, and rely on a developed sense of vision to navigate. The visual receptive fields of neurons in the superior colliculus in these animals form a precise map of the retina, similar to that found in cats and primates. Rodents
The superior colliculus in rodents have been hypothesized to mediate sensory guided approach and avoidance behaviors. Studies employing circuit analysis tools on mouse superior colliculus have revealed several important functions. In a series of studies, researchers have identified a set of Ying Yang circuit modules in the superior colliculus to initiate prey capture and predator avoidance behaviors in mice. By using single cell RNA sequencing, researchers have analyzed the gene expression profiles of superior colliculus neurons and identified the unique genetic markers of these circuit modules. Other vertebrates
Optic tectum
The optic tectum is the visual center in the non mammalian brain which develops from the alar plate of the mesencephalon. In these other vertebrates the connections from the optic tectum are important for the recognition and reaction to various sized objects which is facilitated by excitatory optic nerve transmitters like L glutamate. Disrupting visual experience early on in zebrafish development results in a change in tectal activity. Changes in tectal activity resulted in an inability to successfully hunt and capture prey. Hypothalamus inhibitory signaling to the deep tectal neuropil is important in tectal processing in zebrafish larvae. The tectal neuropil contains structures including periventricular neuronal axons and dendrites. The neuropil also contains GABAergic superficial inhibitory neurons located in stratum opticum. Instead of a large cerebral cortex, zebrafish have a relatively large optic tectum that is hypothesized to carry out some of the visual processing that the cortex performs in mammals. Recent lesion studies have suggested that the optic tectum has no influence over higher order motion responses like the optomotor response or the optokinetic response, but may be more integral to lower order cues in motion perception like in the identification of small objects. The optic tectum is one of the fundamental components of the vertebrate brain, existing across a range of species. Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic tracts to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow (In the superior colliculus the like structure is termed the parabigeminal nucleus). The nucleus isthmii is divided into two parts, called isthmus pars magnocellularis (Imc; "the part with the large cells") and isthmus pars parvocellularis'' (Ipc); "the part with the small cells"). Connections between the three areas — optic tectum, Ipc, and Imc — are topographic. Neurons in the superficial layers of the optic tectum project to corresponding points in the Ipc and Imc. The projections to the Ipc are tightly focused, while the projections to the Imc are somewhat more diffuse. Ipc gives rise to tightly focused cholinergic projections both to Imc and the optic tectum. In the optic tectum, the cholinergic inputs from Ipc ramify to give rise to terminals that extend across an entire column, from top to bottom. Imc, in contrast, gives rise to GABAergic projections to Ipc and optic tectum that spread very broadly in the lateral dimensions, encompassing most of the retinotopic map. Thus, the tectum Ipc Imc circuit causes tectal activity to produce recurrent feedback that involves tightly focused excitation of a small column of neighboring tectal neurons, together with global inhibition of distant tectal neurons. The optic tectum is involved in many responses including swimming in fish, flight in birds, tongue strikes toward prey in frogs, and fang strikes in snakes. In some species, including fish and birds, the optic tectum, also known as the optic lobe, is one of the largest components of the brain. In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. In amphibians, reptiles, and especially birds it is also a very significant component.
Движения глаз
Structure in the midbrain
In neuroanatomy, the superior colliculus is a structure lying on the roof of the mammalian midbrain. The adjective form tectal is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers (stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor related neurons, capable of activating eye movements as well as other responses. In other vertebrates the number of layers in the homologous optic tectum varies. and shifts in attention that do not involve any overt movements. The two inferior colliculi are situated immediately inferior/caudal to the superior colliculi; the inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin for quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent. The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. In the optic tectum this nearby structure is known as the nucleus isthmi. Structure
The superior colliculus is a synaptic layered structure. The top three layers are called superficial:Lamina I or SZ, the stratum zonale, is a thin layer consisting of small myelinated axons together with marginal and horizontal cells. Lamina II or SGS, the stratum griseum superficiale ("superficial gray layer"), contains many neurons of various shapes and sizes. Lamina III or SO, the stratum opticum ("optic layer"), consists mainly of axons coming from the optic tract. Next come two intermediate layers:Lamina IV or SGI, the stratum griseum intermedium ("intermediate gray layer"), is the thickest layer, and is filled with many neurons of many sizes. This layer is often as thick as all the other layers together. It is often subdivided into "upper" and "lower" parts. Lamina V or SAI, the stratum album intermedium ("intermediate white layer"), consists mainly of fibers from various sources. Finally come the two deep layers:Lamina VI or SGP, the stratum griseum profundum ("deep gray layer"), consists of loosely packed neurons and myelinated fibers. Lamina VII or SAP', the stratum album profundum ("deep white layer"), lying directly above the periaqueductal gray, consists entirely of fibers. The superficial layers receive input mainly from the retina, vision related areas of the cerebral cortex, and two tectal related structures called the pretectum and parabigeminal nucleus. The retinal input encompasses the entire superficial zone, and is bilateral, although the contralateral portion is more extensive. The cortical input comes most heavily from the primary visual cortex (area 17, V1), the secondary visual cortex (areas 18 and 19), and the frontal eye fields. The parabigeminal nucleus plays a very important role in tectal function that is described below. In contrast to the vision dominated inputs to the superficial layers, the intermediate and deep layers receive inputs from a very diverse set of sensory and motor structures. Most areas of the cerebral cortex project to these layers, although the input from "association" areas tends to be heavier than the input from primary sensory or motor areas. However, the cortical areas involved, and the strength of their relative projections differs across species. Another important input comes from the substantia nigra, pars reticulata, a component of the basal ganglia. This projection uses the inhibitory neurotransmitter GABA, and is thought to exert a "gating" effect on the superior colliculus. The intermediate and deep layers also receive input from the spinal trigeminal nucleus, which conveys somatosensory information from the face, as well as the hypothalamus, zona incerta, thalamus, and inferior colliculus. In addition to their distinctive inputs, the superficial and deep zones of the superior colliculus also have distinctive outputs. One of the most important outputs goes to the pulvinar and lateral intermediate areas of the thalamus, which in turn project to areas of the cerebral cortex that are involved in controlling eye movements. There are also projections from the superficial zone to the pretectal nuclei, lateral geniculate nucleus of the thalamus, and the parabigeminal nucleus. The projections from the deeper layers are more extensive. There are two large descending pathways, traveling to the brainstem and spinal cord, and numerous ascending projections to a variety of sensory and motor centers, including several that are involved in generating eye movements. Both colliculi also have descending projections to the paramedian pontine reticular formation and spinal cord, and thus can be involved in responses to stimuli faster than cortical processing would allow. Mosaic structure
On detailed examination, the collicular layers are actually not smooth sheets, but divided into a honeycomb arrangement of discrete columns. The clearest indication of columnar structure comes from the cholinergic inputs arising from the parabigeminal nucleus, whose terminals form evenly spaced clusters that extend from top to bottom of the tectum. Several other neurochemical markers including calretinin, parvalbumin, GAP 43, and NMDA receptors, and connections with numerous other brain structures in the brainstem and diencephalon, also show a corresponding inhomogeneity. The total number of columns has been estimated at around 100. From the 1970s to 1990s, however, neural recordings from mammals, mostly monkeys, focused primarily on the role of the superior colliculus in controlling eye movements. This line of investigation came to dominate the literature to such a degree that the majority opinion was that eye movement control is the only important function in mammals, a view still reflected in many current textbooks. In the late 1990s, however, experiments using animals whose heads were free to move showed clearly that the SC actually produces gaze shifts, usually composed of combined head and eye movements, rather than eye movements per se. This discovery reawakened interest in the full breadth of functions of the superior colliculus, and led to studies of multisensory integration in a variety of species and situations. Nevertheless, the role of the SC in controlling eye movements is understood in much greater depth than any other function. Behavioral studies have shown that the SC is not needed for object recognition, but plays a critical role in the ability to direct behaviors toward specific objects, and can support this ability even in the absence of the cerebral cortex. Thus, cats with major damage to the visual cortex cannot recognize objects, but may still be able to follow and orient toward moving stimuli, although more slowly than usual. If one half of the SC is removed, however, the cats will circle constantly toward the side of the lesion, and orient compulsively toward objects located there, but fail to orient at all toward objects located in the opposite hemifield. These deficits diminish over time but never disappear. Eye movements
