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Philosophical views that question the possibility of knowledge or certainty
a more general discussion of skepticism

Philosophical skepticism (UK spelling: scepticism; from Greek σκέψις skepsis, "inquiry") is a family of philosophical views that question the possibility of knowledge. It differs from other forms of skepticism in that it even rejects very plausible knowledge claims that belong to basic common sense. Philosophical skeptics are often classified into two general categories: Those who deny all possibility of knowledge, and those who advocate for the suspension of judgment due to the inadequacy of evidence. In some cases, it is even proclaimed that one does not know that "I have two hands" or that "the sun will come out tomorrow". From this observation, it is argued that the belief does not amount to knowledge. Philosophical skepticism follows from the consideration that this might be the case for most or all beliefs. Because of its wide ranging consequences, it is of central interest to theories of knowledge since it questions their very foundations. In this regard, we may have relatively secure beliefs in some cases but these beliefs never amount to knowledge. Weaker forms of philosophical skepticism restrict this rejection to specific fields, like the external world or moral doctrines. In some cases, knowledge per se is not rejected but it is still denied that one can ever be absolutely certain. In ancient philosophy, skepticism was seen not just as a theory about the existence of knowledge but as a way of life. This outlook is motivated by the idea that suspending one's judgment on all kinds of issues brings with it inner peace and thereby contributes to the skeptic's happiness.

Skepticism can be classified according to its scope. Local skepticism involves being skeptical about particular areas of knowledge (e. g. moral skepticism, skepticism about the external world, or skepticism about other minds), whereas radical skepticism claims that one cannot know anything—including that one cannot know about knowing anything. Skepticism can also be classified according to its method. Western philosophy has two basic approaches to skepticism. Cartesian skepticism—named somewhat misleadingly after René Descartes, who was not a skeptic but used some traditional skeptical arguments in his Meditations to help establish his rationalist approach to knowledge—attempts to show that any proposed knowledge claim can be doubted. Agrippan skepticism focuses on justification rather than the possibility of doubt. According to this view, none of the ways in which one might attempt to justify a claim are adequate. One can justify a claim based on other claims, but this leads to an infinite regress of justifications. One can use a dogmatic assertion, but this is not a justification. One can use circular reasoning, but this fails to justify the conclusion.

A skeptical scenario is a hypothetical situation which can be used in an argument for skepticism about a particular claim or class of claims. Usually the scenario posits the existence of a deceptive power that deceives our senses and undermines the justification of knowledge otherwise accepted as justified, and is proposed in order to call into question our ordinary claims to knowledge on the grounds that we cannot exclude the possibility of skeptical scenarios being true. Skeptical scenarios have received a great deal of attention in modern Western philosophy. The first major skeptical scenario in modern Western philosophy appears in René Descartes' Meditations on First Philosophy. At the end of the first Meditation Descartes writes: "I will suppose that some evil demon of the utmost power and cunning has employed all his energies to deceive me." The "evil demon problem", also known as "Descartes' evil demon", was first proposed by René Descartes. It invokes the possibility of a being who could deliberately mislead one into falsely believing everything that you take to be true. The "brain in a vat" hypothesis is cast in contemporary scientific terms. It supposes that one might be a disembodied brain kept alive in a vat and fed false sensory signals by a mad scientist. Further, it asserts that since a brain in a vat would have no way of knowing that it was a brain in a vat, you cannot prove that you are not a brain in a vat. The "dream argument", proposed by both René Descartes and Zhuangzi, supposes reality to be indistinguishable from a dream. The "five minute hypothesis", most notably proposed by Bertrand Russell, suggests that we cannot prove that the world was not created five minutes ago (along with false memories and false evidence suggesting that it was not only five minutes old). The "simulated reality hypothesis" or "Matrix hypothesis" suggests that everyone, or even the entire universe, might be inside a computer simulation or virtual reality. The "Solipsistic" theory that claims that knowledge of the world is an illusion of the Self.

