Изомальтулоза: альтернатива сахару и её свойства.

Isomaltulose (trade name Palatinose, chemical name 6 O α D glucopyranosyl D fructose) is a disaccharide carbohydrate composed of glucose and fructose. It is naturally present in honey and sugarcane extracts and is also produced industrially from table sugar (sucrose) and used as a sugar alternative. It tastes similar to table sugar with half the sweetness. It has the same energy as table sugar, but is digested slower and thus leads to a lower blood glucose and insulin response. In comparison with sucrose and most other carbohydrates, isomaltulose is not a significant substrate for oral bacteria. Consequently, acid production from isomaltulose in the mouth is too slow to promote tooth decay. Isomaltulose has been used as an alternative to sugar in foods in Japan since 1985, in the EU since 2005, in the US since 2006, and in Australia and New Zealand since 2007, besides other countries worldwide. Like sucrose, isomaltulose can be digested to glucose and fructose. However, while in sucrose the glucose is linked to the anomeric carbon of the fructose (an α 1,2 glycosidic linkage), in isomaltulose the linkage is to the 6 carbon (α 1,6), making isomaltulose a reducing sugar, unlike sucrose. The fructose in isomaltulose exists in a ring structure that readily opens to exhibit a carbonyl group as in ketones and aldehydes, which explains why isomaltulose is a reducing sugar. Isomaltulose is hydrogenated to produce isomalt, a minimally digestible carbohydrate that is used as a sugar replacer, for example in sugar free candies and confectionery.

In nutrition, isomaltulose is a source of food energy, providing the same amount of energy as sucrose. Like sucrose, isomaltulose provides sweetness to foods, but isomaltulose is only about half as sweet as sucrose. When eaten by humans, isomaltulose is digested completely and absorbed. Its intestinal digestion involves the enzyme isomaltase, which is located at the surface of the brush border lining the inner wall of the small intestine. This enzyme is otherwise involved in the digestion of α 1,6 linkages present in starch. The products of isomaltulose digestion are glucose and fructose, which are absorbed and enter the bloodstream. Once absorbed, the glucose and fructose follow the same metabolic pathways through the body as if they were derived from sucrose. the food energy value of isomaltulose is identical to that of sucrose. For both, it is 4 kcal/g (17 kJ/g), a value that is used in food labelling or dietary planning.

Isomaltulose is slow to be digested and absorbed, and is therefore gradually released as glucose and fructose into the bloodstream. After ingestion, the enzymatic digestion of sucrose and isomaltulose occur on the same sucrase isomaltase enzyme complex, which is located in the small intestine. Several studies show that this complex breaks down isomaltulose more slowly than sucrose. The maximum rate at which isomaltase can process isomaltulose (Vmax) is 4.5 times lower than that of sucrase for sucrose. As a result of its slow digestion, isomaltulose travels further through the human small intestine than does sucrose, as evidenced by the difference in incretin responses they elicit. The incretin hormone glucose dependent insulinotropic polypeptide (GIP) is secreted from the earlier (proximal) part of the small intestine in lower amounts after ingestion of isomaltulose than sucrose, whereas the incretin hormone glucagon like peptide 1 (GLP 1) is secreted from a later (distal) part of the small intestine in higher amounts with isomaltulose than with sucrose. Compared with sucrose, the absorption of energy as carbohydrate from isomaltulose is prolonged. compared to 67 for sucrose and 100 for glucose, making isomaltulose a particularly low GI carbohydrate (GI<55). Confirmation of a low glycaemic response to isomaltulose is provided in numerous studies for different population groups including healthy people, overweight or obese persons, prediabetic persons, and type 1 or type 2 diabetes patients. Among these studies, all show the lower blood glucose response of isomaltulose and where tested also show the associated reduction in the blood insulin response. A significant role for the incretin hormone GLP 1 has been established, which is secreted in response to distal carbohydrate absorption and limits the rise in blood glucose concentration after a meal. following the publication of a positive opinion from the European Food Safety Authority. In the long term, when eating a diet including carbohydrate, avoiding undesirably high concentrations of glucose in blood and the associated demand for insulin, is supportive of the prevention and management of diabetes mellitus, cardiovascular disease, and possibly overweight and obesity—as indicated by the International Carbohydrate Quality Consortium consensus of expert nutrition scientists. Continuous monitoring of 24 h blood glucose concentration following diets including isomaltulose instead of sucrose lowers the blood glucose profile over the day, as a result of a lower blood glucose response to individual meals. A lower glycemic diet can be achieved by choosing foods with low or reduced glycemic properties, more specifically by choosing lower GI foods from within each food group (fruit, vegetable, whole grains, etc.). The use of Isomaltulose in place of sucrose and other carbohydrates allows for the production of foods with reduced GI. Several studies provide evidence of improvements in both blood glucose control and lipid metabolism in both diabetic and non diabetic persons upon regular consumption of isomaltulose when compared with other carbohydrates such as sucrose, maltodextrin, or glucose.