In primates, eye movements can be divided into several types: fixation, in which the eyes are directed toward a motionless object, with eye movements only to compensate for movements of the head; smooth pursuit, in which the eyes move steadily to track a moving object; saccades, in which the eyes move very rapidly from one location to another; and vergence, in which the eyes move simultaneously in opposite directions to obtain or maintain single binocular vision. The superior colliculus is involved in all of these, but its role in saccades has been studied most intensively. Each of the two colliculi — one on each side of the brain — contains a two dimensional map representing half of the visual field. The fovea — the region of maximum sensitivity — is represented at the front edge of the map, and the periphery at the back edge. Eye movements are evoked by activity in the deep layers of the SC. During fixation, neurons near the front edge — the foveal zone — are tonically active. During smooth pursuit, neurons a small distance from the front edge are activated, leading to small eye movements. For saccades, neurons are activated in a region that represents the point to which the saccade will be directed. Just prior to a saccade, activity rapidly builds up at the target location and decreases in other parts of the SC. The coding is rather broad, so that for any given saccade the activity profile forms a "hill" that encompasses a substantial fraction of the collicular map: The location of the peak of this "hill" represents the saccade target. The SC encodes the target of a gaze shift, but it does not seem to specify the precise movements needed to get there. The decomposition of a gaze shift into head and eye movements and the precise trajectory of the eye during a saccade depend on integration of collicular and non collicular signals by downstream motor areas, in ways that are not yet well understood. Regardless of how the movement is evoked or performed, the SC encodes it in "retinotopic" coordinates: that is, the location of the SC 'hill" corresponds to a fixed location on the retina. This seems to contradict the observation that stimulation of a single point on the SC can result in different gaze shift directions, depending on initial eye orientation. However, it has been shown that this is because the retinal location of a stimulus is a non linear function of target location, eye orientation, and the spherical geometry of the eye. There has been some controversy about whether the SC merely commands eye movements, and leaves the execution to other structures, or whether it actively participates in the performance of a saccade. In 1991, Munoz et al., on the basis of data they collected, argued that, during a saccade, the "hill" of activity in the SC moves gradually, to reflect the changing offset of the eye from the target location while the saccade is progressing. At present, the predominant view is that, although the "hill" does shift slightly during a saccade, it does not shift in the steady and proportionate way that the "moving hill" hypothesis predicts. However, moving hills may play another role in the superior colliculus; more recent experiments have demonstrated a continuously moving hill of visual memory activity when the eyes move slowly while a separate saccade target is retained. The output from the motor sector of the SC goes to a set of midbrain and brainstem nuclei, which transform the "place" code used by the SC into the "rate" code used by oculomotor neurons. Eye movements are generated by six muscles, arranged in three orthogonally aligned pairs. Thus, at the level of the final common path, eye movements are encoded in essentially a Cartesian coordinate system. Although the SC receives a strong input directly from the retina, in primates it is largely under the control of the cerebral cortex, which contains several areas that are involved in determining eye movements. The frontal eye fields, a portion of the motor cortex, are involved in triggering intentional saccades, and an adjoining area, the supplementary eye fields, are involved in organizing groups of saccades into sequences. The parietal eye fields, farther back in the brain, are involved mainly in reflexive saccades, made in response to changes in the view. Recent evidence suggests that the primary visual cortex (V1) guides reflexive eye movements, according to V1 Saliency Hypothesis, using a bottom up saliency map of the visual field generated in V1 from external visual inputs. The SC only receives visual inputs in its superficial layers, whereas the deeper layers of the colliculus receive also auditory and somatosensory inputs and are connected to many sensorimotor areas of the brain. The colliculus as a whole is thought to help orient the head and eyes toward something seen and heard. The superior colliculus also receives auditory information from the inferior colliculus. This auditory information is integrated with the visual information already present to produce the ventriloquism effect. Distractibility
As well as being related to eye movements, the SC appears to have an important role to play in the circuitry underpinning distractibility. Heightened distractibility occurs in normal aging and is also a central feature in a number of medical conditions, including attention deficit hyperactivity disorder (ADHD). Research has shown that lesions to the SC in a number of species can result in heightened distractibility and, in humans, removing the inhibitory control on the SC from the pre frontal cortex, therefore increasing activity in the area, also increases distractibility. Research in an animal model of ADHD, the spontaneously hypertensive rat, also shows altered collicular dependent behaviours and physiology. Other animals
Other mammals
Primates
It is usually accepted that the primate superior colliculus is unique among mammals, in that it does not contain a complete map of the visual field seen by the contralateral eye. Instead, like the visual cortex and lateral geniculate nucleus, each colliculus represents only the contralateral half of the visual field, up to the midline, and excludes a representation of the ipsilateral half. This functional characteristic is explained by the absence, in primates, of anatomical connections between the retinal ganglion cells in the temporal half of the retina and the contralateral superior colliculus. In other mammals, the retinal ganglion cells throughout the contralateral retina project to the contralateral colliculus. This distinction between primates and non primates has been one of the key lines of evidence in support of the flying primates theory proposed by Australian neuroscientist Jack Pettigrew in 1986, after he discovered that flying foxes (megabats) resemble primates in terms of the pattern of anatomical connections between the retina and superior colliculus. Cats
In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem. Bats
Bats are not, in fact, blind, but they depend much more on echolocation than vision for navigation and prey capture. They obtain information about the surrounding world by emitting sonar chirps and then listening for the echoes. Their brains are highly specialized for this process, and some of these specializations appear in the superior colliculus. In bats, the retinal projection occupies only a thin zone just beneath the surface, but there are extensive inputs from auditory areas, and outputs to motor areas capable of orienting the ears, head, or body. Echoes coming from different directions activate neurons at different locations in the collicular layers, and activation of collicular neurons influences the chirps that the bats emit. Thus, there is a strong case that the superior colliculus performs the same sorts of functions for the auditory guided behaviors of bats that it performs for the visual guided behaviors of other species. Bats are usually classified into two main groups: Microchiroptera (the most numerous, and commonly found throughout the world), and Megachiroptera (fruit bats, found in Asia, Africa and Australasia). With one exception, Megabats do not echolocate, and rely on a developed sense of vision to navigate. The visual receptive fields of neurons in the superior colliculus in these animals form a precise map of the retina, similar to that found in cats and primates. Rodents
The superior colliculus in rodents have been hypothesized to mediate sensory guided approach and avoidance behaviors. Studies employing circuit analysis tools on mouse superior colliculus have revealed several important functions. In a series of studies, researchers have identified a set of Ying Yang circuit modules in the superior colliculus to initiate prey capture and predator avoidance behaviors in mice. By using single cell RNA sequencing, researchers have analyzed the gene expression profiles of superior colliculus neurons and identified the unique genetic markers of these circuit modules. Other vertebrates
Optic tectum
The optic tectum is the visual center in the non mammalian brain which develops from the alar plate of the mesencephalon. In these other vertebrates the connections from the optic tectum are important for the recognition and reaction to various sized objects which is facilitated by excitatory optic nerve transmitters like L glutamate. Disrupting visual experience early on in zebrafish development results in a change in tectal activity. Changes in tectal activity resulted in an inability to successfully hunt and capture prey. Hypothalamus inhibitory signaling to the deep tectal neuropil is important in tectal processing in zebrafish larvae. The tectal neuropil contains structures including periventricular neuronal axons and dendrites. The neuropil also contains GABAergic superficial inhibitory neurons located in stratum opticum. Instead of a large cerebral cortex, zebrafish have a relatively large optic tectum that is hypothesized to carry out some of the visual processing that the cortex performs in mammals. Recent lesion studies have suggested that the optic tectum has no influence over higher order motion responses like the optomotor response or the optokinetic response, but may be more integral to lower order cues in motion perception like in the identification of small objects. The optic tectum is one of the fundamental components of the vertebrate brain, existing across a range of species. Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic tracts to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow (In the superior colliculus the like structure is termed the parabigeminal nucleus). The nucleus isthmii is divided into two parts, called isthmus pars magnocellularis (Imc; "the part with the large cells") and isthmus pars parvocellularis'' (Ipc); "the part with the small cells"). Connections between the three areas — optic tectum, Ipc, and Imc — are topographic. Neurons in the superficial layers of the optic tectum project to corresponding points in the Ipc and Imc. The projections to the Ipc are tightly focused, while the projections to the Imc are somewhat more diffuse. Ipc gives rise to tightly focused cholinergic projections both to Imc and the optic tectum. In the optic tectum, the cholinergic inputs from Ipc ramify to give rise to terminals that extend across an entire column, from top to bottom. Imc, in contrast, gives rise to GABAergic projections to Ipc and optic tectum that spread very broadly in the lateral dimensions, encompassing most of the retinotopic map. Thus, the tectum Ipc Imc circuit causes tectal activity to produce recurrent feedback that involves tightly focused excitation of a small column of neighboring tectal neurons, together with global inhibition of distant tectal neurons. The optic tectum is involved in many responses including swimming in fish, flight in birds, tongue strikes toward prey in frogs, and fang strikes in snakes. In some species, including fish and birds, the optic tectum, also known as the optic lobe, is one of the largest components of the brain. In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. In amphibians, reptiles, and especially birds it is also a very significant component.
