2C-TFM: Химический профиль и свойства

Psychedelic phenethylamine drug
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| ImageFile1 = 2C TFM 2D. svg
| ImageSize1 = 180px
| ImageFile2 = 2C TFM animation. gif
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| PIN = 2 [2,5 Dimethoxy 4 (trifluoromethyl)phenyl]ethan 1 amine
| OtherNames = 2,5 Dimethoxy 4 (trifluoromethyl)phenethylamine
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|Section2=Chembox Properties
| Formula =
| C=11 | H=14 | F=3 | N=1 | O=2
| MolarMass = 249.23 g/mol
| Appearance =
| Density =
| MeltingPtC = 260
| MeltingPt notes = (hydrochloride)

The mechanism that produces the hallucinogenic and entheogenic effects of 2C TFM is most likely to result from action as a 5 HT2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines. 2C TFM displaced radiolabelled ketanserin from 5 HT2A/C receptors with a Ki of 74.5 nM, as compared to a Ki of 80.9 nM for the more well known 5 HT2A agonist DOI, indicating similar binding affinity at the receptor.

The toxicity of 2C TFM is not known.

It is noted in The Shulgin Index Volume 1: Psychedelic Phenethylamines and Related Compounds where the synthesis is written "from 2C I (with trifluoroacetic anhydride) to 1 (2,5 dimethoxy 4 iodophenyl) 2 (trifluoroacetamido)ethane; (with methyl chlorodifluoroacetate, KF, Cul) to 1 (2,5 dimethoxy 4 trifluoromethylphenyl) 2 (trifluoroacetamido)ethane; (with KOH) to 2C TFM." The synthesis was published by Nichols and his research team. Since 2C TFM is usually synthesised from 2C I and the reaction does not generally consume all of the starting material, samples of 2C TFM are likely to be contaminated with detectable traces of unreacted 2C I, which may pose legal issues in jurisdictions where 2C I is illegal, even though 2C TFM itself may not be prohibited.