Compared to other carbohydrates, isomaltulose ingestion is associated with higher rates of fat oxidation and lower rates of fat storage. First, isomaltulose "dives" under entsymatic radar surpassin GIP producing upper part of the small intestine. It finds the degrading entsyme deep down in the GLP part of the intestine. GLP/GIP balance favors late insulin secretion, and shuts down glucagon secretion. Thus the release or new production of liver glucose is slowed down. Mechanistically this involves a lower blood glucose concentration with reduced insulin secretion, which in turn allows more fatty acids to be released from adipose tissue for oxidation as an energy source. The lower insulin concentration also decreases carbohydrate oxidation, allowing more fatty acids to be oxidized. A lower insulin concentration also lowers the rate of liver free fatty acid recycling via plasma VLDL triglycerides and reduces the storage of triglycerides in adipose tissue. Practical implications include higher rates of fat oxidation after ingestion of isomaltulose than higher glycaemic carbohydrates. This has been shown in many studies with different areas of focus:

Studies have looked at the effects on fat oxidation and other metabolic responses when replacing sugars with isomaltulose in meals (or drinks) taken by healthy or overweight to obese adults, with or without impaired glucose tolerance, while largely sedentary. These studies have shown isomaltulose to have a role in reducing adiposity, at least central obesity. Abdominal fat decreases when consuming isomaltulose instead of sucrose (sugar replacement) or instead of breakfast calories (largely carbohydrate replacement).

Others studies have examined the potential benefits of slow and sustained release of carbohydrate during physical activity. Using isomaltulose in place of other ingested carbohydrates, higher rates of fat oxidation also occur during endurance activities, where preserving glycogen is important. In addition, trials using a recovery protein drink have shown that incorporating isomaltulose and a nutritional supplement (β hydroxy β methylbutyrate ) may help recovery from resistance exercise—so reducing of muscle damage and improving athletic performance.

In people with type 1 diabetes, taking isomaltulose instead of glucose during moderate carbohydrate loading before exercise improves blood glucose control and protects against hypoglycemia while maintaining running performance. The reduced risk of exercise induced hypoglycemia arises in part from a lower requirement for insulin by injection (50% lower) when using isomaltulose and in part from the higher contribution of fat oxidation to energy metabolism, which preserves glycogen stores, further reducing the risk of hypoglycemia.

The rate of glucose supply from dietary carbohydrates can affect cognitive performance, with effects on mood and memory having been shown in several studies that compared isomaltulose with higher glycaemic carbohydrates taken at breakfast, showing improvements in mood and memory in healthy children, middle aged adults, and aged adults.

Isomaltulose is ‘kind to teeth’. Fermentation of carbohydrates by bacteria in the mouth (especially on the teeth) is responsible for the formation of dental plaque and oral acids. The acid initiates tooth demineralisation and tooth decay (dental caries). Isomaltulose largely resists fermentation by oral bacteria and is the first carbohydrate of its kind with negligible acid production on teeth, as shown by pH telemetry. The evidence is strong and provides the basis for ‘kind to teeth’ claims approved by both the Food and Drug Administration in the USA and European authorities following a positive opinion from the European Food Safety Authority. Analytical methods for characterization and assay of commercial isomaltulose are laid down, for example, in the Food Chemicals Codex.

Isomaltulose is used in foods, drinks and health products owing to several of its properties. It is used in foods and beverages, where it provides a natural sucrose like sweetness profile with a sweetening power about half that of sucrose, and no aftertaste. Isomaltulose in permitted for use in foods and drinks in many regions worldwide. For example, it is generally recognized as safe (GRAS) by the U. S. Food and Drug Administration, and in Japan has the status FOSHU (food for specific health use). Isomaltulose is hydrogenated to produce isomalt, a minimally digestible carbohydrate that is used as a sugar replacer, for example in sugar free candies and confectionery.