Skepticism, as an epistemological view, calls into question whether knowledge is possible at all. This is distinct from other known skeptical practices, including Cartesian skepticism, as it targets knowledge in general instead of individual types of knowledge. Skeptics argue that belief in something does not justify an assertion of knowledge of it. In this, skeptics oppose foundationalism, which states that there are basic positions that are self justified or beyond justification, without reference to others. (One example of such foundationalism may be found in Spinoza's Ethics.) The skeptical response to this can take several approaches. First, claiming that "basic positions" must exist amounts to the logical fallacy of argument from ignorance combined with the slippery slope. Among other arguments, skeptics use the Münchhausen trilemma and the problem of the criterion to claim that no certain belief can be achieved. This position is known as "global skepticism" or "radical skepticism." Foundationalists have used the same trilemma as a justification for demanding the validity of basic beliefs. Epistemological nihilism rejects the possibility of human knowledge, but not necessarily knowledge in general. There are two different categories of epistemological skepticism, which can be referred to as mitigated and unmitigated skepticism. The two forms are contrasting but are still true forms of skepticism. Mitigated skepticism does not accept "strong" or "strict" knowledge claims but does, however, approve specific weaker ones. These weaker claims can be assigned the title of "virtual knowledge", but must be to justified belief. Some mitigated skeptics are also fallibilists, arguing that knowledge does not require certainty. Mitigated skeptics hold that knowledge does not require certainty and that many beliefs are, in practice, certain to the point that they can be safely acted upon in order to live significant and meaningful lives. Unmitigated skepticism rejects both claims of virtual knowledge and strong knowledge. Characterising knowledge as strong, weak, virtual or genuine can be determined differently depending on a person's viewpoint as well as their characterisation of knowledge. Unmitigated skeptics believe that objective truths are unknowable and that man should live in an isolated environment in order to win mental peace. This is because everything, according to them, is changing and relative. The refusal to make judgments is of uttermost importance since there is no knowledge; only probable opinions. For example, to claim that there is no knowledge seems to be itself a knowledge claim. This problem is particularly relevant for versions of philosophical skepticism that deny any form of knowledge. So the global skeptic denies that any claim is rationally justified but then goes on to provide arguments in an attempt to rationally justify their denial. A closely related objection sees philosophical skepticism as an "idle academic exercise" or a "waste of time". This is often based on the idea that, because of its initial implausibility and distance from everyday life, it has little or no practical value. One defense of philosophical skepticism is that it has had important impacts on the history of philosophy at large and not just among skeptical philosophers. This is due to its critical attitude, which remains a constant challenge to the epistemic foundations of various philosophical theories. It has often provoked creative responses from other philosophers when trying to modify the affected theory to avoid the problem of skepticism. According to Pierre Le Morvan, there are two very common negative responses to philosophical skepticism. The first understands it as a threat to all kinds of philosophical theories and strives to disprove it. According to the second, philosophical skepticism is a useless distraction and should better be avoided altogether. Le Morvan himself proposes a positive third alternative: to use it as a philosophical tool in a few selected cases to overcome prejudices and foster practical wisdom.

Ancient Greek skeptics were not "skeptics" in the contemporary sense of selective, localized doubt. Their concerns were epistemological, noting that truth claims could not be adequately supported, and psychotherapeutic, noting that beliefs caused mental perturbation. The Western tradition of systematic skepticism goes back at least as far as Pyrrho of Elis (b. c. 360 BCE) and arguably to Xenophanes (b. c. 570 BCE). Parts of skepticism also appear among the "5th century sophists [who] develop forms of debate which are ancestors of skeptical argumentation. They take pride in arguing in a persuasive fashion for both sides of an issue." In Hellenistic philosophy, Pyrrhonism and Academic Skepticism were the two schools of skeptical philosophy. Subsequently, the words Academic and Pyrrhonist were often used to mean skeptic.

