Арпад Янош Пуштай: Биография и «Дело Пуштая»

Hungarian born British biochemist (1930–2021)

Árpád János Pusztai (8 September 1930 – 17 December 2021) was a Hungarian born British biochemist and nutritionist who spent 36 years at the Rowett Research Institute in Aberdeen, Scotland. He was a world expert on plant lectins, authoring 270 papers and three books on the subject. In 1998, Árpád Pusztai publicly announced that the results of his research showed feeding genetically modified potatoes to rats had negative effects on their stomach lining and immune system. This led to scientific criticism. Pusztai was suspended and his annual contract was not renewed. The resulting controversy became known as the Pusztai affair.

Pusztai was born in Budapest, Hungary, on 8 September 1930. He was a student of the high school Óbudai Árpád Gimnázium and later obtained a diploma in chemistry in 1953 from the Eötvös Loránd University in Budapest. He worked for three years as an associate scientist at the Hungarian Academy of Sciences before the Hungarian revolution against Soviet control in 1956. After the failed revolution, Pusztai escaped to a refugee camp in Austria and from there made his way to England. He completed his doctorate in biochemistry at the Lister Institute in London and continued there with his post doctorate. In 1963, he was invited to join the Protein Research Department at the Rowett Research Institute in Aberdeen, Scotland. Pusztai worked at the Rowett Institute for the next 36 years, predominately studying plant lectins. During that time, he discovered glycoproteins in plants, authored over 270 research papers, published 3 books, He was made a Fellow of the Royal Society of Edinburgh in 1988 and has received fellowships from the Leverhulme Trust. He died at his home in Aberdeen on December 17, 2021, at the age of 91.

In 1995, Pusztai began research on genetically modified potatoes containing the GNA lectin gene from the snowdrop plant. and sent the raw data to six anonymous reviewers, who also criticized Pusztai's work. Pusztai sent the audit report and his rebuttal to scientists who requested it, and in February 1999, twenty one European and American scientists released a memo supporting Pusztai. James and the Rowett Institute released a statement on August 10 falsely accusing Pusztai of using a lectin (Concanavalin A) that was a known toxin. This wasn't true. Pusztai had used the snowdrop lectin, but a gag order prevented him from defending himself publicly until 1999. Pusztai's experiment was eventually published as a letter in The Lancet in 1999. Because of the controversial nature of his research, the letter was reviewed by six reviewers three times the usual number. One publicly opposed the letter, another thought it was flawed, but wanted it published "to avoid suspicions of a conspiracy against Pusztai and to give colleagues a chance to see the data for themselves," while the other four raised questions that were addressed by the authors. The letter reported significant differences between the thickness of the gut epithelium of rats fed genetically modified potatoes and of rats fed the control diet. For example, too few rats per test group were used to derive meaningful, statistically significant data. In 2005, he received the Whistleblower Award of the Federation of German Scientists and the German section of the International Association of Lawyers against Nuclear Arms (IALANA). In 2009, Pusztai and his wife, Prof. Bardócz Zsuzsa, received the Stuttgart Peace Prize.