In neuroanatomy, the superior colliculus is a structure lying on the roof of the mammalian midbrain. The adjective form tectal is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers (stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor related neurons, capable of activating eye movements as well as other responses. In other vertebrates the number of layers in the homologous optic tectum varies. and shifts in attention that do not involve any overt movements. The two inferior colliculi are situated immediately inferior/caudal to the superior colliculi; the inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin for quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent. The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. In the optic tectum this nearby structure is known as the nucleus isthmi. Structure
The superior colliculus is a synaptic layered structure. The top three layers are called superficial:Lamina I or SZ, the stratum zonale, is a thin layer consisting of small myelinated axons together with marginal and horizontal cells. Lamina II or SGS, the stratum griseum superficiale ("superficial gray layer"), contains many neurons of various shapes and sizes. Lamina III or SO, the stratum opticum ("optic layer"), consists mainly of axons coming from the optic tract. Next come two intermediate layers:Lamina IV or SGI, the stratum griseum intermedium ("intermediate gray layer"), is the thickest layer, and is filled with many neurons of many sizes. This layer is often as thick as all the other layers together. It is often subdivided into "upper" and "lower" parts. Lamina V or SAI, the stratum album intermedium ("intermediate white layer"), consists mainly of fibers from various sources. Finally come the two deep layers:Lamina VI or SGP, the stratum griseum profundum ("deep gray layer"), consists of loosely packed neurons and myelinated fibers. Lamina VII or SAP', the stratum album profundum ("deep white layer"), lying directly above the periaqueductal gray, consists entirely of fibers. The superficial layers receive input mainly from the retina, vision related areas of the cerebral cortex, and two tectal related structures called the pretectum and parabigeminal nucleus. The retinal input encompasses the entire superficial zone, and is bilateral, although the contralateral portion is more extensive. The cortical input comes most heavily from the primary visual cortex (area 17, V1), the secondary visual cortex (areas 18 and 19), and the frontal eye fields. The parabigeminal nucleus plays a very important role in tectal function that is described below. In contrast to the vision dominated inputs to the superficial layers, the intermediate and deep layers receive inputs from a very diverse set of sensory and motor structures. Most areas of the cerebral cortex project to these layers, although the input from "association" areas tends to be heavier than the input from primary sensory or motor areas. However, the cortical areas involved, and the strength of their relative projections differs across species. Another important input comes from the substantia nigra, pars reticulata, a component of the basal ganglia. This projection uses the inhibitory neurotransmitter GABA, and is thought to exert a "gating" effect on the superior colliculus. The intermediate and deep layers also receive input from the spinal trigeminal nucleus, which conveys somatosensory information from the face, as well as the hypothalamus, zona incerta, thalamus, and inferior colliculus. In addition to their distinctive inputs, the superficial and deep zones of the superior colliculus also have distinctive outputs. One of the most important outputs goes to the pulvinar and lateral intermediate areas of the thalamus, which in turn project to areas of the cerebral cortex that are involved in controlling eye movements. There are also projections from the superficial zone to the pretectal nuclei, lateral geniculate nucleus of the thalamus, and the parabigeminal nucleus. The projections from the deeper layers are more extensive. There are two large descending pathways, traveling to the brainstem and spinal cord, and numerous ascending projections to a variety of sensory and motor centers, including several that are involved in generating eye movements. Both colliculi also have descending projections to the paramedian pontine reticular formation and spinal cord, and thus can be involved in responses to stimuli faster than cortical processing would allow. Mosaic structure
On detailed examination, the collicular layers are actually not smooth sheets, but divided into a honeycomb arrangement of discrete columns. The clearest indication of columnar structure comes from the cholinergic inputs arising from the parabigeminal nucleus, whose terminals form evenly spaced clusters that extend from top to bottom of the tectum. Several other neurochemical markers including calretinin, parvalbumin, GAP 43, and NMDA receptors, and connections with numerous other brain structures in the brainstem and diencephalon, also show a corresponding inhomogeneity. The total number of columns has been estimated at around 100. From the 1970s to 1990s, however, neural recordings from mammals, mostly monkeys, focused primarily on the role of the superior colliculus in controlling eye movements. This line of investigation came to dominate the literature to such a degree that the majority opinion was that eye movement control is the only important function in mammals, a view still reflected in many current textbooks. In the late 1990s, however, experiments using animals whose heads were free to move showed clearly that the SC actually produces gaze shifts, usually composed of combined head and eye movements, rather than eye movements per se. This discovery reawakened interest in the full breadth of functions of the superior colliculus, and led to studies of multisensory integration in a variety of species and situations. Nevertheless, the role of the SC in controlling eye movements is understood in much greater depth than any other function. Behavioral studies have shown that the SC is not needed for object recognition, but plays a critical role in the ability to direct behaviors toward specific objects, and can support this ability even in the absence of the cerebral cortex. Thus, cats with major damage to the visual cortex cannot recognize objects, but may still be able to follow and orient toward moving stimuli, although more slowly than usual. If one half of the SC is removed, however, the cats will circle constantly toward the side of the lesion, and orient compulsively toward objects located there, but fail to orient at all toward objects located in the opposite hemifield. These deficits diminish over time but never disappear. Eye movements
In primates, eye movements can be divided into several types: fixation, in which the eyes are directed toward a motionless object, with eye movements only to compensate for movements of the head; smooth pursuit, in which the eyes move steadily to track a moving object; saccades, in which the eyes move very rapidly from one location to another; and vergence, in which the eyes move simultaneously in opposite directions to obtain or maintain single binocular vision. The superior colliculus is involved in all of these, but its role in saccades has been studied most intensively. Each of the two colliculi — one on each side of the brain — contains a two dimensional map representing half of the visual field. The fovea — the region of maximum sensitivity — is represented at the front edge of the map, and the periphery at the back edge. Eye movements are evoked by activity in the deep layers of the SC. During fixation, neurons near the front edge — the foveal zone — are tonically active. During smooth pursuit, neurons a small distance from the front edge are activated, leading to small eye movements. For saccades, neurons are activated in a region that represents the point to which the saccade will be directed. Just prior to a saccade, activity rapidly builds up at the target location and decreases in other parts of the SC. The coding is rather broad, so that for any given saccade the activity profile forms a "hill" that encompasses a substantial fraction of the collicular map: The location of the peak of this "hill" represents the saccade target. The SC encodes the target of a gaze shift, but it does not seem to specify the precise movements needed to get there. The decomposition of a gaze shift into head and eye movements and the precise trajectory of the eye during a saccade depend on integration of collicular and non collicular signals by downstream motor areas, in ways that are not yet well understood. Regardless of how the movement is evoked or performed, the SC encodes it in "retinotopic" coordinates: that is, the location of the SC 'hill" corresponds to a fixed location on the retina. This seems to contradict the observation that stimulation of a single point on the SC can result in different gaze shift directions, depending on initial eye orientation. However, it has been shown that this is because the retinal location of a stimulus is a non linear function of target location, eye orientation, and the spherical geometry of the eye. There has been some controversy about whether the SC merely commands eye movements, and leaves the execution to other structures, or whether it actively participates in the performance of a saccade. In 1991, Munoz et al., on the basis of