Like other Hellenistic philosophies, the goal of Pyrrhonism was eudaimonia, which the Pyrrhonists sought through achieving ataraxia (an untroubled state of mind), which they found could be induced by producing a state of epoché (suspension of judgment) regarding non evident matters. Epoché could be produced by pitting one dogma against another to undermine belief, and by questioning whether a belief could be justified. In support of this questioning Pyrrhonists developed the skeptical arguments cited above (the Ten Modes of Aenesidemus and the Five Modes of Agrippa) demonstrating that beliefs cannot be justified:

Pyrrho's thinking subsequently influenced the Platonic Academy, arising first in the Academic skepticism of the Middle Academy under Arcesilaus (c. 315 – 241 BCE) and then the New Academy under Carneades (c. 213–129 BCE). Clitomachus, a student of Carneades, interpreted his teacher's philosophy as suggesting an account of knowledge based on truth likeness. The Roman politician and philosopher, Cicero, was also an adherent of the skepticism of the New Academy, even though a return to a more dogmatic orientation of the school was already beginning to take place.

The most notable figure of the Skepticism revival in the 1500s, Michel de Montaigne wrote about his studies of Academic Skepticism and Pyrrhonism through his Essais. His most notable writings on skepticism occurred in an essay written mostly in 1575–1576, "Apologie de Raimond Sebond," when he was reading Sextus Empiricus and trying to translate Raimond Sebond's writing, including his proof of Christianity's natural existence. The reception to Montaigne's translations included some criticisms of Sebond's proof. Montaigne responded to some of them in Apologie, including a defense for Sebond's logic that is skeptical in nature and similar to Pyrrhonism. His refutation is as follows:
Critics claiming Sebond's arguments are weak show how egoistic humans believe that their logic is superior to others'. Many animals can be observed to be superior to humans in certain respects. To argue this point, Montaigne even writes about dogs who are logical and creates their own syllogisms to understand the world around them. This was an example used in Sextus Empiricus. Since animals also have rationality, the over glorification of man's mental capabilities is a trap—man's folly. One man's reason cannot be assuredly better than another's as a result. Ignorance is even recommended by religion so that an individual can reach faith through obediently following divine instructions to learn, not by one's logic.

Baruch Spinoza was among the first European philosophers who were religious skeptics. He was quite familiar with the philosophy of Descartes and unprecedentedly extended the application of the Cartesian method to the religious context by analyzing religious texts with it. Spinoza sought to dispute the knowledge claims of the Judeo Christian Islamic religious system by examining its two foundations: the Scripture and the Miracles. He claimed that all Cartesian knowledge, or the rational knowledge should be accessible to the entire population. Therefore, the Scriptures, aside from those by Jesus, should not be considered the secret knowledge attained from God but just the imagination of the prophets. The Scriptures, as a result of this claim, could not serve as a base for knowledge and were reduced to simple ancient historical texts. Moreover, Spinoza also rejected the possibility for the Miracles by simply asserting that people only considered them miraculous due to their lack of understanding of the nature. By rejecting the validity of the Scriptures and the Miracles, Spinoza demolished the foundation for religious knowledge claim and established his understanding of the Cartesian knowledge as the sole authority of knowledge claims. Despite being deeply skeptical of the religions, Spinoza was in fact exceedingly anti skeptical towards reason and rationality. He steadfastly confirmed the legitimacy of reason by associating it with the acknowledgement of God, and thereby skepticism with the rational approach to knowledge was not due to problems with the rational knowledge but from the fundamental lack of understanding of God. Spinoza's religious skepticism and anti skepticism with reason thus helped him transform epistemology by separating the theological knowledge claims and the rational knowledge claims.

Pierre Bayle was a French philosopher in the late 17th century that was described by Richard Popkin to be a "supersceptic" who carried out the sceptic tradition to the extreme. Bayle was born in a Calvinist family in Carla Bayle, and during the early stage of his life, he converted into Catholicism before returning to Calvinism. This conversion between religions caused him to leave France for the more religiously tolerant Holland where he stayed and worked for the rest of his life. Bayle's real intention behind his extremely destructive works remained controversial. Some described him to be a Fideist, while others speculated him to be a secret Atheist. However, no matter what his original intention was, Bayle did cast significant influence on the upcoming Age of Enlightenment with his destruction of some of the most essential theological ideas and his justification of religious tolerance Atheism in his works. He especially espoused skepticism regarding inductive reasoning, and questioned what the foundation of morality was, creating the is–ought problem. His approach to skepticism is considered even more radical than that of Descartes. Hume argued that any coherent idea must be either a mental copy of an impression (a direct sensory perception) or copies of multiple impressions innovatively combined. Since certain human activities like religion, superstition, and metaphysics are not premised on any actual sense impressions, their claims to knowledge are logically unjustified. Furthermore, Hume even demonstrates that science is merely a psychological phenomenon based on the association of ideas: often, specifically, an assumption of cause and effect relationships that is itself not grounded in any sense impressions. Thus, even scientific knowledge is logically unjustified, being not actually objective or provable but, rather, mere conjecture flimsily based on our minds perceiving regular correlations between distinct events. Hume thus falls into extreme skepticism regarding the possibility of any certain knowledge. Ultimately, he offers that, at best, a science of human nature is the "only solid foundation for the other sciences".

