Полисомнография: многопараметрическое исследование сна и расстройств сна.

Multi parameter study of sleep and sleep disorders

Polysomnography (PSG), a type of sleep study, is a multi parameter study of sleep and a diagnostic tool in sleep medicine. The test result is called a polysomnogram, also abbreviated PSG. The name is derived from Greek and Latin roots: the Greek πολύς (polus for "many, much", indicating many channels), the Latin somnus ("sleep"), and the Greek γράφειν (graphein, "to write"). Type I polysomnography is a sleep study performed overnight while being continuously monitored by a credentialed technologist. It records the physiological changes that occur during sleep, usually at night, though some labs can accommodate shift workers and people with circadian rhythm sleep disorders who sleep at other times. The PSG monitors many body functions, including brain activity (EEG), eye movements (EOG), muscle activity or skeletal muscle activation (EMG), and heart rhythm (ECG)1. After the identification of the sleep disorder sleep apnea in the 1970s, the breathing functions, respiratory airflow, and respiratory effort indicators were added along with peripheral pulse oximetry. Polysomnography no longer includes NPT monitoring for erectile dysfunction, as it is reported that all male patients will experience erections during phasic REM sleep, regardless of dream content. Limited channel polysomnography, or unattended home sleep tests, is called Type II – IV channel polysomnography. Polysomnography should only be performed by technicians and technologists who are specifically accredited in sleep medicine. However, at times nurses and respiratory therapists perform polysomnography without specific knowledge and training in the field. Polysomnography data can be directly related to sleep onset latency (SOL), REM sleep onset latency, the number of awakenings during the sleep period, the total sleep duration, percentages and durations of every sleep stage, and the number of arousals. But there can also be other information crucial for diagnostics, that are not directly linked with sleep, such as movements, respiration, and cardiovascular parameters. In any case, through polysomnographic evaluation, other information can be obtained (such as body temperature or esophageal pH) according to the patient's or the study's needs. Video EEG polysomnography which combines polysomnography with video recording has been described as more effective than only polysomnography for the evaluation of sleep troubles such as parasomnias, because it allows easier correlation of EEG and polysomnography with bodily motion.

Polysomnography is used to diagnose, or rule out, many types of sleep disorders, including narcolepsy, idiopathic hypersomnia, periodic limb movement disorder (PLMD), REM behavior disorder, parasomnias, and sleep apnea. Although it is not directly useful in diagnosing circadian rhythm sleep disorders, it may be used to rule out other sleep disorders. The use of polysomnography as a screening test for persons having excessive daytime sleepiness as a sole presenting complaint is controversial.