data they collected, argued that, during a saccade, the "hill" of activity in the SC moves gradually, to reflect the changing offset of the eye from the target location while the saccade is progressing. At present, the predominant view is that, although the "hill" does shift slightly during a saccade, it does not shift in the steady and proportionate way that the "moving hill" hypothesis predicts. However, moving hills may play another role in the superior colliculus; more recent experiments have demonstrated a continuously moving hill of visual memory activity when the eyes move slowly while a separate saccade target is retained. The output from the motor sector of the SC goes to a set of midbrain and brainstem nuclei, which transform the "place" code used by the SC into the "rate" code used by oculomotor neurons. Eye movements are generated by six muscles, arranged in three orthogonally aligned pairs. Thus, at the level of the final common path, eye movements are encoded in essentially a Cartesian coordinate system. Although the SC receives a strong input directly from the retina, in primates it is largely under the control of the cerebral cortex, which contains several areas that are involved in determining eye movements. The frontal eye fields, a portion of the motor cortex, are involved in triggering intentional saccades, and an adjoining area, the supplementary eye fields, are involved in organizing groups of saccades into sequences. The parietal eye fields, farther back in the brain, are involved mainly in reflexive saccades, made in response to changes in the view. Recent evidence suggests that the primary visual cortex (V1) guides reflexive eye movements, according to V1 Saliency Hypothesis, using a bottom up saliency map of the visual field generated in V1 from external visual inputs. The SC only receives visual inputs in its superficial layers, whereas the deeper layers of the colliculus receive also auditory and somatosensory inputs and are connected to many sensorimotor areas of the brain. The colliculus as a whole is thought to help orient the head and eyes toward something seen and heard. The superior colliculus also receives auditory information from the inferior colliculus. This auditory information is integrated with the visual information already present to produce the ventriloquism effect. Distractibility
As well as being related to eye movements, the SC appears to have an important role to play in the circuitry underpinning distractibility. Heightened distractibility occurs in normal aging and is also a central feature in a number of medical conditions, including attention deficit hyperactivity disorder (ADHD). Research has shown that lesions to the SC in a number of species can result in heightened distractibility and, in humans, removing the inhibitory control on the SC from the pre frontal cortex, therefore increasing activity in the area, also increases distractibility. Research in an animal model of ADHD, the spontaneously hypertensive rat, also shows altered collicular dependent behaviours and physiology. Other animals
Other mammals
Primates
It is usually accepted that the primate superior colliculus is unique among mammals, in that it does not contain a complete map of the visual field seen by the contralateral eye. Instead, like the visual cortex and lateral geniculate nucleus, each colliculus represents only the contralateral half of the visual field, up to the midline, and excludes a representation of the ipsilateral half. This functional characteristic is explained by the absence, in primates, of anatomical connections between the retinal ganglion cells in the temporal half of the retina and the contralateral superior colliculus. In other mammals, the retinal ganglion cells throughout the contralateral retina project to the contralateral colliculus. This distinction between primates and non primates has been one of the key lines of evidence in support of the flying primates theory proposed by Australian neuroscientist Jack Pettigrew in 1986, after he discovered that flying foxes (megabats) resemble primates in terms of the pattern of anatomical connections between the retina and superior colliculus. Cats
In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem. Bats
Bats are not, in fact, blind, but they depend much more on echolocation than vision for navigation and prey capture. They obtain information about the surrounding world by emitting sonar chirps and then listening for the echoes. Their brains are highly specialized for this process, and some of these specializations appear in the superior colliculus. In bats, the retinal projection occupies only a thin zone just beneath the surface, but there are extensive inputs from auditory areas, and outputs to motor areas capable of orienting the ears, head, or body. Echoes coming from different directions activate neurons at different locations in the collicular layers, and activation of collicular neurons influences the chirps that the bats emit. Thus, there is a strong case that the superior colliculus performs the same sorts of functions for the auditory guided behaviors of bats that it performs for the visual guided behaviors of other species. Bats are usually classified into two main groups: Microchiroptera (the most numerous, and commonly found throughout the world), and Megachiroptera (fruit bats, found in Asia, Africa and Australasia). With one exception, Megabats do not echolocate, and rely on a developed sense of vision to navigate. The visual receptive fields of neurons in the superior colliculus in these animals form a precise map of the retina, similar to that found in cats and primates. Rodents
The superior colliculus in rodents have been hypothesized to mediate sensory guided approach and avoidance behaviors. Studies employing circuit analysis tools on mouse superior colliculus have revealed several important functions. In a series of studies, researchers have identified a set of Ying Yang circuit modules in the superior colliculus to initiate prey capture and predator avoidance behaviors in mice. By using single cell RNA sequencing, researchers have analyzed the gene expression profiles of superior colliculus neurons and identified the unique genetic markers of these circuit modules. Other vertebrates
Optic tectum
The optic tectum is the visual center in the non mammalian brain which develops from the alar plate of the mesencephalon. In these other vertebrates the connections from the optic tectum are important for the recognition and reaction to various sized objects which is facilitated by excitatory optic nerve transmitters like L glutamate. Disrupting visual experience early on in zebrafish development results in a change in tectal activity. Changes in tectal activity resulted in an inability to successfully hunt and capture prey. Hypothalamus inhibitory signaling to the deep tectal neuropil is important in tectal processing in zebrafish larvae. The tectal neuropil contains structures including periventricular neuronal axons and dendrites. The neuropil also contains GABAergic superficial inhibitory neurons located in stratum opticum. Instead of a large cerebral cortex, zebrafish have a relatively large optic tectum that is hypothesized to carry out some of the visual processing that the cortex performs in mammals. Recent lesion studies have suggested that the optic tectum has no influence over higher order motion responses like the optomotor response or the optokinetic response, but may be more integral to lower order cues in motion perception like in the identification of small objects. The optic tectum is one of the fundamental components of the vertebrate brain, existing across a range of species. Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic tracts to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow (In the superior colliculus the like structure is termed the parabigeminal nucleus). The nucleus isthmii is divided into two parts, called isthmus pars magnocellularis (Imc; "the part with the large cells") and isthmus pars parvocellularis'' (Ipc); "the part with the small cells"). Connections between the three areas — optic tectum, Ipc, and Imc — are topographic. Neurons in the superficial layers of the optic tectum project to corresponding points in the Ipc and Imc. The projections to the Ipc are tightly focused, while the projections to the Imc are somewhat more diffuse. Ipc gives rise to tightly focused cholinergic projections both to Imc and the optic tectum. In the optic tectum, the cholinergic inputs from Ipc ramify to give rise to terminals that extend across an entire column, from top to bottom. Imc, in contrast, gives rise to GABAergic projections to Ipc and optic tectum that spread very broadly in the lateral dimensions, encompassing most of the retinotopic map. Thus, the tectum Ipc Imc circuit causes tectal activity to produce recurrent feedback that involves tightly focused excitation of a small column of neighboring tectal neurons, together with global inhibition of distant tectal neurons. The optic tectum is involved in many responses including swimming in fish, flight in birds, tongue strikes toward prey in frogs, and fang strikes in snakes. In some species, including fish and birds, the optic tectum, also known as the optic lobe, is one of the largest components of the brain. In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. In amphibians, reptiles, and especially birds it is also a very significant component.
