Тайленол: История, Состав и Безопасность Препарата

Medication

Tylenol ('/t//aɪ//l//ə//n//ɒ//l/) is a brand of medication, advertised for reducing pain, reducing fever, and relieving the symptoms of allergies, cold, cough, headache, and influenza. The active ingredient of its original flagship product is paracetamol (known in the United States, Canada, and various other countries as acetaminophen), an analgesic and antipyretic. Like the words paracetamol and acetaminophen, the brand name Tylenol is derived from a chemical name for the compound, N acetyl para aminophenol (APAP). The brand name is owned by McNeil Consumer Healthcare, a subsidiary of Kenvue.

The active ingredient in Tylenol is paracetamol, a widely used over the counter analgesic (pain reliever) and antipyretic (fever reducer). Formulations with additional active ingredients intended to target specific applications are sold under the Tylenol brand. These can include codeine as co codamol, dextromethorphan, methocarbamol, guaifenesin, pseudoephedrine, caffeine, diphenhydramine, chlorpheniramine and phenylephrine.

The brand was introduced in 1955 by McNeil Laboratories, a family owned pharmaceutical manufacturer. Two brothers took over the company from their father that year, and one of them subsequently learned about paracetamol, which was not on the U. S. market at that time. To avoid competing with aspirin, they marketed it as a product to reduce fever in children, packaging it like a red fire truck with the slogan, "for little hotheads". The brand name Tylenol and the United States Adopted Name acetaminophen were generated by McNeil from the chemical name of the drug, N acetyl para aminophenol (APAP). Johnson & Johnson bought McNeil in 1959, and one year later the drug was made available over the counter. As a result of the crisis, all Tylenol capsules were discontinued, as were capsules of other brand names. Retained by McNeil's president, new product consultant Martin Calle of management strategist Calle & Company conceived the world's first tamper resistant gelatin enrobed capsule called "Tylenol Gelcaps",) and a reward offered by Johnson & Johnson remained unclaimed as of 2023. Before the poisonings, Tylenol brands held around 35% of the US market for acetaminophen and in the immediate aftermath, fell to 8%. Within a year sales had rebounded to the prior levels. These events led to the widespread use of tamper resistance packaging of drugs by drug companies, to the 1982 passage of a US federal law making tampering a crime, and to legislation in 1989 requiring tamper proof packaging.

On January 15, 2010, a voluntary recall of several hundred batches of popular medicines was announced, including Benadryl, Motrin, Rolaids, Simply Sleep, St. Joseph Aspirin, and Tylenol. The recall was due to complaints of a musty smell suspected to be due to contamination of the packaging with the chemical 2,4,6 tribromoanisole. The full health effects of 2,4,6 tribromoanisole are not known but no serious events have been documented in medical literature. The recall came 20 months after McNeil first began receiving and investigating consumer complaints about moldy smelling bottles of Tylenol Arthritis Relief caplets, according to the U. S. Food and Drug Administration (FDA). The recall included 53 million bottles of over the counter products, involving lots in the Americas, the United Arab Emirates, and Fiji.

On April 30, 2010, another recall was issued for 40 products including liquid infant and children's pain relievers Tylenol and Motrin, and allergy medications Zyrtec and Benadryl. On May 5, 2010, the FDA confirmed that the bacterium found at the Johnson & Johnson plant that made the recalled Children's Tylenol was Burkholderia cepacia, a bacterium often resistant to common antibiotics. The bacteria were found on the outside of certain product containing drums, but not in the finished product. The CDC has stated that Burkholderia cepacia is not likely to cause health problems for those with healthy immune systems, but those with weaker ones and those with chronic lung diseases, such as cystic fibrosis, could be more susceptible to infection.

Tylenol has many different advertisement approaches. One of these advertisement campaigns focuses on "getting you back to normal", whereas the other commercials focus on Tylenol's current slogan, "Feel better, Tylenol". In the "Feel better, Tylenol" commercials, Tylenol places emphasis on the importance of sleep; various people are seen sleeping in this commercial while a voiceover describes how sleep can help repair and heal the human body during times of aches and pains. In the "getting you back to normal" commercial, Tylenol places more emphasis on helping its consumers get back to their daily routines; many different people are shown first experiencing headaches and other sorts of body pain, where a voiceover then states that Tylenol Rapid Release can help rid aches and pains; the various people are then shown enjoying their everyday lives, and are seen as "back to normal". In an older commercial from 1986, Tylenol emphasized that it is the drug that American hospitals trust the most. In this ad, Susan Sullivan told the consumer that Tylenol was a drug that could be trusted by Americans since many doctors also trusted it; she went on to state that doctors prescribed Tylenol four times more often than other leading pain relieving drugs combined. A form that contains dextromethorphan, pseudoephedrine, acetaminophen, and chlorpheniramine, is sold as Cotylenol.

as of 2021, the "Tylenol" brand was used in Australia, Brazil, Canada, China, Egypt, Kuwait, Lebanon, Mexico, Myanmar, Netherlands, Oman, Paraguay, the Philippines, South Africa, South Korea, Switzerland, Taiwan, Thailand, the United States, Uruguay, Venezuela, and Vietnam.