Карпрофен: қолдану, жанама әсерлер және қауіпсіздік шаралары

Non steroidal anti inflammatory drug
Pfizer voluntarily removed the medication from the market for human use on commercial grounds. It aids in the relief of inflammation, pain, and fever. Carprofen can be administered in pill, chewable tablet, or injection form. Carprofen can be used for long term pain management of such conditions as osteoarthritis, which is common in canine patients, or after surgical procedures for relief of acute pain and inflammation. In patients suffering from pain, carprofen has been shown to improve energy, activity level, comfort, and general well being. In 1999, the Food and Drug Administration (FDA) received more than six thousand anecdotal reports of sudden animal death after usage of Pfizer's Rimadyl brand of carprofen. In response, the FDA requested that Pfizer advise consumers in their advertising that death is a possible side effect; Pfizer refused and pulled their advertising, later including death as a possible side effect on the drug label. Adverse effects can include:
Loss of appetite
Vomiting
Diarrhea
Increase in thirst
Increase in urination
Fatigue and/or lethargy (drowsiness)
Loss of coordination
Seizures
Liver dysfunction: jaundice (yellowing of eyes)
Blood or dark tarry material in urine or stools
Lethargy
Staggering, stumbling, weakness or partial paralysis, full paralysis
Change in skin (redness, scabs, or scratching)
Change in behavior (such as decreased or increased activity level, seizure or aggression)
In rare situations, death has been associated with some of the adverse reactions listed above. Effects of overdose include gastritis and ulcer formation. In healthy dogs given carprofen, no perioperative adverse effects on the cardiovascular system have been reported at recommended dosages. Perioperative administration of carprofen to cats did not affect postoperative respiratory rate nor heart rate. Carprofen should not be administered concurrently with steroids, as this can cause ulcers in the stomach. Dogs should be taken off carprofen for three full days before ingesting a steroid (such as prednisolone). Carprofen should not be given at the same time with other types of medications, such as other NSAIDs (aspirin, etodolac, deracoxib, meloxicam, tepoxalin), or steroids such as dexamethasone, triamcinolone, cortisone, or prednisone. Carprofen must be used with caution within the supervision of a veterinarian in dogs with liver or kidney disease, dehydration, bleeding deficits, or other health problems. It is not recommended for use in dogs with bleeding disorders (such as Von Willebrand's disease), as safety has not been established in dogs with these disorders. It has not been established whether carprofen can be safely used in pregnant dogs, dogs used for breeding purposes, or in lactating dogs. Several laboratory studies and clinical trials have been conducted to establish the safety of using carprofen. Clinical studies were conducted in nearly 300 dogs of different breeds. The dogs were treated with Rimadyl at the recommended dose for two weeks. According to these studies, the drug was clinically well tolerated, and the treated dogs did not have a greater incidence of adverse reactions when compared to the control group. A number of factors may contribute to the high incidence of adverse reports received for carprofen by the Center for Veterinary Medicine in the late 1990s. These include:
The type of drug;
Wide use;
Duration of use. Long term use can result in a higher risk for adverse reactions. It is recommended that blood tests for liver and kidney function are performed both prior to starting and regularly while on NSAIDs to monitor the patient’s tolerance;
Senior dog use. Older dogs are generally more prone to side effects caused by carprofen.

Carprofen may be administered intravenously to horses. A single dose has been shown to reduce prostaglandin E2 production and inflammatory exudate for up to 15 hours, although there was less effect on eicosanoid production when compared to the effects produced by NSAIDs such as phenylbutazone or flunixin. Prostaglandin E2 and inflammatory exudate are also reduced and leukotriene B4 is inhibited. Carprofen can also be given orally, but intramuscular use may produce muscle damage.

Carprofen is used as an analgesic for mouse surgical procedures. Carprofen may also be used on adult fish.

It is marketed under many brand names including: Acticarp, Artriofin, Austiofen, Bomazeal, Canidryl, Carporal, Carprieve, Carprocow, Carprodolor, Carprodyl, Carprofelican, Carprofen, Carprofène, Carprofeno, Carprofenum, Carprogesic, Carprosol, Carprotab, Carprox, Comforion, Dolagis, Dolocarp, Dolox, Eurofen, Kelaprofen, Librevia, Norocarp, Norodyl, Novocox, Ostifen, Prolet, Quellin, Reproval, Rimadyl, Rimifin, Rofeniflex, Rovera, Rycarfa, Scanodyl, Tergive, Vetprofen, and Xelcor. and more recent a 50mg Caplet called Carprox for senior dogs aged 10 years+.