A polysomnogram will typically record a minimum of 12 channels requiring a minimum of 22 wire attachments to the patient. These channels vary in every lab and may be adapted to meet the doctor's requests. There is a minimum of three channels for the EEG, one or two measure airflow, one or two are for chin muscle tone, one or more for leg movements, two for eye movements (EOG), one or two for heart rate and rhythm, one for oxygen saturation, and one each for the belts, which measure chest wall movement and upper abdominal wall movement. The movement of the belts is typically measured with piezoelectric sensors or respiratory inductance plethysmography. This movement is equated to effort and produces a low frequency sinusoidal waveform as the patient inhales and exhales. Wires for each channel of recorded data lead from the patient and converge into a central box, which in turn is connected to a computer system for recording, storing and displaying the data. During sleep, the computer monitor can display multiple channels continuously. In addition, most labs have a small video camera in the room so the technician can observe the patient visually from an adjacent room. The electroencephalogram (EEG) will generally use six "exploring" electrodes and two "reference" electrodes, unless a seizure disorder is suspected, in which case more electrodes will be applied to document the appearance of seizure activity. The exploring electrodes are usually attached to the scalp near the frontal, central (top) and occipital (back) portions of the brain via a paste that will conduct electrical signals originating from the neurons of the cortex. These electrodes will provide a readout of the brain activity that can be "scored" into different stages of sleep (N1, N2, and N3 – which combined are referred to as NREM sleep – and Stage R, which is rapid eye movement sleep, or REM, and Wakefulness). The EEG electrodes are placed according to the International 10 20 system. The electrooculogram (EOG) uses two electrodes; one that is placed 1 cm above the outer canthus of the right eye and one that is placed 1 cm below the outer canthus of the left eye. These electrodes pick up the activity of the eyes in virtue of the electropotential difference between the cornea and the retina (the cornea is positively charged relative to the retina). This helps to determine when REM sleep occurs, of which rapid eye movements are characteristic, and also essentially aids in determining when sleep occurs. The electromyogram (EMG) typically uses four electrodes to measure muscle tension in the body as well as to monitor for an excessive amount of leg movements during sleep (which may be indicative of periodic limb movement disorder, PLMD). Two leads are placed on the chin with one above the jawline and one below. This, like the EOG, helps determine when sleep occurs as well as REM sleep. Sleep generally includes relaxation and so a marked decrease in muscle tension occurs. A further decrease in skeletal muscle tension occurs in REM sleep. A person becomes partially paralyzed to make acting out of dreams impossible, although people that do not have this paralysis can develop REM behavior disorder. Finally, two more leads are placed on the anterior tibialis of each leg to measure leg movements. Though a typical electrocardiogram (ECG or EKG) would use ten electrodes, only two or three are used for a polysomnogram. They can either be placed under the collarbone on each side of the chest or one under the collarbone and the other six inches above the waist on either side of the body. These electrodes measure the electrical activity of the heart as it contracts and expands, recording such features as the "P" wave, "QRS" complex, and "T" wave. These can be analyzed for any abnormalities that might be indicative of an underlying heart pathology. Nasal and oral airflow can be measured using pressure transducers, and/or a thermocouple, fitted in or near the nostrils; the pressure transducer is considered the more sensitive. This allows the clinician/researcher to measure the rate of respiration and identify interruptions in breathing. Respiratory effort is also measured in concert with nasal/oral airflow by the use of belts. These belts expand and contract upon breathing effort. However, this method of respiration may also produce false negatives. Some patients will open and close their mouth while obstructive apneas occur. This forces air in and out of the mouth while no air enters the airway and lungs. Thus, the pressure transducer and thermocouple will detect this diminished airflow and the respiratory event may be falsely identified as a hypopnea, or a period of reduced airflow, instead of an obstructive apnea. Pulse oximetry determines changes in blood oxygen levels that often occur with sleep apnea and other respiratory problems. The pulse oximeter fits over a fingertip or an earlobe. Snoring may be recorded with a sound probe over the neck, though more commonly the sleep technician will just note snoring as "mild", "moderate" or "loud" or give a numerical estimate on a scale of 1 to 10. Also, snoring indicates airflow and can be used during hypopneas to determine whether the hypopnea may be an obstructive apnea.

For the standard test, the patient comes to a sleep lab in the early evening and over the next 1–2 hours is introduced to the setting and "wired up" so that multiple channels of data can be recorded when they fall asleep. The sleep lab may be in a hospital, a free standing medical office, or in a hotel. A sleep technician should always be in attendance and is responsible for attaching the electrodes to the patient and monitoring the patient during the study. During the study, the technician observes sleep activity by looking at the video monitor and the computer screen that displays all the data second by second. In most labs, the test is completed and the patient is discharged home by 7 a. m. unless a Multiple Sleep Latency Test (MSLT) is to be done during the day to test for excessive daytime sleepiness. Most recently, health care providers may prescribe home studies to enhance patient comfort and reduce expense. The patient is given instructions after a screening tool is used, uses the equipment at home and returns it the next day. Most screening tools consist of an airflow measuring device (thermistor) and a blood oxygen monitoring device (pulse oximeter). The patient would sleep with the screening device for one to several days, then return the device to the health care provider. The provider would retrieve data from the device and could make assumptions based on the information given. For example, series of drastic blood oxygen desaturations during night periods may indicate some form of respiratory event (apnea). The equipment monitors, at a minimum, oxygen saturation. More sophisticated home study devices have most of the monitoring capability of their sleep lab technician run counterparts, and can be complex and time consuming to set up for self monitoring.