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Patriarch of Antioch from c.169 to c.183
There is also a Theophilus of Alexandria (c. 412 AD). Theophilus (Θεόφιλος ὁ Ἀντιοχεύς) was Patriarch of Antioch from 169 until 182. He succeeded Eros c. 169, and was succeeded by Maximus I c. 183, according to Henry Fynes Clinton, but these dates are only approximations. His death probably occurred between 183 and 185. His writings (the only remaining being his apology to Autolycus) indicate that he was born a pagan, not far from the Tigris and Euphrates, and was led to embrace Christianity by studying the Holy Scriptures, especially the prophetical books. He makes no reference to his office in his existing writings, nor is any other fact in his life recorded. Eusebius, however, speaks of the zeal which he and the other chief shepherds displayed in driving away the heretics who were attacking Christ's flock, with special mention of his work against Marcion. He made contributions to the departments of Christian literature, polemics, exegetics, and apologetics. William Sanday describes him as "one of the precursors of that group of writers who, from Irenaeus to Cyprian, not only break the obscurity which rests on the earliest history of the Church, but alike in the East and in the West carry it to the front in literary eminence, and distance all their heathen contemporaries".

Theophilus's apology is most notable for being the earliest extant Christian work to use the word "Trinity" (Greek: τριάς trias; English: three), although it does not use the common formula of "the Father, the Son, and the Holy Spirit" to describe the Trinity. Rather, Theophilus himself puts it as "God, his Word (Logos) and his Wisdom (Sophia)," perhaps following the early Christian practice of identifying the Holy Spirit as the Wisdom of God, as he seems to demonstrate in his interpretation of Psalm 33:6, and which is also expressed in the works his contemporary, Irenaeus of Lyon, who commenting on that selfsame verse writes, “By the word of the Lord were the heavens established, and by his spirit all their power." Since then the Word establishes, that is to say, gives body and grants the reality of being, and the Spirit gives order and form to the diversity of the powers; rightly and fittingly is the Word called the Son, and the Spirit the Wisdom of God. This practice served as a way to express Christian doctrine in a way that is more relatable to contemporary views—to ideas found in Greek philosophy or Hellenistic Judaism in which such concepts as Nous (Mind), Logos (Word, Reason) and Sophia (Wisdom) were common. As the Patripassionist heresies arose, however, the formula of "Father, Son, Holy Spirit" became more prominently featured, as such beliefs denied the persons of the Economy (an earlier developed term for the Trinity). As Theophilus does not appear to be introducing the word Trinity in novel fashion, it is probable that the word was in use before this time. The context for his use of the word Trinity is commentary on the successive work of the creation weeks (Genesis chapters 1–3), where Theophilus expresses the Trinity as follows:

The concept of intermediate divine beings was common to Platonism and certain Jewish sects. In Wisdom (as feminine consort) is described as God's Counsellor and Workmistress, who dwelt beside Him before the creation of the world.

Ad Autolycum 1:13, 2:27 illustrate Theophilus' belief in conditional immortality and judgment at the future resurrection.

The theology of Theophilus was rooted in Jewish ideas and the Hebrew scriptures. Theophilus's quotation from the Old Testament scripture is copious, drawing largely from the Pentateuch and to a smaller extent from the other historical books. His references to Psalms, Proverbs, Isaiah, and Jeremiah are also numerous, and he quotes from Ezekiel, Hosea and other minor prophets. His direct evidence respecting the canon of the New Testament does not go much beyond a few precepts from the Sermon on the Mount, a possible quotation from Luke 18:27, Theophilus seems to have known a collection of Pauline epistles which included at least Romans, I and II Corinthians, Ephesians, Philippians, Colossians and the three Pastoral Epistles. More important is a distinct citation from the opening of the Gospel of St. John (1:1 3), mentioning the evangelist by name, as one of the inspired men by whom the Holy Scriptures were written The use of a metaphor found in 2 Peter 1:19 bears on the date of that epistle. According to Eusebius, Theophilus quoted the Book of Revelation in his work against Hermogenes; a very precarious allusion has been seen in ii. 28, cf. Revelation 12:3, 7, etc. A full index of these and other possible references to the Old and New Testament is given by Otto. Although Theophilus cites the opening of the Gospel of St. John (1:1), he does not go on to speak of the incarnation of the Word and his (Jesus's) atoning sacrificial death. While Theophilus makes no mention of the name of Jesus or use the word Christ or the phrase Son of God, he identifies the Logos as the Son of God in his second letter, when he writes,For the divine writing itself teaches us that Adam said that he had heard the voice. But what else is this voice but the Word of God, who is also His Son? Not as the poets and writers of myths talk of the sons of gods begotten from intercourse [with women], but as truth expounds, the Word, that always exists, residing within the heart of God. For before anything came into being He had Him as a counsellor, being His own mind and thought. But when God wished to make all that He determined on, He begot this Word, uttered, the first born of all creation, not Himself being emptied of the Word [Reason], but having begotten Reason, and always conversing with His Reason. And hence the holy writings teach us, and all the spirit bearing [inspired] men, one of whom, John, says, "In the beginning was the Word, and the Word was with God," showing that at first God was alone, and the Word in Him. Then he says, "The Word was God; all things came into existence through Him; and apart from Him not one thing came into existence." The Word, then, being God, and being naturally produced from God, whenever the Father of the universe wills, He sends Him to any place; and He, coming, is both heard and seen, being sent by Him, and is found in a place.

In his third book Theophilus presents a detailed chronology “from the foundation of the world" to emperor Marcus Aurelius. This begins with the Biblical first man Adam through to emperor Marcus Aurelius. Theophilus lived in the reign of this emperor. The chronology puts the creation of the world at about 5529 BC: "All the years from the creation of the world amount to a total of 5,698 years." He uses this chronology to prove that Moses and the other Hebrew prophets preceded the philosophers. The leading chronological epochs correspond to the Old Testament prophets.

The silence regarding his Apology in the East is remarkable; we fail to find the work mentioned or quoted by Greek writers before the time of Eusebius. Several passages in the works of Irenaeus show an undoubted relationship to passages in one small section of the Apologia, but Harnack thinks it probable that the quotations, limited to two chapters, are not taken from the Apologia, but from Theophilus's work against Marcion In the West there are a few references to the Autolycus. It is quoted by Lactantius under the title Liber de Temporibus ad Autolycum. There is a passage first cited by Maranus in Novatian which shows great similarity to the language of Theophilus. In the next century the book is mentioned by Gennadius as "tres libelli de fide." He found them attributed to Theophilus of Alexandria, but the disparity of style caused him to question the authorship.

Jacques Paul Migne's Patrologia Graeca, and a small edition (Cambridge 1852) by W. G. Humphry. Johann Carl Theodor von Otto's edition in the Corpus apologetarum christianorum saeculi secundi vol. ii. (Jena, 1861) is by far the most complete and useful. English translations by Joseph Betty (Oxford 1722), W. B. Flower (London, 1860), Marcus Dods (Clark's Ante Nicene Library), and Robert M. Grant (with the Greek text; Clarendon Press, 1970). This article uses text from A Dictionary of Christian Biography and Literature to the End of the Sixth Century A. D., with an Account of the Principal Sects and Heresies by Henry Wace.