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Substances added to food

Food additives are substances added to food to preserve flavor or enhance taste, appearance, or other sensory qualities. Some additives have been used for centuries as part of an effort to preserve food, for example vinegar (pickling), salt (salting), smoke (smoking), sugar (crystallization), etc. This allows for longer lasting foods such as bacon, sweets or wines. With the advent of ultra processed foods in the second half of the twentieth century, many additives have been introduced, of both natural and artificial origin. Food additives also include substances that may be introduced to food indirectly (called "indirect additives") in the manufacturing process, through packaging, or during storage or transport.

To regulate these additives and inform consumers, each additive is assigned a unique number called an "E number", which is used in Europe for all approved additives. This numbering scheme has now been adopted and extended by the Codex Alimentarius Commission to internationally identify all additives, regardless of whether they are approved for use. E numbers are all prefixed by "E", but countries outside Europe use only the number, whether the additive is approved in Europe or not. For example, acetic acid is written as E260 on products sold in Europe, but is simply known as additive 260 in some countries. Additive 103, alkannin, is not approved for use in Europe so does not have an E number, although it is approved for use in Australia and New Zealand. Since 1987, Australia has had an approved system of labelling for additives in packaged foods. Each food additive has to be named or numbered. The numbers are the same as in Europe, but without the prefix "E". The United States Food and Drug Administration (FDA) lists these items as "generally recognized as safe" (GRAS); they are listed under both their Chemical Abstracts Service number and FDA regulation under the United States Code of Federal Regulations. See list of food additives for a complete list of all the names.

With the increasing use of processed foods since the 19th century, food additives are more widely used. Many countries regulate their use. For example, boric acid was widely used as a food preservative from the 1870s to the 1920s, but was banned after World War I due to its toxicity, as demonstrated in animal and human studies. During World War II, the urgent need for cheap, available food preservatives led to it being used again, but it was finally banned in the 1950s. However, after the banning of cyclamates in the United States and Britain in 1969, saccharin, the only remaining legal artificial sweetener at the time, was found to cause cancer in rats. Widespread public outcry in the United States, partly communicated to Congress by postage paid postcards supplied in the packaging of sweetened soft drinks, led to the retention of saccharin, despite its violation of the Delaney clause. However, in 2000, saccharin was found to be carcinogenic in rats due only to their unique urine chemistry. In 2007, Food Standards Australia New Zealand published an official shoppers' guidance with which the concerns of food additives and their labeling are mediated. In the EU it can take 10 years or more to obtain approval for a new food additive. This includes five years of safety testing, followed by two years for evaluation by the European Food Safety Authority (EFSA) and another three years before the additive receives an EU wide approval for use in every country in the European Union. Apart from testing and analyzing food products during the whole production process to ensure safety and compliance with regulatory standards, Trading Standards officers (in the UK) protect the public from any illegal use or potentially dangerous mis use of food additives by performing random testing of food products. There has been significant controversy associated with the risks and benefits of food additives. Natural additives may be similarly harmful or be the cause of allergic reactions in certain individuals. For example, safrole was used to flavor root beer until it was shown to be carcinogenic. Due to the application of the Delaney clause, it may not be added to foods, even though it occurs naturally in sassafras and sweet basil.

In 2012, the EFSA proposed the tier approach to evaluate the potential toxicity of food additives. It is based on four dimensions: toxicokinetics (absorption, distribution, metabolism and excretion); genotoxicity; subchronic (at least 90 data) and chronic toxicity and carcinogenity; reproductive and developmental toxicity. Recent work has demonstrated that certain food additives such as carboxymethylcellulose may cause encroachment of microbes from the gastrointestinal tract into the protective mucus layer that lines the intestines. Additional preclinical work suggests that emulsifiers may disrupt the gut microbiome, cause or exacerbate inflammation, and increase intestinal permeability. Other food additives in processed foods, such as xanthan gum, have also been shown to influence the ecology of human gut microbiomes and may play a role in the divergence of gut microbiomes in industrialized societies as compared to pre industrialized societies. Although still controversial, some scientists hypothesize that these changes to human gut microbiomes may be a contributing factor to the rise in chronic inflammatory diseases in industrialized populations.

A subset of food additives, micronutrients added in food fortification processes preserve nutrient value by providing vitamins and minerals to foods such as flour, cereal, margarine and milk which normally would not retain such high levels. Added ingredients, such as air, bacteria, fungi, and yeast, also contribute manufacturing and flavor qualities, and reduce spoilage.

The United States Food and Drug Administration (FDA) defines a food additive as "any substance the intended use of which results or may reasonably be expected to result directly or indirectly in its becoming a component or otherwise affecting the characteristics of any food". In order for a novel food additive to be approved in the U. S., a food additive approval petition (FAP) must be submitted to the FDA. The identity of the ingredient, the proposed use in the food system, the technical effect of the ingredient, a method of analysis for the ingredient in foods, information on the manufacturing process, and full safety reports must be defined in a FAP. For FDA approval of a FAP, the FDA evaluates the chemical composition of the ingredient, the quantities that would be typically consumed, acute and chronic health impacts, and other safety factors.