У приматов движения глаз можно разделить на сев…
Structure in the midbrain
In neuroanatomy, the superior colliculus is a structure lying on the roof of the mammalian midbrain. The adjective form tectal is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers (stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor related neurons, capable of activating eye movements as well as other responses. In other vertebrates the number of layers in the homologous optic tectum varies. and shifts in attention that do not involve any overt movements. The two inferior colliculi are situated immediately inferior/caudal to the superior colliculi; the inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin for quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent. The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. In the optic tectum this nearby structure is known as the nucleus isthmi. Structure
The superior colliculus is a synaptic layered structure. The top three layers are called superficial:Lamina I or SZ, the stratum zonale, is a thin layer consisting of small myelinated axons together with marginal and horizontal cells. Lamina II or SGS, the stratum griseum superficiale ("superficial gray layer"), contains many neurons of various shapes and sizes. Lamina III or SO, the stratum opticum ("optic layer"), consists mainly of axons coming from the optic tract. Next come two intermediate layers:Lamina IV or SGI, the stratum griseum intermedium ("intermediate gray layer"), is the thickest layer, and is filled with many neurons of many sizes. This layer is often as thick as all the other layers together. It is often subdivided into "upper" and "lower" parts. Lamina V or SAI, the stratum album intermedium ("intermediate white layer"), consists mainly of fibers from various sources. Finally come the two deep layers:Lamina VI or SGP, the stratum griseum profundum ("deep gray layer"), consists of loosely packed neurons and myelinated fibers. Lamina VII or SAP', the stratum album profundum ("deep white layer"), lying directly above the periaqueductal gray, consists entirely of fibers. The superficial layers receive input mainly from the retina, vision related areas of the cerebral cortex, and two tectal related structures called the pretectum and parabigeminal nucleus. The retinal input encompasses the entire superficial zone, and is bilateral, although the contralateral portion is more extensive. The cortical input comes most heavily from the primary visual cortex (area 17, V1), the secondary visual cortex (areas 18 and 19), and the frontal eye fields. The parabigeminal nucleus plays a very important role in tectal function that is described below. In contrast to the vision dominated inputs to the superficial layers, the intermediate and deep layers receive inputs from a very diverse set of sensory and motor structures. Most areas of the cerebral cortex project to these layers, although the input from "association" areas tends to be heavier than the input from primary sensory or motor areas. However, the cortical areas involved, and the strength of their relative projections differs across species. Another important input comes from the substantia nigra, pars reticulata, a component of the basal ganglia. This projection uses the inhibitory neurotransmitter GABA, and is thought to exert a "gating" effect on the superior colliculus. The intermediate and deep layers also receive input from the spinal trigeminal nucleus, which conveys somatosensory information from the face, as well as the hypothalamus, zona incerta, thalamus, and inferior colliculus. In addition to their distinctive inputs, the superficial and deep zones of the superior colliculus also have distinctive outputs. One of the most important outputs goes to the pulvinar and lateral intermediate areas of the thalamus, which in turn project to areas of the cerebral cortex that are involved in controlling eye movements. There are also projections from the superficial zone to the pretectal nuclei, lateral geniculate nucleus of the thalamus, and the parabigeminal nucleus. The projections from the deeper layers are more extensive. There are two large descending pathways, traveling to the brainstem and spinal cord, and numerous ascending projections to a variety of sensory and motor centers, including several that are involved in generating eye movements. Both colliculi also have descending projections to the paramedian pontine reticular formation and spinal cord, and thus can be involved in responses to stimuli faster than cortical processing would allow. Mosaic structure
On detailed examination, the collicular layers are actually not smooth sheets, but divided into a honeycomb arrangement of discrete columns. The clearest indication of columnar structure comes from the cholinergic inputs arising from the parabigeminal nucleus, whose terminals form evenly spaced clusters that extend from top to bottom of the tectum. Several other neurochemical markers including calretinin, parvalbumin, GAP 43, and NMDA receptors, and connections with numerous other brain structures in the brainstem and diencephalon, also show a corresponding inhomogeneity. The total number of columns has been estimated at around 100. From the 1970s to 1990s, however, neural recordings from mammals, mostly monkeys, focused primarily on the role of the superior colliculus in controlling eye movements. This line of investigation came to dominate the literature to such a degree that the majority opinion was that eye movement control is the only important function in mammals, a view still reflected in many current textbooks. In the late 1990s, however, experiments using animals whose heads were free to move showed clearly that the SC actually produces gaze shifts, usually composed of combined head and eye movements, rather than eye movements per se. This discovery reawakened interest in the full breadth of functions of the superior colliculus, and led to studies of multisensory integration in a variety of species and situations. Nevertheless, the role of the SC in controlling eye movements is understood in much greater depth than any other function. Behavioral studies have shown that the SC is not needed for object recognition, but plays a critical role in the ability to direct behaviors toward specific objects, and can support this ability even in the absence of the cerebral cortex. Thus, cats with major damage to the visual cortex cannot recognize objects, but may still be able to follow and orient toward moving stimuli, although more slowly than usual. If one half of the SC is removed, however, the cats will circle constantly toward the side of the lesion, and orient compulsively toward objects located there, but fail to orient at all toward objects located in the opposite hemifield. These deficits diminish over time but never disappear. Eye movements
In primates, eye movements can be divided into several types: fixation, in which the eyes are directed toward a motionless object, with eye movements only to compensate for movements of the head; smooth pursuit, in which the eyes move steadily to track a moving object; saccades, in which the eyes move very rapidly from one location to another; and vergence, in which the eyes move simultaneously in opposite directions to obtain or maintain single binocular vision. The superior colliculus is involved in all of these, but its role in saccades has been studied most intensively. Each of the two colliculi — one on each side of the brain — contains a two dimensional map representing half of the visual field. The fovea — the region of maximum sensitivity — is represented at the front edge of the map, and the periphery at the back edge. Eye movements are evoked by activity in the deep layers of the SC. During fixation, neurons near the front edge — the foveal zone — are tonically active. During smooth pursuit, neurons a small distance from the front edge are activated, leading to small eye movements. For saccades, neurons are activated in a region that represents the point to which the saccade will be directed. Just prior to a saccade, activity rapidly builds up at the target location and decreases in other parts of the SC. The coding is rather broad, so that for any given saccade the activity profile forms a "hill" that encompasses a substantial fraction of the collicular map: The location of the peak of this "hill" represents the saccade target. The SC encodes the target of a gaze shift, but it does not seem to specify the precise movements needed to get there. The decomposition of a gaze shift into head and eye movements and the precise trajectory of the eye during a saccade depend on integration of collicular and non collicular signals by downstream motor areas, in ways that are not yet well understood. Regardless of how the movement is evoked or performed, the SC encodes it in "retinotopic" coordinates: that is, the location of the SC 'hill" corresponds to a fixed location on the retina. This seems to contradict the observation that stimulation of a single point on the SC can result in different gaze shift directions, depending on initial eye orientation. However, it has been shown that this is because the retinal location of a stimulus is a non linear function of target location, eye orientation, and the spherical geometry of the eye. There has been some controversy about whether the SC merely commands eye movements, and leaves the execution to other structures, or whether it actively participates in the performance of a saccade. In 