Гиподермическая игла: история, применение и влияние на медицинские исследования.

Device to inject substances into the circulatory system
the theory on mass media effects

A hypodermic needle (from Greek ὑπο (hypo = under), and δέρμα (derma = skin)), one of a category of medical tools which enter the skin, called sharps, is a very thin, hollow tube with one sharp tip. It is commonly used with a syringe, a hand operated device with a plunger, to inject substances into the body (e. g., saline solution, solutions containing various drugs or liquid medicines) or extract fluids from the body (e. g., blood). Large bore hypodermic intervention is especially useful in catastrophic blood loss or treating shock. A hypodermic needle is used for rapid delivery of liquids, or when the injected substance cannot be ingested, either because it would not be absorbed (as with insulin), or because it would harm the liver. It is also useful to deliver certain medications that cannot be delivered orally due to vomiting. There are many possible routes for an injection, with intramuscular (into a muscle) and intravenous (into a vein) being the most common. A hypodermic syringe has the ability to retain liquid and blood in it up to years after the last use and a great deal of caution should be taken to use a new syringe every time. The hypodermic needle also serves an important role in research environments where sterile conditions are required. The hypodermic needle significantly reduces contamination during inoculation of a sterile substrate. The hypodermic needle reduces contamination for two reasons: First, its surface is extremely smooth, which prevents airborne pathogens from becoming trapped between irregularities on the needle's surface, which would subsequently be transferred into the media (e. g. agar) as contaminants; second, the needle's surface is extremely sharp, which significantly reduces the diameter of the hole remaining after puncturing the membrane and consequently prevents microbes larger than this hole from contaminating the substrate.

The ancient Greeks and Romans knew injection as a method of medicinal delivery from observations of snakebites and poisoned weapons. There are also references to "anointing" and "inunction" in the Old Testament as well as the works of Homer, but injection as a legitimate medical tool was not truly explored until the 17th century. Christopher Wren performed the earliest confirmed experiments with crude hypodermic needles, performing intravenous injection into dogs in 1656.

The 19th century saw the development of medicines that were effective in small doses, such as opiates and strychnine. This spurred a renewed interest in direct, controlled application of medicine. "Some controversy surrounds the question of priority in hypodermic medication." Irish physician Francis Rynd is generally credited with the first successful injection in 1844, in the Meath Hospital in Dublin, Ireland. Alexander Wood's main contribution was the all glass syringe in 1851, which allowed the user to estimate dosage based on the levels of liquid observed through the glass. Wood used hypodermic needles and syringes primarily for the application of localized, subcutaneous injection (localized anesthesia) and therefore was not as interested in precise dosages. Charles Hunter, a London surgeon, is credited with the coining of the term "hypodermic" to describe subcutaneous injection in 1858. The name originates from two Greek words: hypo, "under", and derma, "skin". Furthermore, Hunter is credited with acknowledging the systemic effects of injection after noticing that a patient's pain was alleviated regardless of the injection's proximity to the pained area.

Dr. Francis Rynd (1801–1861) used the first "Hollow Needle" as a hypodermic syringe on Ms. Margaret Cox 6/3/1844 in Ireland. Dr. Wood can be largely credited with the popularization and acceptance of injection as a medical technique, as well as the widespread use and acceptance of the hypodermic needle. The basic technology of the hypodermic needle has stayed largely unchanged since the 19th century, but as the years progressed and medical and chemical knowledge improved, small refinements have been made to increase safety and efficacy, with needles being designed and tailored for very particular uses. Hypodermic needles remain essential to large volume administration or exchange in settings of trauma or dialysis. The trend of needle specification for use began in the 1920s, particularly for the administration of insulin to diabetics. The onset of World War II spurred the early development of partially disposable syringes for the administration of morphine and penicillin on the battlefield. Development of the fully disposable hypodermic needle was spurred on in the 1950s for several reasons. The Korean War created blood shortages and in response disposable, sterile syringes were developed for collecting blood. The widespread immunization against polio during the period required the development of a fully disposable syringe system. This period also marked a shift in interest from needle specifications to general sterility and safety.

Hypodermic needles are normally made from a stainless steel or Niobium tube through a process known as tube drawing where the tube is drawn through progressively smaller dies to make the needle. The end of the needle is bevelled to create a sharp pointed tip, letting the needle easily penetrate the skin.

The main system for measuring the diameter of a hypodermic needle is the Birmingham gauge (also known as the Stubs Iron Wire Gauge); the French gauge is used mainly for catheters. Various needle lengths are available for any given gauge. Needles in common medical use range from 7 gauge (the largest) to 34 (the smallest). 21 gauge needles are most commonly used for drawing blood for testing purposes, and 16 or 17 gauge needles are most commonly used for blood donation, as the larger luminal cross sectional area results in lower fluid shear, reducing harm to red blood cells while also allowing more blood to be collected in a shorter time. Although reusable needles remain useful for some scientific applications, disposable needles are far more common in medicine. Disposable needles are embedded in a plastic or aluminium hub that attaches to the syringe barrel by means of a press fit or twist on fitting. These are sometimes referred to as "Luer Lock" connections, referring to the trademark Luer Lok. The male and female luer lock and hub—produced by pharmaceutical equipment manufacturers—are two of the most critical parts of disposable hypodermic needles.

Hypodermic needles are usually used by medical professionals (dentists, phlebotomists, physicians, pharmacists, nurses, paramedics), but they are sometimes used by patients themselves. This is most common with type one diabetics, who may require several insulin injections a day. It also occurs with patients who have asthma or other severe allergies. Such patients may need to take desensitization injections or they may need to carry injectable medicines to use for first aid in case of a severe allergic reaction. In the latter case, such patients often carry a syringe loaded with epinephrine (e. g. EpiPen), diphenhydramine (e. g. Benadryl), or dexamethasone. Rapid injection of one of these drugs may stop a severe allergic reaction. Multiple sclerosis patients may also treat themselves by injection; several MS therapies, including various interferon preparations, are designed to be self administered by subcutaneous or intramuscular injection. Hypodermic needles are also used for erotic piercing.

It is estimated that anywhere from nearly 3.5 to 10% of the world's population may have a phobia of needles (trypanophobia), and it is much more common in children, ages 5–17. Topical anesthetics can be used to desensitize the area where the injection will take place to reduce pain and discomfort. For children various techniques may be effective at reducing distress or pain related to needles. Techniques include: distraction, hypnosis, combined cognitive behavioral therapy, and breathing techniques.