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Neuroscience textbook

First published in 1981 by Elsevier, Principles of Neural Science is an influential neuroscience textbook edited by Columbia University professors Eric R. Kandel, James H. Schwartz, and Thomas M. Jessell. The original edition was 468 pages; now on the sixth edition, the book has grown to 1646 pages. The second edition was published in 1985, third in 1991, fourth in 2000. The fifth was published on October 26, 2012 and included Steven A. Siegelbaum and A. J. Hudspeth as editors. The sixth and latest edition was published on March 8, 2021.

Kandel was one of the recipients of the 2000 Nobel Prize in Physiology or Medicine. He is currently a professor of biochemistry, molecular biophysics, physiology, cellular biophysics, and psychiatry at Columbia University. He is a senior investigator at the Howard Hughes Medical Institute and a recipient of the National Medal of Science. Schwartz was a professor of physiology, cellular biophysics, neurology, and psychiatry at Columbia University. Jessell became an editor of the book starting from the third edition. He was a professor of biochemistry and molecular biophysics at Columbia University, and an investigator at the Howard Hughes Medical Institute. Hudspeth is a professor of sensory neuroscience at Rockefeller University. He is also an investigator at the Howard Hughes Medical Institute. Siegelbaum is Chair of the Department of Neuroscience at Columbia University and is also an investigator at the Howard Hughes Medical Institute.

Including the editors—all of whom also contributed to individual chapters in the book—there are a total of 45 authors of this text. Included among them are several notable researchers and physicians. Several authors are also highly decorated scientists, including Nobel laureate Linda B. Buck and renowned neurophysiologist Roger M. Enoka.