Ихтиол: Қолданысы мен қасиеттері

Chemical compound

Ichthammol or ammonium bituminosulfonate (brand name Ichthyol) is a medication derived from sulfur rich oil shale (bituminous schists). It is used (sometimes in combination with zinc oxide) as a treatment for different skin diseases, including eczema and psoriasis (see below). It is applied on the skin as an ointments, most commonly containing 10% or 20% ichthammol. Bituminosulfonates are considered topical therapeutic agents with very good tolerability. The use of ichthammol in dermatology was promoted by German physician Paul Gerson Unna. Ichthammol ointments, commonly known as black ointment or drawing salve, should not be confused with black salve, an escharotic (corrosive) paste intended to destroy skin tissue. In contrast, ichthammol does not have any corrosive properties on the skin.

Ichthammol is obtained through three steps from bituminous schists: dry distillation, sulfonation of the resulting oil (or purified fractions thereof), and finally neutralization with ammonia. However, as a product of natural origin, it is a mixture of many different compounds.

Similar substances can be made by altering the starting material. An "ammonium sufobitol" (Tumenol Ammonium), made from light shale oil of the Messel pit, was sold until 2000 in Germany. The Chinese material labelled as "ichthammol" are actually an ersatz product made from vegetable oil.

Ichtasol (USAN: Ictasol) is produced from the light (as opposed to heavy) fraction of distilled shale oil. It has a pale appearance. There appears to be an oral preparation made from this mixture.</blockquote>

As a result, Chinese "ichthammol" is very different from standard ichthammol. The characteristic bitumen like odor (originating from the bituminous source material) is missing with Chinese material.

It is used to treat a variety of skin disorders as e. g. eczema, psoriasis, Acne rosacea and acne. According to the "list of preferred Specials" by the British Association of Dermatologists (BAD) ichthammol can be used in dermatology prescribing to treat acutely inflamed atopic eczema, among others. A corresponding recommendation exists for bituminosulfonates in Germany. According to “guideline atopic eczema” bituminosulfonates can be considered for treatment of atopic eczema based on general clinic experience. In the European Dermatology Forum (EDF) guidelines for treatment of atopic eczema ichthammol is recommended as a useful addition to the basic treatment regimen, especially in mild disease or if TCS treatment is not possible from a patient’s perspective, e. g. corticophobia (steroid phobia).

In otology, a mixture of glycerol and ichthammol (G & I) is used for the topical treatment of ear infections. It is effective against Gram positive bacteria. The anti inflammatory action is explained by its influence on the formation, secretion, and effect of inflammation mediators.

Ichthammol is available in pharmacies for compounding medications. Different sources of information exist for exemplary formulations (creams, shake lotions, suppositories, etc. ).

Ichthammol has anti inflammatory, bactericidal, and fungicidal properties.

The European Medicines Agency published a summary report on ichthyol substances (synonym: bituminosulfonates) during the course of the European Maximum Residue Limits (MRL) procedure in veterinary medicine. The Committee for Medicinal Products for Veterinary Use (CVMP) decided that due to good tolerance and safety, there is no need to establish an MRL for ichthyol substances. As a result, ichthyol substances can be applied topically in all mammalian food producing species without restriction.