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This list of dog diseases is a selection of diseases and other conditions found in the dog. Some of these diseases are unique to dogs or closely related species, while others are found in other animals, including humans. Not all of the articles listed here contain information specific to dogs. Articles with non dog information are marked with an asterisk (*).

Rabies (hydrophobia) is a fatal viral disease that can affect any mammal, although the close relationship of dogs with humans makes canine rabies a zoonotic concern. Vaccination of dogs for rabies is commonly required by law. Please see the article dog health for information on this disease in dogs. Canine parvovirus is a sometimes fatal gastrointestinal infection that mainly affects puppies. It occurs worldwide. Canine coronavirus is a gastrointestinal disease that is usually asymptomatic or with mild clinical signs. The signs are worse in puppies. Canine distemper is an often fatal infectious disease that mainly has respiratory and neurological signs. Canine influenza is a newly emerging infectious respiratory disease. Up to 80 percent of dogs infected will have symptoms, but the mortality rate is only 5 to 8 percent. Infectious canine hepatitis is a sometimes fatal infectious disease of the liver. Canine herpesvirus is an infectious disease that is a common cause of death in puppies less than three weeks old. Pseudorabies (Morbus Aujeszky) is an infectious disease that primarily affects swine, but can also cause a fatal disease in dogs with signs similar to rabies. Canine minute virus is an infectious disease that can cause respiratory and gastrointestinal signs in young puppies.

Brucellosis is a sexually transmitted bacterial disease that can cause uveitis, abortion, and orchitis in dogs. Lyme disease* is a disease caused by Borrelia burgdorferi, a spirochaete, and spread by ticks of the genus Ixodes. Symptoms in dogs include acute arthritis, anorexia and lethargy. There is no rash as is typically seen in humans. Ehrlichiosis is a disease caused by Ehrlichia canis and spread by the brown dog tick, Rhipicephalus sanguineus. Signs include fever, vasculitis, and low blood counts. Clostridium species are a potential cause of diarrhea in dogs. Associated species include C. perfringens and C. difficile. Kennel cough is an infectious respiratory disease which can be caused by one of several viruses or by Bordetella bronchiseptica. It most commonly occurs in dogs in close confinement such as kennels.

Megaesophagus is a disease of the esophagus characterized by low motility and dilation. Most cases in adult dogs are idiopathic. It is the most common cause of regurgitation in dogs. Other causes of megaesophagus include myasthenia gravis, lead poisoning, and Addison's disease. Gastric dilatation volvulus, commonly known as bloat, is a serious condition in which the stomach swells with air (gastric dilatation), sometimes twisting on itself (volvulus). Deep chested breeds are at a higher risk of bloating. Factors that predispose dogs to this condition are intestinal foreign bodies, intestinal cancer, intussusception, and other intestinal diseases. It has a poor prognosis. Foreign body is an object foreign to the body that becomes lodged in the gastrointestinal tract (or other part of the dog). Dogs are susceptible to gastrointestinal obstruction due to their ability to swallow relatively large objects and pass them through the esophagus. Foreign bodies most commonly become lodged in the stomach because of the inability to pass through the pyloric sphincter, and in the jejunum. Anal fistulae*, known as perianal fistulae in dogs, are most common in German Shepherd Dogs. They are characterized by draining tracts in the skin around the anus. The cause is unknown. Surgical treatment is common, but recently use of cyclosporine in combination with ketoconazole has been shown to be effective. Exocrine pancreatic insufficiency is the inability to properly digest food due to a lack of digestive enzymes made by the pancreas. This disease is found frequently in dogs. Inflammatory bowel disease (IBD)* is a group of diseases in dogs that are idiopathic and characterized by the presence of inflammatory cell infiltrates in the stomach and/or intestinal walls. It is a common condition. Signs include vomiting, diarrhea, and weight loss. Treatment is with dietary modification and use of medications such as corticosteroids, metronidazole, sulfasalazine, and azathioprine. Bilious vomiting syndrome is vomiting in response to bile induced inflammation of the stomach. Bile salts interfere with the gastric mucosal barrier, allowing acid to irritate the stomach lining and cause gastritis. Intussusception* is characterized by telescoping of one part of the gastrointestinal tract into another part, forming an obstruction. It is most common in dogs six to eight months old. Surgery is necessary for treatment. Lymphangiectasia is an intestinal disease of dogs characterized by chronic diarrhea and loss of proteins such as serum albumin and globulin. It is considered to be a chronic form of protein losing enteropathy. Breeds commonly affected include the Soft Coated Wheaten Terrier, Norwegian Lundehund, Basenji, and Yorkshire Terrier.

Canine transmissible venereal tumor is a tumor of the external genitalia (penis, vulva). It is spread by sexual contact and is more common in hot and humid climates. Osteosarcoma is an aggressive bone tumor that commonly spreads to the lungs. It is more common in large and giant breed dogs. Lymphoma (lymphosarcoma) is a malignant cancer that is classified by location, cell type, and histological grade. The most common form in dogs is multicentric, involving the lymph nodes. * can be either metastatic or primary in dogs. The incidence of primary tumors is 14.5 per 100,000 dogs at risk. Types include meningioma, astrocytoma, oligodendroglioma, and undifferentiated sarcoma. Coprophagia is the ingestion by a dog of feces, either its own or those of another dog or animal. It can be caused by medical conditions such as exocrine pancreatic insufficiency, overfeeding, or malabsorption. It can also be a behavioral problem characterized by attention seeking, reinforcement, or as a learned behavior. Numerous health problems can arise from this activity, including internal parasites or infection with canine parvovirus or toxoplasmosis. Treatment includes behavioral modification therapy or altering the feces to affect its taste.

