Иттердің мидың қабынуы және некрозы (NME) ауруы

Dog disease
Necrotizing meningoencephalitis (NME) is a fatal inflammatory central nervous system (CNS) disorder in dogs, where an extensive cerebral necrosis is associated with a multifocal, non suppurative meningoencephalitis of the neuro cortex. It was originally identified and recorded in the 1960s in pure breed pugs, with which this disease is nowadays mostly associated with, occurring essentially in small breed dogs ranging from six months to seven years of age. It causes intense necrotizing inflammatory lesions in the brain stem and Cerebellum. The pathogen that triggers the disease and contributes to its development has not yet been identified. It is presumed to have a multifactorial, heritable, autoimmune etiology.

In several studies the animals were given immunosuppressive drugs, such as cytarabine, prednisolone and dexamethasone on the behalf that the cause of NME is autoimmune related. Corticosteroids inhibit T and B Cells and slow down the production of cytokines, which restrain the immune system from attacking its own cells but also enfeeble its natural protection – the immune answer. However, since the etiopathogenesis is still not totally understood, the inflammatory reactions are only partly reacting to the corticosteroids, such as the malacic or granulomatous changes.

Even after several years of research, the complete pathogenesis of this disease is still not understood. Immunosuppressive and anticonvulsant drugs have extended the lives of several dogs for up to 7 months after the outbreak of the symptoms, although a complete recovery is not yet possible. The disease remains fatal, making euthanasia an invariable necessity.