1991, Munoz et al., on the basis of data they collected, argued that, during a saccade, the "hill" of activity in the SC moves gradually, to reflect the changing offset of the eye from the target location while the saccade is progressing. At present, the predominant view is that, although the "hill" does shift slightly during a saccade, it does not shift in the steady and proportionate way that the "moving hill" hypothesis predicts. However, moving hills may play another role in the superior colliculus; more recent experiments have demonstrated a continuously moving hill of visual memory activity when the eyes move slowly while a separate saccade target is retained. The output from the motor sector of the SC goes to a set of midbrain and brainstem nuclei, which transform the "place" code used by the SC into the "rate" code used by oculomotor neurons. Eye movements are generated by six muscles, arranged in three orthogonally aligned pairs. Thus, at the level of the final common path, eye movements are encoded in essentially a Cartesian coordinate system. Although the SC receives a strong input directly from the retina, in primates it is largely under the control of the cerebral cortex, which contains several areas that are involved in determining eye movements. The frontal eye fields, a portion of the motor cortex, are involved in triggering intentional saccades, and an adjoining area, the supplementary eye fields, are involved in organizing groups of saccades into sequences. The parietal eye fields, farther back in the brain, are involved mainly in reflexive saccades, made in response to changes in the view. Recent evidence suggests that the primary visual cortex (V1) guides reflexive eye movements, according to V1 Saliency Hypothesis, using a bottom up saliency map of the visual field generated in V1 from external visual inputs. The SC only receives visual inputs in its superficial layers, whereas the deeper layers of the colliculus receive also auditory and somatosensory inputs and are connected to many sensorimotor areas of the brain. The colliculus as a whole is thought to help orient the head and eyes toward something seen and heard. The superior colliculus also receives auditory information from the inferior colliculus. This auditory information is integrated with the visual information already present to produce the ventriloquism effect. Distractibility
As well as being related to eye movements, the SC appears to have an important role to play in the circuitry underpinning distractibility. Heightened distractibility occurs in normal aging and is also a central feature in a number of medical conditions, including attention deficit hyperactivity disorder (ADHD). Research has shown that lesions to the SC in a number of species can result in heightened distractibility and, in humans, removing the inhibitory control on the SC from the pre frontal cortex, therefore increasing activity in the area, also increases distractibility. Research in an animal model of ADHD, the spontaneously hypertensive rat, also shows altered collicular dependent behaviours and physiology. Other animals
Other mammals
Primates
It is usually accepted that the primate superior colliculus is unique among mammals, in that it does not contain a complete map of the visual field seen by the contralateral eye. Instead, like the visual cortex and lateral geniculate nucleus, each colliculus represents only the contralateral half of the visual field, up to the midline, and excludes a representation of the ipsilateral half. This functional characteristic is explained by the absence, in primates, of anatomical connections between the retinal ganglion cells in the temporal half of the retina and the contralateral superior colliculus. In other mammals, the retinal ganglion cells throughout the contralateral retina project to the contralateral colliculus. This distinction between primates and non primates has been one of the key lines of evidence in support of the flying primates theory proposed by Australian neuroscientist Jack Pettigrew in 1986, after he discovered that flying foxes (megabats) resemble primates in terms of the pattern of anatomical connections between the retina and superior colliculus. Cats
In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem. Bats
Bats are not, in fact, blind, but they depend much more on echolocation than vision for navigation and prey capture. They obtain information about the surrounding world by emitting sonar chirps and then listening for the echoes. Their brains are highly specialized for this process, and some of these specializations appear in the superior colliculus. In bats, the retinal projection occupies only a thin zone just beneath the surface, but there are extensive inputs from auditory areas, and outputs to motor areas capable of orienting the ears, head, or body. Echoes coming from different directions activate neurons at different locations in the collicular layers, and activation of collicular neurons influences the chirps that the bats emit. Thus, there is a strong case that the superior colliculus performs the same sorts of functions for the auditory guided behaviors of bats that it performs for the visual guided behaviors of other species. Bats are usually classified into two main groups: Microchiroptera (the most numerous, and commonly found throughout the world), and Megachiroptera (fruit bats, found in Asia, Africa and Australasia). With one exception, Megabats do not echolocate, and rely on a developed sense of vision to navigate. The visual receptive fields of neurons in the superior colliculus in these animals form a precise map of the retina, similar to that found in cats and primates. Rodents
The superior colliculus in rodents have been hypothesized to mediate sensory guided approach and avoidance behaviors. Studies employing circuit analysis tools on mouse superior colliculus have revealed several important functions. In a series of studies, researchers have identified a set of Ying Yang circuit modules in the superior colliculus to initiate prey capture and predator avoidance behaviors in mice. By using single cell RNA sequencing, researchers have analyzed the gene expression profiles of superior colliculus neurons and identified the unique genetic markers of these circuit modules. Other vertebrates
Optic tectum
The optic tectum is the visual center in the non mammalian brain which develops from the alar plate of the mesencephalon. In these other vertebrates the connections from the optic tectum are important for the recognition and reaction to various sized objects which is facilitated by excitatory optic nerve transmitters like L glutamate. Disrupting visual experience early on in zebrafish development results in a change in tectal activity. Changes in tectal activity resulted in an inability to successfully hunt and capture prey. Hypothalamus inhibitory signaling to the deep tectal neuropil is important in tectal processing in zebrafish larvae. The tectal neuropil contains structures including periventricular neuronal axons and dendrites. The neuropil also contains GABAergic superficial inhibitory neurons located in stratum opticum. Instead of a large cerebral cortex, zebrafish have a relatively large optic tectum that is hypothesized to carry out some of the visual processing that the cortex performs in mammals. Recent lesion studies have suggested that the optic tectum has no influence over higher order motion responses like the optomotor response or the optokinetic response, but may be more integral to lower order cues in motion perception like in the identification of small objects. The optic tectum is one of the fundamental components of the vertebrate brain, existing across a range of species. Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic tracts to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow (In the superior colliculus the like structure is termed the parabigeminal nucleus). The nucleus isthmii is divided into two parts, called isthmus pars magnocellularis (Imc; "the part with the large cells") and isthmus pars parvocellularis'' (Ipc); "the part with the small cells"). Connections between the three areas — optic tectum, Ipc, and Imc — are topographic. Neurons in the superficial layers of the optic tectum project to corresponding points in the Ipc and Imc. The projections to the Ipc are tightly focused, while the projections to the Imc are somewhat more diffuse. Ipc gives rise to tightly focused cholinergic projections both to Imc and the optic tectum. In the optic tectum, the cholinergic inputs from Ipc ramify to give rise to terminals that extend across an entire column, from top to bottom. Imc, in contrast, gives rise to GABAergic projections to Ipc and optic tectum that spread very broadly in the lateral dimensions, encompassing most of the retinotopic map. Thus, the tectum Ipc Imc circuit causes tectal activity to produce recurrent feedback that involves tightly focused excitation of a small column of neighboring tectal neurons, together with global inhibition of distant tectal neurons. The optic tectum is involved in many responses including swimming in fish, flight in birds, tongue strikes toward prey in frogs, and fang strikes in snakes. In some species, including fish and birds, the optic tectum, also known as the optic lobe, is one of the largest components of the brain. In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. In amphibians, reptiles, and especially birds it is also a very significant component.