Immanuel Kant (1724–1804) tried to provide a ground for empirical science against David Hume's skeptical treatment of the notion of cause and effect. Hume (1711–1776) argued that for the notion of cause and effect no analysis is possible which is also acceptable to the empiricist program primarily outlined by John Locke (1632–1704). But, Kant's attempt to give a ground to knowledge in the empirical sciences at the same time cut off the possibility of knowledge of any other knowledge, especially what Kant called "metaphysical knowledge". So, for Kant, empirical science was legitimate, but metaphysics and philosophy was mostly illegitimate. The most important exception to this demarcation of the legitimate from the illegitimate was ethics, the principles of which Kant argued can be known by pure reason without appeal to the principles required for empirical knowledge. Thus, with respect to metaphysics and philosophy in general (ethics being the exception), Kant was a skeptic. This skepticism as well as the explicit skepticism of G. E. Schulze gave rise to a robust discussion of skepticism in German idealistic philosophy, especially by Hegel. Kant's idea was that the real world (the noumenon or thing in itself) was inaccessible to human reason (though the empirical world of nature can be known to human understanding) and therefore we can never know anything about the ultimate reality of the world. Hegel argued against Kant that although Kant was right that using what Hegel called "finite" concepts of "the understanding" precluded knowledge of reality, we were not constrained to use only "finite" concepts and could actually acquire knowledge of reality using "infinite concepts" that arise from self consciousness.

G. E. Moore famously presented the "Here is one hand" argument against skepticism in his 1925 paper, "A Defence of Common Sense". In contemporary philosophy, Richard Popkin was a particularly influential scholar on the topic of skepticism. His account of the history of skepticism given in The History of Scepticism from Savonarola to Bayle (first edition published as The History of Scepticism From Erasmus to Descartes) was accepted as the standard for contemporary scholarship in the area for decades after its release in 1960. Barry Stroud also published a number of works on philosophical skepticism, most notably his 1984 monograph, The Significance of Philosophical Scepticism. From the mid 1990s, Stroud, alongside Richard Fumerton, put forward influential anti externalist arguments in favour of a position called "metaepistemological scepticism". Other contemporary philosophers known for their work on skepticism include James Pryor, Keith DeRose, and Peter Klein. Later Buddhist philosophy remained highly skeptical of Indian metaphysical arguments. The Buddhist philosopher Nagarjuna in particular has been seen as the founder of the Madhyamaka school, which has been in turn compared with Greek Skepticism. Nagarjuna's statement that he has "no thesis" (pratijña) has parallels in the statements of Sextus Empiricus of having "no position". Nagarjuna famously opens his magnum opus, the Mulamadhyamakakarika, with the statement that the Buddha claimed that true happiness was found through dispelling 'vain thinking' (prapañca, also "conceptual proliferation"). According to Richard P. Hayes, the Buddhist philosopher Dignaga is also a kind of skeptic, which is in line with most early Buddhist philosophy. Hayes writes:

in both early Buddhism and in the Skeptics one can find the view put forward that man's pursuit of happiness, the highest good, is obstructed by his tenacity in holding ungrounded and unnecessary opinions about all manner of things. Much of Buddhist philosophy, I shall argue, can be seen as an attempt to break this habit of holding on to opinions. Scholars like Adrian Kuzminski have argued that Pyrrho of Elis (ca. 365–270) might have been influenced by Indian Buddhists during his journey with Alexander the Great.

