Буфоталин: Қасиеттері, қауіптері және қатерлі ісікке қарсы әлеуеті

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| ImageFile=Bufotalin. svg
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| IUPACName = 3β,14 Dihydroxy 5β bufa 20,22 dienolid 16β yl acetate
| SystematicName = (1R,2S,3aS,3bR,5aR,7S,9aS,9bS,11aR) 3a,7 Dihydroxy 9a,11a dimethyl 1 (1 oxo 1H oxan 5 yl)hexadecahydro 1H cyclopenta[a]phenanthren 2 yl acetate
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| MainHazards=Toxic
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| LD50= 4.13 mg·kg−1 (mouse, IV)
0.4 mg·kg−1 (mouse, SC)
0.136 mg·kg−1 (cat, IV) Bufotalin can be extracted from the skin parotoid glands of several types of toad.

Bufotalin is part of Ch'an Su, a traditional Chinese medicine used for cancer. It is also known as Venenum Bufonis or senso (Japanese).

Specifically, in cats the lethal median dose is 0.13 mg/kg. and in dogs is 0.36 mg/kg (intravenous). Recent animal studies have shown that taurine restores cardiac functions. Symptomatic measures include lignocaine, atropine and phenytoin for cardiac toxicity and intravenous potassium compounds to correct hyperkalaemia from its effect on the Na+/K+ ATPase pump. It also increases cancer cell's susceptibility to apoptosis via TNF α signalling by the BH3 interacting domain death agonist and STAT proteins. Bufotalin induces apoptosis in vitro in human hepatocellular carcinoma Hep 3B cells and might involve caspases and apoptosis inducing factor (AIF). The use of bufotalin as a cancer treating compound is still in the experimental phase. It also arrests cell cycle at G(2)/M, by up and down regulation of several enzymes.

The mechanism of the biotransformation of bufotalin is still unknown. Researches found, that bufotalin is biotransformed into at least 5 different compounds.

If bufotalin is esterified with suberyl arginine, the bufotalin like steroid bufotoxin is obtained.