In neuroanatomy, the superior colliculus is a structure lying on the roof of the mammalian midbrain. The adjective form tectal is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers (stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor related neurons, capable of activating eye movements as well as other responses. In other vertebrates the number of layers in the homologous optic tectum varies. and shifts in attention that do not involve any overt movements. The two inferior colliculi are situated immediately inferior/caudal to the superior colliculi; the inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin for quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent. The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. In the optic tectum this nearby structure is known as the nucleus isthmi. Structure
The superior colliculus is a synaptic layered structure. The top three layers are called superficial:Lamina I or SZ, the stratum zonale, is a thin layer consisting of small myelinated axons together with marginal and horizontal cells. Lamina II or SGS, the stratum griseum superficiale ("superficial gray layer"), contains many neurons of various shapes and sizes. Lamina III or SO, the stratum opticum ("optic layer"), consists mainly of axons coming from the optic tract. Next come two intermediate layers:Lamina IV or SGI, the stratum griseum intermedium ("intermediate gray layer"), is the thickest layer, and is filled with many neurons of many sizes. This layer is often as thick as all the other layers together. It is often subdivided into "upper" and "lower" parts. Lamina V or SAI, the stratum album intermedium ("intermediate white layer"), consists mainly of fibers from various sources. Finally come the two deep layers:Lamina VI or SGP, the stratum griseum profundum ("deep gray layer"), consists of loosely packed neurons and myelinated fibers. Lamina VII or SAP', the stratum album profundum ("deep white layer"), lying directly above the periaqueductal gray, consists entirely of fibers. The superficial layers receive input mainly from the retina, vision related areas of the cerebral cortex, and two tectal related structures called the pretectum and parabigeminal nucleus. The retinal input encompasses the entire superficial zone, and is bilateral, although the contralateral portion is more extensive. The cortical input comes most heavily from the primary visual cortex (area 17, V1), the secondary visual cortex (areas 18 and 19), and the frontal eye fields. The parabigeminal nucleus plays a very important role in tectal function that is described below. In contrast to the vision dominated inputs to the superficial layers, the intermediate and deep layers receive inputs from a very diverse set of sensory and motor structures. Most areas of the cerebral cortex project to these layers, although the input from "association" areas tends to be heavier than the input from primary sensory or motor areas. However, the cortical areas involved, and the strength of their relative projections differs across species. Another important input comes from the substantia nigra, pars reticulata, a component of the basal ganglia. This projection uses the inhibitory neurotransmitter GABA, and is thought to exert a "gating" effect on the superior colliculus. The intermediate and deep layers also receive input from the spinal trigeminal nucleus, which conveys somatosensory information from the face, as well as the hypothalamus, zona incerta, thalamus, and inferior colliculus. In addition to their distinctive inputs, the superficial and deep zones of the superior colliculus also have distinctive outputs. One of the most important outputs goes to the pulvinar and lateral intermediate areas of the thalamus, which in turn project to areas of the cerebral cortex that are involved in controlling eye movements. There are also projections from the superficial zone to the pretectal nuclei, lateral geniculate nucleus of the thalamus, and the parabigeminal nucleus. The projections from the deeper layers are more extensive. There are two large descending pathways, traveling to the brainstem and spinal cord, and numerous ascending projections to a variety of sensory and motor centers, including several that are involved in generating eye movements. Both colliculi also have descending projections to the paramedian pontine reticular formation and spinal cord, and thus can be involved in responses to stimuli faster than cortical processing would allow. Mosaic structure
On detailed examination, the collicular layers are actually not smooth sheets, but divided into a honeycomb arrangement of discrete columns. The clearest indication of columnar structure comes from the cholinergic inputs arising from the parabigeminal nucleus, whose terminals form evenly spaced clusters that extend from top to bottom of the tectum. Several other neurochemical markers including calretinin, parvalbumin, GAP 43, and NMDA receptors, and connections with numerous other brain structures in the brainstem and diencephalon, also show a corresponding inhomogeneity. The total number of columns has been estimated at around 100. From the 1970s to 1990s, however, neural recordings from mammals, mostly monkeys, focused primarily on the role of the superior colliculus in controlling eye movements. This line of investigation came to dominate the literature to such a degree that the majority opinion was that eye movement control is the only important function in mammals, a view still reflected in many current textbooks. In the late 1990s, however, experiments using animals whose heads were free to move showed clearly that the SC actually produces gaze shifts, usually composed of combined head and eye movements, rather than eye movements per se. This discovery reawakened interest in the full breadth of functions of the superior colliculus, and led to studies of multisensory integration in a variety of species and situations. Nevertheless, the role of the SC in controlling eye movements is understood in much greater depth than any other function. Behavioral studies have shown that the SC is not needed for object recognition, but plays a critical role in the ability to direct behaviors toward specific objects, and can support this ability even in the absence of the cerebral cortex. Thus, cats with major damage to the visual cortex cannot recognize objects, but may still be able to follow and orient toward moving stimuli, although more slowly than usual. If one half of the SC is removed, however, the cats will circle constantly toward the side of the lesion, and orient compulsively toward objects located there, but fail to orient at all toward objects located in the opposite hemifield. These deficits diminish over time but never disappear. Eye movements
In primates, eye movements can be divided into several types: fixation, in which the eyes are directed toward a motionless object, with eye movements only to compensate for movements of the head; smooth pursuit, in which the eyes move steadily to track a moving object; saccades, in which the eyes move very rapidly from one location to another; and vergence, in which the eyes move simultaneously in opposite directions to obtain or maintain single binocular vision. The superior colliculus is involved in all of these, but its role in saccades has been studied most intensively. Each of the two colliculi — one on each side of the brain — contains a two dimensional map representing half of the visual field. The fovea — the region of maximum sensitivity — is represented at the front edge of the map, and the periphery at the back edge. Eye movements are evoked by activity in the deep layers of the SC. During fixation, neurons near the front edge — the foveal zone — are tonically active. During smooth pursuit, neurons a small distance from the front edge are activated, leading to small eye movements. For saccades, neurons are activated in a region that represents the point to which the saccade will be directed. Just prior to a saccade, activity rapidly builds up at the target location and decreases in other parts of the SC. The coding is rather broad, so that for any given saccade the activity profile forms a "hill" that encompasses a substantial fraction of the collicular map: The location of the peak of this "hill" represents the saccade target. The SC encodes the target of a gaze shift, but it does not seem to specify the precise movements needed to get there. The decomposition of a gaze shift into head and eye movements and the precise trajectory of the eye during a saccade depend on integration of collicular and non collicular signals by downstream motor areas, in ways that are not yet well understood. Regardless of how the movement is evoked or performed, the SC encodes it in "retinotopic" coordinates: that is, the location of the SC 'hill" corresponds to a fixed location on the retina. This seems to contradict the observation that stimulation of a single point on the SC can result in different gaze shift directions, depending on initial eye orientation. However, it has been shown that this is because the retinal location of a stimulus is a non linear function of target location, eye orientation, and the spherical geometry of the eye. There has been some controversy about whether the SC merely commands eye movements, and leaves the execution to other structures, or whether it actively participates in the performance of a saccade. In 1991, Munoz et al., on the basis of data they collected, argued that, during a saccade, the "hill" of activity in the SC moves gradually, to reflect the changing offset of the eye from the target location while the saccade is progressing. At present, the predominant view is that, although the "hill" does shift slightly during a saccade, it does not shift in the steady and proportionate way that the "moving hill" hypothesis predicts. However, moving hills may play another role in the superior colliculus; more recent experiments have demonstrated a continuously moving hill of visual memory activity when the eyes move slowly while a separate saccade target is retained. The output from the motor sector of the SC goes to a set of midbrain and brainstem nuclei, which transform the "place" code used by the SC into the "rate" code used by oculomotor neurons. Eye movements are generated by six muscles, arranged in three orthogonally aligned pairs. Thus, at the level of the final common path, eye movements are encoded in essentially a Cartesian coordinate system. Although the SC receives a strong input directly from the retina, in primates it is largely under the control of the cerebral cortex, which contains several areas that are involved in determining eye movements. The frontal eye fields, a portion of the motor cortex, are involved in triggering intentional saccades, and an adjoining area, the supplementary eye fields, are involved in organizing groups of saccades into sequences. The parietal eye fields, farther back in the brain, are involved mainly in reflexive saccades, made in response to changes in the view. Recent evidence suggests that the primary visual cortex (V1) guides reflexive eye movements, according to V1 Saliency Hypothesis, using a bottom up saliency map of the visual field generated in V1 from external visual inputs. The SC only receives visual inputs in its superficial layers, whereas the deeper layers of the colliculus receive also auditory and somatosensory inputs and are connected to many sensorimotor areas of the brain. The colliculus as a whole is thought to help orient the head and eyes toward something seen and heard. The superior colliculus also receives auditory information from the inferior colliculus. This auditory information is integrated with the visual information already present to produce the ventriloquism effect. Distractibility