The Cārvāka (Sanskrit: चार्वाक) school of materialism, also known as Lokāyata, is a classically cited (but historically disputed) school of ancient Indian philosophy. While no texts or authoritative doctrine have survived, followers of this system are frequently mentioned in philosophical treatises of other schools, often as an initial counterpoint against which to assert their own arguments. Cārvāka is classified as a "heterodox" (nāstika) system, characterized as a materialistic and atheistic school of thought. This school was also known for being strongly skeptical of the claims of Indian religions, such as reincarnation and karma.

While Jain philosophy claims that is it possible to achieve omniscience, absolute knowledge (Kevala Jnana), at the moment of enlightenment, their theory of anekāntavāda or 'many sided ness', also known as the principle of relative pluralism, allows for a practical form of skeptical thought regarding philosophical and religious doctrines (for un enlightened beings, not all knowing arihants). According to this theory, the truth or the reality is perceived differently from different points of view, and that no single point of view is the complete truth. Syādvāda is not only an extension of Anekānta ontology, but a separate system of logic capable of standing on its own force. As reality is complex, no single proposition can express the nature of reality fully. Thus the term "syāt" should be prefixed before each proposition giving it a conditional point of view and thus removing any dogmatism in the statement. For Jains, fully enlightened beings are able to see reality from all sides and thus have ultimate knowledge of all things. This idea of omniscience was criticized by Buddhists such as Dharmakirti.

Zhuang Zhou (莊子，"Master Zhuang") was a famous ancient Chinese Taoism philosopher during the Hundred Schools of Thought period. Zhuang Zhou demonstrated his skeptical thinking through several anecdotes in the preeminent work Zhuangzi attributed to him:
"The Debate on the Joy of Fish" (知魚之樂) : In this anecdote, Zhuang Zhou argued with his fellow philosopher Hui Shi whether they knew the fish in the pond were happy or not, and Zhuang Zhou made the famous observation that "You are not I. How do you know that I do not know that the fish are happy?" (Autumn Floods 秋水篇, Zhuangzi)
"The Butterfly of the Dream"(周公夢蝶) : The paradox of "Butterfly Dream" described Zhuang Zhou's confusion after dreaming himself to be a butterfly: "But he didn't know if he was Zhuang Zhou who had dreamt he was a butterfly, or a butterfly dreaming that he was Zhuang Zhou."

Wang Chong (王充) was the leading figure of the skeptic branch of the Confucianism school in China during the first century CE. He introduced a method of rational critique and applied it to the widespread dogmatism thinking of his age like phenomenology (the main contemporary Confucianism ideology that linked all natural phenomena with human ethics), state led cults, and popular superstition. His own philosophy incorporated both Taoism and Confucianism thinkings, and it was based on a secular, rational practice of developing hypotheses based on natural events to explain the universe which exemplified a form of naturalism that resembled the philosophical idea of Epicureans like Lucretius.

The Incoherence of the Philosophers, written by the scholar Al Ghazali (1058–1111), marks a major turn in Islamic epistemology. His encounter with skepticism led Ghazali to embrace a form of theological occasionalism, or the belief that all causal events and interactions are not the product of material conjunctions but rather the immediate and present will of God. In the autobiography Ghazali wrote towards the end of his life, The Deliverance From Error (Al munqidh min al ḍalāl ), Ghazali recounts how, once a crisis of epistemological skepticism was resolved by "a light which God Most High cast into my breast the key to most knowledge," he studied and mastered the arguments of Kalam, Islamic philosophy, and Ismailism. Though appreciating what was valid in the first two of these, at least, he determined that all three approaches were inadequate and found ultimate value only in the mystical experience and spiritual insight he attained as a result of following Sufi practices. William James, in Varieties of Religious Experience, considered the autobiography an important document for "the purely literary student who would like to become acquainted with the inwardness of religions other than the Christian", comparing it to recorded personal religious confessions and autobiographical literature in the Christian tradition.

Recordings of Aztec philosophy suggest that the elite classes believed in an essentially panentheistic worldview, in which teotl represents a unified, underlying universal force. Human beings cannot truly perceive teotl due to its chaotic, constantly changing nature, just the "masks"/facets it is manifested as.