Sensitivity to anaesthesia can occur in any breed, but sighthounds have been the breeds most documented to have anesthetic concerns. Sighthounds are known to have prolonged recovery times from ultra short acting thiobarbiturates such as thiopental. Heat stroke can occur in dogs, especially in flat faced breeds such as the Bulldog or in giant breeds. Breed, lack of water, exercise, and high ambient temperature predispose dogs to heat stroke. Signs include vomiting, diarrhea, collapse, difficulty breathing, and body temperature approaching 42 °C to 43 °C. Treatment includes cooling the dogs with wet towels and fans, intravenous fluid therapy, and other supportive care. If a dog's temperature begins to drop to around 40 °C, stop the cooling process. Allow the dog only a couple of laps of water until the temperature begins to drop to a more normal level. Do not allow a dog to gulp large quantities of water. If a dog is panting excessively and then drinks a lot of water, large amounts of air may be swallowed along with the water and this can cause an equally life threatening case of gastric dilatation volvulus (bloat) in the stomach. Foxtails and sandburs can penetrate the lining of the mouth or skin and migrate, causing abscesses and draining tracts.

Acetaminophen (paracetamol, Tylenol) can cause liver damage in dogs. The toxic dose is 150 mg/kg. Ibuprofen (Advil)* can cause gastrointestinal irritation, stomach ulcers, and kidney damage in dogs. Naproxen (Aleve)* has a long half life in dogs and can cause gastrointestinal irritation, anemia, melena (digested blood in feces), and vomiting. Insecticides* used in dogs for fleas and ticks commonly contain either organophosphates or carbamates. They can be absorbed through the skin, conjunctiva, gastrointestinal tract, and lungs. Organophosphates inhibit acetylcholinesterase irreversibly and carbamates inhibit cholinesterase reversibly. Toxicity occurs through overdosage with an appropriate product or use of an agricultural product. Signs for both include hypersalivation, vomiting, lethargy, tremors, difficulty walking, weakness, and death. Lead poisoning* is uncommon in dogs. Exposure to lead is from eating paint chips from lead based paint (found in houses painted prior to 1950), and eating lead objects such as shot, fishing sinkers, or counterweights. Signs of poisoning include vomiting, diarrhea, blindness, seizures, and tremors. Garlic, onions, and chives are toxic to dogs. They cause the destruction of red blood cells known as Heinz body anemia, a form of hemolytic anemia. No clear quantity has been established as to the onset of the anemia. Poisonous reactions can result from raw, cooked or dried onions, garlic, and chives, including those included in powdered or dehydrated forms. Avoid all foods that contain onions or onion variants (such as spaghetti sauce).

Vestibular disease is an uncommon condition in older dogs. Most cases are idiopathic, but it can also be caused by otitis interna, or inner ear infection, tumors, and encephalitis. Signs include nystagmus, head tilt, circling, vomiting, and falling to one side. Idiopathic vestibular disease will usually resolve in a few days to a few weeks. Molera (hole in skull), better known as an open fontanelle, may be a sign of hydrocephalus, but is also a normal finding in toy breeds such as Chihuahua. Anal gland problems are very common, and may include impaction, infection, or abscessation. These glands are normally emptied when the dog defecates. Shar Pei fever is characterized by recurring fever and swelling of the hocks in Shar Peis. It can result in renal and liver failure. Dental disease is very common. Calculus is the most obvious sign, but gingivitis progressing to periodontitis is what results in tooth loss. Treatment involves scaling and polishing of the teeth under general anesthesia and treatment of any periodontal disease. Prevention is very important and can be accomplished through the use of special diets or treats, brushing, and plaque prevention gels. Portosystemic shunt is a bypass of the liver by the body's circulatory system. It can be either a congenital or acquired condition. Perineal hernia is characterized by herniation of abdominal contents through the pelvic diaphragm, which causes swelling on one side of the anus. Primary ciliary dyskinesia is a dysfunction of cilia, which manifests as sperm immotility and respiratory disease. Signs include nasal discharge, recurring pneumonia, and infertility. Symptoms develop soon after birth. Cleft lip and cleft palate are uncommon and generally cause difficulty with nursing, and, more seriously aspiration pneumonia. Gingival hyperplasia is seen in brachycephalic breeds, especially Boxers. It is generally benign, although food and hair impaction is common. Salmon poisoning disease is a fatal disease caused by infection with a rickettsia, either Neorickettsia helminthoeca or Neorickettsia elokominica. Dogs are infected by eating raw salmon from the Pacific Northwest. Systemic lupus erythematosus (SLE) is an immune system disease characterized by the presence of antibodies to nucleic acid and/or antibodies to red blood cells, platelets, lymphocytes, clotting factors, and thyroglobulin. The disease can result in deposition of immune complexes or autoimmune disease. Immune complex deposition can cause vasculitis, meningitis, neuritis, and joint and skin disease. The most commons signs are hemolytic anemia or thrombocytopenia. Myasthenia gravis results from the presence of antibodies to the acetylcholine receptor. Signs include megaesophagus and muscle weakness. Tetanus is a disease caused by the bacteria Clostridium tetani following wound contamination. Dogs are not very susceptible to tetanus. Signs include difficulty opening the mouth and eating, contraction of the facial muscles, and rigid extension of the limbs. Dogs may also get localized tetanus, signs of which include stiffness of a limb spreading to the rest of the body. Polydactyly is the occurrence of extra toes, generally on the preaxial (dewclaw) side. This is more common in certain breeds, such as the Great Pyrenees. Tracheal collapse is characterized by incomplete formation or weakening of the cartilagenous rings of the trachea. It is most common in small and toy breeds. Signs include a cough (often called a "goose honk cough" due to its sound), especially when excited.