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Facility that manages aerospace vehicle flights

A mission control center (MCC, sometimes called a flight control center or operations center) is a facility that manages space flights, usually from the point of launch until landing or the end of the mission. It is part of the ground segment of spacecraft operations. A staff of flight controllers and other support personnel monitor all aspects of the mission using telemetry, and send commands to the vehicle using ground stations. Personnel supporting the mission from an MCC can include representatives of the attitude control system, power, propulsion, thermal, attitude dynamics, orbital operations and other subsystem disciplines. The training for these missions usually falls under the responsibility of the flight controllers, typically including extensive rehearsals in the MCC.

United States missions are, prior to liftoff, controlled from the Launch Control Center (LCC) located at NASA's Kennedy Space Center on Merritt Island, Florida. Responsibility for the booster and spacecraft remains with the Launch Control Center until the booster has cleared the launch tower. After liftoff, responsibility is handed over to NASA's Mission Control Center in Houston, Texas (abbreviated MCC H, full name Christopher C. Kraft Jr. Mission Control Center), at the Lyndon B. Johnson Space Center. NASA's Mission Control Center in Houston also manages the U. S. portions of the International Space Station (ISS).

The Mission Control Center of the Russian Federal Space Agency (Центр управления полётами), also known by its acronym ЦУП ("TsUP") is located in Korolyov, near the RKK Energia plant. It contains an active control room for the ISS. It also houses a memorial control room for the Mir where the last few orbits of Mir before it burned up in the atmosphere are shown on the display screens.

The Mission Control Center of the Indian Space Research Organisation is located at Satish Dhawan Space Centre, Sriharikota, India.

European Space Operations Centre (ESOC) is responsible for ESA's satellites and space probes. It is located in Darmstadt, Germany.

German Space Operations Center (GSOC) is responsible for DLR's satellites and other customers' missions. It is located in Oberpfaffenhofen near Munich, Germany. The Columbus Control Centre (Col CC) at the German Aerospace Center (DLR) in Oberpfaffenhofen, Germany. It is the mission control center for the European Columbus research laboratory at the International Space Station. The Galileo Control Center (GCC) at the German Aerospace Center (DLR) in Oberpfaffenhofen, Germany. It is one of the mission control centers for the European Galileo Navigation System.

The French National Centre for Space Studies (CNES) ATV Control Centre (ATV CC) is located at the Toulouse Space Centre (CST) in Toulouse, France. It is the mission control center for the European Automated Transfer Vehicles, that regularly resupply ISS.

Beijing Aerospace Command and Control Center is a command center for the Chinese space program which includes the Shenzhou missions. The building is inside a complex nicknamed Aerospace City. The city is located in a suburb northwest of Beijing.

The Jet Propulsion Laboratory (JPL) in Pasadena, California manages all of NASA's uncrewed spacecraft outside Earth's orbit and several research probes within along with the Deep Space Network from the Space Flight Operations Facility.