Тайениоз: симптомы, диагностика и профилактика тениозов.

Parasitic disease due to infection with tapeworms belonging to the genus Taenia
the infection by the adult worms
Prevention is by properly cooking meat. The disease is most common in the developing world. Infection may be suspected when a portion of the worm is passed in the stool.

Infection in the intestines by the adult T. solium worms is normally asymptomatic. Heavy infection can result in anaemia and indigestion. A complication, known as cysticercosis, may occur if the eggs of the pork tapeworm are eaten. This typically occurs from vegetables or water contaminated by feces from someone with pork tapeworm taeniasis. The eggs enter the intestine where they develop into larvae which then enter the bloodstream and invade host tissues. This is the most frequent and severe disease caused by any tapeworm. It can lead to headaches, dizziness, seizures, dementia, hypertension, lesions in the brain, blindness, tumor like growths, and low eosinophil levels. It is a cause of major neurological problems, such as hydrocephalus, paraplegy, meningitis, and death.

Taenia saginata infection is usually asymptomatic, but heavy infection causes weight loss, dizziness, abdominal pain, diarrhea, headaches, nausea, constipation, chronic indigestion, and loss of appetite. It can cause antigen reaction that induce allergic reaction. It is also a rare cause of ileus, pancreatitis, cholecystitis, and cholangitis.

Taenia asiatica is also usually asymptomatic. It is unclear if T. asiatica can cause cysticercosis.

Taeniasis is contracted after eating undercooked pork or beef that contain the larvae. The adult worms develop and live in the lumen of the intestine. They acquire nutrients from the intestine. The gravid proglottids, body segments containing fertilised eggs, are released in the faeces. If consumed by an intermediate host such as a cow or pig, they hatch within the duodenum to become larvae, penetrate through the intestinal wall into nearby blood vessels, and enter the bloodstream. Once they reach organs such as the skeletal muscles, liver or lungs, the larvae then develop into a cyst, a fluid filled cysticercus. These contaminated tissues are then consumed through raw or undercooked meat.

Diagnosis of taeniasis is mainly using stool sample, particularly by identifying the eggs. However, this has limitation at the species level because tapeworms basically have similar eggs. Examination of the scolex or the gravid proglottids can resolve the exact species. But body segments are not often available, therefore, laborious histological observation of the uterine branches and PCR detection of ribosomal 5.8S gene are sometimes necessary. Ziehl–Neelsen stain is also used for T. saginata and T. solium, in most cases only the former will stain, but the method is not entirely reliable. Loop mediated isothermal amplification (LAMP) is highly sensitive (~2.5 times that of multiplex PCR), without false positives, for differentiating the taenid species from faecal samples. To date the most relevant test for T. asiatica is by enzyme linked immunoelectrotransfer blot (EITB). EITB can effectively identify asiatica from other taenid infections since the serological test indicates an immunoblot band of 21.5 kDa exhibited specifically by T. asiatica. Even though it gives 100% sensitivity, it has not been tested with human sera for cross reactivity, and it may show a high false positive result.

Prevention efforts include properly cooking meat, treating active cases in humans, vaccinating and treating pigs against the disease, stricter meat inspection standards, health education, improved sanitation, and improved pig raising practices. Usual treatments are with praziquantel (5–10 mg/kg, single administration) or niclosamide (adults and children over 6 years: 2 g, single administration after a light breakfast, followed after 2 hours by a laxative; children aged 2–6 years: 1 g; children under 2 years: 500 mg). Mepacrine is quite effective but has adverse effects in humans.

The total global infection is estimated to be between 40 and 60 million people. In the US, the incidence of infection is low, but 25% of cattle sold are still infected. the Philippines, and Latin America. It is most prevalent in Sub Saharan Africa and the Middle East. Taenia asiatica is restricted to East Asia, including Taiwan, Korea, Indonesia, Nepal, Thailand and China.