As well as being related to eye movements, the SC appears to have an important role to play in the circuitry underpinning distractibility. Heightened distractibility occurs in normal aging and is also a central feature in a number of medical conditions, including attention deficit hyperactivity disorder (ADHD). Research has shown that lesions to the SC in a number of species can result in heightened distractibility and, in humans, removing the inhibitory control on the SC from the pre frontal cortex, therefore increasing activity in the area, also increases distractibility. Research in an animal model of ADHD, the spontaneously hypertensive rat, also shows altered collicular dependent behaviours and physiology. Other animals
Other mammals
Primates
It is usually accepted that the primate superior colliculus is unique among mammals, in that it does not contain a complete map of the visual field seen by the contralateral eye. Instead, like the visual cortex and lateral geniculate nucleus, each colliculus represents only the contralateral half of the visual field, up to the midline, and excludes a representation of the ipsilateral half. This functional characteristic is explained by the absence, in primates, of anatomical connections between the retinal ganglion cells in the temporal half of the retina and the contralateral superior colliculus. In other mammals, the retinal ganglion cells throughout the contralateral retina project to the contralateral colliculus. This distinction between primates and non primates has been one of the key lines of evidence in support of the flying primates theory proposed by Australian neuroscientist Jack Pettigrew in 1986, after he discovered that flying foxes (megabats) resemble primates in terms of the pattern of anatomical connections between the retina and superior colliculus. Cats
In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem. Bats
Bats are not, in fact, blind, but they depend much more on echolocation than vision for navigation and prey capture. They obtain information about the surrounding world by emitting sonar chirps and then listening for the echoes. Their brains are highly specialized for this process, and some of these specializations appear in the superior colliculus. In bats, the retinal projection occupies only a thin zone just beneath the surface, but there are extensive inputs from auditory areas, and outputs to motor areas capable of orienting the ears, head, or body. Echoes coming from different directions activate neurons at different locations in the collicular layers, and activation of collicular neurons influences the chirps that the bats emit. Thus, there is a strong case that the superior colliculus performs the same sorts of functions for the auditory guided behaviors of bats that it performs for the visual guided behaviors of other species. Bats are usually classified into two main groups: Microchiroptera (the most numerous, and commonly found throughout the world), and Megachiroptera (fruit bats, found in Asia, Africa and Australasia). With one exception, Megabats do not echolocate, and rely on a developed sense of vision to navigate. The visual receptive fields of neurons in the superior colliculus in these animals form a precise map of the retina, similar to that found in cats and primates. Rodents
The superior colliculus in rodents have been hypothesized to mediate sensory guided approach and avoidance behaviors. Studies employing circuit analysis tools on mouse superior colliculus have revealed several important functions. In a series of studies, researchers have identified a set of Ying Yang circuit modules in the superior colliculus to initiate prey capture and predator avoidance behaviors in mice. By using single cell RNA sequencing, researchers have analyzed the gene expression profiles of superior colliculus neurons and identified the unique genetic markers of these circuit modules. Other vertebrates
Optic tectum
The optic tectum is the visual center in the non mammalian brain which develops from the alar plate of the mesencephalon. In these other vertebrates the connections from the optic tectum are important for the recognition and reaction to various sized objects which is facilitated by excitatory optic nerve transmitters like L glutamate. Disrupting visual experience early on in zebrafish development results in a change in tectal activity. Changes in tectal activity resulted in an inability to successfully hunt and capture prey. Hypothalamus inhibitory signaling to the deep tectal neuropil is important in tectal processing in zebrafish larvae. The tectal neuropil contains structures including periventricular neuronal axons and dendrites. The neuropil also contains GABAergic superficial inhibitory neurons located in stratum opticum. Instead of a large cerebral cortex, zebrafish have a relatively large optic tectum that is hypothesized to carry out some of the visual processing that the cortex performs in mammals. Recent lesion studies have suggested that the optic tectum has no influence over higher order motion responses like the optomotor response or the optokinetic response, but may be more integral to lower order cues in motion perception like in the identification of small objects. The optic tectum is one of the fundamental components of the vertebrate brain, existing across a range of species. Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic tracts to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow (In the superior colliculus the like structure is termed the parabigeminal nucleus). The nucleus isthmii is divided into two parts, called isthmus pars magnocellularis (Imc; "the part with the large cells") and isthmus pars parvocellularis'' (Ipc); "the part with the small cells"). Connections between the three areas — optic tectum, Ipc, and Imc — are topographic. Neurons in the superficial layers of the optic tectum project to corresponding points in the Ipc and Imc. The projections to the Ipc are tightly focused, while the projections to the Imc are somewhat more diffuse. Ipc gives rise to tightly focused cholinergic projections both to Imc and the optic tectum. In the optic tectum, the cholinergic inputs from Ipc ramify to give rise to terminals that extend across an entire column, from top to bottom. Imc, in contrast, gives rise to GABAergic projections to Ipc and optic tectum that spread very broadly in the lateral dimensions, encompassing most of the retinotopic map. Thus, the tectum Ipc Imc circuit causes tectal activity to produce recurrent feedback that involves tightly focused excitation of a small column of neighboring tectal neurons, together with global inhibition of distant tectal neurons. The optic tectum is involved in many responses including swimming in fish, flight in birds, tongue strikes toward prey in frogs, and fang strikes in snakes. In some species, including fish and birds, the optic tectum, also known as the optic lobe, is one of the largest components of the brain. In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. In amphibians, reptiles, and especially birds it is also a very significant component.
Лампрей
Лампрей широко изучается, поскольку у него относительно простой мозг, который, как считается, во многих отношениях отражает структуру мозга ранних предков позвоночных. Вдохновленные пионерской работой Карла Ровайнена, начатой в 1960-х годах (см. ), с 1970-х годов Стен Гриллнер и его коллеги из Института Каролински в Стокгольме используют лампрею в качестве модельной системы для изучения принципов управления движением у позвоночных, начиная с спинного мозга и продвигаясь к мозгу. Подобно другим системам (см. для исторической перспективы этой идеи), нейронные цепи в спинном мозге, по-видимому, способны генерировать некоторые базовые ритмические двигательные паттерны, лежащие в основе плавания, и эти цепи подвержены влиянию специфических локомоторных областей в стволе мозга и среднем мозге, которые, в свою очередь, находятся под влиянием высших структур мозга, включая базальные ганглии и тектум. В исследовании тектома лампрей, опубликованном в 2007 году, было обнаружено, что электрическая стимуляция может вызывать движения глаз, боковые изгибы или плавательную активность, при этом тип, амплитуда и направление движения менялись в зависимости от места стимуляции в тектоме. Эти результаты были интерпретированы как подтверждающие идею о том, что тектум генерирует целенаправленное передвижение у лампрей, как это наблюдается у других видов.
The lamprey has been extensively studied because it has a relatively simple brain that is thought in many respects to reflect the brain structure of early vertebrate ancestors. Inspired by the pioneering work of Carl Rovainen that began in the 1960s (see ), since the 1970s Sten Grillner and his colleagues at the Karolinska Institute in Stockholm have used the lamprey as a model system to try to work out the principles of motor control in vertebrates, starting in the spinal cord and working upward into the brain. In common with other systems (see for a historical perspective of the idea), neural circuits within the spinal cord seem capable of generating some basic rhythmic motor patterns underlying swimming, and that these circuits are influenced by specific locomotor areas in the brainstem and midbrain, that are in turn influenced by higher brain structures including the basal ganglia and tectum. In a study of the lamprey tectum published in 2007, they found that electrical stimulation could elicit eye movements, lateral bending movements, or swimming activity, and that the type, amplitude, and direction of movement varied as a function of the location within the tectum that was stimulated. These findings were interpreted as consistent with the idea that the tectum generates goal directed locomotion in the lamprey as shown in other species.
Птицы
У птиц зрительное текто́м участвует в полёте и является одним из самых крупных компонентов мозга. Изучение зрительной обработки у птиц позволило глубже понять её у млекопитающих, включая человека.
In birds the optic tectum is involved in flight and is one of the largest brain components. The study of avian visual processing has enabled a greater understanding of that in mammals including humans.